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Entry version 178 (13 Feb 2019)
Sequence version 2 (10 Jul 2007)
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Protein

T-lymphoma invasion and metastasis-inducing protein 1

Gene

TIAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-9032845 Activated NTRK2 signals through CDK5

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q13009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-lymphoma invasion and metastasis-inducing protein 1
Short name:
TIAM-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIAM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000156299.12

Human Gene Nomenclature Database

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HGNCi
HGNC:11805 TIAM1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600687 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q13009

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi879K → E: Strongly reduces affinity for SDC1. 1 Publication1
Mutagenesisi912K → E: Strongly reduces affinity for SDC1. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7074

Open Targets

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OpenTargetsi
ENSG00000156299

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36514

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TIAM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
152031709

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedSequence analysis
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809762 – 1591T-lymphoma invasion and metastasis-inducing protein 1Add BLAST1590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei231PhosphoserineCombined sources1
Modified residuei356PhosphoserineBy similarity1
Modified residuei358PhosphoserineBy similarity1
Modified residuei695PhosphoserineBy similarity1
Modified residuei829Phosphotyrosine; by NTRK2By similarity1
Modified residuei1323PhosphotyrosineBy similarity1
Modified residuei1519PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q13009

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q13009

MaxQB - The MaxQuant DataBase

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MaxQBi
Q13009

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q13009

PeptideAtlas

More...
PeptideAtlasi
Q13009

PRoteomics IDEntifications database

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PRIDEi
Q13009

ProteomicsDB human proteome resource

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ProteomicsDBi
59099

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q13009

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q13009

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000156299 Expressed in 218 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q13009 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q13009 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010416
HPA034853

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus).By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112930, 77 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q13009

Database of interacting proteins

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DIPi
DIP-38309N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q13009

Protein interaction database and analysis system

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IntActi
Q13009, 14 interactors

Molecular INTeraction database

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MINTi
Q13009

STRING: functional protein association networks

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STRINGi
9606.ENSP00000286827

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11591
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8INMR-A835-935[»]
3KZDX-ray1.30A841-930[»]
3KZEX-ray1.80A/B/C841-930[»]
4GVCX-ray1.54A841-930[»]
4GVDX-ray1.85A/B841-930[»]
4K2OX-ray2.15A429-702[»]
4K2PX-ray1.98A/B/C/D429-702[»]
4NXPX-ray2.30A841-930[»]
4NXQX-ray2.10A/B/C841-930[»]
4NXRX-ray1.90A841-930[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q13009

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q13009

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q13009

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini434 – 549PH 1PROSITE-ProRule annotationAdd BLAST116
Domaini765 – 832RBDPROSITE-ProRule annotationAdd BLAST68
Domaini845 – 908PDZPROSITE-ProRule annotationAdd BLAST64
Domaini1040 – 1234DHPROSITE-ProRule annotationAdd BLAST195
Domaini1261 – 1397PH 2PROSITE-ProRule annotationAdd BLAST137

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi595 – 598Poly-Lys4
Compositional biasi1445 – 1449Poly-Arg5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first PH domain mediates interaction with membranes enriched in phosphoinositides.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TIAM family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ITS1 Eukaryota
ENOG410XPCM LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156294

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154573

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG059279

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q13009

KEGG Orthology (KO)

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KOi
K05731

Identification of Orthologs from Complete Genome Data

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OMAi
DLANHKM

Database of Orthologous Groups

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OrthoDBi
34437at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q13009

TreeFam database of animal gene trees

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TreeFami
TF319686

Family and domain databases

Conserved Domains Database

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CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR003116 RBD_dom
IPR033360 TIAM1

