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Protein

Interleukin-24

Gene

IL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ13007

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-24
Short name:
IL-24
Alternative name(s):
Melanoma differentiation-associated gene 7 protein
Short name:
MDA-7
Suppression of tumorigenicity 16 protein
Gene namesi
Name:IL24
Synonyms:MDA7, ST16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162892.15
HGNCiHGNC:11346 IL24
MIMi604136 gene
neXtProtiNX_Q13007

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11009
OpenTargetsiENSG00000162892
PharmGKBiPA29825

Polymorphism and mutation databases

BioMutaiIL24
DMDMi2497340

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 511 PublicationAdd BLAST51
ChainiPRO_000001538652 – 206Interleukin-24Add BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Ubiquitination at Lys-122 promotes proteasomal degradation.1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ13007
PRIDEiQ13007
ProteomicsDBi59095
59096 [Q13007-2]
59097 [Q13007-3]
59098 [Q13007-4]

PTM databases

iPTMnetiQ13007
PhosphoSitePlusiQ13007

Expressioni

Tissue specificityi

Up-regulated in melanoma cells induced to terminally differentiate.

Gene expression databases

BgeeiENSG00000162892
CleanExiHS_IL24
ExpressionAtlasiQ13007 baseline and differential
GenevisibleiQ13007 HS

Organism-specific databases

HPAiCAB025972

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116199, 26 interactors
IntActiQ13007, 25 interactors
MINTiQ13007
STRINGi9606.ENSP00000375795

Structurei

3D structure databases

ProteinModelPortaliQ13007
SMRiQ13007
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZYS Eukaryota
ENOG41119SI LUCA
GeneTreeiENSGT00410000025637
HOGENOMiHOG000113033
HOVERGENiHBG098494
InParanoidiQ13007
KOiK22668
OMAiWEAFWAV
OrthoDBiEOG091G0Q0Q
PhylomeDBiQ13007
TreeFamiTF333253

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020423 IL-10_CS
IPR020444 IL-24
PRINTSiPR01937 INTRLEUKIN24
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13007-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFQQRLQSL WTLARPFCPP LLATASQMQM VVLPCLGFTL LLWSQVSGAQ
60 70 80 90 100
GQEFHFGPCQ VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV
110 120 130 140 150
SDAESCYLVH TLLEFYLKTV FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ
160 170 180 190 200
LQPSQENEMF SIRDSAHRRF LLFRRAFKQL DVEAALTKAL GEVDILLTWM

QKFYKL
Length:206
Mass (Da):23,825
Last modified:November 1, 1996 - v1
Checksum:iCB8135083EAB8DDD
GO
Isoform 2 (identifier: Q13007-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: A → AS

Show »
Length:207
Mass (Da):23,912
Checksum:i17687A467B9CB551
GO
Isoform 3 (identifier: Q13007-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: A → AS
     101-153: Missing.

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):17,751
Checksum:i1AAAE1B2FD252B4E
GO
Isoform 4 (identifier: Q13007-4) [UniParc]FASTAAdd to basket
Also known as: mda-7s

The sequence of this isoform differs from the canonical sequence as follows:
     15-206: RPFCPPLLAT...LTWMQKFYKL → SKLRITSRVP...YSGEHSNSWT

Show »
Length:63
Mass (Da):7,347
Checksum:iBEC50016AB595409
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011974124Y → H2 PublicationsCorresponds to variant dbSNP:rs1150258Ensembl.1
Natural variantiVAR_013097125H → R1 PublicationCorresponds to variant dbSNP:rs3093431Ensembl.1
Natural variantiVAR_013098131V → L1 PublicationCorresponds to variant dbSNP:rs3093446Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04267314A → AS in isoform 2 and isoform 3. 3 Publications1
Alternative sequenceiVSP_04391515 – 206RPFCP…KFYKL → SKLRITSRVPGCCSRRFCRT SRKKMRCFPSETVHTGGFCY SGEHSNSWT in isoform 4. 1 PublicationAdd BLAST192
Alternative sequenceiVSP_042674101 – 153Missing in isoform 3. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16261 mRNA Translation: AAA91780.1
AF276916 Genomic DNA Translation: AAG41401.1
AF235005 Genomic DNA Translation: AAK52589.1
AY237723 mRNA Translation: AAO67513.1
AY062931 Genomic DNA Translation: AAL34146.1
AY641441 mRNA Translation: AAV52801.1
BT007156 mRNA Translation: AAP35820.1
AC098935 Genomic DNA No translation available.
BC009681 mRNA Translation: AAH09681.1
CCDSiCCDS1471.1 [Q13007-1]
CCDS53465.1 [Q13007-2]
CCDS53466.1 [Q13007-3]
CCDS73021.1 [Q13007-4]
RefSeqiNP_001172085.1, NM_001185156.1 [Q13007-2]
NP_001172086.1, NM_001185157.1 [Q13007-3]
NP_001172087.1, NM_001185158.1 [Q13007-4]
NP_006841.1, NM_006850.3 [Q13007-1]
UniGeneiHs.58831
Hs.744273

Genome annotation databases

EnsembliENST00000294984; ENSP00000294984; ENSG00000162892 [Q13007-1]
ENST00000367093; ENSP00000356060; ENSG00000162892 [Q13007-3]
ENST00000391929; ENSP00000375795; ENSG00000162892 [Q13007-2]
ENST00000611909; ENSP00000484900; ENSG00000162892 [Q13007-4]
GeneIDi11009
KEGGihsa:11009
UCSCiuc001hes.3 human [Q13007-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL24_HUMAN
AccessioniPrimary (citable) accession number: Q13007
Secondary accession number(s): Q2YHE5
, Q53XZ7, Q5YLN8, Q96DB0, Q96KG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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