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Protein

MAL-like protein

Gene

MALL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of myelin sheath Source: GO_Central

GO - Biological processi

  • cholesterol homeostasis Source: HGNC
  • myelination Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
MAL-like protein
Alternative name(s):
Protein BENE
Gene namesi
Name:MALL
Synonyms:BENE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144063.3
HGNCiHGNC:6818 MALL
MIMi602022 gene
neXtProtiNX_Q13021

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7851
OpenTargetsiENSG00000144063
PharmGKBiPA30567

Polymorphism and mutation databases

BioMutaiMALL
DMDMi21264403

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568111 – 153MAL-like proteinAdd BLAST153

Proteomic databases

PaxDbiQ13021
PeptideAtlasiQ13021
PRIDEiQ13021
ProteomicsDBi59108

PTM databases

iPTMnetiQ13021
PhosphoSitePlusiQ13021

Expressioni

Gene expression databases

BgeeiENSG00000144063 Expressed in 165 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_MALL
ExpressionAtlasiQ13021 baseline and differential
GenevisibleiQ13021 HS

Organism-specific databases

HPAiHPA051410

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113606, 10 interactors
IntActiQ13021, 56 interactors
STRINGi9606.ENSP00000272462

Structurei

3D structure databases

ProteinModelPortaliQ13021
SMRiQ13021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 153MARVELPROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWII Eukaryota
ENOG410YQN9 LUCA
GeneTreeiENSGT00730000110762
HOGENOMiHOG000231752
HOVERGENiHBG000925
InParanoidiQ13021
OMAiFGCWVWI
OrthoDBiEOG091G0OS1
PhylomeDBiQ13021
TreeFamiTF316174

Family and domain databases

InterProiView protein in InterPro
IPR013295 MAL
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR01884 MALPROTEIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q13021-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPDPPATS YAPSDVPSGV ALFLTIPFAF FLPELIFGFL VWTMVAATHI
60 70 80 90 100
VYPLLQGWVM YVSLTSFLIS LMFLLSYLFG FYKRFESWRV LDSLYHGTTG
110 120 130 140 150
ILYMSAAVLQ VHATIVSEKL LDPRIYYINS AASFFAFIAT LLYILHAFSI

YYH
Length:153
Mass (Da):17,350
Last modified:May 27, 2002 - v2
Checksum:i83B30F1D950C5745
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WE57F8WE57_HUMAN
MAL-like protein
MALL
120Annotation score:
C9IZ55C9IZ55_HUMAN
MAL-like protein
MALL
55Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125647 mRNA Translation: BAG54228.1
CH878608 Genomic DNA Translation: EAW50639.1
BC003179 mRNA Translation: AAH03179.1
U17077 mRNA Translation: AAA76738.1
CCDSiCCDS2085.1
PIRiI38891
RefSeqiNP_005425.1, NM_005434.4
UniGeneiHs.185055

Genome annotation databases

EnsembliENST00000272462; ENSP00000272462; ENSG00000144063
GeneIDi7851
KEGGihsa:7851
UCSCiuc002tfk.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125647 mRNA Translation: BAG54228.1
CH878608 Genomic DNA Translation: EAW50639.1
BC003179 mRNA Translation: AAH03179.1
U17077 mRNA Translation: AAA76738.1
CCDSiCCDS2085.1
PIRiI38891
RefSeqiNP_005425.1, NM_005434.4
UniGeneiHs.185055

3D structure databases

ProteinModelPortaliQ13021
SMRiQ13021
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113606, 10 interactors
IntActiQ13021, 56 interactors
STRINGi9606.ENSP00000272462

PTM databases

iPTMnetiQ13021
PhosphoSitePlusiQ13021

Polymorphism and mutation databases

BioMutaiMALL
DMDMi21264403

Proteomic databases

PaxDbiQ13021
PeptideAtlasiQ13021
PRIDEiQ13021
ProteomicsDBi59108

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272462; ENSP00000272462; ENSG00000144063
GeneIDi7851
KEGGihsa:7851
UCSCiuc002tfk.3 human

Organism-specific databases

CTDi7851
DisGeNETi7851
EuPathDBiHostDB:ENSG00000144063.3
GeneCardsiMALL
HGNCiHGNC:6818 MALL
HPAiHPA051410
MIMi602022 gene
neXtProtiNX_Q13021
OpenTargetsiENSG00000144063
PharmGKBiPA30567
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWII Eukaryota
ENOG410YQN9 LUCA
GeneTreeiENSGT00730000110762
HOGENOMiHOG000231752
HOVERGENiHBG000925
InParanoidiQ13021
OMAiFGCWVWI
OrthoDBiEOG091G0OS1
PhylomeDBiQ13021
TreeFamiTF316174

Miscellaneous databases

ChiTaRSiMALL human
GeneWikiiMALL
GenomeRNAii7851
PROiPR:Q13021
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144063 Expressed in 165 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_MALL
ExpressionAtlasiQ13021 baseline and differential
GenevisibleiQ13021 HS

Family and domain databases

InterProiView protein in InterPro
IPR013295 MAL
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR01884 MALPROTEIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMALL_HUMAN
AccessioniPrimary (citable) accession number: Q13021
Secondary accession number(s): B3KWR6, Q9BTU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 27, 2002
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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