The PANTHER Classification System

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PANTHERi
PTHR22826:SF88 PTHR22826:SF88, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 2 hits
PF02196 RBD, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SM00455 RBD, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50898 RBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q13009-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNAESQHVE HEFYGEKHAS LGRKHTSRSL RLSHKTRRTR HASSGKVIHR
60 70 80 90 100
NSEVSTRSSS TPSIPQSLAE NGLEPFSQDG TLEDFGSPIW VDRVDMGLRP
110 120 130 140 150
VSYTDSSVTP SVDSSIVLTA ASVQSMPDTE ESRLYGDDAT YLAEGGRRQH
160 170 180 190 200
SYTSNGPTFM ETASFKKKRS KSADIWREDS LEFSLSDLSQ EHLTSNEEIL
210 220 230 240 250
GSAEEKDCEE ARGMETRASP RQLSTCQRAN SLGDLYAQKN SGVTANGGPG
260 270 280 290 300
SKFAGYCRNL VSDIPNLANH KMPPAAAEET PPYSNYNTLP CRKSHCLSEG
310 320 330 340 350
ATNPQISHSN SMQGRRAKTT QDVNAGEGSE FADSGIEGAT TDTDLLSRRS
360 370 380 390 400
NATNSSYSPT TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTTNSES
410 420 430 440 450
LEEAGSAHSD EQSSGTLSSP GQSDILLTAA QGTVRKAGAL AVKNFLVHKK
460 470 480 490 500
NKKVESATRR KWKHYWVSLK GCTLFFYESD GRSGIDHNSI PKHAVWVENS
510 520 530 540 550
IVQAVPEHPK KDFVFCLSNS LGDAFLFQTT SQTELENWIT AIHSACATAV
560 570 580 590 600
ARHHHKEDTL RLLKSEIKKL EQKIDMDEKM KKMGEMQLSS VTDSKKKKTI
610 620 630 640 650
LDQIFVWEQN LEQFQMDLFR FRCYLASLQG GELPNPKRLL AFASRPTKVA
660 670 680 690 700
MGRLGIFSVS SFHALVAART GETGVRRRTQ AMSRSASKRR SRFSSLWGLD
710 720 730 740 750
TTSKKKQGRP SINQVFGEGT EAVKKSLEGI FDDIVPDGKR EKEVVLPNVH
760 770 780 790 800
QHNPDCDIWV HEYFTPSWFC LPNNQPALTV VRPGDTARDT LELICKTHQL
810 820 830 840 850
DHSAHYLRLK FLIENKMQLY VPQPEEDIYE LLYKEIEICP KVTQSIHIEK
860 870 880 890 900
SDTAADTYGF SLSSVEEDGI RRLYVNSVKE TGLASKKGLK AGDEILEINN
910 920 930 940 950
RAADALNSSM LKDFLSQPSL GLLVRTYPEL EEGVELLESP PHRVDGPADL
960 970 980 990 1000
GESPLAFLTS NPGHSLCSEQ GSSAETAPEE TEGPDLESSD ETDHSSKSTE
1010 1020 1030 1040 1050
QVAAFCRSLH EMNPSDQSPS PQDSTGPQLA TMRQLSDADK LRKVICELLE
1060 1070 1080 1090 1100
TERTYVKDLN CLMERYLKPL QKETFLTQDE LDVLFGNLTE MVEFQVEFLK
1110 1120 1130 1140 1150
TLEDGVRLVP DLEKLEKVDQ FKKVLFSLGG SFLYYADRFK LYSAFCASHT
1160 1170 1180 1190 1200
KVPKVLVKAK TDTAFKAFLD AQNPKQQHSS TLESYLIKPI QRILKYPLLL
1210 1220 1230 1240 1250
RELFALTDAE SEEHYHLDVA IKTMNKVASH INEMQKIHEE FGAVFDQLIA
1260 1270 1280 1290 1300
EQTGEKKEVA DLSMGDLLLH TTVIWLNPPA SLGKWKKEPE LAAFVFKTAV
1310 1320 1330 1340 1350
VLVYKDGSKQ KKKLVGSHRL SIYEDWDPFR FRHMIPTEAL QVRALASADA
1360 1370 1380 1390 1400
EANAVCEIVH VKSESEGRPE RVFHLCCSSP ESRKDFLKAV HSILRDKHRR
1410 1420 1430 1440 1450
QLLKTESLPS SQQYVPFGGK RLCALKGARP AMSRAVSAPS KSLGRRRRRL
1460 1470 1480 1490 1500
ARNRFTIDSD AVSASSPEKE SQQPPGGGDT DRWVEEQFDL AQYEEQDDIK
1510 1520 1530 1540 1550
ETDILSDDDE FCESVKGASV DRDLQERLQA TSISQRERGR KTLDSHASRM
1560 1570 1580 1590
AQLKKQAALS GINGGLESAS EEVIWVRRED FAPSRKLNTE I
Length:1,591
Mass (Da):177,508
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DAFBEE9A84B3452
GO
Isoform 2 (identifier: Q13009-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     715-739: Missing.
     797-831: Missing.

