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Entry version 171 (13 Feb 2019)
Sequence version 2 (10 Jun 2008)
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Protein

Rho GTPase-activating protein 5

Gene

ARHGAP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein for Rho family members (PubMed:8537347).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: Reactome
  • GTPase activity Source: ProtInc
  • GTP binding Source: InterPro
  • SH2 domain binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q13017

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13017

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 5
Alternative name(s):
Rho-type GTPase-activating protein 5
p190-B2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP5
Synonyms:RHOGAP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100852.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:675 ARHGAP5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602680 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13017

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
394

Open Targets

More...
OpenTargetsi
ENSG00000100852

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24959

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGAP5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190358871

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567021 – 1502Rho GTPase-activating protein 5Add BLAST1502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei550Nitrated tyrosineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei765PhosphoserineCombined sources1
Modified residuei951PhosphoserineCombined sources1
Modified residuei968PhosphoserineCombined sources1
Modified residuei1115PhosphoserineCombined sources1
Modified residuei1173PhosphoserineCombined sources1
Modified residuei1176PhosphoserineCombined sources1
Modified residuei1195PhosphoserineCombined sources1
Modified residuei1202PhosphoserineCombined sources1
Modified residuei1218PhosphoserineCombined sources1

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13017

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q13017

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q13017

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q13017

PeptideAtlas

More...
PeptideAtlasi
Q13017

PRoteomics IDEntifications database

More...
PRIDEi
Q13017

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59102
59103 [Q13017-2]
59104 [Q13017-3]
59105 [Q13017-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q13017

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q13017

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q13017

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in skin fibroblasts (at protein level) (PubMed:8537347).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100852 Expressed in 229 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13017 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q13017 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046993
HPA056507

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with RASA1/p120GAP.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Rnd3P615882EBI-7237884,EBI-6930266From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106887, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q13017, 3 interactors

Molecular INTeraction database

More...
MINTi
Q13017

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371897

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EE4NMR-A1255-1456[»]
2EE5NMR-A1245-1456[»]
5U4VX-ray2.60A590-763[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q13017

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13017

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q13017

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini267 – 325FF 1Add BLAST59
Domaini366 – 420FF 2Add BLAST55
Domaini427 – 481FF 3Add BLAST55
Domaini482 – 548FF 4Add BLAST67
Domaini590 – 763pG1 pseudoGTPasePROSITE-ProRule annotationAdd BLAST174
Domaini779 – 944pG2 pseudoGTPasePROSITE-ProRule annotationAdd BLAST166
Domaini1262 – 1449Rho-GAPPROSITE-ProRule annotationAdd BLAST188

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1225 – 1245Lys-richAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The pG1 pseudoGTPase domain does not bind GTP.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4271 Eukaryota
ENOG410XR4E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154553

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051844

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q13017

KEGG Orthology (KO)

More...
KOi
K13709

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKYITEA

Database of Orthologous Groups

More...
OrthoDBi
110157at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q13017

