BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• GTPase binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 20436456
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • 10381623
  • 16189514
  • 25416956
  • 27107012
• protein heterodimerization activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 10381623
• protein homodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • 10381623
  • 9396766

GO - Biological processⁱ

• apoptotic process Source: MGIInferred from physical interactionⁱ
  • 7954800
• autophagic cell death Source: Ensembl
• autophagy of mitochondrion Source: ParkinsonsUK-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 22505714
• brown fat cell differentiation Source: Ensembl
• cardiac muscle cell apoptotic process Source: Ensembl
• cell death Source: UniProtKB
• cellular response to cobalt ion Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 20436456
• cellular response to hydrogen peroxide Source: Ensembl
• cellular response to hypoxia Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 20436456
• cellular response to mechanical stimulus Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 19593445
• cerebral cortex development Source: Ensembl
• defense response to virus Source: UniProtKBInferred from direct assayⁱ
  • 9973195
• granzyme-mediated apoptotic signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • 9396766
• intrinsic apoptotic signaling pathway in response to hypoxia Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 20436456
• mitochondrial fragmentation involved in apoptotic process Source: BHF-UCLInferred from direct assayⁱ
  • 20436456
• mitochondrial outer membrane permeabilization Source: UniProtKBInferred from direct assayⁱ
  • 18371312
• mitochondrial protein catabolic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • 22292033
• negative regulation of apoptotic process Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 7954800
• negative regulation of cell death Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 19273585
• negative regulation of membrane potential Source: UniProtKBInferred from direct assayⁱ
  • 10891486
• negative regulation of mitochondrial fusion Source: BHF-UCLInferred from direct assayⁱ
  • 20436456
• negative regulation of mitochondrial membrane permeability involved in apoptotic process Source: Ensembl
• negative regulation of mitochondrial membrane potential Source: Ensembl
• negative regulation of reactive oxygen species metabolic process Source: Ensembl
• neuron apoptotic process Source: UniProtKB
• oligodendrocyte differentiation Source: Ensembl
• positive regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • 10381623
  • 9973195
• positive regulation of autophagy Source: UniProtKBTraceable author statementⁱ
  • 18309324
• positive regulation of autophagy of mitochondrion Source: Ensembl
• positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
• positive regulation of macroautophagy Source: MGIInferred from genetic interactionⁱ
  • 19273585
• positive regulation of mitochondrial calcium ion concentration Source: Ensembl
• positive regulation of mitochondrial fission Source: BHF-UCLInferred from direct assayⁱ
  • 20436456
• positive regulation of necrotic cell death Source: Ensembl
• positive regulation of programmed cell death Source: UniProtKBInferred from direct assayⁱ
  • 10891486
• positive regulation of protein complex disassembly Source: BHF-UCLInferred from direct assayⁱ
  • 20436456
• positive regulation of release of cytochrome c from mitochondria Source: BHF-UCLInferred from direct assayⁱ
  • 20436456
• reactive oxygen species metabolic process Source: UniProtKBInferred from direct assayⁱ
  • 10891486
• regulation of aerobic respiration Source: Ensembl
• regulation of mitochondrial membrane permeability Source: UniProtKBInferred from direct assayⁱ
  • 10891486
• response to bacterium Source: Ensembl
• response to hyperoxia Source: Ensembl
• response to hypoxia Source: UniProtKB
• toxin transport Source: Ensembl
• viral process Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• GTPase binding Source: BHF-UCLInferred from physical interactionⁱ
  • 20436456
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • 10381623
  • 16189514
  • 25416956
  • 27107012
• protein heterodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • 10381623
• protein homodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • 10381623
  • 9396766

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MGDAAADPPG PALPCEFLRP GCGAPLSPGA QLGRGAPTSA FPPPAAEAHP 
        60         70         80         90        100
AARRGLRSPQ LPSGAMSQNG APGMQEESLQ GSWVELHFSN NGNGGSVPAS 
       110        120        130        140        150
VSIYNGDMEK ILLDAQHESG RSSSKSSHCD SPPRSQTPQD TNRASETDTH 
       160        170        180        190        200
SIGEKNSSQS EEDDIERRKE VESILKKNSD WIWDWSSRPE NIPPKEFLFK 
       210        220        230        240        250
HPKRTATLSM RNTSVMKKGG IFSAEFLKVF LPSLLLSHLL AIGLGIYIGR 

RLTTSTSTF                                              

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. Human chromosome 10
   Human chromosome 10: entries, gene names and cross-references to MIM