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Protein

Protein tyrosine phosphatase type IVA 2

Gene

PTP4A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.1 Publication

Miscellaneous

A processed pseudogene with 96% sequence identity was found in the BRCA1 (113705) region of 17q21.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulationi

Inhibited by sodium orthovanadate and pentamidine.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei69Proton donorBy similarity1
Active sitei101Phosphocysteine intermediate1
Binding sitei107SubstrateBy similarity1

GO - Molecular functioni

  • prenylated protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation
SIGNORiQ12974

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase type IVA 2 (EC:3.1.3.48)
Alternative name(s):
HU-PP-1
OV-1
PTP(CAAXII)
Protein-tyrosine phosphatase 4a2
Protein-tyrosine phosphatase of regenerating liver 2
Short name:
PRL-2
Gene namesi
Name:PTP4A2
Synonyms:PRL2, PTPCAAX2
ORF Names:BM-008
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000184007.17
HGNCiHGNC:9635 PTP4A2
MIMi601584 gene
neXtProtiNX_Q12974

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi164 – 167Missing : Locates in the nucleus and cytosol. No interaction with RABGGTB. 1 Publication4
Mutagenesisi165C → S: No effect on interaction with RABGGTB. 1 Publication1

Organism-specific databases

DisGeNETi8073
OpenTargetsiENSG00000184007
PharmGKBiPA33978

Chemistry databases

ChEMBLiCHEMBL1075105

Polymorphism and mutation databases

BioMutaiPTP4A2
DMDMi68566159

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947851 – 164Protein tyrosine phosphatase type IVA 2Add BLAST164
PropeptideiPRO_0000396731165 – 167Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 101By similarity
Modified residuei164Cysteine methyl esterCurated1
Lipidationi164S-farnesyl cysteine2 Publications1

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ12974
MaxQBiQ12974
PaxDbiQ12974
PeptideAtlasiQ12974
PRIDEiQ12974
ProteomicsDBi59070
59071 [Q12974-2]

PTM databases

DEPODiQ12974
iPTMnetiQ12974
PhosphoSitePlusiQ12974

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.3 Publications

Gene expression databases

BgeeiENSG00000184007
CleanExiHS_PTP4A2
ExpressionAtlasiQ12974 baseline and differential
GenevisibleiQ12974 HS

Organism-specific databases

HPAiCAB011204
HPA003281

Interactioni

Subunit structurei

In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB.1 Publication

Protein-protein interaction databases

BioGridi113747, 34 interactors
IntActiQ12974, 11 interactors
MINTiQ12974
STRINGi9606.ENSP00000344909

Chemistry databases

BindingDBiQ12974

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 10Combined sources4
Beta strandi15 – 19Combined sources5
Turni24 – 26Combined sources3
Helixi27 – 36Combined sources10
Beta strandi39 – 44Combined sources6
Helixi53 – 56Combined sources4
Turni57 – 59Combined sources3
Beta strandi61 – 64Combined sources4
Helixi75 – 91Combined sources17
Beta strandi96 – 100Combined sources5
Beta strandi102 – 106Combined sources5
Helixi107 – 118Combined sources12
Helixi123 – 133Combined sources11
Beta strandi134 – 136Combined sources3
Helixi140 – 148Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5K22X-ray3.00A1-163[»]
5K23X-ray2.96A1-167[»]
5K25X-ray3.05A1-167[»]
ProteinModelPortaliQ12974
SMRiQ12974
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 145Tyrosine-protein phosphataseAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 107Phosphate bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2836 Eukaryota
ENOG4111I7J LUCA
GeneTreeiENSGT00390000009788
HOGENOMiHOG000231265
HOVERGENiHBG071295
InParanoidiQ12974
KOiK18041
OMAiAPIEKEG
OrthoDBiEOG091G0MYM
PhylomeDBiQ12974
TreeFamiTF313384