TreeFam database of animal gene trees

More...
TreeFami
TF324451

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.440, 3 hits
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR027417 P-loop_NTPase
IPR039007 pG1
IPR008936 Rho_GTPase_activation_prot
IPR032835 RhoGAP-FF1
IPR000198 RhoGAP_dom
IPR039006 RhoGAP_pG2
IPR001806 Small_GTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01846 FF, 1 hit
PF00071 Ras, 1 hit
PF00620 RhoGAP, 1 hit
PF16512 RhoGAP-FF1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00441 FF, 4 hits
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF52540 SSF52540, 1 hit
SSF81698 SSF81698, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51676 FF, 4 hits
PS51852 PG1, 1 hit
PS51853 PG2, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13017-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAKNKEPRP PSYTISIVGL SGTEKDKGNC GVGKSCLCNR FVRSKADEYY
60 70 80 90 100
PEHTSVLSTI DFGGRVVNND HFLYWGDIIQ NSEDGVECKI HVIEQTEFID
110 120 130 140 150
DQTFLPHRST NLQPYIKRAA ASKLQSAEKL MYICTDQLGL EQDFEQKQMP
160 170 180 190 200
EGKLNVDGFL LCIDVSQGCN RKFDDQLKFV NNLFVQLSKS KKPVIIAATK
210 220 230 240 250
CDECVDHYLR EVQAFASNKK NLLVVETSAR FNVNIETCFT ALVQMLDKTR
260 270 280 290 300
SKPKIIPYLD AYKTQRQLVV TATDKFEKLV QTVRDYHATW KTVSNKLKNH
310 320 330 340 350
PDYEEYINLE GTRKARNTFS KHIEQLKQEH IRKRREEYIN TLPRAFNTLL
360 370 380 390 400
PNLEEIEHLN WSEALKLMEK RADFQLCFVV LEKTPWDETD HIDKINDRRI
410 420 430 440 450
PFDLLSTLEA EKVYQNHVQH LISEKRRVEM KEKFKKTLEK IQFISPGQPW
460 470 480 490 500
EEVMCFVMED EAYKYITEAD SKEVYGRHQR EIVEKAKEEF QEMLFEHSEL
510 520 530 540 550
FYDLDLNATP SSDKMSEIHT VLSEEPRYKA LQKLAPDRES LLLKHIGFVY
560 570 580 590 600
HPTKETCLSG QNCTDIKVEQ LLASSLLQLD HGRLRLYHDS TNIDKVNLFI
610 620 630 640 650
LGKDGLAQEL ANEIRTQSTD DEYALDGKIY ELDLRPVDAK SPYFLSQLWT
660 670 680 690 700
AAFKPHGCFC VFNSIESLSF IGEFIGKIRT EASQIRKDKY MANLPFTLIL
710 720 730 740 750
ANQRDSISKN LPILRHQGQQ LANKLQCPFV DVPAGTYPRK FNETQIKQAL
760 770 780 790 800
RGVLESVKHN LDVVSPIPAN KDLSEADLRI VMCAMCGDPF SVDLILSPFL
810 820 830 840 850
DSHSCSAAQA GQNNSLMLDK IIGEKRRRIQ ITILSYHSSI GVRKDELVHG
860 870 880 890 900
YILVYSAKRK ASMGMLRAFL SEVQDTIPVQ LVAVTDSQAD FFENEAIKEL
910 920 930 940 950
MTEGEHIATE ITAKFTALYS LSQYHRQTEV FTLFFSDVLE KKNMIENSYL
960 970 980 990 1000
SDNTRESTHQ SEDVFLPSPR DCFPYNNYPD SDDDTEAPPP YSPIGDDVQL
1010 1020 1030 1040 1050
LPTPSDRSRY RLDLEGNEYP IHSTPNCHDH ERNHKVPPPI KPKPVVPKTN
1060 1070 1080 1090 1100
VKKLDPNLLK TIEAGIGKNP RKQTSRVPLA HPEDMDPSDN YAEPIDTIFK
1110 1120 1130 1140 1150
QKGYSDEIYV VPDDSQNRIK IRNSFVNNTQ GDEENGFSDR TSKSHGERRP
1160 1170 1180 1190 1200
SKYKYKSKTL FSKAKSYYRR THSDASDDEA FTTSKTKRKG RHRGSEEDPL
1210 1220 1230 1240 1250
LSPVETWKGG IDNPAITSDQ ELDDKKMKKK THKVKEDKKQ KKKTKNFNPP
1260 1270 1280 1290 1300
TRRNWESNYF GMPLQDLVTA EKPIPLFVEK CVEFIEDTGL CTEGLYRVSG
1310 1320 1330 1340 1350
NKTDQDNIQK QFDQDHNINL VSMEVTVNAV AGALKAFFAD LPDPLIPYSL
1360 1370 1380 1390 1400
HPELLEAAKI PDKTERLHAL KEIVKKFHPV NYDVFRYVIT HLNRVSQQHK
1410 1420 1430 1440 1450
INLMTADNLS ICFWPTLMRP DFENREFLST TKIHQSVVET FIQQCQFFFY
1460 1470 1480 1490 1500
NGEIVETTNI VAPPPPSNPG QLVEPMVPLQ LPPPLQPQLI QPQLQTDPLG

II
Length:1,502
Mass (Da):172,460
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E01B5B1D007984D
GO
Isoform 2 (identifier: Q13017-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1240-1240: Missing.

