Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock protein beta-3

Gene

HSPB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of actin polymerization.

GO - Biological processi

  • response to unfolded protein Source: ProtInc

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-3
Short name:
HspB3
Alternative name(s):
Heat shock 17 kDa protein
Short name:
HSP 17
Protein 3
Gene namesi
Name:HSPB3
Synonyms:HSP27, HSPL27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169271.2
HGNCiHGNC:5248 HSPB3
MIMi604624 gene
neXtProtiNX_Q12988

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Neuronopathy, distal hereditary motor, 2C (HMN2C)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
See also OMIM:613376
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0637737R → S in HMN2C. 1 PublicationCorresponds to variant dbSNP:rs139382018EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNETi8988
MalaCardsiHSPB3
MIMi613376 phenotype
OpenTargetsiENSG00000169271
Orphaneti139525 Distal hereditary motor neuropathy type 2
PharmGKBiPA29513

Polymorphism and mutation databases

BioMutaiHSPB3
DMDMi6016270

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259361 – 150Heat shock protein beta-3Add BLAST150

Proteomic databases

PaxDbiQ12988
PeptideAtlasiQ12988
PRIDEiQ12988
ProteomicsDBi59085

PTM databases

iPTMnetiQ12988
PhosphoSitePlusiQ12988

Expressioni

Gene expression databases

BgeeiENSG00000169271 Expressed in 135 organ(s), highest expression level in heart right ventricle
CleanExiHS_HSPB3
ExpressionAtlasiQ12988 baseline and differential
GenevisibleiQ12988 HS

Interactioni

Protein-protein interaction databases

BioGridi114470, 17 interactors
IntActiQ12988, 18 interactors
STRINGi9606.ENSP00000303394

Structurei

3D structure databases

ProteinModelPortaliQ12988
SMRiQ12988
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 150sHSPPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000286024
HOVERGENiHBG052039
InParanoidiQ12988
KOiK09544
OMAiFCHDGIL
OrthoDBiEOG091G0USC
PhylomeDBiQ12988
TreeFamiTF105049

Family and domain databases

CDDicd06477 ACD_HspB3_Like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
IPR033894 HSPB3
PANTHERiPTHR11527 PTHR11527, 1 hit
PTHR11527:SF29 PTHR11527:SF29, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

Q12988-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKIILRHLI EIPVRYQEEF EARGLEDCRL DHALYALPGP TIVDLRKTRA
60 70 80 90 100
AQSPPVDSAA ETPPREGKSH FQILLDVVQF LPEDIIIQTF EGWLLIKAQH
110 120 130 140 150
GTRMDEHGFI SRSFTRQYKL PDGVEIKDLS AVLCHDGILV VEVKDPVGTK
Length:150
Mass (Da):16,966
Last modified:May 1, 1999 - v2
Checksum:iCE5A4DF34CD38715
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0637737R → S in HMN2C. 1 PublicationCorresponds to variant dbSNP:rs139382018EnsemblClinVar.1
Natural variantiVAR_06127167G → S. Corresponds to variant dbSNP:rs35258119EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15590 mRNA Translation: AAD05360.1
Y17782 mRNA Translation: CAA76848.1
CCDSiCCDS3961.1
RefSeqiNP_006299.1, NM_006308.2
UniGeneiHs.41707

Genome annotation databases

EnsembliENST00000302005; ENSP00000303394; ENSG00000169271
GeneIDi8988
KEGGihsa:8988

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15590 mRNA Translation: AAD05360.1
Y17782 mRNA Translation: CAA76848.1
CCDSiCCDS3961.1
RefSeqiNP_006299.1, NM_006308.2
UniGeneiHs.41707

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6F2RX-ray3.90Q/T/V1-149[»]
ProteinModelPortaliQ12988
SMRiQ12988
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114470, 17 interactors
IntActiQ12988, 18 interactors
STRINGi9606.ENSP00000303394

PTM databases

iPTMnetiQ12988
PhosphoSitePlusiQ12988

Polymorphism and mutation databases

BioMutaiHSPB3
DMDMi6016270

Proteomic databases

PaxDbiQ12988
PeptideAtlasiQ12988
PRIDEiQ12988
ProteomicsDBi59085

Protocols and materials databases

DNASUi8988
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302005; ENSP00000303394; ENSG00000169271
GeneIDi8988
KEGGihsa:8988

Organism-specific databases

CTDi8988
DisGeNETi8988
EuPathDBiHostDB:ENSG00000169271.2
GeneCardsiHSPB3
HGNCiHGNC:5248 HSPB3
MalaCardsiHSPB3
MIMi604624 gene
613376 phenotype
neXtProtiNX_Q12988
OpenTargetsiENSG00000169271
Orphaneti139525 Distal hereditary motor neuropathy type 2
PharmGKBiPA29513
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000286024
HOVERGENiHBG052039
InParanoidiQ12988
KOiK09544
OMAiFCHDGIL
OrthoDBiEOG091G0USC
PhylomeDBiQ12988
TreeFamiTF105049

Miscellaneous databases

GenomeRNAii8988
PROiPR:Q12988
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169271 Expressed in 135 organ(s), highest expression level in heart right ventricle
CleanExiHS_HSPB3
ExpressionAtlasiQ12988 baseline and differential
GenevisibleiQ12988 HS

Family and domain databases

CDDicd06477 ACD_HspB3_Like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
IPR033894 HSPB3
PANTHERiPTHR11527 PTHR11527, 1 hit
PTHR11527:SF29 PTHR11527:SF29, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB3_HUMAN
AccessioniPrimary (citable) accession number: Q12988
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: October 10, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again