UniProtKB - Q13015 (AF1Q_HUMAN)
Protein
Protein AF1q
Gene
MLLT11
Organism
Homo sapiens (Human)
Status
Functioni
Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).2 Publications
GO - Biological processi
- extrinsic apoptotic signaling pathway Source: UniProtKB
- intrinsic apoptotic signaling pathway Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of mitochondrial depolarization Source: UniProtKB
- positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
Enzyme and pathway databases
SIGNORi | Q13015 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein AF1q |
Gene namesi | Name:MLLT11 Synonyms:AF1Q |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16997 MLLT11 |
MIMi | 604684 gene |
neXtProti | NX_Q13015 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytoskeleton
- centrosome 1 Publication
Other locations
- Cytoplasm 2 Publications
Note: Continuous nuclear export is followed by degradation.1 Publication
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 24 – 32 | LSELEGLGL → ASEAEGAGA: Constitutive nuclear sequestration. 1 Publication | 9 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 10962 |
OpenTargetsi | ENSG00000213190 |
PharmGKBi | PA142671347 |
Miscellaneous databases
Pharosi | Q13015 |
Polymorphism and mutation databases
BioMutai | MLLT11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064471 | 1 – 90 | Protein AF1qAdd BLAST | 90 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 84 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Ubiquitinated, leading to degradation.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q13015 |
jPOSTi | Q13015 |
MassIVEi | Q13015 |
PaxDbi | Q13015 |
PeptideAtlasi | Q13015 |
PRIDEi | Q13015 |
ProteomicsDBi | 59101 |
TopDownProteomicsi | Q13015 |
PTM databases
iPTMneti | Q13015 |
PhosphoSitePlusi | Q13015 |
Expressioni
Tissue specificityi
Expressed in myoepithelial cells of normal breast tissue (at protein level) (PubMed:26079538). Highly expressed in thymus (PubMed:7833468). Expressed in colon, small intestine, prostate and ovary. Not detected in peripheral blood lymphocytes and spleen (PubMed:7833468).2 Publications
Gene expression databases
Bgeei | ENSG00000213190 Expressed in 224 organ(s), highest expression level in forebrain |
ExpressionAtlasi | Q13015 baseline and differential |
Genevisiblei | Q13015 HS |
Organism-specific databases
HPAi | HPA000540 |
Interactioni
Subunit structurei
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
P36402 | 2 | EBI-6269719,EBI-2119465 |
Protein-protein interaction databases
BioGridi | 116161, 10 interactors |
IntActi | Q13015, 14 interactors |
MINTi | Q13015 |
STRINGi | 9606.ENSP00000357917 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 24 – 32 | Nuclear export signal1 Publication | 9 |
Sequence similaritiesi
Belongs to the MLLT11 family.Curated
Phylogenomic databases
eggNOGi | ENOG410IZF7 Eukaryota ENOG4112CHF LUCA |
GeneTreei | ENSGT00390000009895 |
HOGENOMi | HOG000033833 |
InParanoidi | Q13015 |
OMAi | YWKEPIA |
OrthoDBi | 1586302at2759 |
PhylomeDBi | Q13015 |
TreeFami | TF336906 |
Family and domain databases
InterProi | View protein in InterPro IPR026778 MLLT11_fam IPR033461 WRNPLPNID |
PANTHERi | PTHR15404 PTHR15404, 1 hit |
Pfami | View protein in Pfam PF15017 WRNPLPNID, 1 hit |
i Sequence
Sequence statusi: Complete.
Q13015-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTATYKV KDSSVGKMIG
60 70 80 90
QATAADQEKN PEGDGLLEYS TFNFWRAPIA SIHSFELDLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U16954 mRNA Translation: AAA70088.1 BT006799 mRNA Translation: AAP35445.1 CR456879 mRNA Translation: CAG33160.1 AL590133 Genomic DNA No translation available. BC006471 mRNA No translation available. BC008445 mRNA Translation: AAH08445.1 BC009624 mRNA Translation: AAH09624.1 BC019253 mRNA Translation: AAH19253.1 BC021703 mRNA Translation: AAH21703.1 BC022448 mRNA Translation: AAH22448.1 |
CCDSi | CCDS982.1 |
PIRi | I38889 |
RefSeqi | NP_006809.1, NM_006818.3 |
Genome annotation databases
Ensembli | ENST00000368921; ENSP00000357917; ENSG00000213190 |
GeneIDi | 10962 |
KEGGi | hsa:10962 |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U16954 mRNA Translation: AAA70088.1 BT006799 mRNA Translation: AAP35445.1 CR456879 mRNA Translation: CAG33160.1 AL590133 Genomic DNA No translation available. BC006471 mRNA No translation available. BC008445 mRNA Translation: AAH08445.1 BC009624 mRNA Translation: AAH09624.1 BC019253 mRNA Translation: AAH19253.1 BC021703 mRNA Translation: AAH21703.1 BC022448 mRNA Translation: AAH22448.1 |
CCDSi | CCDS982.1 |
PIRi | I38889 |
RefSeqi | NP_006809.1, NM_006818.3 |
3D structure databases
SMRi | Q13015 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 116161, 10 interactors |
IntActi | Q13015, 14 interactors |
MINTi | Q13015 |
STRINGi | 9606.ENSP00000357917 |
PTM databases
iPTMneti | Q13015 |
PhosphoSitePlusi | Q13015 |
Polymorphism and mutation databases
BioMutai | MLLT11 |
Proteomic databases
EPDi | Q13015 |
jPOSTi | Q13015 |
MassIVEi | Q13015 |
PaxDbi | Q13015 |
PeptideAtlasi | Q13015 |
PRIDEi | Q13015 |
ProteomicsDBi | 59101 |
TopDownProteomicsi | Q13015 |
Protocols and materials databases
DNASUi | 10962 |
Genome annotation databases
Ensembli | ENST00000368921; ENSP00000357917; ENSG00000213190 |
GeneIDi | 10962 |
KEGGi | hsa:10962 |
Organism-specific databases
CTDi | 10962 |
DisGeNETi | 10962 |
GeneCardsi | MLLT11 |
HGNCi | HGNC:16997 MLLT11 |
HPAi | HPA000540 |
MIMi | 604684 gene |
neXtProti | NX_Q13015 |
OpenTargetsi | ENSG00000213190 |
PharmGKBi | PA142671347 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IZF7 Eukaryota ENOG4112CHF LUCA |
GeneTreei | ENSGT00390000009895 |
HOGENOMi | HOG000033833 |
InParanoidi | Q13015 |
OMAi | YWKEPIA |
OrthoDBi | 1586302at2759 |
PhylomeDBi | Q13015 |
TreeFami | TF336906 |
Enzyme and pathway databases
SIGNORi | Q13015 |
Miscellaneous databases
ChiTaRSi | MLLT11 human |
GenomeRNAii | 10962 |
Pharosi | Q13015 |
PROi | PR:Q13015 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213190 Expressed in 224 organ(s), highest expression level in forebrain |
ExpressionAtlasi | Q13015 baseline and differential |
Genevisiblei | Q13015 HS |
Family and domain databases
InterProi | View protein in InterPro IPR026778 MLLT11_fam IPR033461 WRNPLPNID |
PANTHERi | PTHR15404 PTHR15404, 1 hit |
Pfami | View protein in Pfam PF15017 WRNPLPNID, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AF1Q_HUMAN | |
Accessioni | Q13015Primary (citable) accession number: Q13015 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | October 16, 2019 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot