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Entry version 208 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Transcription initiation factor TFIID subunit 10

Gene

TAF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q12962

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-3214847, HATs acetylate histones
R-HSA-5689880, Ub-specific processing proteases
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q12962

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 10
Alternative name(s):
STAF28
Transcription initiation factor TFIID 30 kDa subunit
Short name:
TAF(II)30
Short name:
TAFII-30
Short name:
TAFII30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF10
Synonyms:TAF2A, TAF2H, TAFII30
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11543, TAF10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600475, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q12962

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000166337.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi189K → Q: Abolishes methylation. Does not affect interaction with LOXL2 but greatly reduces deamination by LOXL2. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6881

Open Targets

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OpenTargetsi
ENSG00000166337

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36318

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12962, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAF10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3024688

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001188972 – 218Transcription initiation factor TFIID subunit 10Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei48PhosphothreonineCombined sources1
Modified residuei189Allysine; alternate1 Publication1
Modified residuei189N6,N6,N6-trimethyllysine; alternate3 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II.2 Publications
Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q12962

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q12962

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q12962

MaxQB - The MaxQuant DataBase

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MaxQBi
Q12962

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12962

PeptideAtlas

More...
PeptideAtlasi
Q12962

PRoteomics IDEntifications database

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PRIDEi
Q12962

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
59056

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12962

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12962

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166337, Expressed in right testis and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12962, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12962, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166337, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC.

Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, SUPT3H, TAF5L TAF6L, TAF9, TAF10, TAF12 and TRRAP (PubMed:9885574).

Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP (PubMed:10373431, PubMed:12601814).

Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9 (PubMed:11564863, PubMed:18206972). The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22.

Interacts with TAF3 (PubMed:11438666).

Interacts with LOXL2 (PubMed:25959397).

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112744, 86 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-900, SAGA complex
CPX-903, TFTC histone acetylation complex
CPX-915, General transcription factor complex TFIID
CPX-930, General transcription factor complex TFIID, TAF4B variant
CPX-989, PCAF histone acetylase complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q12962

Database of interacting proteins

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DIPi
DIP-297N

Protein interaction database and analysis system

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IntActi
Q12962, 32 interactors

Molecular INTeraction database

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MINTi
Q12962

STRING: functional protein association networks

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STRINGi
9606.ENSP00000299424

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12962, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q12962

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi187 – 189[KR]-[STA]-K motif1 Publication3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3423, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000009368

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_064104_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q12962

Identification of Orthologs from Complete Genome Data

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OMAi
CIANDNA

Database of Orthologous Groups

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OrthoDBi
1478962at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q12962

TreeFam database of animal gene trees

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TreeFami
TF313156

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07982, TAF10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00465

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003923, TFIID_30kDa

The PANTHER Classification System

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PANTHERi
PTHR21242, PTHR21242, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03540, TFIID_30kDa, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF017246, TFIID_TAF10, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01443, TFIID30KDSUB

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q12962-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCSGSGADP EAAPASAASA PGPAPPVSAP AALPSSTAAE NKASPAGTAG
60 70 80 90 100
GPGAGAAAGG TGPLAARAGE PAERRGAAPV SAGGAAPPEG AISNGVYVLP
110 120 130 140 150
SAANGDVKPV VSSTPLVDFL MQLEDYTPTI PDAVTGYYLN RAGFEASDPR
160 170 180 190 200
IIRLISLAAQ KFISDIANDA LQHCKMKGTA SGSSRSKSKD RKYTLTMEDL
210
TPALSEYGIN VKKPHYFT
Length:218
Mass (Da):21,711
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i032ED5CA97EBE411
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWP5A0A087WWP5_HUMAN
Transcription initiation factor TFI...
TAF10
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01370692I → T1 PublicationCorresponds to variant dbSNP:rs3176311EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U13991 mRNA Translation: AAA62230.1
U25816 Genomic DNA Translation: AAB61242.1
AF498312 Genomic DNA Translation: AAM14627.1
CR541943 mRNA Translation: CAG46741.1
CH471064 Genomic DNA Translation: EAW68687.1
BC012088 mRNA Translation: AAH12088.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7769.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A57694

NCBI Reference Sequences

More...
RefSeqi
NP_006275.1, NM_006284.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299424; ENSP00000299424; ENSG00000166337

