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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Multifunctional enzyme, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

Enzyme and pathway databases

BioCyciMBUR259564:G1G6A-2550-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Alternative name(s):
Exodeoxyribonuclease large subunitUniRule annotation (EC:3.1.11.1UniRule annotation)
Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:Mbur_2423
OrganismiMethanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Taxonomic identifieri259564 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanococcoides
Proteomesi
  • UP000001979 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002946851 – 1145DNA polymerase II large subunitAdd BLAST1145

Proteomic databases

PRIDEiQ12TF2

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi259564.Mbur_2423

Structurei

3D structure databases

SMRiQ12TF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447 Archaea
COG1933 LUCA
HOGENOMiHOG000286435
KOiK02322
OrthoDBiPOG093Z06CT

Family and domain databases

HAMAPiMF_00324 DNApol_II_L_arch, 1 hit
InterProiView protein in InterPro
IPR004475 PolC_DP2
IPR016033 PolC_DP2_N
PANTHERiPTHR42210 PTHR42210, 2 hits
PfamiView protein in Pfam
PF03833 PolC_DP2, 1 hit
PIRSFiPIRSF016275 PolC_DP2, 1 hit
TIGRFAMsiTIGR00354 polC, 1 hit

Sequencei

Sequence statusi: Complete.

Q12TF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIVASDEM NEYFNTLEGT LKKEIDIVND ARSRGKDPKP HVEIPLAKDL
60 70 80 90 100
ADRVENLIGV KGVAELIRKL EETMSREEAA LALGREVAQG KVGEFDSKSE
110 120 130 140 150
AIEAAIRVSV AMLTEGVVAA PIEGIDRASI GKNDDGSEYV SIFYAGPIRS
160 170 180 190 200
AGGTAQALSV LVGDYVRRGV GIDRYKPRKE EVERYIEEIM LYKRVASLQY
210 220 230 240 250
TPSEEEIRLI VENCPICIDG EPTEAEEVEG HRNLERIDTN RVRGGMALVL
260 270 280 290 300
AEGLALKAPK IQKHVKNLKI DGWEWLEQLI SGVKSSSESD EDEETDGKPK
310 320 330 340 350
IKPKDKYMRD LIAGRPVFSH PSRPGGFRLR YGRSRNTSFA AAGISPAGMI
360 370 380 390 400
VMDDFIAPGT QLKVERPGKA AGMAPVDSIE GPTVRLNNGD VIRIDTIDEA
410 420 430 440 450
YALRSEVEEI IDIGEILINY GDFLENNHPL APSPYCFEWW IQEYRKAAPD
460 470 480 490 500
TETNEAELKE PTQEVALDLC KELNIPLHPK FTYLWHDIDN SQYTALADLI
510 520 530 540 550
SKDGLLEADG SFLKLPLQRT IDTGMKKVLE DLLVQHKIQG QALTIEEPLP
560 570 580 590 600
LIHSLGLDEE LSKGWDSLGH EELLENINEI AGFVVRPRAP TRIGARMGRP
610 620 630 640 650
EKSDKRKMTP APHALFPIAE AGGNTRSLEK AANFKVNTNS KAGTIPVEIG
660 670 680 690 700
NRICPACGVE GFEFRCECGE YTLPKLFCPR CGISVNKEKC PKCNSKTTCT
710 720 730 740 750
SMRKIDFKSI YQKAFESIGE RDHLDSFKGV KKMMSKHMTP EPLEKGILRA
760 770 780 790 800
KHGLFTFKDG TVRYDMSDIP LTHIRPAEIG VSCERMIELG YLKDIYGKPL
810 820 830 840 850
IDSEQVLCLK VQDLVISYDA ADYILRITQY IDDLLVKYYK VAPYYNAKHI
860 870 880 890 900
DDIVGVLLMG LAPHTSAGVL GRLIGFTTAS VGYAHPYFHA AKRRNCDGDE
910 920 930 940 950
DCVMLLMDGL LNFSRDYLPD KRGGQMDAPL VLTTRLDPSE VDKEAHNIDM
960 970 980 990 1000
CASYPLEFYE ATQNIANPKD FEGTMDLVSG RLGTTLQYEE FMFTHDTSNI
1010 1020 1030 1040 1050
AAGPLKSAYK TLGTMVEKMD AQLELAKKIR AVDAPDVAER VLTSHFLPDM
1060 1070 1080 1090 1100
FGNLRAFSRQ RTRCVKCAAK FRRPPLTGSC PKCGGRVILT VHEGAVKKYL
1110 1120 1130 1140
QVSIKIAEEY NVSSYTKQRI ELIGYDMKSL FENDKSKQMG LSDFM
Length:1,145
Mass (Da):127,582
Last modified:July 10, 2007 - v2
Checksum:i2E4E696ABF9D18E4
GO

Sequence cautioni

The sequence ABE53274 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000300 Genomic DNA Translation: ABE53274.1 Different initiation.
RefSeqiWP_048063431.1, NC_007955.1

Genome annotation databases

EnsemblBacteriaiABE53274; ABE53274; Mbur_2423
GeneIDi3999013
KEGGimbu:Mbur_2423

Similar proteinsi

Entry informationi

Entry nameiDP2L_METBU
AccessioniPrimary (citable) accession number: Q12TF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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