DLG1

Functionⁱ

Essential multidomain scaffolding protein required for normal development (By similarity).

Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497).

By similarity7 Publications

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction

Biological process

Host-virus interaction

Enzyme and pathway databases

BRENDAⁱ	2.7.4.8, 2681
PathwayCommonsⁱ	Q12959
Reactomeⁱ	R-HSA-399719, Trafficking of AMPA receptors R-HSA-438066, Unblocking of NMDA receptors, glutamate binding and activation R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor R-HSA-447038, NrCAM interactions R-HSA-451308, Activation of Ca-permeable Kainate Receptor R-HSA-5673001, RAF/MAP kinase cascade R-HSA-8849932, Synaptic adhesion-like molecules R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors R-HSA-9617324, Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9620244, Long-term potentiation
SignaLinkⁱ	Q12959
SIGNORⁱ	Q12959

Protein family/group databases

TCDBⁱ	8.A.24.1.7, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

TCDBⁱ

8.A.24.1.7, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Disks large homolog 1Curated Alternative name(s): Synapse-associated protein 97 Short name: SAP-97 Short name: SAP97 hDlg
Gene namesⁱ	Name:DLG1Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2900, DLG1
MIMⁱ	601014, gene
neXtProtⁱ	NX_Q12959
VEuPathDBⁱ	HostDB:ENSG00000075711

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Synapse

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	38 – 40	INI → ANA: Loss of membrane association and DLG2-binding. 1 Publication		3

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1739
MalaCards human disease database More...MalaCardsⁱ	DLG1
Open Targets More...OpenTargetsⁱ	ENSG00000075711
Orphanetⁱ	199306, Cleft lip/palate
PharmGKBⁱ	PA27356

Miscellaneous databases

Pharosⁱ	Q12959, Tbio

Pharosⁱ

Q12959, Tbio

Genetic variation databases

BioMutaⁱ	DLG1
DMDMⁱ	223590196

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000094548	1 – 904	Disks large homolog 1Add BLAST		904

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	115	PhosphothreonineCombined sources	1
Modified residueⁱ	122	PhosphoserineCombined sources	1
Modified residueⁱ	138	PhosphoserineCombined sources	1
Modified residueⁱ	158	PhosphoserineCombined sources	1
Modified residueⁱ	232	PhosphoserineBy similarity	1
Modified residueⁱ	399	PhosphotyrosineBy similarity	1
Modified residueⁱ	568	PhosphoserineCombined sources	1
Modified residueⁱ	573	PhosphoserineCombined sources	1
Modified residueⁱ	575	PhosphoserineCombined sources	1
Modified residueⁱ	579	PhosphoserineCombined sources	1
Modified residueⁱ	598	PhosphoserineBy similarity	1
Modified residueⁱ	619	PhosphoserineCombined sources	1
Modified residueⁱ	684	PhosphoserineCombined sources	1
Modified residueⁱ	687	PhosphoserineCombined sources	1
Modified residueⁱ	834	PhosphoserineBy similarity	1
Isoform 4 (identifier: Q12959-4)
Modified residueⁱ	676	PhosphoserineCombined sources	1
Isoform 2 (identifier: Q12959-2)
Modified residueⁱ	709	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity).By similarity

Ubiquitinated; by MARCHF2 which results in its degradation.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q12959
jPOSTⁱ	Q12959
MassIVEⁱ	Q12959
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q12959
PaxDbⁱ	Q12959
PeptideAtlas More...PeptideAtlasⁱ	Q12959
PRIDEⁱ	Q12959
ProteomicsDBⁱ	18869 20226 59049 [Q12959-1] 59050 [Q12959-2] 59051 [Q12959-3] 59052 [Q12959-4] 59053 [Q12959-5] 59054 [Q12959-6] 59055 [Q12959-7]

PTM databases

GlyConnectⁱ	1182, 1 N-Linked glycan (1 site)
GlyGenⁱ	Q12959, 1 site, 1 N-linked glycan (1 site)
iPTMnetⁱ	Q12959
PhosphoSitePlusⁱ	Q12959
SwissPalmⁱ	Q12959

Expressionⁱ

Tissue specificityⁱ

Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Expressed in the brain (at protein level) (PubMed:23676497). Widely expressed, with isoforms displaying different expression profiles.4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000075711, Expressed in corpus callosum and 243 other tissues
ExpressionAtlasⁱ	Q12959, baseline and differential
Genevisibleⁱ	Q12959, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000075711, Low tissue specificity

HPAⁱ

ENSG00000075711, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Homotetramer (Probable).

Interacts (via guanylate kinase-like domain) with DLGAP1, DLGAP2, DLGAP3, DLGAP4 and MAP1A (By similarity).

Interacts (via guanylate kinase-like domain) with KIF13B (PubMed:10859302). May interact with HTR2A (By similarity).

Interacts (via PDZ domains) with GRIA1 (By similarity).

Interacts (via PDZ domains) with GRIN2A (By similarity).

Interacts (via PDZ domains) with KCND2 and KCND3 (PubMed:19213956).

Interacts (via PDZ domains) with KCNA1, KCNA2, KCNA3 and KCNA4 (PubMed:7477295).

Interacts (via PDZ domains) with ADGRA3 (PubMed:15021905).

Interacts with KCNF1 (PubMed:12445884).

Interacts with CAMK2 (By similarity).

Interacts with cytoskeleton-associated protein EPB41 (PubMed:7937897, PubMed:8922391).

Interacts with cytoskeleton-associated protein EZR (By similarity).

Found in a complex with KCNA5 and CAV3 (By similarity).

Found in a complex with APC and CTNNB1 (PubMed:8638125, PubMed:10656683).

Interacts with CDH1 through binding to PIK3R1 (PubMed:14699157). Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12 (By similarity).

Interacts with TOPK (PubMed:10779557).

Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C) (PubMed:17237226, PubMed:17332497, PubMed:20702775). May interact with TJAP1 (PubMed:11602598).

Interacts with PTEN (By similarity).

Interacts with FRMPD4 (via C-terminus) (PubMed:19118189).

Interacts with LRFN1, LRFN2 and LRFN4 (PubMed:16630835).

Interacts with SFPQ (PubMed:20605917).

Interacts (via PDZ domains) with ADGRA2 (via PDZ-binding motif) (PubMed:15021905, PubMed:25558062).

Interacts with ADAM10; this interaction recruits ADAM10 to the cell membrane during long-term depression in hippocampal neurons (PubMed:23676497).

Interacts with DGKI (via PDZ-binding motif) (By similarity).

Interacts (via PDZ domains) with MARCHF2 (via PDZ domain); the interaction leads to DLG1 ubiqtuitination and degradation (PubMed:17980554).

By similarityCurated21 Publications

(Microbial infection) Interacts with HTLV-1 protein Tax.

1 Publication

(Microbial infection) Interacts with human papillomavirus 18/HPV-18 protein E6.

