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Entry version 171 (16 Oct 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Cleavage stimulation factor subunit 3

Gene

CSTF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-73856 RNA Polymerase II Transcription Termination
R-HSA-77595 Processing of Intronless Pre-mRNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cleavage stimulation factor subunit 3
Alternative name(s):
CF-1 77 kDa subunit
Cleavage stimulation factor 77 kDa subunit
Short name:
CSTF 77 kDa subunit
Short name:
CstF-77
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSTF3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2485 CSTF3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600367 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12996

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1479

Open Targets

More...
OpenTargetsi
ENSG00000176102

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26987

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12996

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CSTF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153231

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002057222 – 717Cleavage stimulation factor subunit 3Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei691PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12996

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q12996

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q12996

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12996

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12996

PeptideAtlas

More...
PeptideAtlasi
Q12996

PRoteomics IDEntifications database

More...
PRIDEi
Q12996

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19137
59086 [Q12996-1]
59087 [Q12996-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12996

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12996

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q12996

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q12996

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176102 Expressed in 231 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12996 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12996 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039743
HPA040168

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2.

Interacts with FIP1L1.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107861, 71 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q12996

Database of interacting proteins

More...
DIPi
DIP-48674N

Protein interaction database and analysis system

More...
IntActi
Q12996, 29 interactors

Molecular INTeraction database

More...
MINTi
Q12996

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000315791

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1717
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12996

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati45 – 77HAT 1Add BLAST33
Repeati79 – 110HAT 2Add BLAST32
Repeati117 – 152HAT 3Add BLAST36
Repeati163 – 196HAT 4Add BLAST34
Repeati221 – 261HAT 5Add BLAST41
Repeati271 – 303HAT 6Add BLAST33
Repeati319 – 352HAT 7Add BLAST34
Repeati354 – 387HAT 8Add BLAST34
Repeati458 – 494HAT 9Add BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi559 – 626Pro-richAdd BLAST68

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1914 Eukaryota
COG5107 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006758

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231786

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12996

KEGG Orthology (KO)

More...
KOi
K14408

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCYIDYL

Database of Orthologous Groups

More...
OrthoDBi
331411at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12996

TreeFam database of animal gene trees

More...
TreeFami
TF105867

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107 HAT
IPR008847 Suf
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05843 Suf, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386 HAT, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12996-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGDGATEQA AEYVPEKVKK AEKKLEENPY DLDAWSILIR EAQNQPIDKA
60 70 80 90 100
RKTYERLVAQ FPSSGRFWKL YIEAEIKAKN YDKVEKLFQR CLMKVLHIDL
110 120 130 140 150
WKCYLSYVRE TKGKLPSYKE KMAQAYDFAL DKIGMEIMSY QIWVDYINFL
160 170 180 190 200
KGVEAVGSYA ENQRITAVRR VYQRGCVNPM INIEQLWRDY NKYEEGINIH
210 220 230 240 250
LAKKMIEDRS RDYMNARRVA KEYETVMKGL DRNAPSVPPQ NTPQEAQQVD
260 270 280 290 300
MWKKYIQWEK SNPLRTEDQT LITKRVMFAY EQCLLVLGHH PDIWYEAAQY
310 320 330 340 350
LEQSSKLLAE KGDMNNAKLF SDEAANIYER AISTLLKKNM LLYFAYADYE
360 370 380 390 400
ESRMKYEKVH SIYNRLLAIE DIDPTLVYIQ YMKFARRAEG IKSGRMIFKK
410 420 430 440 450
AREDTRTRHH VYVTAALMEY YCSKDKSVAF KIFELGLKKY GDIPEYVLAY
460 470 480 490 500
IDYLSHLNED NNTRVLFERV LTSGSLPPEK SGEIWARFLA FESNIGDLAS
510 520 530 540 550
ILKVEKRRFT AFKEEYEGKE TALLVDRYKF MDLYPCSASE LKALGYKDVS
560 570 580 590 600
RAKLAAIIPD PVVAPSIVPV LKDEVDRKPE YPKPDTQQMI PFQPRHLAPP
610 620 630 640 650
GLHPVPGGVF PVPPAAVVLM KLLPPPICFQ GPFVQVDELM EIFRRCKIPN
660 670 680 690 700
TVEEAVRIIT GGAPELAVEG NGPVESNAVL TKAVKRPNED SDEDEEKGAV
710
VPPVHDIYRA RQQKRIR
Length:717
Mass (Da):82,922
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9ADE7AC86FBB3E93
GO
Isoform 2 (identifier: Q12996-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-103: IKAKNYDKVEKLFQRCLMKVLHIDLWKC → VTILFYFFLYQYCSIHCSDRKQVRNIAN
     104-717: Missing.

Note: No experimental confirmation available.
Show »
Length:103
Mass (Da):12,102
Checksum:i990E37CFFE2B2732
GO
Isoform 3 (identifier: Q12996-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: N → V
     45-717: Missing.

