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Protein

Cleavage stimulation factor subunit 3

Gene

CSTF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.

GO - Molecular functioni

GO - Biological processi

  • mRNA 3'-end processing Source: Reactome
  • mRNA cleavage Source: ProtInc
  • mRNA polyadenylation Source: ProtInc
  • mRNA splicing, via spliceosome Source: Reactome
  • termination of RNA polymerase II transcription Source: Reactome

Keywordsi

Biological processmRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-77595 Processing of Intronless Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage stimulation factor subunit 3
Alternative name(s):
CF-1 77 kDa subunit
Cleavage stimulation factor 77 kDa subunit
Short name:
CSTF 77 kDa subunit
Short name:
CstF-77
Gene namesi
Name:CSTF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176102.11
HGNCiHGNC:2485 CSTF3
MIMi600367 gene
neXtProtiNX_Q12996

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176102
PharmGKBiPA26987

Polymorphism and mutation databases

BioMutaiCSTF3
DMDMi71153231

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002057222 – 717Cleavage stimulation factor subunit 3Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei691PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ12996
MaxQBiQ12996
PaxDbiQ12996
PeptideAtlasiQ12996
PRIDEiQ12996
ProteomicsDBi59086
59087 [Q12996-2]

PTM databases

iPTMnetiQ12996
PhosphoSitePlusiQ12996
SwissPalmiQ12996

Miscellaneous databases

PMAP-CutDBiQ12996

Expressioni

Gene expression databases

BgeeiENSG00000176102
CleanExiHS_CSTF3
ExpressionAtlasiQ12996 baseline and differential
GenevisibleiQ12996 HS

Organism-specific databases

HPAiHPA039743
HPA040168

Interactioni

Subunit structurei

Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1.2 Publications

Protein-protein interaction databases

BioGridi107861, 56 interactors
CORUMiQ12996
DIPiDIP-48674N
IntActiQ12996, 17 interactors
MINTiQ12996
STRINGi9606.ENSP00000315791

Structurei

Secondary structure

1717
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi586 – 588Combined sources3
Beta strandi589 – 591Combined sources3

3D structure databases

ProteinModelPortaliQ12996
SMRiQ12996
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 77HAT 1Add BLAST33
Repeati79 – 110HAT 2Add BLAST32
Repeati117 – 152HAT 3Add BLAST36
Repeati163 – 196HAT 4Add BLAST34
Repeati221 – 261HAT 5Add BLAST41
Repeati271 – 303HAT 6Add BLAST33
Repeati319 – 352HAT 7Add BLAST34
Repeati354 – 387HAT 8Add BLAST34
Repeati458 – 494HAT 9Add BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi559 – 626Pro-richAdd BLAST68

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1914 Eukaryota
COG5107 LUCA
GeneTreeiENSGT00390000006758
HOGENOMiHOG000231786
HOVERGENiHBG053813
InParanoidiQ12996
KOiK14408
OMAiKSVDIWN
OrthoDBiEOG091G02LY
PhylomeDBiQ12996
TreeFamiTF105867

