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UniProtKB - Q12986 (NFX1_HUMAN)

Entry version 198 (02 Jun 2021)
Sequence version 2 (20 May 2008)
Previous versions | rss
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Protein

Transcriptional repressor NF-X1

Gene

NFX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.

3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri358 – 409RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52
Zinc fingeri453 – 471NF-X1-type 1Add BLAST19
Zinc fingeri506 – 525NF-X1-type 2Add BLAST20
Zinc fingeri567 – 586NF-X1-type 3Add BLAST20
Zinc fingeri632 – 655NF-X1-type 4Add BLAST24
Zinc fingeri694 – 713NF-X1-type 5Add BLAST20
Zinc fingeri721 – 740NF-X1-type 6Add BLAST20
Zinc fingeri832 – 854NF-X1-type 7Add BLAST23
Zinc fingeri863 – 884NF-X1-type 8Add BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor, Transferase
Biological processHost-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q12986

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q12986

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional repressor NF-X1 (EC:2.3.2.-)
Alternative name(s):
Nuclear transcription factor, X box-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFX1
Synonyms:NFX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7803, NFX1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603255, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q12986

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000086102.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi20F → A: Reduces PABPC1 and PABC4 binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4799

Open Targets

More...OpenTargetsi		ENSG00000086102

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31608

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q12986, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NFX1

Domain mapping of disease mutations (DMDM)

More...DMDMi		189047116

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000559791 – 1120Transcriptional repressor NF-X1Add BLAST1120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineCombined sources1
Modified residuei82PhosphoserineBy similarity1
Modified residuei95PhosphoserineCombined sources1
Modified residuei129PhosphoserineBy similarity1
Modified residuei150PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation. Isoform 1 is not polyubiquitinated.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q12986

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q12986

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q12986

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q12986

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q12986

PeptideAtlas

More...PeptideAtlasi		Q12986

PRoteomics IDEntifications database

More...PRIDEi		Q12986

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59082 [Q12986-1]
59083 [Q12986-2]
59084 [Q12986-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q12986

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q12986

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IFNG/IFN-gamma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000086102, Expressed in buccal mucosa cell and 228 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q12986, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000086102, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 interacts with PABPC1 and PABPC4.

1 Publication

(Microbial infection) Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110865, 429 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q12986

Protein interaction database and analysis system

More...IntActi		Q12986, 16 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000368856

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q12986, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q12986

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini994 – 1062R3HPROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni9 – 26Interaction with PABPC1 and PABC41 PublicationAdd BLAST18
Regioni22 – 295DisorderedSequence analysisAdd BLAST274
Regioni1081 – 1109DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 107Polar residuesSequence analysisAdd BLAST37
Compositional biasi122 – 140Polar residuesSequence analysisAdd BLAST19
Compositional biasi141 – 164Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi230 – 272Basic and acidic residuesSequence analysisAdd BLAST43

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFX1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri358 – 409RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52
Zinc fingeri453 – 471NF-X1-type 1Add BLAST19
Zinc fingeri506 – 525NF-X1-type 2Add BLAST20
Zinc fingeri567 – 586NF-X1-type 3Add BLAST20
Zinc fingeri632 – 655NF-X1-type 4Add BLAST24
Zinc fingeri694 – 713NF-X1-type 5Add BLAST20
Zinc fingeri721 – 740NF-X1-type 6Add BLAST20
Zinc fingeri832 – 854NF-X1-type 7Add BLAST23
Zinc fingeri863 – 884NF-X1-type 8Add BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1952, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156325

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005714_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q12986

Identification of Orthologs from Complete Genome Data

More...OMAi		HPCEHPP

Database of Orthologous Groups

More...OrthoDBi		299100at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q12986

TreeFam database of animal gene trees

More...TreeFami		TF105889

Family and domain databases

Conserved Domains Database

More...CDDi		cd02643, R3H_NF-X1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1370.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034078, NFX1_fam
IPR001374, R3H_dom
IPR036867, R3H_dom_sf
IPR034076, R3H_NF-X1
IPR019786, Zinc_finger_PHD-type_CS
IPR000967, Znf_NFX1
IPR019787, Znf_PHD-finger
IPR001841, Znf_RING

The PANTHER Classification System

More...PANTHERi		PTHR12360, PTHR12360, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01424, R3H, 1 hit
PF01422, zf-NF-X1, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00393, R3H, 1 hit
SM00184, RING, 1 hit
SM00438, ZnF_NFX, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82708, SSF82708, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51061, R3H, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q12986-1) [UniParc]FASTAAdd to basket
Also known as: NFX-123