1 Publication

Binary interactionsⁱ

Hide details

Q12959

With	#Exp.	IntAct
ADAM17 [P78536]	7	EBI-357481,EBI-78188
ADGRA2 [Q96PE1]	2	EBI-357481,EBI-10893263
ANO2 [Q9NQ90]	2	EBI-357481,EBI-20731422
ANO9 [A1A5B4]	2	EBI-357481,EBI-3843564
APC [P25054]	2	EBI-357481,EBI-727707
ARHGEF16 [Q5VV41]	3	EBI-357481,EBI-1057448
BTRC [Q9Y297]	2	EBI-357481,EBI-307461
CALHM3 [Q86XJ0]	2	EBI-357481,EBI-20731541
CD1D [P15813]	2	EBI-357481,EBI-15643544
CRHR1 [P34998]	2	EBI-357481,EBI-3870393
CTNND2 [Q9UQB3]	2	EBI-357481,EBI-7266482
CYSLTR2 [Q9NS75]	7	EBI-357481,EBI-3843579
EVI5 [O60447]	2	EBI-357481,EBI-852291
FAM163B [P0C2L3]	3	EBI-357481,EBI-11793223
FRMPD4 [Q14CM0]	4	EBI-357481,EBI-311279
GRIN2B [Q13224]	3	EBI-357481,EBI-2256942
GRIN2C [Q14957]	2	EBI-357481,EBI-8285963
GUCY1A2 [P33402]	2	EBI-357481,EBI-6911715
HEATR5B [Q9P2D3]	2	EBI-357481,EBI-2832021
KIF1B - isoform 3 [O60333-3]	4	EBI-357481,EBI-465669
MAP2K2 [P36507]	10	EBI-357481,EBI-1056930
MAPK12 [P53778]	2	EBI-357481,EBI-602406
NET1 [Q7Z628]	5	EBI-357481,EBI-2511306
PKP4 [Q99569]	3	EBI-357481,EBI-726447
PRR5 [P85299]	2	EBI-357481,EBI-1387467
RALBP1 [Q15311]	5	EBI-357481,EBI-749285
SLC16A3 [O15427]	2	EBI-357481,EBI-7600166
TANC1 [Q9C0D5]	3	EBI-357481,EBI-11023211
VANGL2 [Q9ULK5]	2	EBI-357481,EBI-1054279
E6 [O57125] from Kappapapillomavirus 2.	2	EBI-357481,EBI-7461590
E6 [P03126] from Human papillomavirus type 16.	3	EBI-357481,EBI-1177242
E6 [P06427] from Human papillomavirus 33.	3	EBI-357481,EBI-11737184
E6 [P06463] from Human papillomavirus type 18.	4	EBI-357481,EBI-1186926
E6 [P17386] from Human papillomavirus 31.	2	EBI-357481,EBI-8516807
E6 [P21735] from Human papillomavirus 45.	2	EBI-357481,EBI-11793794
E6 [P24835] from Human papillomavirus 39.	3	EBI-357481,EBI-11793707
E6 [P27228] from Human papillomavirus 35.	2	EBI-357481,EBI-11793748
E6 [P36799] from Human papillomavirus 3.	2	EBI-357481,EBI-7363822
E6 [P50804] from Human papillomavirus type 70.	3	EBI-357481,EBI-11793696
E6 [P54667] from Human papillomavirus 68.	2	EBI-357481,EBI-11793910
se6 [Q9ICL1] from Kappapapillomavirus 2.	3	EBI-357481,EBI-7461477
US32 [P09708] from Human cytomegalovirus (strain AD169).	2	EBI-357481,EBI-11793940

Isoform 2 [Q12959-2]

With	#Exp.	IntAct
ADGRA2 [Q96PE1]	2	EBI-357500,EBI-10893263
ADGRA3 - isoform 3 [Q8IWK6-3]	2	EBI-357500,EBI-10949249
KIF13B [Q9NQT8]	3	EBI-357500,EBI-766408
Dlg4 [P31016] from Rattus norvegicus.	9	EBI-357500,EBI-375655

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	108083, 144 interactors
ComplexPortalⁱ	CPX-6168, Scribble cell polarity complex, DLG1-LLGL2-SCRIB variant CPX-6192, Scribble cell polarity complex, DLG1-LLGL1-SCRIB variant
CORUMⁱ	Q12959
Database of interacting proteins More...DIPⁱ	DIP-33957N
ELMⁱ	Q12959
IntActⁱ	Q12959, 154 interactors
Molecular INTeraction database More...MINTⁱ	Q12959
STRINGⁱ	9606.ENSP00000345731

Miscellaneous databases

RNActⁱ	Q12959, protein

RNActⁱ

Q12959, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 20	Combined sources	16
Beta strandⁱ	24 – 26	Combined sources	3
Helixⁱ	30 – 42	Combined sources	13
Helixⁱ	44 – 55	Combined sources	12
Turnⁱ	60 – 62	Combined sources	3
Helixⁱ	64 – 66	Combined sources	3
Beta strandⁱ	221 – 228	Combined sources	8
Beta strandⁱ	233 – 239	Combined sources	7
Beta strandⁱ	254 – 258	Combined sources	5
Helixⁱ	263 – 267	Combined sources	5
Beta strandⁱ	275 – 279	Combined sources	5
Helixⁱ	289 – 298	Combined sources	10
Beta strandⁱ	301 – 309	Combined sources	9
Beta strandⁱ	317 – 323	Combined sources	7
Beta strandⁱ	331 – 337	Combined sources	7
Beta strandⁱ	348 – 353	Combined sources	6
Helixⁱ	358 – 362	Combined sources	5
Beta strandⁱ	370 – 374	Combined sources	5
Beta strandⁱ	377 – 382	Combined sources	6
Helixⁱ	384 – 392	Combined sources	9
Beta strandⁱ	396 – 403	Combined sources	8
Beta strandⁱ	465 – 470	Combined sources	6
Beta strandⁱ	472 – 474	Combined sources	3
Beta strandⁱ	477 – 482	Combined sources	6
Beta strandⁱ	484 – 487	Combined sources	4
Beta strandⁱ	489 – 494	Combined sources	6
Helixⁱ	499 – 503	Combined sources	5
Beta strandⁱ	510 – 515	Combined sources	6
Helixⁱ	525 – 533	Combined sources	9
Beta strandⁱ	537 – 545	Combined sources	9
Helixⁱ	547 – 554	Combined sources	8
Beta strandⁱ	717 – 721	Combined sources	5
Helixⁱ	724 – 734	Combined sources	11
Turnⁱ	736 – 738	Combined sources	3
Turnⁱ	756 – 758	Combined sources	3
Helixⁱ	766 – 774	Combined sources	9
Beta strandⁱ	778 – 784	Combined sources	7
Beta strandⁱ	787 – 792	Combined sources	6
Helixⁱ	793 – 800	Combined sources	8
Turnⁱ	801 – 803	Combined sources	3
Beta strandⁱ	805 – 808	Combined sources	4
Helixⁱ	813 – 820	Combined sources	8
Beta strandⁱ	826 – 830	Combined sources	5
Helixⁱ	855 – 864	Combined sources	10
Helixⁱ	865 – 867	Combined sources	3
Beta strandⁱ	869 – 872	Combined sources	4
Helixⁱ	877 – 892	Combined sources	16
Helixⁱ	900 – 902	Combined sources	3

Show more details

3D structure databases

SMRⁱ	Q12959
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q12959

EvolutionaryTraceⁱ

Q12959

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	4 – 64	L27PROSITE-ProRule annotationAdd BLAST	61
Domainⁱ	224 – 310	PDZ 1PROSITE-ProRule annotationAdd BLAST	87
Domainⁱ	319 – 405	PDZ 2PROSITE-ProRule annotationAdd BLAST	87
Domainⁱ	466 – 546	PDZ 3PROSITE-ProRule annotationAdd BLAST	81
Domainⁱ	581 – 651	SH3PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	714 – 889	Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST	176

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	162 – 212	Interaction with SH3 domainsAdd BLAST	51
Regionⁱ	224 – 546	Required for interaction with MARCHF21 PublicationAdd BLAST	323
Regionⁱ	662 – 693	DisorderedSequence analysisAdd BLAST	32

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	662 – 676	Basic and acidic residuesSequence analysisAdd BLAST		15

Domainⁱ

The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells.

The PDZ domains may also mediate association to membranes by binding to EPB41 and ADGRA2 together with the L27 domain that binds CASK and DLG2.

The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization.