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q12974-1) [UniParc]FASTAAdd to basket
Also known as: Ptp-IV1a, Ptp-IV1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY
60 70 80 90 100
DKAPVEKEGI HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH
110 120 130 140 150
CVAGLGRAPV LVALALIECG MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR
160
PKMRLRFRDT NGHCCVQ
Length:167
Mass (Da):19,127
Last modified:November 1, 1996 - v1
Checksum:iE97B88BF87B87943
GO
Isoform 2 (identifier: Q12974-2) [UniParc]FASTAAdd to basket
Also known as: PTP4Ar

The sequence of this isoform differs from the canonical sequence as follows:
     64-82: DWPFDDGAPPPNQIVDDWL → KKKGSVQFQTAALFGEIPT
     83-167: Missing.

Show »
Length:82
Mass (Da):9,241
Checksum:i9B230FA7EA3F8A57
GO
Isoform 3 (identifier: Q12974-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-63: Missing.

Note: No experimental confirmation available.
Show »
Length:136
Mass (Da):15,669
Checksum:i906A2AF8CDF7C2C5
GO
Isoform 4 (identifier: Q12974-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-132: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:142
Mass (Da):16,367
Checksum:i777A719A36214008
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13N → D in AAB39331 (PubMed:8661118).Curated1
Sequence conflicti53A → D in AAB59575 (PubMed:7490091).Curated1
Sequence conflicti102V → F in BAG59751 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04481333 – 63Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_01440464 – 82DWPFD…VDDWL → KKKGSVQFQTAALFGEIPT in isoform 2. CuratedAdd BLAST19
Alternative sequenceiVSP_01440583 – 167Missing in isoform 2. CuratedAdd BLAST85
Alternative sequenceiVSP_055056108 – 132Missing in isoform 4. CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14603 mRNA Translation: AAA90979.1
U48297 mRNA Translation: AAB40598.1
L48722 Genomic DNA Translation: AAB42169.1
L48723 Genomic DNA Translation: AAB42170.1
L48937 Genomic DNA Translation: AAB39331.1
AF208850 mRNA Translation: AAF64264.1
AK292703 mRNA Translation: BAF85392.1
AK297280 mRNA Translation: BAG59751.1
AL136115 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07578.1
CH471059 Genomic DNA Translation: EAX07579.1
CH471059 Genomic DNA Translation: EAX07582.1
CH471059 Genomic DNA Translation: EAX07583.1
BC070182 mRNA Translation: AAH70182.1
L39000 mRNA Translation: AAB59575.1
CCDSiCCDS348.1 [Q12974-1]
CCDS53292.1 [Q12974-3]
CCDS59193.1 [Q12974-4]
PIRiI68523
RefSeqiNP_001182029.1, NM_001195100.1 [Q12974-4]
NP_001182030.1, NM_001195101.1 [Q12974-3]
NP_536316.1, NM_080391.3 [Q12974-1]
XP_005271288.1, XM_005271231.3 [Q12974-4]
XP_005271289.1, XM_005271232.3 [Q12974-3]
XP_016857890.1, XM_017002401.1 [Q12974-3]
UniGeneiHs.470477
Hs.713025

Genome annotation databases

EnsembliENST00000457805; ENSP00000409260; ENSG00000184007 [Q12974-3]
ENST00000602683; ENSP00000473490; ENSG00000184007 [Q12974-4]
ENST00000602725; ENSP00000473259; ENSG00000184007 [Q12974-1]
ENST00000647444; ENSP00000493688; ENSG00000184007 [Q12974-1]
GeneIDi8073
KEGGihsa:8073
UCSCiuc001btx.3 human [Q12974-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTP4A2_HUMAN
AccessioniPrimary (citable) accession number: Q12974
Secondary accession number(s): A8K9I8
, B4DM39, D3DPP0, E9PGJ6, O00649, Q15197, Q15259, Q15260, Q15261, R4GN50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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