Note: No experimental confirmation available.
Show »
Length:1,501
Mass (Da):172,332
Checksum:i801C2D39400ACA51
GO
Isoform 3 (identifier: Q13017-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1265: Missing.
     1266-1288: DLVTAEKPIPLFVEKCVEFIEDT → MSLPPPPPGPLPLRRRRRRPTLL

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):26,979
Checksum:iC5044B056AC7297A
GO
Isoform 4 (identifier: Q13017-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1261: Missing.

Note: No experimental confirmation available.
Show »
Length:241
Mass (Da):27,411
Checksum:i63966DC0890DDB5E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSK6A0A0A0MSK6_HUMAN
Rho GTPase-activating protein 5
ARHGAP5
1,498Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V360G3V360_HUMAN
Rho GTPase-activating protein 5
ARHGAP5
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V444G3V444_HUMAN
Rho GTPase-activating protein 5
ARHGAP5
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK04H0YK04_HUMAN
Rho GTPase-activating protein 5
ARHGAP5
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5I7G3V5I7_HUMAN
Rho GTPase-activating protein 5
ARHGAP5
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA95963 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAH32723 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti80Q → R in AAH50059 (PubMed:15489334).Curated1
Sequence conflicti409E → G in BAF85655 (PubMed:14702039).Curated1
Sequence conflicti541L → F in BAD92988 (Ref. 5) Curated1
Sequence conflicti620D → G in BAF85655 (PubMed:14702039).Curated1
Sequence conflicti1383D → G in AAH50059 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04398017I → V. Corresponds to variant dbSNP:rs17386818Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0341641 – 1265Missing in isoform 3. 1 PublicationAdd BLAST1265
Alternative sequenceiVSP_0341651 – 1261Missing in isoform 4. 1 PublicationAdd BLAST1261
Alternative sequenceiVSP_0341661240Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_0341671266 – 1288DLVTA…FIEDT → MSLPPPPPGPLPLRRRRRRP TLL in isoform 3. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U17032 mRNA Translation: AAA95963.1 Frameshift.
CH471078 Genomic DNA Translation: EAW65935.1
CH471078 Genomic DNA Translation: EAW65936.1
CH471078 Genomic DNA Translation: EAW65937.1
CH471078 Genomic DNA Translation: EAW65938.1
BC032723 mRNA Translation: AAH32723.1 Sequence problems.
BC050059 mRNA Translation: AAH50059.1
BC075799 mRNA Translation: AAH75799.1
BC129928 mRNA Translation: AAI29929.1
BC129929 mRNA Translation: AAI29930.1
AK292966 mRNA Translation: BAF85655.1
AB209751 mRNA Translation: BAD92988.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32062.1 [Q13017-1]
CCDS45095.1 [Q13017-2]

Protein sequence database of the Protein Information Resource

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PIRi
B59431

NCBI Reference Sequences

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RefSeqi
NP_001025226.1, NM_001030055.1 [Q13017-1]
NP_001164.2, NM_001173.2 [Q13017-2]
XP_005267692.1, XM_005267635.3 [Q13017-1]
XP_005267693.1, XM_005267636.3 [Q13017-1]
XP_016876776.1, XM_017021287.1
XP_016876777.1, XM_017021288.1 [Q13017-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.592313

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000345122; ENSP00000371897; ENSG00000100852 [Q13017-1]
ENST00000396582; ENSP00000379827; ENSG00000100852 [Q13017-3]
ENST00000433497; ENSP00000407395; ENSG00000100852 [Q13017-4]
ENST00000539826; ENSP00000441692; ENSG00000100852 [Q13017-1]
ENST00000556611; ENSP00000452222; ENSG00000100852 [Q13017-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
394