Sequence similaritiesⁱ

Belongs to the MAGUK family.Curated

Keywords - Domainⁱ

Repeat, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG0708, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159409
HOGENOMⁱ	CLU_001715_4_2_1
InParanoidⁱ	Q12959
OMAⁱ	TQHMENH
Database of Orthologous Groups More...OrthoDBⁱ	807583at2759
PhylomeDBⁱ	Q12959
TreeFamⁱ	TF323171

Family and domain databases

Gene3Dⁱ	2.30.42.10, 3 hits 3.40.50.300, 1 hit
IDEALⁱ	IID00513
InterProⁱ	View protein in InterPro IPR016313, DLG1-like IPR019590, DLG1_PEST_dom IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR015143, L27_1 IPR004172, L27_dom IPR036892, L27_dom_sf IPR027417, P-loop_NTPase IPR001478, PDZ IPR019583, PDZ_assoc IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00625, Guanylate_kin, 1 hit PF09058, L27_1, 1 hit PF10608, MAGUK_N_PEST, 1 hit PF00595, PDZ, 3 hits PF10600, PDZ_assoc, 1 hit PF00018, SH3_1, 1 hit
PIRSFⁱ	PIRSF001741, MAGUK_DLGH, 1 hit
SMARTⁱ	View protein in SMART SM00072, GuKc, 1 hit SM00569, L27, 1 hit SM01277, MAGUK_N_PEST, 1 hit SM00228, PDZ, 3 hits SM00326, SH3, 1 hit
SUPFAMⁱ	SSF101288, SSF101288, 1 hit SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS51022, L27, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit

Sequences (9+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 9 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 9 described isoforms and 37 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q12959-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI 
        60         70         80         90        100
DIQEFYEVTL LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS 
       110        120        130        140        150
LSPSVEKYRY QDEDTPPQEH ISPQITNEVI GPELVHVSEK NLSEIENVHG 
       160        170        180        190        200
FVSHSHISPI KPTEAVLPSP PTVPVIPVLP VPAENTVILP TIPQANPPPV 
       210        220        230        240        250
LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG GTDNPHIGDD 
       260        270        280        290        300
SSIFITKIIT GGAAAQDGRL RVNDCILRVN EVDVRDVTHS KAVEALKEAG 
       310        320        330        340        350
SIVRLYVKRR KPVSEKIMEI KLIKGPKGLG FSIAGGVGNQ HIPGDNSIYV 
       360        370        380        390        400
TKIIEGGAAH KDGKLQIGDK LLAVNNVCLE EVTHEEAVTA LKNTSDFVYL 
       410        420        430        440        450
KVAKPTSMYM NDGYAPPDIT NSSSQPVDNH VSPSSFLGQT PASPARYSPV 
       460        470        480        490        500
SKAVLGDDEI TREPRKVVLH RGSTGLGFNI VGGEDGEGIF ISFILAGGPA 
       510        520        530        540        550
DLSGELRKGD RIISVNSVDL RAASHEQAAA ALKNAGQAVT IVAQYRPEEY 
       560        570        580        590        600
SRFEAKIHDL REQMMNSSIS SGSGSLRTSQ KRSLYVRALF DYDKTKDSGL 
       610        620        630        640        650
PSQGLNFKFG DILHVINASD DEWWQARQVT PDGESDEVGV IPSKRRVEKK 
       660        670        680        690        700
ERARLKTVKF NSKTRDKGEI PDDMGSKGLK HVTSNASDSE SSYRGQEEYV 
       710        720        730        740        750
LSYEPVNQQE VNYTRPVIIL GPMKDRINDD LISEFPDKFG SCVPHTTRPK 
       760        770        780        790        800
RDYEVDGRDY HFVTSREQME KDIQEHKFIE AGQYNNHLYG TSVQSVREVA 
       810        820        830        840        850
EKGKHCILDV SGNAIKRLQI AQLYPISIFI KPKSMENIME MNKRLTEEQA 
       860        870        880        890        900
RKTFERAMKL EQEFTEHFTA IVQGDTLEDI YNQVKQIIEE QSGSYIWVPA 

KEKL

Length:904

Mass (Da):100,455

Last modified:February 10, 2009 - v2

Checksum:ⁱ6722993A84D0F761

GO

Isoform 2 (identifier: Q12959-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
669-680: EIPDDMGSKGLK → QSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQ

« Hide

        10         20         30         40         50
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI 
        60         70         80         90        100
DIQEFYEVTL LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS 
       110        120        130        140        150
LSPSVEKYRY QDEDTPPQEH ISPQITNEVI GPELVHVSEK NLSEIENVHG 
       160        170        180        190        200
FVSHSHISPI KPTEAVLPSP PTVPVIPVLP VPAENTVILP TIPQANPPPV 
       210        220        230        240        250
LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG GTDNPHIGDD 
       260        270        280        290        300
SSIFITKIIT GGAAAQDGRL RVNDCILRVN EVDVRDVTHS KAVEALKEAG 
       310        320        330        340        350
SIVRLYVKRR KPVSEKIMEI KLIKGPKGLG FSIAGGVGNQ HIPGDNSIYV 
       360        370        380        390        400
TKIIEGGAAH KDGKLQIGDK LLAVNNVCLE EVTHEEAVTA LKNTSDFVYL 
       410        420        430        440        450
KVAKPTSMYM NDGYAPPDIT NSSSQPVDNH VSPSSFLGQT PASPARYSPV 
       460        470        480        490        500
SKAVLGDDEI TREPRKVVLH RGSTGLGFNI VGGEDGEGIF ISFILAGGPA 
       510        520        530        540        550
DLSGELRKGD RIISVNSVDL RAASHEQAAA ALKNAGQAVT IVAQYRPEEY 
       560        570        580        590        600
SRFEAKIHDL REQMMNSSIS SGSGSLRTSQ KRSLYVRALF DYDKTKDSGL 
       610        620        630        640        650
PSQGLNFKFG DILHVINASD DEWWQARQVT PDGESDEVGV IPSKRRVEKK 
       660        670        680        690        700
ERARLKTVKF NSKTRDKGQS FNDKRKKNLF SRKFPFYKNK DQSEQETSDA 
       710        720        730        740        750
DQHVTSNASD SESSYRGQEE YVLSYEPVNQ QEVNYTRPVI ILGPMKDRIN 
       760        770        780        790        800
DDLISEFPDK FGSCVPHTTR PKRDYEVDGR DYHFVTSREQ MEKDIQEHKF 
       810        820        830        840        850
IEAGQYNNHL YGTSVQSVRE VAEKGKHCIL DVSGNAIKRL QIAQLYPISI 
       860        870        880        890        900
FIKPKSMENI MEMNKRLTEE QARKTFERAM KLEQEFTEHF TAIVQGDTLE 
       910        920 
DIYNQVKQII EEQSGSYIWV PAKEKL

Show »

Length:926

Mass (Da):103,321

Checksum:ⁱ85BD4E93A17D74C4

GO

Isoform 3 (identifier: Q12959-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
162-194: Missing.

« Hide

        10         20         30         40         50
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI 
        60         70         80         90        100
DIQEFYEVTL LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS 
       110        120        130        140        150
LSPSVEKYRY QDEDTPPQEH ISPQITNEVI GPELVHVSEK NLSEIENVHG 
       160        170        180        190        200
FVSHSHISPI KANPPPVLVN TDSLETPTYV NGTDADYEYE EITLERGNSG 
       210        220        230        240        250
LGFSIAGGTD NPHIGDDSSI FITKIITGGA AAQDGRLRVN DCILRVNEVD 
       260        270        280        290        300
VRDVTHSKAV EALKEAGSIV RLYVKRRKPV SEKIMEIKLI KGPKGLGFSI 
       310        320        330        340        350
AGGVGNQHIP GDNSIYVTKI IEGGAAHKDG KLQIGDKLLA VNNVCLEEVT 
       360        370        380        390        400
HEEAVTALKN TSDFVYLKVA KPTSMYMNDG YAPPDITNSS SQPVDNHVSP 
       410        420        430        440        450
SSFLGQTPAS PARYSPVSKA VLGDDEITRE PRKVVLHRGS TGLGFNIVGG 
       460        470        480        490        500
EDGEGIFISF ILAGGPADLS GELRKGDRII SVNSVDLRAA SHEQAAAALK 
       510        520        530        540        550
NAGQAVTIVA QYRPEEYSRF EAKIHDLREQ MMNSSISSGS GSLRTSQKRS 
       560        570        580        590        600
LYVRALFDYD KTKDSGLPSQ GLNFKFGDIL HVINASDDEW WQARQVTPDG 
       610        620        630        640        650
ESDEVGVIPS KRRVEKKERA RLKTVKFNSK TRDKGEIPDD MGSKGLKHVT 
       660        670        680        690        700
SNASDSESSY RGQEEYVLSY EPVNQQEVNY TRPVIILGPM KDRINDDLIS 
       710        720        730        740        750
EFPDKFGSCV PHTTRPKRDY EVDGRDYHFV TSREQMEKDI QEHKFIEAGQ 
       760        770        780        790        800
YNNHLYGTSV QSVREVAEKG KHCILDVSGN AIKRLQIAQL YPISIFIKPK 
       810        820        830        840        850
SMENIMEMNK RLTEEQARKT FERAMKLEQE FTEHFTAIVQ GDTLEDIYNQ 
       860        870 
VKQIIEEQSG SYIWVPAKEK L

