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Protein

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Gene

BNIP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.2 Publications

GO - Molecular functioni

  • GTPase binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis, Host-virus interaction

Enzyme and pathway databases

SIGNORiQ12983

Protein family/group databases

TCDBi1.A.20.1.1 the bcl2/adenovirus e1b-interacting protein 3 (bnip3) family

Names & Taxonomyi

Protein namesi
Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Gene namesi
Name:BNIP3
Synonyms:NIP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000176171.11
HGNCiHGNC:1084 BNIP3
MIMi603293 gene
neXtProtiNX_Q12983

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi664
OpenTargetsiENSG00000176171
PharmGKBiPA25394

Polymorphism and mutation databases

BioMutaiBNIP3
DMDMi20532402

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649641 – 259BCL2/adenovirus E1B 19 kDa protein-interacting protein 3Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei157PhosphoserineBy similarity1
Modified residuei160PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ12983
PaxDbiQ12983
PeptideAtlasiQ12983
PRIDEiQ12983
ProteomicsDBi59081

PTM databases

iPTMnetiQ12983
PhosphoSitePlusiQ12983

Expressioni

Gene expression databases

BgeeiENSG00000176171 Expressed in 234 organ(s), highest expression level in endothelial cell
CleanExiHS_BNIP3
ExpressionAtlasiQ12983 baseline and differential
GenevisibleiQ12983 HS

Organism-specific databases

HPAiCAB011676
HPA003015

Interactioni

Subunit structurei

Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Interacts with BOK; promotes BOK oligomerization (PubMed:15868100).5 Publications
(Microbial infection) Interacts with adenovirus E1B 19 kDa protein.1 Publication
(Microbial infection) Interacts with Epstein-Barr virus BHRF1.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107132, 30 interactors
DIPiDIP-34429N
IntActiQ12983, 52 interactors
MINTiQ12983
STRINGi9606.ENSP00000357625

Structurei

Secondary structure

1259
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ12983
SMRiQ12983
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12983

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi165 – 190BH3Add BLAST26

Sequence similaritiesi

Belongs to the NIP3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHYW Eukaryota
ENOG4111KXP LUCA
GeneTreeiENSGT00390000013415
HOVERGENiHBG050707
InParanoidiQ12983
KOiK15464
OMAiKDWKFKH
OrthoDBiEOG091G0REJ
PhylomeDBiQ12983
TreeFamiTF315424

Family and domain databases

InterProiView protein in InterPro
IPR010548 BNIP3
PANTHERiPTHR15186 PTHR15186, 1 hit
PfamiView protein in Pfam
PF06553 BNIP3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q12983-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDAAADPPG PALPCEFLRP GCGAPLSPGA QLGRGAPTSA FPPPAAEAHP
60 70 80 90 100
AARRGLRSPQ LPSGAMSQNG APGMQEESLQ GSWVELHFSN NGNGGSVPAS
110 120 130 140 150
VSIYNGDMEK ILLDAQHESG RSSSKSSHCD SPPRSQTPQD TNRASETDTH
160 170 180 190 200
SIGEKNSSQS EEDDIERRKE VESILKKNSD WIWDWSSRPE NIPPKEFLFK
210 220 230 240 250
HPKRTATLSM RNTSVMKKGG IFSAEFLKVF LPSLLLSHLL AIGLGIYIGR

RLTTSTSTF
Length:259
Mass (Da):27,832
Last modified:June 7, 2017 - v3
Checksum:i53967696EDA005E2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RP06F6RP06_HUMAN
BCL2/adenovirus E1B 19 kDa protein-...
BNIP3
219Annotation score:
A0A0J9YW18A0A0J9YW18_HUMAN
BCL2/adenovirus E1B 19 kDa protein-...
BNIP3
243Annotation score:

Sequence cautioni

The sequence AAC00022 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC16738 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH21989 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAW62256 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68Q → E in AAC00022 (PubMed:7954800).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886764 Genomic DNA Translation: AAW62256.1 Different initiation.
AL162274 Genomic DNA No translation available.
BC009342 mRNA No translation available.
BC021989 mRNA Translation: AAH21989.1 Different initiation.
AF002697 mRNA Translation: AAC16738.1 Different initiation.
U15174 mRNA Translation: AAC00022.1 Different initiation.
CCDSiCCDS7663.2
PIRiI38865
RefSeqiNP_004043.3, NM_004052.3
UniGeneiHs.144873

Genome annotation databases

EnsembliENST00000368636; ENSP00000357625; ENSG00000176171
GeneIDi664
KEGGihsa:664
UCSCiuc001lkv.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886764 Genomic DNA Translation: AAW62256.1 Different initiation.
AL162274 Genomic DNA No translation available.
BC009342 mRNA No translation available.
BC021989 mRNA Translation: AAH21989.1 Different initiation.
AF002697 mRNA Translation: AAC16738.1 Different initiation.
U15174 mRNA Translation: AAC00022.1 Different initiation.
CCDSiCCDS7663.2
PIRiI38865
RefSeqiNP_004043.3, NM_004052.3
UniGeneiHs.144873

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J5DNMR-A/B211-255[»]
2KA1NMR-A/B219-253[»]
2KA2NMR-A/B219-253[»]
ProteinModelPortaliQ12983
SMRiQ12983
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107132, 30 interactors
DIPiDIP-34429N
IntActiQ12983, 52 interactors
MINTiQ12983
STRINGi9606.ENSP00000357625

Protein family/group databases

TCDBi1.A.20.1.1 the bcl2/adenovirus e1b-interacting protein 3 (bnip3) family

PTM databases

iPTMnetiQ12983
PhosphoSitePlusiQ12983

Polymorphism and mutation databases

BioMutaiBNIP3
DMDMi20532402

Proteomic databases

EPDiQ12983
PaxDbiQ12983
PeptideAtlasiQ12983
PRIDEiQ12983
ProteomicsDBi59081

Protocols and materials databases

DNASUi664
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368636; ENSP00000357625; ENSG00000176171
GeneIDi664
KEGGihsa:664
UCSCiuc001lkv.2 human

Organism-specific databases

CTDi664
DisGeNETi664
EuPathDBiHostDB:ENSG00000176171.11
GeneCardsiBNIP3
H-InvDBiHIX0037770
HGNCiHGNC:1084 BNIP3
HPAiCAB011676
HPA003015
MIMi603293 gene
neXtProtiNX_Q12983
OpenTargetsiENSG00000176171
PharmGKBiPA25394
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHYW Eukaryota
ENOG4111KXP LUCA
GeneTreeiENSGT00390000013415
HOVERGENiHBG050707
InParanoidiQ12983
KOiK15464
OMAiKDWKFKH
OrthoDBiEOG091G0REJ
PhylomeDBiQ12983
TreeFamiTF315424

Enzyme and pathway databases

SIGNORiQ12983

Miscellaneous databases

EvolutionaryTraceiQ12983
GeneWikiiBNIP3
GenomeRNAii664
PROiPR:Q12983
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176171 Expressed in 234 organ(s), highest expression level in endothelial cell
CleanExiHS_BNIP3
ExpressionAtlasiQ12983 baseline and differential
GenevisibleiQ12983 HS

Family and domain databases

InterProiView protein in InterPro
IPR010548 BNIP3
PANTHERiPTHR15186 PTHR15186, 1 hit
PfamiView protein in Pfam
PF06553 BNIP3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBNIP3_HUMAN
AccessioniPrimary (citable) accession number: Q12983
Secondary accession number(s): O14620, Q96GP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 7, 2017
Last modified: November 7, 2018
This is version 180 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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