Note: No experimental confirmation available.
Show »
Length:44
Mass (Da):4,952
Checksum:i9303D542E58B7162
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLP8E9PLP8_HUMAN
Cleavage stimulation factor subunit...
CSTF3
749Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE74H0YE74_HUMAN
Cleavage stimulation factor subunit...
CSTF3
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNK2E9PNK2_HUMAN
Cleavage stimulation factor subunit...
CSTF3
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ06E9PJ06_HUMAN
Cleavage stimulation factor subunit...
CSTF3
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04567544N → V in isoform 3. 1 Publication1
Alternative sequenceiVSP_04567645 – 717Missing in isoform 3. 1 PublicationAdd BLAST673
Alternative sequenceiVSP_04273176 – 103IKAKN…DLWKC → VTILFYFFLYQYCSIHCSDR KQVRNIAN in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_042732104 – 717Missing in isoform 2. 1 PublicationAdd BLAST614

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U15782 mRNA Translation: AAA61417.1
AK290836 mRNA Translation: BAF83525.1
AC131263 Genomic DNA No translation available.
AL121926 Genomic DNA Translation: CAC48252.1
CH471064 Genomic DNA Translation: EAW68200.1
CH471064 Genomic DNA Translation: EAW68201.1
CH471064 Genomic DNA Translation: EAW68202.1
BC009792 mRNA Translation: AAH09792.1
BC010533 mRNA Translation: AAH10533.1
BC059948 mRNA Translation: AAH59948.1
BC108319 mRNA Translation: AAI08320.1
BM014288 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44563.1 [Q12996-2]
CCDS44564.1 [Q12996-3]
CCDS7883.1 [Q12996-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S50852

NCBI Reference Sequences

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RefSeqi
NP_001028677.1, NM_001033505.1 [Q12996-2]
NP_001028678.1, NM_001033506.1 [Q12996-3]
NP_001317.1, NM_001326.2 [Q12996-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000323959; ENSP00000315791; ENSG00000176102 [Q12996-1]
ENST00000431742; ENSP00000393064; ENSG00000176102 [Q12996-3]
ENST00000438862; ENSP00000388711; ENSG00000176102 [Q12996-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1479

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1479

UCSC genome browser

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UCSCi
uc001muh.4 human [Q12996-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15782 mRNA Translation: AAA61417.1
AK290836 mRNA Translation: BAF83525.1
AC131263 Genomic DNA No translation available.
AL121926 Genomic DNA Translation: CAC48252.1
CH471064 Genomic DNA Translation: EAW68200.1
CH471064 Genomic DNA Translation: EAW68201.1
CH471064 Genomic DNA Translation: EAW68202.1
BC009792 mRNA Translation: AAH09792.1
BC010533 mRNA Translation: AAH10533.1
BC059948 mRNA Translation: AAH59948.1
BC108319 mRNA Translation: AAI08320.1
BM014288 mRNA No translation available.
CCDSiCCDS44563.1 [Q12996-2]
CCDS44564.1 [Q12996-3]
CCDS7883.1 [Q12996-1]
PIRiS50852
RefSeqiNP_001028677.1, NM_001033505.1 [Q12996-2]
NP_001028678.1, NM_001033506.1 [Q12996-3]
NP_001317.1, NM_001326.2 [Q12996-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6B3XX-ray2.30B581-600[»]
SMRiQ12996
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107861, 71 interactors
CORUMiQ12996
DIPiDIP-48674N
IntActiQ12996, 29 interactors
MINTiQ12996
STRINGi9606.ENSP00000315791

PTM databases

iPTMnetiQ12996
PhosphoSitePlusiQ12996
SwissPalmiQ12996

Polymorphism and mutation databases

BioMutaiCSTF3
DMDMi71153231

Proteomic databases

EPDiQ12996
jPOSTiQ12996
MassIVEiQ12996
MaxQBiQ12996
PaxDbiQ12996
PeptideAtlasiQ12996
PRIDEiQ12996
ProteomicsDBi19137
59086 [Q12996-1]
59087 [Q12996-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1479

Genome annotation databases

EnsembliENST00000323959; ENSP00000315791; ENSG00000176102 [Q12996-1]
ENST00000431742; ENSP00000393064; ENSG00000176102 [Q12996-3]
ENST00000438862; ENSP00000388711; ENSG00000176102 [Q12996-2]
GeneIDi1479
KEGGihsa:1479
UCSCiuc001muh.4 human [Q12996-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1479
DisGeNETi1479

GeneCards: human genes, protein and diseases

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GeneCardsi
CSTF3
HGNCiHGNC:2485 CSTF3
HPAiHPA039743
HPA040168
MIMi600367 gene
neXtProtiNX_Q12996
OpenTargetsiENSG00000176102
PharmGKBiPA26987

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1914 Eukaryota
COG5107 LUCA
GeneTreeiENSGT00390000006758
HOGENOMiHOG000231786
InParanoidiQ12996
KOiK14408
OMAiLCYIDYL
OrthoDBi331411at2759
PhylomeDBiQ12996
TreeFamiTF105867

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-73856 RNA Polymerase II Transcription Termination
R-HSA-77595 Processing of Intronless Pre-mRNAs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CSTF3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CSTF3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1479
PharosiQ12996
PMAP-CutDBiQ12996

Protein Ontology

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PROi
PR:Q12996

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000176102 Expressed in 231 organ(s), highest expression level in tendon
ExpressionAtlasiQ12996 baseline and differential
GenevisibleiQ12996 HS

Family and domain databases

InterProiView protein in InterPro
IPR003107 HAT
IPR008847 Suf
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF05843 Suf, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 10 hits
SUPFAMiSSF48452 SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSTF3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12996
Secondary accession number(s): A8K471
, D3DR04, E9PB40, Q32P22, Q96FQ8, Q96QD6, Q96QK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 1, 1996
Last modified: October 16, 2019
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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