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Entry version 157 (18 Sep 2019)
Sequence version 2 (13 Nov 2007)
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Protein

Secretory phospholipase A2 receptor

Gene

PLA2R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • phospholipase binding Source: UniProtKB
  • signaling receptor activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Secretory phospholipase A2 receptor
Short name:
PLA2-R
Short name:
PLA2R
Alternative name(s):
180 kDa secretory phospholipase A2 receptor
C-type lectin domain family 13 member C
M-type receptor
Cleaved into the following chain:
Soluble secretory phospholipase A2 receptor
Short name:
Soluble PLA2-R
Short name:
Soluble PLA2R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLA2R1
Synonyms:CLEC13C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9042 PLA2R1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604939 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13018

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1397ExtracellularSequence analysisAdd BLAST1377
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1398 – 1418HelicalSequence analysisAdd BLAST21
Topological domaini1419 – 1463CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22925

Open Targets

More...
OpenTargetsi
ENSG00000153246

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33369

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3713395

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLA2R1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160419241

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20By similarityAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500014434921 – 1463Secretory phospholipase A2 receptorAdd BLAST1443
ChainiPRO_000031125021 – ?Soluble secretory phospholipase A2 receptorBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 64By similarity
Disulfide bondi89 ↔ 106By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 204By similarity
Disulfide bondi192 ↔ 219By similarity
Disulfide bondi260 ↔ 354By similarity
Disulfide bondi330 ↔ 346By similarity
Disulfide bondi406 ↔ 501By similarity
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi478 ↔ 493By similarity
Disulfide bondi617 ↔ 634By similarity
Disulfide bondi699 ↔ 796By similarity
Disulfide bondi774 ↔ 788By similarity
Disulfide bondi840 ↔ 937By similarity
Disulfide bondi914 ↔ 929By similarity
Disulfide bondi1067 ↔ 1087By similarity
Glycosylationi1123N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1209 ↔ 1223By similarity
Disulfide bondi1280 ↔ 1377By similarity
Disulfide bondi1354 ↔ 1369By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13018

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13018

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q13018

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13018

PeptideAtlas

More...
PeptideAtlasi
Q13018

PRoteomics IDEntifications database

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PRIDEi
Q13018

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59106 [Q13018-1]
59107 [Q13018-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
674

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13018

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13018

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q13018

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153246 Expressed in 163 organ(s), highest expression level in metanephros

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13018 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB068217
CAB068218

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q13018, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000283243

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13018

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 161Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST124
Domaini173 – 221Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
Domaini238 – 355C-type lectin 1PROSITE-ProRule annotationAdd BLAST118
Domaini385 – 502C-type lectin 2PROSITE-ProRule annotationAdd BLAST118
Domaini522 – 643C-type lectin 3PROSITE-ProRule annotationAdd BLAST122
Domaini673 – 797C-type lectin 4PROSITE-ProRule annotationAdd BLAST125
Domaini819 – 938C-type lectin 5PROSITE-ProRule annotationAdd BLAST120
Domaini965 – 1096C-type lectin 6PROSITE-ProRule annotationAdd BLAST132
Domaini1121 – 1232C-type lectin 7PROSITE-ProRule annotationAdd BLAST112
Domaini1257 – 1378C-type lectin 8PROSITE-ProRule annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1436 – 1442Endocytosis signal7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
The endocytosis signal probably mediates endocytosis via clathrin-coated pits.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IS42 Eukaryota
ENOG4111FAE LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182821

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13018

KEGG Orthology (KO)

More...
KOi
K06560

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEYHCGT

Database of Orthologous Groups

More...
OrthoDBi
29241at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13018