Note: No experimental confirmation available.
Show »
Length:1,531
Mass (Da):170,580
Checksum:i8A5611505BD43336
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GW57A0A1B0GW57_HUMAN
T-lymphoma invasion and metastasis-...
TIAM1
624Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C079H7C079_HUMAN
T-lymphoma invasion and metastasis-...
TIAM1
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMB5C9JMB5_HUMAN
T-lymphoma invasion and metastasis-...
TIAM1
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24 – 25KH → ND in AAA98443 (PubMed:7731688).Curated2
Sequence conflicti247G → M in AAA98443 (PubMed:7731688).Curated1
Sequence conflicti881T → I in AAI43981 (PubMed:15489334).Curated1
Sequence conflicti951G → D in AAA98443 (PubMed:7731688).Curated1
Sequence conflicti1018S → N in AAA98443 (PubMed:7731688).Curated1
Sequence conflicti1040 – 1041KL → NV in AAA98443 (PubMed:7731688).Curated2
Sequence conflicti1148S → I in AAA98443 (PubMed:7731688).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051991247G → R. Corresponds to variant dbSNP:rs2070418Ensembl.1
Natural variantiVAR_051992247G → V. Corresponds to variant dbSNP:rs2070417Ensembl.1
Natural variantiVAR_035977678R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1192824496Ensembl.1
Natural variantiVAR_051993844Q → H1 PublicationCorresponds to variant dbSNP:rs16987932Ensembl.1
Natural variantiVAR_0674241007R → H1 PublicationCorresponds to variant dbSNP:rs77092908Ensembl.1
Natural variantiVAR_0711021023D → V1 PublicationCorresponds to variant dbSNP:rs75483199Ensembl.1
Natural variantiVAR_0359781339A → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1319513413Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055865715 – 739Missing in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_055866797 – 831Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U16296 mRNA Translation: AAA98443.1
AP000246 Genomic DNA No translation available.
AP000247 Genomic DNA No translation available.
AP000248 Genomic DNA No translation available.
AP000249 Genomic DNA No translation available.
AP000250 Genomic DNA No translation available.
AP000251 Genomic DNA No translation available.
AP000563 Genomic DNA No translation available.
BC117192 mRNA Translation: AAI17193.1
BC117196 mRNA Translation: AAI17197.1
BC143980 mRNA Translation: AAI43981.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13609.1 [Q13009-1]

NCBI Reference Sequences

More...
RefSeqi
NP_003244.2, NM_003253.2 [Q13009-1]
XP_005261094.1, XM_005261037.1
XP_005261095.1, XM_005261038.2 [Q13009-1]
XP_011528013.1, XM_011529711.1
XP_011528014.1, XM_011529712.1 [Q13009-1]
XP_011528015.1, XM_011529713.1 [Q13009-1]
XP_016883936.1, XM_017028447.1
XP_016883937.1, XM_017028448.1 [Q13009-1]
XP_016883938.1, XM_017028449.1
XP_016883939.1, XM_017028450.1 [Q13009-1]
XP_016883940.1, XM_017028451.1 [Q13009-1]
XP_016883941.1, XM_017028452.1
XP_016883942.1, XM_017028453.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.517228

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286827; ENSP00000286827; ENSG00000156299 [Q13009-1]
ENST00000541036; ENSP00000441570; ENSG00000156299 [Q13009-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7074