Show »

Length:871

Mass (Da):97,076

Checksum:ⁱ78CB64FC6DE66BB1

GO

Isoform 4 (identifier: Q12959-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
162-194: Missing.
669-680: EIPDDMGSKGLK → QSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQ

« Hide

        10         20         30         40         50
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI 
        60         70         80         90        100
DIQEFYEVTL LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS 
       110        120        130        140        150
LSPSVEKYRY QDEDTPPQEH ISPQITNEVI GPELVHVSEK NLSEIENVHG 
       160        170        180        190        200
FVSHSHISPI KANPPPVLVN TDSLETPTYV NGTDADYEYE EITLERGNSG 
       210        220        230        240        250
LGFSIAGGTD NPHIGDDSSI FITKIITGGA AAQDGRLRVN DCILRVNEVD 
       260        270        280        290        300
VRDVTHSKAV EALKEAGSIV RLYVKRRKPV SEKIMEIKLI KGPKGLGFSI 
       310        320        330        340        350
AGGVGNQHIP GDNSIYVTKI IEGGAAHKDG KLQIGDKLLA VNNVCLEEVT 
       360        370        380        390        400
HEEAVTALKN TSDFVYLKVA KPTSMYMNDG YAPPDITNSS SQPVDNHVSP 
       410        420        430        440        450
SSFLGQTPAS PARYSPVSKA VLGDDEITRE PRKVVLHRGS TGLGFNIVGG 
       460        470        480        490        500
EDGEGIFISF ILAGGPADLS GELRKGDRII SVNSVDLRAA SHEQAAAALK 
       510        520        530        540        550
NAGQAVTIVA QYRPEEYSRF EAKIHDLREQ MMNSSISSGS GSLRTSQKRS 
       560        570        580        590        600
LYVRALFDYD KTKDSGLPSQ GLNFKFGDIL HVINASDDEW WQARQVTPDG 
       610        620        630        640        650
ESDEVGVIPS KRRVEKKERA RLKTVKFNSK TRDKGQSFND KRKKNLFSRK 
       660        670        680        690        700
FPFYKNKDQS EQETSDADQH VTSNASDSES SYRGQEEYVL SYEPVNQQEV 
       710        720        730        740        750
NYTRPVIILG PMKDRINDDL ISEFPDKFGS CVPHTTRPKR DYEVDGRDYH 
       760        770        780        790        800
FVTSREQMEK DIQEHKFIEA GQYNNHLYGT SVQSVREVAE KGKHCILDVS 
       810        820        830        840        850
GNAIKRLQIA QLYPISIFIK PKSMENIMEM NKRLTEEQAR KTFERAMKLE 
       860        870        880        890 
QEFTEHFTAI VQGDTLEDIY NQVKQIIEEQ SGSYIWVPAK EKL

Show »

Length:893

Mass (Da):99,942

Checksum:ⁱ3A026E9BAA62FFB7

GO

Isoform 5 (identifier: Q12959-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
162-194: Missing.
195-212: Missing.

« Hide

        10         20         30         40         50
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI 
        60         70         80         90        100
DIQEFYEVTL LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS 
       110        120        130        140        150
LSPSVEKYRY QDEDTPPQEH ISPQITNEVI GPELVHVSEK NLSEIENVHG 
       160        170        180        190        200
FVSHSHISPI KVNGTDADYE YEEITLERGN SGLGFSIAGG TDNPHIGDDS 
       210        220        230        240        250
SIFITKIITG GAAAQDGRLR VNDCILRVNE VDVRDVTHSK AVEALKEAGS 
       260        270        280        290        300
IVRLYVKRRK PVSEKIMEIK LIKGPKGLGF SIAGGVGNQH IPGDNSIYVT 
       310        320        330        340        350
KIIEGGAAHK DGKLQIGDKL LAVNNVCLEE VTHEEAVTAL KNTSDFVYLK 
       360        370        380        390        400
VAKPTSMYMN DGYAPPDITN SSSQPVDNHV SPSSFLGQTP ASPARYSPVS 
       410        420        430        440        450
KAVLGDDEIT REPRKVVLHR GSTGLGFNIV GGEDGEGIFI SFILAGGPAD 
       460        470        480        490        500
LSGELRKGDR IISVNSVDLR AASHEQAAAA LKNAGQAVTI VAQYRPEEYS 
       510        520        530        540        550
RFEAKIHDLR EQMMNSSISS GSGSLRTSQK RSLYVRALFD YDKTKDSGLP 
       560        570        580        590        600
SQGLNFKFGD ILHVINASDD EWWQARQVTP DGESDEVGVI PSKRRVEKKE 
       610        620        630        640        650
RARLKTVKFN SKTRDKGEIP DDMGSKGLKH VTSNASDSES SYRGQEEYVL 
       660        670        680        690        700
SYEPVNQQEV NYTRPVIILG PMKDRINDDL ISEFPDKFGS CVPHTTRPKR 
       710        720        730        740        750
DYEVDGRDYH FVTSREQMEK DIQEHKFIEA GQYNNHLYGT SVQSVREVAE 
       760        770        780        790        800
KGKHCILDVS GNAIKRLQIA QLYPISIFIK PKSMENIMEM NKRLTEEQAR 
       810        820        830        840        850
KTFERAMKLE QEFTEHFTAI VQGDTLEDIY NQVKQIIEEQ SGSYIWVPAK 

EKL

Show »

Length:853

Mass (Da):95,166

Checksum:ⁱ2E7EE3F5954BA3E0

GO

Isoform 6 (identifier: Q12959-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
681-693: Missing.

« Hide

        10         20         30         40         50
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI 
        60         70         80         90        100
DIQEFYEVTL LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS 
       110        120        130        140        150
LSPSVEKYRY QDEDTPPQEH ISPQITNEVI GPELVHVSEK NLSEIENVHG 
       160        170        180        190        200
FVSHSHISPI KPTEAVLPSP PTVPVIPVLP VPAENTVILP TIPQANPPPV 
       210        220        230        240        250
LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG GTDNPHIGDD 
       260        270        280        290        300
SSIFITKIIT GGAAAQDGRL RVNDCILRVN EVDVRDVTHS KAVEALKEAG 
       310        320        330        340        350
SIVRLYVKRR KPVSEKIMEI KLIKGPKGLG FSIAGGVGNQ HIPGDNSIYV 
       360        370        380        390        400
TKIIEGGAAH KDGKLQIGDK LLAVNNVCLE EVTHEEAVTA LKNTSDFVYL 
       410        420        430        440        450
KVAKPTSMYM NDGYAPPDIT NSSSQPVDNH VSPSSFLGQT PASPARYSPV 
       460        470        480        490        500
SKAVLGDDEI TREPRKVVLH RGSTGLGFNI VGGEDGEGIF ISFILAGGPA 
       510        520        530        540        550
DLSGELRKGD RIISVNSVDL RAASHEQAAA ALKNAGQAVT IVAQYRPEEY 
       560        570        580        590        600
SRFEAKIHDL REQMMNSSIS SGSGSLRTSQ KRSLYVRALF DYDKTKDSGL 
       610        620        630        640        650
PSQGLNFKFG DILHVINASD DEWWQARQVT PDGESDEVGV IPSKRRVEKK 
       660        670        680        690        700
ERARLKTVKF NSKTRDKGEI PDDMGSKGLK RGQEEYVLSY EPVNQQEVNY 
       710        720        730        740        750
TRPVIILGPM KDRINDDLIS EFPDKFGSCV PHTTRPKRDY EVDGRDYHFV 
       760        770        780        790        800
TSREQMEKDI QEHKFIEAGQ YNNHLYGTSV QSVREVAEKG KHCILDVSGN 
       810        820        830        840        850
AIKRLQIAQL YPISIFIKPK SMENIMEMNK RLTEEQARKT FERAMKLEQE 
       860        870        880        890 
FTEHFTAIVQ GDTLEDIYNQ VKQIIEEQSG SYIWVPAKEK L