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:394

UCSC genome browser

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UCSCi
uc001wrl.4 human [Q13017-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17032 mRNA Translation: AAA95963.1 Frameshift.
CH471078 Genomic DNA Translation: EAW65935.1
CH471078 Genomic DNA Translation: EAW65936.1
CH471078 Genomic DNA Translation: EAW65937.1
CH471078 Genomic DNA Translation: EAW65938.1
BC032723 mRNA Translation: AAH32723.1 Sequence problems.
BC050059 mRNA Translation: AAH50059.1
BC075799 mRNA Translation: AAH75799.1
BC129928 mRNA Translation: AAI29929.1
BC129929 mRNA Translation: AAI29930.1
AK292966 mRNA Translation: BAF85655.1
AB209751 mRNA Translation: BAD92988.1
CCDSiCCDS32062.1 [Q13017-1]
CCDS45095.1 [Q13017-2]
PIRiB59431
RefSeqiNP_001025226.1, NM_001030055.1 [Q13017-1]
NP_001164.2, NM_001173.2 [Q13017-2]
XP_005267692.1, XM_005267635.3 [Q13017-1]
XP_005267693.1, XM_005267636.3 [Q13017-1]
XP_016876776.1, XM_017021287.1
XP_016876777.1, XM_017021288.1 [Q13017-2]
UniGeneiHs.592313

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EE4NMR-A1255-1456[»]
2EE5NMR-A1245-1456[»]
5U4VX-ray2.60A590-763[»]
ProteinModelPortaliQ13017
SMRiQ13017
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106887, 15 interactors
IntActiQ13017, 3 interactors
MINTiQ13017
STRINGi9606.ENSP00000371897

PTM databases

iPTMnetiQ13017
PhosphoSitePlusiQ13017

Polymorphism and mutation databases

BioMutaiARHGAP5
DMDMi190358871

Proteomic databases

EPDiQ13017
jPOSTiQ13017
MaxQBiQ13017
PaxDbiQ13017
PeptideAtlasiQ13017
PRIDEiQ13017
ProteomicsDBi59102
59103 [Q13017-2]
59104 [Q13017-3]
59105 [Q13017-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345122; ENSP00000371897; ENSG00000100852 [Q13017-1]
ENST00000396582; ENSP00000379827; ENSG00000100852 [Q13017-3]
ENST00000433497; ENSP00000407395; ENSG00000100852 [Q13017-4]
ENST00000539826; ENSP00000441692; ENSG00000100852 [Q13017-1]
ENST00000556611; ENSP00000452222; ENSG00000100852 [Q13017-2]
GeneIDi394
KEGGihsa:394
UCSCiuc001wrl.4 human [Q13017-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
394
DisGeNETi394
EuPathDBiHostDB:ENSG00000100852.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ARHGAP5
HGNCiHGNC:675 ARHGAP5
HPAiHPA046993
HPA056507
MIMi602680 gene
neXtProtiNX_Q13017
OpenTargetsiENSG00000100852
PharmGKBiPA24959

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4271 Eukaryota
ENOG410XR4E LUCA
GeneTreeiENSGT00940000154553
HOVERGENiHBG051844
InParanoidiQ13017
KOiK13709
OMAiFKYITEA
OrthoDBi110157at2759
PhylomeDBiQ13017
TreeFamiTF324451

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
SignaLinkiQ13017
SIGNORiQ13017

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARHGAP5 human
EvolutionaryTraceiQ13017

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ARHGAP5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
394
PMAP-CutDBiQ13017

Protein Ontology

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PROi
PR:Q13017

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100852 Expressed in 229 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ13017 baseline and differential
GenevisibleiQ13017 HS

Family and domain databases

Gene3Di1.10.10.440, 3 hits
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR027417 P-loop_NTPase
IPR039007 pG1
IPR008936 Rho_GTPase_activation_prot
IPR032835 RhoGAP-FF1
IPR000198 RhoGAP_dom
IPR039006 RhoGAP_pG2
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF01846 FF, 1 hit
PF00071 Ras, 1 hit
PF00620 RhoGAP, 1 hit
PF16512 RhoGAP-FF1, 1 hit
SMARTiView protein in SMART
SM00441 FF, 4 hits
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF52540 SSF52540, 1 hit
SSF81698 SSF81698, 1 hit
PROSITEiView protein in PROSITE
PS51676 FF, 4 hits
PS51852 PG1, 1 hit
PS51853 PG2, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG05_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13017
Secondary accession number(s): A1L375
, A1L376, A8KAA1, D3DS89, D3DS90, Q05BE8, Q05BU8, Q59ER0, Q6DHZ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 10, 2008
Last modified: February 13, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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