TreeFam database of animal gene trees

More...
TreeFami
TF316663

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00062 FN2, 1 hit
cd00161 RICIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.10.10.10, 1 hit
3.10.100.10, 8 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 3 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q13018-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLSPSLLLL LLLGAPRGCA EGVAAALTPE RLLEWQDKGI FVIQSESLKK
60 70 80 90 100
CIQAGKSVLT LENCKQANKH MLWKWVSNHG LFNIGGSGCL GLNFSAPEQP
110 120 130 140 150
LSLYECDSTL VSLRWRCNRK MITGPLQYSV QVAHDNTVVA SRKYIHKWIS
160 170 180 190 200
YGSGGGDICE YLHKDLHTIK GNTHGMPCMF PFQYNHQWHH ECTREGREDD
210 220 230 240 250
LLWCATTSRY ERDEKWGFCP DPTSAEVGCD TIWEKDLNSH ICYQFNLLSS
260 270 280 290 300
LSWSEAHSSC QMQGGTLLSI TDETEENFIR EHMSSKTVEV WMGLNQLDEH
310 320 330 340 350
AGWQWSDGTP LNYLNWSPEV NFEPFVEDHC GTFSSFMPSA WRSRDCESTL
360 370 380 390 400
PYICKKYLNH IDHEIVEKDA WKYYATHCEP GWNPYNRNCY KLQKEEKTWH
410 420 430 440 450
EALRSCQADN SALIDITSLA EVEFLVTLLG DENASETWIG LSSNKIPVSF
460 470 480 490 500
EWSNDSSVIF TNWHTLEPHI FPNRSQLCVS AEQSEGHWKV KNCEERLFYI
510 520 530 540 550
CKKAGHVLSD AESGCQEGWE RHGGFCYKID TVLRSFDQAS SGYYCPPALV
560 570 580 590 600
TITNRFEQAF ITSLISSVVK MKDSYFWIAL QDQNDTGEYT WKPVGQKPEP
610 620 630 640 650
VQYTHWNTHQ PRYSGGCVAM RGRHPLGRWE VKHCRHFKAM SLCKQPVENQ
660 670 680 690 700
EKAEYEERWP FHPCYLDWES EPGLASCFKV FHSEKVLMKR TWREAEAFCE
710 720 730 740 750
EFGAHLASFA HIEEENFVNE LLHSKFNWTE ERQFWIGFNK RNPLNAGSWE
760 770 780 790 800
WSDRTPVVSS FLDNTYFGED ARNCAVYKAN KTLLPLHCGS KREWICKIPR
810 820 830 840 850
DVKPKIPFWY QYDVPWLFYQ DAEYLFHTFA SEWLNFEFVC SWLHSDLLTI
860 870 880 890 900
HSAHEQEFIH SKIKALSKYG ASWWIGLQEE RANDEFRWRD GTPVIYQNWD
910 920 930 940 950
TGRERTVNNQ SQRCGFISSI TGLWGSEECS VSMPSICKRK KVWLIEKKKD
960 970 980 990 1000
TPKQHGTCPK GWLYFNYKCL LLNIPKDPSS WKNWTHAQHF CAEEGGTLVA
1010 1020 1030 1040 1050
IESEVEQAFI TMNLFGQTTS VWIGLQNDDY ETWLNGKPVV YSNWSPFDII
1060 1070 1080 1090 1100
NIPSHNTTEV QKHIPLCALL SSNPNFHFTG KWYFEDCGKE GYGFVCEKMQ
1110 1120 1130 1140 1150
DTSGHGVNTS DMYPMPNTLE YGNRTYKIIN ANMTWYAAIK TCLMHKAQLV
1160 1170 1180 1190 1200
SITDQYHQSF LTVVLNRLGY AHWIGLFTTD NGLNFDWSDG TKSSFTFWKD
1210 1220 1230 1240 1250
EESSLLGDCV FADSNGRWHS TACESFLQGA ICHVPPETRQ SEHPELCSET
1260 1270 1280 1290 1300
SIPWIKFKSN CYSFSTVLDS MSFEAAHEFC KKEGSNLLTI KDEAENAFLL
1310 1320 1330 1340 1350
EELFAFGSSV QMVWLNAQFD GNNETIKWFD GTPTDQSNWG IRKPDTDYFK
1360 1370 1380 1390 1400
PHHCVALRIP EGLWQLSPCQ EKKGFICKME ADIHTAEALP EKGPSHSIIP
1410 1420 1430 1440 1450
LAVVLTLIVI VAICTLSFCI YKHNGGFFRR LAGFRNPYYP ATNFSTVYLE
1460
ENILISDLEK SDQ
Length:1,463
Mass (Da):168,600
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E65EA5AC5D597E2
GO
Isoform 2 (identifier: Q13018-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1323-1324: NE → SK
     1325-1463: Missing.

Show »
Length:1,324
Mass (Da):152,805
Checksum:iE00D5FDFF05DC9FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15 – 17APR → GAA in AAA70110 (PubMed:7721806).Curated3
Sequence conflicti15 – 17APR → GAA in AAC50163 (PubMed:7721806).Curated3
Sequence conflicti62 – 64ENC → GRTGS in AAA70110 (PubMed:7721806).Curated3
Sequence conflicti62 – 64ENC → GRTGS in AAC50163 (PubMed:7721806).Curated3
Sequence conflicti521 – 523RHG → ETC in AAA70110 (PubMed:7721806).Curated3
Sequence conflicti521 – 523RHG → ETC in AAC50163 (PubMed:7721806).Curated3
Sequence conflicti724S → P in AAA70110 (PubMed:7721806).Curated1
Sequence conflicti724S → P in AAC50163 (PubMed:7721806).Curated1
Sequence conflicti779A → P in AAA70110 (PubMed:7721806).Curated1
Sequence conflicti779A → P in AAC50163 (PubMed:7721806).Curated1
Sequence conflicti1224E → D in AAA70110 (PubMed:7721806).Curated1
Sequence conflicti1224E → D in AAC50163 (PubMed:7721806).Curated1
Sequence conflicti1263S → K in AAA70110 (PubMed:7721806).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037203142R → Q. Corresponds to variant dbSNP:rs12327936Ensembl.1
Natural variantiVAR_037204177P → S. Corresponds to variant dbSNP:rs13394676Ensembl.1
Natural variantiVAR_037205279I → V. Corresponds to variant dbSNP:rs965290Ensembl.1
Natural variantiVAR_037206292M → V1 PublicationCorresponds to variant dbSNP:rs3749117Ensembl.1
Natural variantiVAR_037207300H → D1 PublicationCorresponds to variant dbSNP:rs35771982Ensembl.1
Natural variantiVAR_061354370A → E. Corresponds to variant dbSNP:rs34916310Ensembl.1
Natural variantiVAR_037208404R → H. Corresponds to variant dbSNP:rs33985939Ensembl.1
Natural variantiVAR_0372091106G → S. Corresponds to variant dbSNP:rs3828323Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0294931323 – 1324NE → SK in isoform 2. 1 Publication2
Alternative sequenceiVSP_0294941325 – 1463Missing in isoform 2. 1 PublicationAdd BLAST139

