Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 191 (17 Jun 2020)
Sequence version 3 (07 Jun 2017)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Gene

BNIP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Host-virus interaction

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q12983

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.20.1.1 the bcl2/adenovirus e1b-interacting protein 3 (bnip3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BNIP3
Synonyms:NIP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000176171.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1084 BNIP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603293 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12983

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei229 – 249HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
664

Open Targets

More...
OpenTargetsi
ENSG00000176171

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25394

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12983 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BNIP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20532402

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000649641 – 259BCL2/adenovirus E1B 19 kDa protein-interacting protein 3Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei119PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei157PhosphoserineBy similarity1
Modified residuei160PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12983

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q12983

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q12983

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12983

PeptideAtlas

More...
PeptideAtlasi
Q12983

PRoteomics IDEntifications database

More...
PRIDEi
Q12983

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59081

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12983

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12983

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176171 Expressed in endothelial cell and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12983 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12983 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000176171 Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds to BCL2.

Interacts with BNIP3L and ACAA2.

Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains).

Interacts with BOK; promotes BOK oligomerization (PubMed:15868100).

5 Publications

(Microbial infection) Interacts with adenovirus E1B 19 kDa protein.

1 Publication

(Microbial infection) Interacts with Epstein-Barr virus BHRF1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q12983
With#Exp.IntAct
AMIGO1 [Q86WK6]3EBI-749464,EBI-19125216
ARL13B [Q3SXY8]3EBI-749464,EBI-11343438
BIK [Q13323]3EBI-749464,EBI-700794
BNIP2 [Q12982]3EBI-749464,EBI-752094
itself8EBI-749464,EBI-749464
BNIP3L [O60238]21EBI-749464,EBI-849893
CD3E [P07766]3EBI-749464,EBI-1211297
CLDN9 [O95484]3EBI-749464,EBI-18341636
CLEC7A [Q9BXN2]3EBI-749464,EBI-3939278
CLEC7A - isoform 6 [Q9BXN2-6]3EBI-749464,EBI-11989440
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-749464,EBI-11522780
CREB3L1 [Q96BA8]3EBI-749464,EBI-6942903
EBAG9 [O00559]3EBI-749464,EBI-8787095
EBP [Q15125]3EBI-749464,EBI-3915253
ELOVL4 [Q9GZR5]3EBI-749464,EBI-18535450
ERGIC3 [Q9Y282]3EBI-749464,EBI-781551
FAM209A [Q5JX71]3EBI-749464,EBI-18304435
FAM241B - isoform 2 [Q96D05-2]3EBI-749464,EBI-12118888
FAM3C [Q92520]3EBI-749464,EBI-2876774
FATE1 [Q969F0]6EBI-749464,EBI-743099
FFAR2 [O15552]3EBI-749464,EBI-2833872
GPR152 [Q8TDT2]3EBI-749464,EBI-13345167
GPR42 [O15529]3EBI-749464,EBI-18076404
HPN [P05981]3EBI-749464,EBI-12816745
IFNGR2 [P38484]3EBI-749464,EBI-3905457
JAGN1 [Q8N5M9]3EBI-749464,EBI-10266796
KTN1 [Q86UP2]3EBI-749464,EBI-359761
KTN1 - isoform 3 [Q86UP2-3]3EBI-749464,EBI-12007212
LDLRAD1 [Q5T700]6EBI-749464,EBI-10173166
MALL [Q13021]3EBI-749464,EBI-750078
MFSD14B [Q5SR56]3EBI-749464,EBI-373355
MS4A3 [Q96HJ5]3EBI-749464,EBI-12806656
OPA1 [O60313]10EBI-749464,EBI-1054131
PLP2 [Q04941]3EBI-749464,EBI-608347
PPTC7 [Q8NI37]8EBI-749464,EBI-9089276
REEP2 [Q9BRK0]3EBI-749464,EBI-11337973
RNASEK [Q6P5S7]3EBI-749464,EBI-18397230
RNF24 - isoform 2 [Q9Y225-2]3EBI-749464,EBI-13044680
RPRM [Q9NS64]3EBI-749464,EBI-1052363
SCN3B [Q9NY72]3EBI-749464,EBI-17247926
SEC22A [Q96IW7]3EBI-749464,EBI-8652744
SEC23A [Q15436]3EBI-749464,EBI-81088
SLC31A2 [O15432]3EBI-749464,EBI-17867220
SLC35B1 [P78383]3EBI-749464,EBI-12147661
SLC6A17 [Q9H1V8]3EBI-749464,EBI-18396863
SMIM3 [Q9BZL3]3EBI-749464,EBI-741850
SPACA1 [Q9HBV2]3EBI-749464,EBI-17498703
TLCD4 [Q96MV1]3EBI-749464,EBI-12947623
TM4SF18 [Q96CE8]3EBI-749464,EBI-13351685
TMEM101 [Q96IK0]3EBI-749464,EBI-3922699
TMEM106C [Q9BVX2]3EBI-749464,EBI-2821497
TMEM11 [P17152]11EBI-749464,EBI-723946
TMEM205 [Q6UW68]3EBI-749464,EBI-6269551
TMPRSS2 - isoform 2 [O15393-2]3EBI-749464,EBI-12345267
TMX2 [Q9Y320]3EBI-749464,EBI-6447886
TNMD - isoform 2 [Q9H2S6-2]3EBI-749464,EBI-12003398
ZDHHC15 [Q96MV8]3EBI-749464,EBI-12837904
sidF [Q5ZSD5] from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513).3EBI-749464,EBI-15625247