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6881

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6881

UCSC genome browser

More...
UCSCi
uc001mej.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13991 mRNA Translation: AAA62230.1
U25816 Genomic DNA Translation: AAB61242.1
AF498312 Genomic DNA Translation: AAM14627.1
CR541943 mRNA Translation: CAG46741.1
CH471064 Genomic DNA Translation: EAW68687.1
BC012088 mRNA Translation: AAH12088.1
CCDSiCCDS7769.1
PIRiA57694
RefSeqiNP_006275.1, NM_006284.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F69X-ray1.30B186-195[»]
3M53X-ray1.85B186-195[»]
3M54X-ray1.60B186-195[»]
3M55X-ray1.55B186-195[»]
3M56X-ray1.65B186-195[»]
3M57X-ray1.70B186-195[»]
3M58X-ray1.40B186-195[»]
3M59X-ray1.70B186-195[»]
3M5AX-ray1.75B186-195[»]
4J7FX-ray1.59B186-195[»]
4J7IX-ray2.56B186-195[»]
4J83X-ray1.70B186-195[»]
4J8OX-ray1.63B186-195[»]
4WV4X-ray1.91A112-212[»]
5EG2X-ray1.55B186-195[»]
6MZCelectron microscopy4.50O1-218[»]
6MZDelectron microscopy9.80N1-218[»]
6MZLelectron microscopy23.00N/O1-218[»]
6MZMelectron microscopy7.50O1-218[»]
SMRiQ12962
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112744, 86 interactors
ComplexPortaliCPX-900, SAGA complex
CPX-903, TFTC histone acetylation complex
CPX-915, General transcription factor complex TFIID
CPX-930, General transcription factor complex TFIID, TAF4B variant
CPX-989, PCAF histone acetylase complex
CORUMiQ12962
DIPiDIP-297N
IntActiQ12962, 32 interactors
MINTiQ12962
STRINGi9606.ENSP00000299424

PTM databases

iPTMnetiQ12962
PhosphoSitePlusiQ12962

Genetic variation databases

BioMutaiTAF10
DMDMi3024688

Proteomic databases

EPDiQ12962
jPOSTiQ12962
MassIVEiQ12962
MaxQBiQ12962
PaxDbiQ12962
PeptideAtlasiQ12962
PRIDEiQ12962
ProteomicsDBi59056

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1301, 146 antibodies

The DNASU plasmid repository

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DNASUi
6881

Genome annotation databases

EnsembliENST00000299424; ENSP00000299424; ENSG00000166337
GeneIDi6881
KEGGihsa:6881
UCSCiuc001mej.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6881
DisGeNETi6881

GeneCards: human genes, protein and diseases

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GeneCardsi
TAF10
HGNCiHGNC:11543, TAF10
HPAiENSG00000166337, Low tissue specificity
MIMi600475, gene
neXtProtiNX_Q12962
OpenTargetsiENSG00000166337
PharmGKBiPA36318
VEuPathDBiHostDB:ENSG00000166337.9

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3423, Eukaryota
GeneTreeiENSGT00390000009368
HOGENOMiCLU_064104_1_0_1
InParanoidiQ12962
OMAiCIANDNA
OrthoDBi1478962at2759
PhylomeDBiQ12962
TreeFamiTF313156

Enzyme and pathway databases

PathwayCommonsiQ12962
ReactomeiR-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-3214847, HATs acetylate histones
R-HSA-5689880, Ub-specific processing proteases
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
SABIO-RKiQ12962

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6881, 622 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TAF10, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TAF10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6881
PharosiQ12962, Tbio

Protein Ontology

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PROi
PR:Q12962
RNActiQ12962, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166337, Expressed in right testis and 236 other tissues
ExpressionAtlasiQ12962, baseline and differential
GenevisibleiQ12962, HS

Family and domain databases

CDDicd07982, TAF10, 1 hit
IDEALiIID00465
InterProiView protein in InterPro
IPR003923, TFIID_30kDa
PANTHERiPTHR21242, PTHR21242, 1 hit
PfamiView protein in Pfam
PF03540, TFIID_30kDa, 1 hit
PIRSFiPIRSF017246, TFIID_TAF10, 1 hit
PRINTSiPR01443, TFIID30KDSUB

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12962
Secondary accession number(s): O00703, Q13175, Q6FH13
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 208 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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