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Protein

Tetraspanin-31

Gene

TSPAN31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • positive regulation of cell proliferation Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-31
Short name:
Tspan-31
Alternative name(s):
Sarcoma-amplified sequence
Gene namesi
Name:TSPAN31
Synonyms:SAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135452.9
HGNCiHGNC:10539 TSPAN31
MIMi181035 gene
neXtProtiNX_Q12999

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 44ExtracellularSequence analysisAdd BLAST11
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 173ExtracellularSequence analysisAdd BLAST80
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 210CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6302
OpenTargetsiENSG00000135452
PharmGKBiPA34949

Polymorphism and mutation databases

BioMutaiTSPAN31
DMDMi6174973

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192701 – 210Tetraspanin-31Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ12999
PaxDbiQ12999
PeptideAtlasiQ12999
PRIDEiQ12999
ProteomicsDBi59088

PTM databases

iPTMnetiQ12999
PhosphoSitePlusiQ12999

Expressioni

Gene expression databases

BgeeiENSG00000135452 Expressed in 229 organ(s), highest expression level in oviduct epithelium
CleanExiHS_TSPAN31
ExpressionAtlasiQ12999 baseline and differential
GenevisibleiQ12999 HS

Organism-specific databases

HPAiHPA057489

Interactioni

Protein-protein interaction databases

BioGridi112209, 45 interactors
IntActiQ12999, 3 interactors
STRINGi9606.ENSP00000257910

Structurei

3D structure databases

ProteinModelPortaliQ12999
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00500000044851
HOGENOMiHOG000005650
HOVERGENiHBG009195
InParanoidiQ12999
KOiK17356
OMAiAWGKGFG
OrthoDBiEOG091G0PBF
PhylomeDBiQ12999
TreeFamiTF323367

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q12999-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVCGGFACSK NALCALNVVY MLVSLLLIGV AAWGKGLGLV SSIHIIGGVI
60 70 80 90 100
AVGVFLLLIA VAGLVGAVNH HQVLLFFYMI ILGLVFIFQF VISCSCLAIN
110 120 130 140 150
RSKQTDVINA SWWVMSNKTR DELERSFDCC GLFNLTTLYQ QDYDFCTAIC
160 170 180 190 200
KSQSPTCQMC GEKFLKHSDE ALKILGGVGL FFSFTEILGV WLAMRFRNQK
210
DPRANPSAFL
Length:210
Mass (Da):23,053
Last modified:November 1, 1996 - v1
Checksum:i8A1FF8CC5319755E
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VP43F8VP43_HUMAN
Tetraspanin-31
TSPAN31
128Annotation score:
F8VNT7F8VNT7_HUMAN
Tetraspanin-31
TSPAN31
113Annotation score:
F8VWE0F8VWE0_HUMAN
Tetraspanin-31
TSPAN31
127Annotation score:
F8VS78F8VS78_HUMAN
Tetraspanin-31
TSPAN31
126Annotation score:
F8VW54F8VW54_HUMAN
Tetraspanin-31
TSPAN31
86Annotation score:
F8VVF8F8VVF8_HUMAN
Tetraspanin-31
TSPAN31
72Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01160 mRNA Translation: AAA17782.1
U81031 Genomic DNA Translation: AAC39524.2
AK315765 mRNA Translation: BAG38117.1
CR407647 mRNA Translation: CAG28575.1
CH471054 Genomic DNA Translation: EAW97057.1
BC010377 mRNA Translation: AAH10377.1
CCDSiCCDS8952.1
PIRiI58391
RefSeqiNP_001317097.1, NM_001330168.1
NP_001317098.1, NM_001330169.1
NP_005972.1, NM_005981.4
UniGeneiHs.632708

Genome annotation databases

EnsembliENST00000257910; ENSP00000257910; ENSG00000135452
GeneIDi6302
KEGGihsa:6302
UCSCiuc001spt.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01160 mRNA Translation: AAA17782.1
U81031 Genomic DNA Translation: AAC39524.2
AK315765 mRNA Translation: BAG38117.1
CR407647 mRNA Translation: CAG28575.1
CH471054 Genomic DNA Translation: EAW97057.1
BC010377 mRNA Translation: AAH10377.1
CCDSiCCDS8952.1
PIRiI58391
RefSeqiNP_001317097.1, NM_001330168.1
NP_001317098.1, NM_001330169.1
NP_005972.1, NM_005981.4
UniGeneiHs.632708

3D structure databases

ProteinModelPortaliQ12999
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112209, 45 interactors
IntActiQ12999, 3 interactors
STRINGi9606.ENSP00000257910

PTM databases

iPTMnetiQ12999
PhosphoSitePlusiQ12999

Polymorphism and mutation databases

BioMutaiTSPAN31
DMDMi6174973

Proteomic databases

EPDiQ12999
PaxDbiQ12999
PeptideAtlasiQ12999
PRIDEiQ12999
ProteomicsDBi59088

Protocols and materials databases

DNASUi6302
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257910; ENSP00000257910; ENSG00000135452
GeneIDi6302
KEGGihsa:6302
UCSCiuc001spt.4 human

Organism-specific databases

CTDi6302
DisGeNETi6302
EuPathDBiHostDB:ENSG00000135452.9
GeneCardsiTSPAN31
HGNCiHGNC:10539 TSPAN31
HPAiHPA057489
MIMi181035 gene
neXtProtiNX_Q12999
OpenTargetsiENSG00000135452
PharmGKBiPA34949
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00500000044851
HOGENOMiHOG000005650
HOVERGENiHBG009195
InParanoidiQ12999
KOiK17356
OMAiAWGKGFG
OrthoDBiEOG091G0PBF
PhylomeDBiQ12999
TreeFamiTF323367

Miscellaneous databases

ChiTaRSiTSPAN31 human
GeneWikiiTSPAN31
GenomeRNAii6302
PROiPR:Q12999
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135452 Expressed in 229 organ(s), highest expression level in oviduct epithelium
CleanExiHS_TSPAN31
ExpressionAtlasiQ12999 baseline and differential
GenevisibleiQ12999 HS

Family and domain databases

InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
ProtoNetiSearch...

Entry informationi

Entry nameiTSN31_HUMAN
AccessioniPrimary (citable) accession number: Q12999
Secondary accession number(s): O00577, Q53X76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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