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7074

UCSC genome browser

More...
UCSCi
uc002yow.2 human [Q13009-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16296 mRNA Translation: AAA98443.1
AP000246 Genomic DNA No translation available.
AP000247 Genomic DNA No translation available.
AP000248 Genomic DNA No translation available.
AP000249 Genomic DNA No translation available.
AP000250 Genomic DNA No translation available.
AP000251 Genomic DNA No translation available.
AP000563 Genomic DNA No translation available.
BC117192 mRNA Translation: AAI17193.1
BC117196 mRNA Translation: AAI17197.1
BC143980 mRNA Translation: AAI43981.1
CCDSiCCDS13609.1 [Q13009-1]
RefSeqiNP_003244.2, NM_003253.2 [Q13009-1]
XP_005261094.1, XM_005261037.1
XP_005261095.1, XM_005261038.2 [Q13009-1]
XP_011528013.1, XM_011529711.1
XP_011528014.1, XM_011529712.1 [Q13009-1]
XP_011528015.1, XM_011529713.1 [Q13009-1]
XP_016883936.1, XM_017028447.1
XP_016883937.1, XM_017028448.1 [Q13009-1]
XP_016883938.1, XM_017028449.1
XP_016883939.1, XM_017028450.1 [Q13009-1]
XP_016883940.1, XM_017028451.1 [Q13009-1]
XP_016883941.1, XM_017028452.1
XP_016883942.1, XM_017028453.1
UniGeneiHs.517228

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8INMR-A835-935[»]
3KZDX-ray1.30A841-930[»]
3KZEX-ray1.80A/B/C841-930[»]
4GVCX-ray1.54A841-930[»]
4GVDX-ray1.85A/B841-930[»]
4K2OX-ray2.15A429-702[»]
4K2PX-ray1.98A/B/C/D429-702[»]
4NXPX-ray2.30A841-930[»]
4NXQX-ray2.10A/B/C841-930[»]
4NXRX-ray1.90A841-930[»]
ProteinModelPortaliQ13009
SMRiQ13009
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112930, 77 interactors
CORUMiQ13009
DIPiDIP-38309N
ELMiQ13009
IntActiQ13009, 14 interactors
MINTiQ13009
STRINGi9606.ENSP00000286827

PTM databases

iPTMnetiQ13009
PhosphoSitePlusiQ13009

Polymorphism and mutation databases

BioMutaiTIAM1
DMDMi152031709

Proteomic databases

EPDiQ13009
jPOSTiQ13009
MaxQBiQ13009
PaxDbiQ13009
PeptideAtlasiQ13009
PRIDEiQ13009
ProteomicsDBi59099

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286827; ENSP00000286827; ENSG00000156299 [Q13009-1]
ENST00000541036; ENSP00000441570; ENSG00000156299 [Q13009-2]
GeneIDi7074
KEGGihsa:7074
UCSCiuc002yow.2 human [Q13009-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7074
DisGeNETi7074
EuPathDBiHostDB:ENSG00000156299.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TIAM1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0016054
HGNCiHGNC:11805 TIAM1
HPAiCAB010416
HPA034853
MIMi600687 gene
neXtProtiNX_Q13009
OpenTargetsiENSG00000156299
PharmGKBiPA36514

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITS1 Eukaryota
ENOG410XPCM LUCA
GeneTreeiENSGT00940000156294
HOGENOMiHOG000154573
HOVERGENiHBG059279
InParanoidiQ13009
KOiK05731
OMAiDLANHKM
OrthoDBi34437at2759
PhylomeDBiQ13009
TreeFamiTF319686

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-9032845 Activated NTRK2 signals through CDK5
SIGNORiQ13009

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TIAM1 human
EvolutionaryTraceiQ13009

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7074

Protein Ontology

More...
PROi
PR:Q13009

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156299 Expressed in 218 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ13009 baseline and differential
GenevisibleiQ13009 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR003116 RBD_dom
IPR033360 TIAM1
PANTHERiPTHR22826:SF88 PTHR22826:SF88, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 2 hits
PF02196 RBD, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SM00455 RBD, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50898 RBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIAM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q13009
Secondary accession number(s): B7ZLR6, F5GZ53, Q17RT7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 10, 2007
Last modified: February 13, 2019
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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