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
107132, 33 interactors

Database of interacting proteins

More...
DIPi
DIP-34429N

Protein interaction database and analysis system

More...
IntActi
Q12983, 66 interactors

Molecular INTeraction database

More...
MINTi
Q12983

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357625

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12983 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1259
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12983

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q12983

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi165 – 190BH3Add BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NIP3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHYW Eukaryota
ENOG4111KXP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013415

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12983

KEGG Orthology (KO)

More...
KOi
K15464

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDWKFKH

Database of Orthologous Groups

More...
OrthoDBi
1250566at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12983

TreeFam database of animal gene trees

More...
TreeFami
TF315424

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010548 BNIP3

The PANTHER Classification System

More...
PANTHERi
PTHR15186 PTHR15186, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06553 BNIP3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q12983-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDAAADPPG PALPCEFLRP GCGAPLSPGA QLGRGAPTSA FPPPAAEAHP
60 70 80 90 100
AARRGLRSPQ LPSGAMSQNG APGMQEESLQ GSWVELHFSN NGNGGSVPAS
110 120 130 140 150
VSIYNGDMEK ILLDAQHESG RSSSKSSHCD SPPRSQTPQD TNRASETDTH
160 170 180 190 200
SIGEKNSSQS EEDDIERRKE VESILKKNSD WIWDWSSRPE NIPPKEFLFK
210 220 230 240 250
HPKRTATLSM RNTSVMKKGG IFSAEFLKVF LPSLLLSHLL AIGLGIYIGR

RLTTSTSTF
Length:259
Mass (Da):27,832
Last modified:June 7, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53967696EDA005E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RP06F6RP06_HUMAN
BCL2/adenovirus E1B 19 kDa protein-...
BNIP3
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YW18A0A0J9YW18_HUMAN
BCL2/adenovirus E1B 19 kDa protein-...
BNIP3
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC00022 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAC16738 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH21989 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAW62256 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68Q → E in AAC00022 (PubMed:7954800).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY886764 Genomic DNA Translation: AAW62256.1 Different initiation.
AL162274 Genomic DNA No translation available.
BC009342 mRNA No translation available.
BC021989 mRNA Translation: AAH21989.1 Different initiation.
AF002697 mRNA Translation: AAC16738.1 Different initiation.
U15174 mRNA Translation: AAC00022.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7663.2

Protein sequence database of the Protein Information Resource

More...
PIRi
I38865

NCBI Reference Sequences

More...
RefSeqi
NP_004043.3, NM_004052.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368636; ENSP00000357625; ENSG00000176171

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
664

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:664

UCSC genome browser

More...
UCSCi
uc001lkv.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886764 Genomic DNA Translation: AAW62256.1 Different initiation.
AL162274 Genomic DNA No translation available.
BC009342 mRNA No translation available.
BC021989 mRNA Translation: AAH21989.1 Different initiation.
AF002697 mRNA Translation: AAC16738.1 Different initiation.
U15174 mRNA Translation: AAC00022.1 Different initiation.
CCDSiCCDS7663.2
PIRiI38865
RefSeqiNP_004043.3, NM_004052.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J5DNMR-A/B211-255[»]
2KA1NMR-A/B219-253[»]
2KA2NMR-A/B219-253[»]
SMRiQ12983
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107132, 33 interactors
DIPiDIP-34429N
IntActiQ12983, 66 interactors
MINTiQ12983
STRINGi9606.ENSP00000357625

Protein family/group databases

TCDBi1.A.20.1.1 the bcl2/adenovirus e1b-interacting protein 3 (bnip3) family

PTM databases

iPTMnetiQ12983
PhosphoSitePlusiQ12983

Polymorphism and mutation databases

BioMutaiBNIP3
DMDMi20532402

Proteomic databases

EPDiQ12983
jPOSTiQ12983
MassIVEiQ12983
PaxDbiQ12983
PeptideAtlasiQ12983
PRIDEiQ12983
ProteomicsDBi59081

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31 558 antibodies

The DNASU plasmid repository

More...
DNASUi
664

Genome annotation databases

EnsembliENST00000368636; ENSP00000357625; ENSG00000176171
GeneIDi664
KEGGihsa:664
UCSCiuc001lkv.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
664
DisGeNETi664
EuPathDBiHostDB:ENSG00000176171.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BNIP3
HGNCiHGNC:1084 BNIP3
HPAiENSG00000176171 Tissue enhanced (pancreas)
MIMi603293 gene
neXtProtiNX_Q12983
OpenTargetsiENSG00000176171
PharmGKBiPA25394

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHYW Eukaryota
ENOG4111KXP LUCA
GeneTreeiENSGT00390000013415
InParanoidiQ12983
KOiK15464
OMAiKDWKFKH
OrthoDBi1250566at2759
PhylomeDBiQ12983
TreeFamiTF315424

Enzyme and pathway databases

SIGNORiQ12983

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
664 115 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BNIP3 human
EvolutionaryTraceiQ12983

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BNIP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
664
PharosiQ12983 Tbio

Protein Ontology

More...
PROi
PR:Q12983
RNActiQ12983 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176171 Expressed in endothelial cell and 233 other tissues
ExpressionAtlasiQ12983 baseline and differential
GenevisibleiQ12983 HS

Family and domain databases

InterProiView protein in InterPro
IPR010548 BNIP3
PANTHERiPTHR15186 PTHR15186, 1 hit
PfamiView protein in Pfam
PF06553 BNIP3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBNIP3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12983
Secondary accession number(s): O14620, Q96GP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 7, 2017
Last modified: June 17, 2020
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again