Family and domain databases

InterProiView protein in InterPro
IPR003107 HAT
IPR008847 Suf
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF05843 Suf, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 10 hits
SUPFAMiSSF48452 SSF48452, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12996-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGDGATEQA AEYVPEKVKK AEKKLEENPY DLDAWSILIR EAQNQPIDKA
60 70 80 90 100
RKTYERLVAQ FPSSGRFWKL YIEAEIKAKN YDKVEKLFQR CLMKVLHIDL
110 120 130 140 150
WKCYLSYVRE TKGKLPSYKE KMAQAYDFAL DKIGMEIMSY QIWVDYINFL
160 170 180 190 200
KGVEAVGSYA ENQRITAVRR VYQRGCVNPM INIEQLWRDY NKYEEGINIH
210 220 230 240 250
LAKKMIEDRS RDYMNARRVA KEYETVMKGL DRNAPSVPPQ NTPQEAQQVD
260 270 280 290 300
MWKKYIQWEK SNPLRTEDQT LITKRVMFAY EQCLLVLGHH PDIWYEAAQY
310 320 330 340 350
LEQSSKLLAE KGDMNNAKLF SDEAANIYER AISTLLKKNM LLYFAYADYE
360 370 380 390 400
ESRMKYEKVH SIYNRLLAIE DIDPTLVYIQ YMKFARRAEG IKSGRMIFKK
410 420 430 440 450
AREDTRTRHH VYVTAALMEY YCSKDKSVAF KIFELGLKKY GDIPEYVLAY
460 470 480 490 500
IDYLSHLNED NNTRVLFERV LTSGSLPPEK SGEIWARFLA FESNIGDLAS
510 520 530 540 550
ILKVEKRRFT AFKEEYEGKE TALLVDRYKF MDLYPCSASE LKALGYKDVS
560 570 580 590 600
RAKLAAIIPD PVVAPSIVPV LKDEVDRKPE YPKPDTQQMI PFQPRHLAPP
610 620 630 640 650
GLHPVPGGVF PVPPAAVVLM KLLPPPICFQ GPFVQVDELM EIFRRCKIPN
660 670 680 690 700
TVEEAVRIIT GGAPELAVEG NGPVESNAVL TKAVKRPNED SDEDEEKGAV
710
VPPVHDIYRA RQQKRIR
Length:717
Mass (Da):82,922
Last modified:November 1, 1996 - v1
Checksum:i9ADE7AC86FBB3E93
GO
Isoform 2 (identifier: Q12996-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-103: IKAKNYDKVEKLFQRCLMKVLHIDLWKC → VTILFYFFLYQYCSIHCSDRKQVRNIAN
     104-717: Missing.

Note: No experimental confirmation available.
Show »
Length:103
Mass (Da):12,102
Checksum:i990E37CFFE2B2732
GO
Isoform 3 (identifier: Q12996-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: N → V
     45-717: Missing.

Note: No experimental confirmation available.
Show »
Length:44
Mass (Da):4,952
Checksum:i9303D542E58B7162
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04567544N → V in isoform 3. 1 Publication1
Alternative sequenceiVSP_04567645 – 717Missing in isoform 3. 1 PublicationAdd BLAST673
Alternative sequenceiVSP_04273176 – 103IKAKN…DLWKC → VTILFYFFLYQYCSIHCSDR KQVRNIAN in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_042732104 – 717Missing in isoform 2. 1 PublicationAdd BLAST614

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15782 mRNA Translation: AAA61417.1
AK290836 mRNA Translation: BAF83525.1
AC131263 Genomic DNA No translation available.
AL121926 Genomic DNA Translation: CAC48252.1
CH471064 Genomic DNA Translation: EAW68200.1
CH471064 Genomic DNA Translation: EAW68201.1
CH471064 Genomic DNA Translation: EAW68202.1
BC009792 mRNA Translation: AAH09792.1
BC010533 mRNA Translation: AAH10533.1
BC059948 mRNA Translation: AAH59948.1
BC108319 mRNA Translation: AAI08320.1
BM014288 mRNA No translation available.
CCDSiCCDS44563.1 [Q12996-2]
CCDS44564.1 [Q12996-3]
CCDS7883.1 [Q12996-1]
PIRiS50852
RefSeqiNP_001028677.1, NM_001033505.1 [Q12996-2]
NP_001028678.1, NM_001033506.1 [Q12996-3]
NP_001317.1, NM_001326.2 [Q12996-1]
UniGeneiHs.44402

Genome annotation databases

EnsembliENST00000323959; ENSP00000315791; ENSG00000176102 [Q12996-1]
ENST00000431742; ENSP00000393064; ENSG00000176102 [Q12996-3]
ENST00000438862; ENSP00000388711; ENSG00000176102 [Q12996-2]
GeneIDi1479
KEGGihsa:1479
UCSCiuc001muh.4 human [Q12996-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCSTF3_HUMAN
AccessioniPrimary (citable) accession number: Q12996
Secondary accession number(s): A8K471
, D3DR04, E9PB40, Q32P22, Q96FQ8, Q96QD6, Q96QK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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