Show »

Length:891

Mass (Da):99,090

Checksum:ⁱ5DB5256100623D0B

GO

Isoform 7 (identifier: Q12959-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
693-693: Y → YLILITDEYGCSKG

« Hide

        10         20         30         40         50
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI 
        60         70         80         90        100
DIQEFYEVTL LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS 
       110        120        130        140        150
LSPSVEKYRY QDEDTPPQEH ISPQITNEVI GPELVHVSEK NLSEIENVHG 
       160        170        180        190        200
FVSHSHISPI KPTEAVLPSP PTVPVIPVLP VPAENTVILP TIPQANPPPV 
       210        220        230        240        250
LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG GTDNPHIGDD 
       260        270        280        290        300
SSIFITKIIT GGAAAQDGRL RVNDCILRVN EVDVRDVTHS KAVEALKEAG 
       310        320        330        340        350
SIVRLYVKRR KPVSEKIMEI KLIKGPKGLG FSIAGGVGNQ HIPGDNSIYV 
       360        370        380        390        400
TKIIEGGAAH KDGKLQIGDK LLAVNNVCLE EVTHEEAVTA LKNTSDFVYL 
       410        420        430        440        450
KVAKPTSMYM NDGYAPPDIT NSSSQPVDNH VSPSSFLGQT PASPARYSPV 
       460        470        480        490        500
SKAVLGDDEI TREPRKVVLH RGSTGLGFNI VGGEDGEGIF ISFILAGGPA 
       510        520        530        540        550
DLSGELRKGD RIISVNSVDL RAASHEQAAA ALKNAGQAVT IVAQYRPEEY 
       560        570        580        590        600
SRFEAKIHDL REQMMNSSIS SGSGSLRTSQ KRSLYVRALF DYDKTKDSGL 
       610        620        630        640        650
PSQGLNFKFG DILHVINASD DEWWQARQVT PDGESDEVGV IPSKRRVEKK 
       660        670        680        690        700
ERARLKTVKF NSKTRDKGEI PDDMGSKGLK HVTSNASDSE SSYLILITDE 
       710        720        730        740        750
YGCSKGRGQE EYVLSYEPVN QQEVNYTRPV IILGPMKDRI NDDLISEFPD 
       760        770        780        790        800
KFGSCVPHTT RPKRDYEVDG RDYHFVTSRE QMEKDIQEHK FIEAGQYNNH 
       810        820        830        840        850
LYGTSVQSVR EVAEKGKHCI LDVSGNAIKR LQIAQLYPIS IFIKPKSMEN 
       860        870        880        890        900
IMEMNKRLTE EQARKTFERA MKLEQEFTEH FTAIVQGDTL EDIYNQVKQI 
       910 
IEEQSGSYIW VPAKEKL

Show »

Length:917

Mass (Da):101,849

Checksum:ⁱFE8911BB05B03211

GO

Isoform 8 (identifier: Q12959-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-77: MPVRKQDTQR...DRSKPSEPIQ → MNYIFGNNTL...DCISVATSST
78-193: Missing.

« Hide

        10         20         30         40         50
MNYIFGNNTL LYSRGSRGGN TSSSHGSAGP KQKHWAKKGS SDELQAEPEP 
        60         70         80         90        100
SRWQQIVAFF TRRHSFIDCI SVATSSTQAN PPPVLVNTDS LETPTYVNGT 
       110        120        130        140        150
DADYEYEEIT LERGNSGLGF SIAGGTDNPH IGDDSSIFIT KIITGGAAAQ 
       160        170        180        190        200
DGRLRVNDCI LRVNEVDVRD VTHSKAVEAL KEAGSIVRLY VKRRKPVSEK 
       210        220        230        240        250
IMEIKLIKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIEG GAAHKDGKLQ 
       260        270        280        290        300
IGDKLLAVNN VCLEEVTHEE AVTALKNTSD FVYLKVAKPT SMYMNDGYAP 
       310        320        330        340        350
PDITNSSSQP VDNHVSPSSF LGQTPASPAR YSPVSKAVLG DDEITREPRK 
       360        370        380        390        400
VVLHRGSTGL GFNIVGGEDG EGIFISFILA GGPADLSGEL RKGDRIISVN 
       410        420        430        440        450
SVDLRAASHE QAAAALKNAG QAVTIVAQYR PEEYSRFEAK IHDLREQMMN 
       460        470        480        490        500
SSISSGSGSL RTSQKRSLYV RALFDYDKTK DSGLPSQGLN FKFGDILHVI 
       510        520        530        540        550
NASDDEWWQA RQVTPDGESD EVGVIPSKRR VEKKERARLK TVKFNSKTRD 
       560        570        580        590        600
KGEIPDDMGS KGLKHVTSNA SDSESSYRGQ EEYVLSYEPV NQQEVNYTRP 
       610        620        630        640        650
VIILGPMKDR INDDLISEFP DKFGSCVPHT TRPKRDYEVD GRDYHFVTSR 
       660        670        680        690        700
EQMEKDIQEH KFIEAGQYNN HLYGTSVQSV REVAEKGKHC ILDVSGNAIK 
       710        720        730        740        750
RLQIAQLYPI SIFIKPKSME NIMEMNKRLT EEQARKTFER AMKLEQEFTE 
       760        770        780 
HFTAIVQGDT LEDIYNQVKQ IIEEQSGSYI WVPAKEKL

Show »

Length:788

Mass (Da):87,248

Checksum:ⁱ8EB77B3368768FBD

GO

Isoform 9 (identifier: Q12959-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: MPVRKQDTQR...DRSKPSEPIQ → MNYIFGNNTL...DCISVATSST
     78-193: Missing.
     693-693: Y → YLILITDEYGCSKG
     694-694: Missing.

« Hide

        10         20         30         40         50
MNYIFGNNTL LYSRGSRGGN TSSSHGSAGP KQKHWAKKGS SDELQAEPEP 
        60         70         80         90        100
SRWQQIVAFF TRRHSFIDCI SVATSSTQAN PPPVLVNTDS LETPTYVNGT 
       110        120        130        140        150
DADYEYEEIT LERGNSGLGF SIAGGTDNPH IGDDSSIFIT KIITGGAAAQ 
       160        170        180        190        200
DGRLRVNDCI LRVNEVDVRD VTHSKAVEAL KEAGSIVRLY VKRRKPVSEK 
       210        220        230        240        250
IMEIKLIKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIEG GAAHKDGKLQ 
       260        270        280        290        300
IGDKLLAVNN VCLEEVTHEE AVTALKNTSD FVYLKVAKPT SMYMNDGYAP 
       310        320        330        340        350
PDITNSSSQP VDNHVSPSSF LGQTPASPAR YSPVSKAVLG DDEITREPRK 
       360        370        380        390        400
VVLHRGSTGL GFNIVGGEDG EGIFISFILA GGPADLSGEL RKGDRIISVN 
       410        420        430        440        450
SVDLRAASHE QAAAALKNAG QAVTIVAQYR PEEYSRFEAK IHDLREQMMN 
       460        470        480        490        500
SSISSGSGSL RTSQKRSLYV RALFDYDKTK DSGLPSQGLN FKFGDILHVI 
       510        520        530        540        550
NASDDEWWQA RQVTPDGESD EVGVIPSKRR VEKKERARLK TVKFNSKTRD 
       560        570        580        590        600
KGEIPDDMGS KGLKHVTSNA SDSESSYLIL ITDEYGCSKG GQEEYVLSYE 
       610        620        630        640        650
PVNQQEVNYT RPVIILGPMK DRINDDLISE FPDKFGSCVP HTTRPKRDYE 
       660        670        680        690        700
VDGRDYHFVT SREQMEKDIQ EHKFIEAGQY NNHLYGTSVQ SVREVAEKGK 
       710        720        730        740        750
HCILDVSGNA IKRLQIAQLY PISIFIKPKS MENIMEMNKR LTEEQARKTF 
       760        770        780        790        800
ERAMKLEQEF TEHFTAIVQG DTLEDIYNQV KQIIEEQSGS YIWVPAKEKL