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U17033 mRNA Translation: AAA70110.1
U17034 mRNA Translation: AAC50163.1
AC080166 Genomic DNA Translation: AAY24052.1
AC093873 Genomic DNA Translation: AAY24190.1
CH471058 Genomic DNA Translation: EAX11392.1
CH471058 Genomic DNA Translation: EAX11393.1
BC140823 mRNA Translation: AAI40824.1
D30780 mRNA Translation: BAA06444.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33309.1 [Q13018-1]
CCDS42767.1 [Q13018-2]

Protein sequence database of the Protein Information Resource

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PIRi
A56395
B56395

NCBI Reference Sequences

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RefSeqi
NP_001007268.1, NM_001007267.2 [Q13018-2]
NP_001182570.1, NM_001195641.1
NP_031392.3, NM_007366.4 [Q13018-1]
XP_005246449.1, XM_005246392.3 [Q13018-1]
XP_011509122.1, XM_011510820.2 [Q13018-1]
XP_016859087.1, XM_017003598.1 [Q13018-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000283243; ENSP00000283243; ENSG00000153246 [Q13018-1]
ENST00000392771; ENSP00000376524; ENSG00000153246 [Q13018-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22925

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22925

UCSC genome browser

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UCSCi
uc002ube.3 human [Q13018-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Phospholipase A2 receptor

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17033 mRNA Translation: AAA70110.1
U17034 mRNA Translation: AAC50163.1
AC080166 Genomic DNA Translation: AAY24052.1
AC093873 Genomic DNA Translation: AAY24190.1
CH471058 Genomic DNA Translation: EAX11392.1
CH471058 Genomic DNA Translation: EAX11393.1
BC140823 mRNA Translation: AAI40824.1
D30780 mRNA Translation: BAA06444.1
CCDSiCCDS33309.1 [Q13018-1]
CCDS42767.1 [Q13018-2]
PIRiA56395
B56395
RefSeqiNP_001007268.1, NM_001007267.2 [Q13018-2]
NP_001182570.1, NM_001195641.1
NP_031392.3, NM_007366.4 [Q13018-1]
XP_005246449.1, XM_005246392.3 [Q13018-1]
XP_011509122.1, XM_011510820.2 [Q13018-1]
XP_016859087.1, XM_017003598.1 [Q13018-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6JLIX-ray1.78A1108-1234[»]
SMRiQ13018
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ13018, 2 interactors
STRINGi9606.ENSP00000283243

Chemistry databases

ChEMBLiCHEMBL3713395

PTM databases

GlyConnecti674
iPTMnetiQ13018
PhosphoSitePlusiQ13018
UniCarbKBiQ13018

Polymorphism and mutation databases

BioMutaiPLA2R1
DMDMi160419241

Proteomic databases

EPDiQ13018
jPOSTiQ13018
MassIVEiQ13018
PaxDbiQ13018
PeptideAtlasiQ13018
PRIDEiQ13018
ProteomicsDBi59106 [Q13018-1]
59107 [Q13018-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283243; ENSP00000283243; ENSG00000153246 [Q13018-1]
ENST00000392771; ENSP00000376524; ENSG00000153246 [Q13018-2]
GeneIDi22925
KEGGihsa:22925
UCSCiuc002ube.3 human [Q13018-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22925
DisGeNETi22925

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLA2R1
HGNCiHGNC:9042 PLA2R1
HPAiCAB068217
CAB068218
MIMi604939 gene
neXtProtiNX_Q13018
OpenTargetsiENSG00000153246
PharmGKBiPA33369

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IS42 Eukaryota
ENOG4111FAE LUCA
GeneTreeiENSGT00950000182821
InParanoidiQ13018
KOiK06560
OMAiVEYHCGT
OrthoDBi29241at2759
PhylomeDBiQ13018
TreeFamiTF316663

Enzyme and pathway databases

ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLA2R1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22925

Pharos

More...
Pharosi
Q13018

Protein Ontology

More...
PROi
PR:Q13018

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153246 Expressed in 163 organ(s), highest expression level in metanephros
GenevisibleiQ13018 HS

Family and domain databases

CDDicd00062 FN2, 1 hit
cd00161 RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits
SMARTiView protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 3 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLA2R_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13018
Secondary accession number(s): B2RTU9
, D3DPB1, Q13019, Q15095, Q53R45, Q53RR7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 18, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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