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS 
        60         70         80         90        100
PPPCHLSRQV PYDEISAVHQ HSYHPSGSKP KSQQTSFQSS PCNKSPKSHG 
       110        120        130        140        150
LQNQPWQKLR NEKHHIRVKK AQSLAEQTSD TAGLESSTRS ESGTDLREHS 
       160        170        180        190        200
PSESEKEVVG ADPRGAKPKK ATQFVYSYGR GPKVKGKLKC EWSNRTTPKP 
       210        220        230        240        250
EDAGPESTKP VGVFHPDSSE ASSRKGVLDG YGARRNEQRR YPQKRPPWEV 
       260        270        280        290        300
EGARPRPGRN PPKQEGHRHT NAGHRNNMGP IPKDDLNERP AKSTCDSENL 
       310        320        330        340        350
AVINKSSRRV DQEKCTVRRQ DPQVVSPFSR GKQNHVLKNV ETHTGSLIEQ 
       360        370        380        390        400
LTTEKYECMV CCELVRVTAP VWSCQSCYHV FHLNCIKKWA RSPASQADGQ 
       410        420        430        440        450
SGWRCPACQN VSAHVPNTYT CFCGKVKNPE WSRNEIPHSC GEVCRKKQPG 
       460        470        480        490        500
QDCPHSCNLL CHPGPCPPCP AFMTKTCECG RTRHTVRCGQ AVSVHCSNPC 
       510        520        530        540        550
ENILNCGQHQ CAELCHGGQC QPCQIILNQV CYCGSTSRDV LCGTDVGKSD 
       560        570        580        590        600
GFGDFSCLKI CGKDLKCGNH TCSQVCHPQP CQQCPRLPQL VRCCPCGQTP 
       610        620        630        640        650
LSQLLELGSS SRKTCMDPVP SCGKVCGKPL PCGSLDFIHT CEKLCHEGDC 
       660        670        680        690        700
GPCSRTSVIS CRCSFRTKEL PCTSLKSEDA TFMCDKRCNK KRLCGRHKCN 
       710        720        730        740        750
EICCVDKEHK CPLICGRKLR CGLHRCEEPC HRGNCQTCWQ ASFDELTCHC 
       760        770        780        790        800
GASVIYPPVP CGTRPPECTQ TCARVHECDH PVYHSCHSEE KCPPCTFLTQ 
       810        820        830        840        850
KWCMGKHEFR SNIPCHLVDI SCGLPCSATL PCGMHKCQRL CHKGECLVDE 
       860        870        880        890        900
PCKQPCTTPR ADCGHPCMAP CHTSSPCPVT ACKAKVELQC ECGRRKEMVI 
       910        920        930        940        950
CSEASSTYQR IAAISMASKI TDMQLGGSVE ISKLITKKEV HQARLECDEE 
       960        970        980        990       1000
CSALERKKRL AEAFHISEDS DPFNIRSSGS KFSDSLKEDA RKDLKFVSDV 
      1010       1020       1030       1040       1050
EKEMETLVEA VNKGKNSKKS HSFPPMNRDH RRIIHDLAQV YGLESVSYDS 
      1060       1070       1080       1090       1100
EPKRNVVVTA IRGKSVCPPT TLTGVLEREM QARPPPPIPH HRHQSDKNPG 
      1110       1120
SSNLQKITKE PIIDYFDVQD
Length:1,120
Mass (Da):124,395
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2203BE1DB6437E6
GO
Isoform 2 (identifier: Q12986-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1014-1024: GKNSKKSHSFP → VEVETSHWTFL
     1025-1120: Missing.

Show »
Length:1,024
Mass (Da):113,623
Checksum:i4228E14EEF42E3BC
GO
Isoform 3 (identifier: Q12986-3) [UniParc]FASTAAdd to basket
Also known as: NFX-91

The sequence of this isoform differs from the canonical sequence as follows:
     809-833: FRSNIPCHLVDISCGLPCSATLPCG → QSHYWASTQKKRSHYMKKIPAHACL
     834-1120: Missing.

Show »
Length:833
Mass (Da):92,679
Checksum:iAD2A1E26911EA705
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA69517 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti179G → A in AAA69517 (Ref. 1) Curated1
Sequence conflicti186G → E in AAA69517 (Ref. 1) Curated1
Sequence conflicti312Q → P in AAA69517 (Ref. 1) Curated1
Sequence conflicti419 – 420YT → FS in AAA69517 (Ref. 1) Curated2
Sequence conflicti560I → T in AAA69517 (Ref. 1) Curated1
Sequence conflicti653C → V in AAA69517 (Ref. 1) Curated1
Sequence conflicti678E → EA in BAF84332 (PubMed:14702039).Curated1
Sequence conflicti714I → N in AAA69517 (Ref. 1) Curated1
Sequence conflicti786C → G in AAA69517 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043380731H → Y. Corresponds to variant dbSNP:rs5017299Ensembl.1
Natural variantiVAR_043381760P → S. Corresponds to variant dbSNP:rs2860036Ensembl.1
Natural variantiVAR_0433821086P → Q. Corresponds to variant dbSNP:rs2274866Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033682809 – 833FRSNI…TLPCG → QSHYWASTQKKRSHYMKKIP AHACL in isoform 3. CuratedAdd BLAST25
Alternative sequenceiVSP_033683834 – 1120Missing in isoform 3. CuratedAdd BLAST287
Alternative sequenceiVSP_0336841014 – 1024GKNSKKSHSFP → VEVETSHWTFL in isoform 2. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_0336851025 – 1120Missing in isoform 2. 2 PublicationsAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF332009 mRNA Translation: AAK16545.1
AK291643 mRNA Translation: BAF84332.1
AL356472 Genomic DNA No translation available.
AL356218 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58510.1
CH471071 Genomic DNA Translation: EAW58511.1
BC012151 mRNA Translation: AAH12151.1
U15306 mRNA Translation: AAA69517.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6538.1 [Q12986-1]
CCDS6540.1 [Q12986-3]