Show »

Length:800

Mass (Da):88,485

Checksum:ⁱC67306E88A5A473D

GO

Computationally mapped potential isoform sequencesⁱ

There are 37 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A0C4DFT3	A0A0C4DFT3_HUMAN	Disks large homolog 1 Disks large homolog 1	DLG1	892	Annotation score:
	A0A590UJ08	A0A590UJ08_HUMAN	Disks large homolog 1 Disks large homolog 1	DLG1	875	Annotation score:
	A0A590UJD9	A0A590UJD9_HUMAN	Disks large homolog 1 Disks large homolog 1	DLG1	925	Annotation score:
	A0A590UJ18	A0A590UJ18_HUMAN	Disks large homolog 1 Disks large homolog 1	DLG1	868	Annotation score:
	A0A590UJR5	A0A590UJR5_HUMAN	Disks large homolog 1 Disks large homolog 1	DLG1	878	Annotation score:
	A0A590UJ68	A0A590UJ68_HUMAN	Disks large homolog 1 Disks large homolog 1	DLG1	865	Annotation score:
	A0A590UKA8	A0A590UKA8_HUMAN	Disks large homolog 1 Disks large homolog 1	DLG1	883	Annotation score:
	A0A590UK48	A0A590UK48_HUMAN	Disks large homolog 1 Disks large homolog 1	DLG1	821	Annotation score:
	A0A590UJR4	A0A590UJR4_HUMAN	Disks large homolog 1 Disks large homolog 1	DLG1	819	Annotation score:
	A0A590UJX2	A0A590UJX2_HUMAN	Disks large homolog 1 Disks large homolog 1	DLG1	833	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	237	S → N in BAG57902 (PubMed:14702039).Curated	1
Sequence conflictⁱ	801	E → G in AAA50598 (PubMed:7937897).Curated	1
Sequence conflictⁱ	801	E → G in AAA50599 (PubMed:7937897).Curated	1
Isoform 4 (identifier: Q12959-4)
Sequence conflictⁱ	636	Missing in AAI44652 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_054334	140	K → R. Corresponds to variant dbSNP:rs1802668Ensembl.	1
Natural variantⁱVAR_054335	278	R → Q2 PublicationsCorresponds to variant dbSNP:rs1134986Ensembl.	1
Natural variantⁱVAR_054336	899	P → L. Corresponds to variant dbSNP:rs34492126Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045896	1 – 77	MPVRK…SEPIQ → MNYIFGNNTLLYSRGSRGGN TSSSHGSAGPKQKHWAKKGS SDELQAEPEPSRWQQIVAFF TRRHSFIDCISVATSST in isoform 8 and isoform 9. 1 PublicationAdd BLAST	77
Alternative sequenceⁱVSP_045897	78 – 193	Missing in isoform 8 and isoform 9. 1 PublicationAdd BLAST	116
Alternative sequenceⁱVSP_012862	162 – 194	Missing in isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST	33
Alternative sequenceⁱVSP_012863	195 – 212	Missing in isoform 5. CuratedAdd BLAST	18
Alternative sequenceⁱVSP_003150	669 – 680	EIPDD…SKGLK → QSFNDKRKKNLFSRKFPFYK NKDQSEQETSDADQ in isoform 2 and isoform 4. 2 PublicationsAdd BLAST	12
Alternative sequenceⁱVSP_012864	681 – 693	Missing in isoform 6. CuratedAdd BLAST	13
Alternative sequenceⁱVSP_012865	693	Y → YLILITDEYGCSKG in isoform 7 and isoform 9. 1 Publication	1
Alternative sequenceⁱVSP_045898	694	Missing in isoform 9. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U13896 mRNA Translation: AAA50598.1 U13897 mRNA Translation: AAA50599.1 AK294772 mRNA Translation: BAG57902.1 AK294855 mRNA Translation: BAG57959.1 EF553524 mRNA Translation: ABQ66269.1 AC068302 Genomic DNA No translation available. AC092937 Genomic DNA No translation available. CH471191 Genomic DNA Translation: EAW53610.1 CH471191 Genomic DNA Translation: EAW53611.1 CH471191 Genomic DNA Translation: EAW53612.1 CH471191 Genomic DNA Translation: EAW53614.1 BC140841 mRNA Translation: AAI40842.1 BC144651 mRNA Translation: AAI44652.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3327.1 [Q12959-2] CCDS43194.1 [Q12959-1] CCDS56300.1 [Q12959-8] CCDS56301.1 [Q12959-9] CCDS87192.1 [Q12959-4]
PIRⁱ	I38756 I38757
NCBI Reference Sequences More...RefSeqⁱ	NP_001091894.1, NM_001098424.1 [Q12959-1] NP_001191315.1, NM_001204386.1 NP_001191316.1, NM_001204387.1 [Q12959-9] NP_001191317.1, NM_001204388.1 [Q12959-8] NP_001277912.1, NM_001290983.1 [Q12959-1] NP_004078.2, NM_004087.2 [Q12959-2] XP_005269346.1, XM_005269289.3 [Q12959-2] XP_011510804.1, XM_011512502.2 [Q12959-1] XP_011510805.1, XM_011512503.1 XP_011510807.1, XM_011512505.1 XP_011510808.1, XM_011512506.1 XP_016861289.1, XM_017005800.1 [Q12959-2] XP_016861290.1, XM_017005801.1 [Q12959-2] XP_016861291.1, XM_017005802.1 [Q12959-2] XP_016861292.1, XM_017005803.1 [Q12959-2] XP_016861294.1, XM_017005805.1 XP_016861295.1, XM_017005806.1 XP_016861296.1, XM_017005807.1 XP_016861297.1, XM_017005808.1 XP_016861298.1, XM_017005809.1 XP_016861299.1, XM_017005810.1 XP_016861305.1, XM_017005816.1 XP_016861306.1, XM_017005817.1 XP_016861307.1, XM_017005818.1 XP_016861308.1, XM_017005819.1 [Q12959-3] XP_016861309.1, XM_017005820.1

Genome annotation databases

Ensemblⁱ	ENST00000346964; ENSP00000345731; ENSG00000075711 [Q12959-2] ENST00000357674; ENSP00000350303; ENSG00000075711 [Q12959-4] ENST00000392382; ENSP00000376187; ENSG00000075711 [Q12959-3] ENST00000419354; ENSP00000407531; ENSG00000075711 ENST00000422288; ENSP00000413238; ENSG00000075711 [Q12959-5] ENST00000443183; ENSP00000396658; ENSG00000075711 [Q12959-9] ENST00000448528; ENSP00000391732; ENSG00000075711 ENST00000450955; ENSP00000411278; ENSG00000075711 [Q12959-4] ENST00000452595; ENSP00000398939; ENSG00000075711 [Q12959-8] ENST00000655488; ENSP00000499657; ENSG00000075711 [Q12959-3] ENST00000659716; ENSP00000499602; ENSG00000075711 [Q12959-3] ENST00000661453; ENSP00000499514; ENSG00000075711 [Q12959-3] ENST00000663148; ENSP00000499384; ENSG00000075711 [Q12959-3] ENST00000666007; ENSP00000499793; ENSG00000075711 [Q12959-5] ENST00000667157; ENSP00000499414; ENSG00000075711 [Q12959-4] ENST00000669565; ENSP00000499413; ENSG00000075711 [Q12959-4] ENST00000670455; ENSP00000499542; ENSG00000075711 [Q12959-4] ENST00000670935; ENSP00000499437; ENSG00000075711 ENST00000671185; ENSP00000499580; ENSG00000075711 [Q12959-3]
GeneIDⁱ	1739
KEGGⁱ	hsa:1739
MANE-Selectⁱ	ENST00000667157.1; ENSP00000499414.1; NM_001366207.1; NP_001353136.1 [Q12959-4]
UCSC genome browser More...UCSCⁱ	uc003fxn.4, human [Q12959-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q12959	Discs large MAGUK scaffold protein 1		GORGO		904	UniRef100_Q12959
+1
Q12959-2	Discs large MAGUK scaffold protein 1		GORGO		926	UniRef100_G3QQG4
Q12959-5	Discs large MAGUK scaffold protein 1		GORGO		853	UniRef100_A0A2I2ZVE4
Q12959-9	Discs large MAGUK scaffold protein 1		PAPAN		800	UniRef100_A0A096MSS0
Discs large MAGUK scaffold protein 1		GORGO		800
Discs large MAGUK scaffold protein 1		THEGE		800

Protein	Similar proteins		Species	Score	Length	Source
Q12959	Discs large MAGUK scaffold protein 1		GORGO		904	UniRef90_Q12959
Discs large MAGUK scaffold protein 1		PANTR		926
Discs large MAGUK scaffold protein 1		PANPA		926
DLG1 isoform 5		PONAB		926
Isoform 2 of Disks large homolog 1		HUMAN		926
+34
Q12959-3	disks large homolog 1 isoform X4		VICPA		894	UniRef90_Q12959-3
Discs large MAGUK scaffold protein 1		MOSMO		894
disks large homolog 1 isoform X8		SHEEP		894
disks large homolog 1 isoform X4		CAMFR		894
disks large homolog 1 isoform X4		TURTR		894
+34
Q12959-4	Discs large MAGUK scaffold protein 1		PANTR		893	UniRef90_Q12959-4
DLG1 isoform 10		PANTR		893
Q12959-5	Discs large MAGUK scaffold protein 1		GORGO		853	UniRef90_A0A2I2ZVE4
DLG1 isoform 6		PANTR		853
Discs large MAGUK scaffold protein 1		PANPA		853
Discs large MAGUK scaffold protein 1		PANTR		853
Q12959-8	Discs large MAGUK scaffold protein 1		PANTR		788	UniRef90_Q12959-8
DLG1 isoform 5		PANTR		788
+2
Q12959-9	Uncharacterized protein		CHLSB		800	UniRef90_A0A0D9R8Q0
DLG1 isoform 8		PANTR		800
Discs large MAGUK scaffold protein 1		PANPA		800
Discs large MAGUK scaffold protein 1		MACFA		800
Discs large MAGUK scaffold protein 1		MACNE		800
+4

Protein	Similar proteins		Species	Score	Length	Source
Q12959	Disks large homolog 1	)	RAT		911	UniRef50_Q12959
Discs large MAGUK scaffold protein 1		GORGO		904
DLG1 isoform 5		PONAB		926
Isoform 2 of Disks large homolog 1		HUMAN		926
Discs large MAGUK scaffold protein 1		PANTR		926
+805
Q12959-3	Isoform 4 of Disks large homolog 1		HUMAN		893	UniRef50_Q12959-4
Discs large MAGUK scaffold protein 1		PANTR		893
Discs large MAGUK scaffold protein 2		PANPA		830
Discs large MAGUK scaffold protein 2		JUNHY		781
disks large homolog 1 isoform X12		Wire-tailed manakin		896
+466
Q12959-5	Discs large MAGUK scaffold protein 1		FELCA		876	UniRef50_A0A2I2USD7
disks large homolog 1 isoform X15		ACIJB		876
Discs large MAGUK scaffold protein 1		PANLE		876
disks large homolog 1 isoform X5		Enhydra lutris kenyoni		801
Disks large homolog 1		HUMAN		875
+63
Q12959-8	Discs large homolog 1-like protein		DANRE		827	UniRef50_Q12959-8
Discs large MAGUK scaffold protein 1		PANTR		788
Discs large MAGUK scaffold protein 1		BOVIN		779
disks large homolog 1 isoform X11		SALSA		819
disks large homolog 1 isoform X22		Wire-tailed manakin		821
+778

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U13896 mRNA Translation: AAA50598.1 U13897 mRNA Translation: AAA50599.1 AK294772 mRNA Translation: BAG57902.1 AK294855 mRNA Translation: BAG57959.1 EF553524 mRNA Translation: ABQ66269.1 AC068302 Genomic DNA No translation available. AC092937 Genomic DNA No translation available. CH471191 Genomic DNA Translation: EAW53610.1 CH471191 Genomic DNA Translation: EAW53611.1 CH471191 Genomic DNA Translation: EAW53612.1 CH471191 Genomic DNA Translation: EAW53614.1 BC140841 mRNA Translation: AAI40842.1 BC144651 mRNA Translation: AAI44652.1
CCDSⁱ	CCDS3327.1 [Q12959-2] CCDS43194.1 [Q12959-1] CCDS56300.1 [Q12959-8] CCDS56301.1 [Q12959-9] CCDS87192.1 [Q12959-4]
PIRⁱ	I38756 I38757
RefSeqⁱ	NP_001091894.1, NM_001098424.1 [Q12959-1] NP_001191315.1, NM_001204386.1 NP_001191316.1, NM_001204387.1 [Q12959-9] NP_001191317.1, NM_001204388.1 [Q12959-8] NP_001277912.1, NM_001290983.1 [Q12959-1] NP_004078.2, NM_004087.2 [Q12959-2] XP_005269346.1, XM_005269289.3 [Q12959-2] XP_011510804.1, XM_011512502.2 [Q12959-1] XP_011510805.1, XM_011512503.1 XP_011510807.1, XM_011512505.1 XP_011510808.1, XM_011512506.1 XP_016861289.1, XM_017005800.1 [Q12959-2] XP_016861290.1, XM_017005801.1 [Q12959-2] XP_016861291.1, XM_017005802.1 [Q12959-2] XP_016861292.1, XM_017005803.1 [Q12959-2] XP_016861294.1, XM_017005805.1 XP_016861295.1, XM_017005806.1 XP_016861296.1, XM_017005807.1 XP_016861297.1, XM_017005808.1 XP_016861298.1, XM_017005809.1 XP_016861299.1, XM_017005810.1 XP_016861305.1, XM_017005816.1 XP_016861306.1, XM_017005817.1 XP_016861307.1, XM_017005818.1 XP_016861308.1, XM_017005819.1 [Q12959-3] XP_016861309.1, XM_017005820.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1PDR	X-ray	2.80	A	457-555	[»]
	2M3M	NMR	-	A	318-406	[»]
	2OQS	NMR	-	A	318-406	[»]
	2X7Z	X-ray	2.00	A	311-407	[»]
	3LRA	X-ray	2.95	A	2-65	[»]
	3RL7	X-ray	2.30	A/B/C/D/E/F	220-317	[»]
	3RL8	X-ray	2.20	A/B/C/D/E	315-410	[»]
	3W9Y	X-ray	2.20	A	712-904	[»]
	4AMH	X-ray	2.30	A/B	315-405	[»]
	4G69	X-ray	2.00	A	310-407	[»]
SMRⁱ	Q12959
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	108083, 144 interactors
ComplexPortalⁱ	CPX-6168, Scribble cell polarity complex, DLG1-LLGL2-SCRIB variant CPX-6192, Scribble cell polarity complex, DLG1-LLGL1-SCRIB variant
CORUMⁱ	Q12959
DIPⁱ	DIP-33957N
ELMⁱ	Q12959
IntActⁱ	Q12959, 154 interactors
MINTⁱ	Q12959
STRINGⁱ	9606.ENSP00000345731