Protein sequence database of the Protein Information Resource

More...PIRi		I38869

NCBI Reference Sequences

More...RefSeqi		NP_002495.2, NM_002504.5 [Q12986-1]
NP_667345.1, NM_147134.3 [Q12986-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000318524; ENSP00000317695; ENSG00000086102 [Q12986-3]
ENST00000379540; ENSP00000368856; ENSG00000086102 [Q12986-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4799

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4799

UCSC genome browser

More...UCSCi		uc003zso.4, human [Q12986-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332009 mRNA Translation: AAK16545.1
AK291643 mRNA Translation: BAF84332.1
AL356472 Genomic DNA No translation available.
AL356218 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58510.1
CH471071 Genomic DNA Translation: EAW58511.1
BC012151 mRNA Translation: AAH12151.1
U15306 mRNA Translation: AAA69517.1 Frameshift.
CCDSiCCDS6538.1 [Q12986-1]
CCDS6540.1 [Q12986-3]
PIRiI38869
RefSeqiNP_002495.2, NM_002504.5 [Q12986-1]
NP_667345.1, NM_147134.3 [Q12986-3]

3D structure databases

SMRiQ12986
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110865, 429 interactors
ELMiQ12986
IntActiQ12986, 16 interactors
STRINGi9606.ENSP00000368856

PTM databases

iPTMnetiQ12986
PhosphoSitePlusiQ12986

Genetic variation databases

BioMutaiNFX1
DMDMi189047116

Proteomic databases

EPDiQ12986
jPOSTiQ12986
MassIVEiQ12986
MaxQBiQ12986
PaxDbiQ12986
PeptideAtlasiQ12986
PRIDEiQ12986
ProteomicsDBi59082 [Q12986-1]
59083 [Q12986-2]
59084 [Q12986-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25201, 135 antibodies

The DNASU plasmid repository

More...DNASUi		4799

Genome annotation databases

EnsembliENST00000318524; ENSP00000317695; ENSG00000086102 [Q12986-3]
ENST00000379540; ENSP00000368856; ENSG00000086102 [Q12986-1]
GeneIDi4799
KEGGihsa:4799
UCSCiuc003zso.4, human [Q12986-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4799
DisGeNETi4799

GeneCards: human genes, protein and diseases

More...GeneCardsi		NFX1
HGNCiHGNC:7803, NFX1
HPAiENSG00000086102, Low tissue specificity
MIMi603255, gene
neXtProtiNX_Q12986
OpenTargetsiENSG00000086102
PharmGKBiPA31608
VEuPathDBiHostDB:ENSG00000086102.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1952, Eukaryota
GeneTreeiENSGT00940000156325
HOGENOMiCLU_005714_1_2_1
InParanoidiQ12986
OMAiHPCEHPP
OrthoDBi299100at2759
PhylomeDBiQ12986
TreeFamiTF105889

Enzyme and pathway databases

PathwayCommonsiQ12986
SIGNORiQ12986

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4799, 11 hits in 1016 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NFX1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NFX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4799
PharosiQ12986, Tbio

Protein Ontology

More...PROi		PR:Q12986
RNActiQ12986, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000086102, Expressed in buccal mucosa cell and 228 other tissues
GenevisibleiQ12986, HS

Family and domain databases

CDDicd02643, R3H_NF-X1, 1 hit
Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR034078, NFX1_fam
IPR001374, R3H_dom
IPR036867, R3H_dom_sf
IPR034076, R3H_NF-X1
IPR019786, Zinc_finger_PHD-type_CS
IPR000967, Znf_NFX1
IPR019787, Znf_PHD-finger
IPR001841, Znf_RING
PANTHERiPTHR12360, PTHR12360, 1 hit
PfamiView protein in Pfam
PF01424, R3H, 1 hit
PF01422, zf-NF-X1, 8 hits
SMARTiView protein in SMART
SM00393, R3H, 1 hit
SM00184, RING, 1 hit
SM00438, ZnF_NFX, 9 hits
SUPFAMiSSF82708, SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS51061, R3H, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12986
Secondary accession number(s): A8K6H8
, Q5VXW6, Q96EL5, Q9BXI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 20, 2008
Last modified: June 2, 2021
This is version 198 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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