Protein family/group databases

TCDBⁱ	8.A.24.1.7, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

TCDBⁱ

8.A.24.1.7, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

PTM databases

GlyConnectⁱ	1182, 1 N-Linked glycan (1 site)
GlyGenⁱ	Q12959, 1 site, 1 N-linked glycan (1 site)
iPTMnetⁱ	Q12959
PhosphoSitePlusⁱ	Q12959
SwissPalmⁱ	Q12959

Genetic variation databases

BioMutaⁱ	DLG1
DMDMⁱ	223590196

Proteomic databases

EPDⁱ	Q12959
jPOSTⁱ	Q12959
MassIVEⁱ	Q12959
MaxQBⁱ	Q12959
PaxDbⁱ	Q12959
PeptideAtlasⁱ	Q12959
PRIDEⁱ	Q12959
ProteomicsDBⁱ	18869 20226 59049 [Q12959-1] 59050 [Q12959-2] 59051 [Q12959-3] 59052 [Q12959-4] 59053 [Q12959-5] 59054 [Q12959-6] 59055 [Q12959-7]

Protocols and materials databases

ABCDⁱ	Q12959, 1 sequenced antibody
Antibodypediaⁱ	4273, 285 antibodies from 41 providers
The DNASU plasmid repository More...DNASUⁱ	1739

Genome annotation databases

Ensemblⁱ	ENST00000346964; ENSP00000345731; ENSG00000075711 [Q12959-2] ENST00000357674; ENSP00000350303; ENSG00000075711 [Q12959-4] ENST00000392382; ENSP00000376187; ENSG00000075711 [Q12959-3] ENST00000419354; ENSP00000407531; ENSG00000075711 ENST00000422288; ENSP00000413238; ENSG00000075711 [Q12959-5] ENST00000443183; ENSP00000396658; ENSG00000075711 [Q12959-9] ENST00000448528; ENSP00000391732; ENSG00000075711 ENST00000450955; ENSP00000411278; ENSG00000075711 [Q12959-4] ENST00000452595; ENSP00000398939; ENSG00000075711 [Q12959-8] ENST00000655488; ENSP00000499657; ENSG00000075711 [Q12959-3] ENST00000659716; ENSP00000499602; ENSG00000075711 [Q12959-3] ENST00000661453; ENSP00000499514; ENSG00000075711 [Q12959-3] ENST00000663148; ENSP00000499384; ENSG00000075711 [Q12959-3] ENST00000666007; ENSP00000499793; ENSG00000075711 [Q12959-5] ENST00000667157; ENSP00000499414; ENSG00000075711 [Q12959-4] ENST00000669565; ENSP00000499413; ENSG00000075711 [Q12959-4] ENST00000670455; ENSP00000499542; ENSG00000075711 [Q12959-4] ENST00000670935; ENSP00000499437; ENSG00000075711 ENST00000671185; ENSP00000499580; ENSG00000075711 [Q12959-3]
GeneIDⁱ	1739
KEGGⁱ	hsa:1739
MANE-Selectⁱ	ENST00000667157.1; ENSP00000499414.1; NM_001366207.1; NP_001353136.1 [Q12959-4]
UCSCⁱ	uc003fxn.4, human [Q12959-1]

Organism-specific databases

CTDⁱ	1739
DisGeNETⁱ	1739
GeneCardsⁱ	DLG1
HGNCⁱ	HGNC:2900, DLG1
HPAⁱ	ENSG00000075711, Low tissue specificity
MalaCardsⁱ	DLG1
MIMⁱ	601014, gene
neXtProtⁱ	NX_Q12959
OpenTargetsⁱ	ENSG00000075711
Orphanetⁱ	199306, Cleft lip/palate
PharmGKBⁱ	PA27356
VEuPathDBⁱ	HostDB:ENSG00000075711
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0708, Eukaryota
GeneTreeⁱ	ENSGT00940000159409
HOGENOMⁱ	CLU_001715_4_2_1
InParanoidⁱ	Q12959
OMAⁱ	TQHMENH
OrthoDBⁱ	807583at2759
PhylomeDBⁱ	Q12959
TreeFamⁱ	TF323171

Enzyme and pathway databases

BRENDAⁱ	2.7.4.8, 2681
PathwayCommonsⁱ	Q12959
Reactomeⁱ	R-HSA-399719, Trafficking of AMPA receptors R-HSA-438066, Unblocking of NMDA receptors, glutamate binding and activation R-HSA-442982, Ras activation upon Ca2+ influx through NMDA receptor R-HSA-447038, NrCAM interactions R-HSA-451308, Activation of Ca-permeable Kainate Receptor R-HSA-5673001, RAF/MAP kinase cascade R-HSA-8849932, Synaptic adhesion-like molecules R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors R-HSA-9617324, Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9620244, Long-term potentiation
SignaLinkⁱ	Q12959
SIGNORⁱ	Q12959

Miscellaneous databases

BioGRID-ORCSⁱ	1739, 211 hits in 1065 CRISPR screens
ChiTaRSⁱ	DLG1, human
EvolutionaryTraceⁱ	Q12959
GeneWikiⁱ	DLG1
GenomeRNAiⁱ	1739
Pharosⁱ	Q12959, Tbio
Protein Ontology More...PROⁱ	PR:Q12959
RNActⁱ	Q12959, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000075711, Expressed in corpus callosum and 243 other tissues
ExpressionAtlasⁱ	Q12959, baseline and differential
Genevisibleⁱ	Q12959, HS

Family and domain databases

Gene3Dⁱ	2.30.42.10, 3 hits 3.40.50.300, 1 hit
IDEALⁱ	IID00513
InterProⁱ	View protein in InterPro IPR016313, DLG1-like IPR019590, DLG1_PEST_dom IPR008145, GK/Ca_channel_bsu IPR008144, Guanylate_kin-like_dom IPR020590, Guanylate_kinase_CS IPR015143, L27_1 IPR004172, L27_dom IPR036892, L27_dom_sf IPR027417, P-loop_NTPase IPR001478, PDZ IPR019583, PDZ_assoc IPR036034, PDZ_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain
Pfamⁱ	View protein in Pfam PF00625, Guanylate_kin, 1 hit PF09058, L27_1, 1 hit PF10608, MAGUK_N_PEST, 1 hit PF00595, PDZ, 3 hits PF10600, PDZ_assoc, 1 hit PF00018, SH3_1, 1 hit
PIRSFⁱ	PIRSF001741, MAGUK_DLGH, 1 hit
SMARTⁱ	View protein in SMART SM00072, GuKc, 1 hit SM00569, L27, 1 hit SM01277, MAGUK_N_PEST, 1 hit SM00228, PDZ, 3 hits SM00326, SH3, 1 hit
SUPFAMⁱ	SSF101288, SSF101288, 1 hit SSF50044, SSF50044, 1 hit SSF50156, SSF50156, 3 hits SSF52540, SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00856, GUANYLATE_KINASE_1, 1 hit PS50052, GUANYLATE_KINASE_2, 1 hit PS51022, L27, 1 hit PS50106, PDZ, 3 hits PS50002, SH3, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DLG1_HUMAN
Accessionⁱ	Q12959Primary (citable) accession number: Q12959 Secondary accession number(s): A5YKK7 Q12958
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	February 10, 2009
	Last modified:	February 23, 2022
	This is version 236 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q12959 (DLG1_HUMAN)

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Disks large homolog 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoplasm and Cytosol

Endoplasmic reticulum

Other locations

Cytoskeleton

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q12959

Isoform 2 [Q12959-2]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

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Genetic variation databases

Proteomic databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