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UniProtKB - Q12955 (ANK3_HUMAN)

Entry version 201 (10 Feb 2021)
Sequence version 3 (01 Sep 2009)
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Protein

Ankyrin-3

Gene

ANK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg2+ levels, and thereby contributes to the regulation of renal Mg2+ reabsorption (PubMed:23903368).By similarity1 Publication
May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q12955

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-445095, Interaction between L1 and Ankyrins
R-HSA-6807878, COPI-mediated anterograde transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin-31 Publication
Short name:
ANK-31 Publication
Alternative name(s):
Ankyrin-G1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:494, ANK3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600465, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q12955

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151150.20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Lysosome, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Genetic variations in ANK3 may be associated with autism spectrum disorders susceptibility.1 Publication
Mental retardation, autosomal recessive 37 (MRT37)
The disease is caused by variants affecting the gene represented in this entry. A homozygous deletion in ANK3 predicted to result in frameshift and premature truncation, has been shown to be the cause of moderate intellectual disability, an ADHD-like phenotype and behavioral problems in a consanguineous family (PubMed:23390136).1 Publication
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT37 patients manifest delayed global development with speech delay, hypotonia, spasticity, and a sleep disorder. Severe behavioral abnormalities include aggression, hyperactivity, and grinding of the teeth.
Related information in OMIM

Keywords - Diseasei

Autism spectrum disorder, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		288

MalaCards human disease database

More...MalaCardsi		ANK3
MIMi615493, phenotype

Open Targets

More...OpenTargetsi		ENSG00000151150

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		356996, ANK3-related intellectual disability-sleep disturbance syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24800

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q12955, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ANK3

Domain mapping of disease mutations (DMDM)

More...DMDMi		257051061

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000668861 – 4377Ankyrin-3Add BLAST4377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39PhosphoserineCombined sources1
Modified residuei623PhosphoserineBy similarity1
Modified residuei847PhosphoserineCombined sources1
Modified residuei861PhosphoserineBy similarity1
Modified residuei867PhosphoserineBy similarity1
Modified residuei913PhosphoserineBy similarity1
Modified residuei916PhosphoserineBy similarity1
Modified residuei922PhosphoserineBy similarity1
Modified residuei957PhosphoserineBy similarity1
Modified residuei959PhosphoserineBy similarity1
Modified residuei1113PhosphoserineBy similarity1
Modified residuei1445PhosphoserineCombined sources1
Modified residuei1459PhosphoserineCombined sources1
Modified residuei1470PhosphoserineBy similarity1
Modified residuei1622PhosphoserineBy similarity1
Modified residuei1625PhosphoserineBy similarity1
Modified residuei1984PhosphoserineBy similarity1
Modified residuei2111PhosphoserineBy similarity1
Modified residuei2123PhosphoserineBy similarity1
Modified residuei2126PhosphoserineBy similarity1
Modified residuei4211PhosphoserineBy similarity1
Modified residuei4229PhosphoserineCombined sources1
Modified residuei4290PhosphoserineCombined sources1
Modified residuei4298PhosphoserineCombined sources1
Modified residuei4350PhosphoserineCombined sources1
Isoform 5 (identifier: Q12955-7)
Modified residuei468PhosphoserineCombined sources1
Isoform 4 (identifier: Q12955-6)
Modified residuei765PhosphoserineCombined sources1
Modified residuei791PhosphoserineCombined sources1
Isoform 3 (identifier: Q12955-5)
Modified residuei1625PhosphoserineCombined sources1
Modified residuei1651PhosphoserineCombined sources1
Isoform 2 (identifier: Q12955-4)
Modified residuei1632PhosphoserineCombined sources1
Modified residuei1658PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q12955

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q12955

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q12955

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q12955

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q12955

PeptideAtlas

More...PeptideAtlasi		Q12955

PRoteomics IDEntifications database

More...PRIDEi		Q12955

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19802
3339
59048 [Q12955-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q12955

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q12955

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q12955

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, neurons, muscles and other tissues.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Up-regulated during muscle cell differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151150, Expressed in substantia nigra and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q12955, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q12955, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151150, Tissue enhanced (brain, parathyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with DMD and betaDAG1. This interaction does not interfere with binding between DMD and betaDAG1. It is also required for DMD and betaDAG1 retention at costameres (By similarity).

Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 5 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). May be a constituent of a NFASC/NRCAM/ankyrin G complex.

Interacts with RHBG (PubMed:15611082).

Interacts with PLEC and FLNC (PubMed:21223964).

Interacts with KCNA1; this inhibits channel activity (PubMed:23903368).

Interacts (via ANK repeats) with IQCJ-SCHIP1; required for IQCJ-SCHIP1 localization at axon initial segments (AIS) and nodes of Ranvier (PubMed:25950943).

Interacts with SCHIP1 (PubMed:25950943).

Interacts with SCN5A (PubMed:15579534).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106785, 59 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q12955

Database of interacting proteins

More...DIPi		DIP-49017N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q12955

Protein interaction database and analysis system

More...IntActi		Q12955, 41 interactors

Molecular INTeraction database

More...MINTi		Q12955

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000280772

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q12955, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q12955

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati73 – 102ANK 1Add BLAST30
Repeati106 – 135ANK 2Add BLAST30
Repeati139 – 168ANK 3Add BLAST30
Repeati172 – 201ANK 4Add BLAST30
Repeati203 – 230ANK 5Add BLAST28
Repeati234 – 263ANK 6Add BLAST30
Repeati267 – 296ANK 7Add BLAST30
Repeati300 – 329ANK 8Add BLAST30
Repeati333 – 362ANK 9Add BLAST30
Repeati366 – 395ANK 10Add BLAST30
Repeati399 – 428ANK 11Add BLAST30
Repeati432 – 461ANK 12Add BLAST30
Repeati465 – 494ANK 13Add BLAST30
Repeati498 – 527ANK 14Add BLAST30
Repeati531 – 560ANK 15Add BLAST30
Repeati564 – 593ANK 16Add BLAST30
Repeati597 – 626ANK 17Add BLAST30
Repeati630 – 659ANK 18Add BLAST30
Repeati663 – 692ANK 19Add BLAST30
Repeati696 – 725ANK 20Add BLAST30
Repeati729 – 758ANK 21Add BLAST30
Repeati762 – 791ANK 22Add BLAST30
Repeati795 – 825ANK 23Add BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini984 – 1139ZU5 1PROSITE-ProRule annotationAdd BLAST156
Domaini1141 – 1288ZU5 2PROSITE-ProRule annotationAdd BLAST148
Domaini4090 – 4174DeathPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1273 – 1407UPA domainBy similarityAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1519 – 1898Ser-richAdd BLAST380
Compositional biasi2247 – 2250Poly-Thr4
Compositional biasi2393 – 2396Poly-Glu4
Compositional biasi3205 – 3211Poly-Glu7
Compositional biasi3255 – 3259Poly-Pro5
Compositional biasi3482 – 3487Poly-Ser6
Compositional biasi3785 – 3791Poly-Asn7
Compositional biasi3957 – 3981Thr-richAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The tandem configuration of the two ZU5 and the UPA domains forms a structural supramodule termed ZZU. ZU5-1 mediates interaction with beta-spectrin, and the ZU5-1/UPA interface is required for ankyrin's function other than binding to spectrin (By similarity).By similarity

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154939

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000134_29_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q12955

Identification of Orthologs from Complete Genome Data

More...OMAi		MPDYFSE

Database of Orthologous Groups

More...OrthoDBi		1011028at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q12955

TreeFam database of animal gene trees

More...TreeFami		TF351263

Family and domain databases

Conserved Domains Database

More...CDDi		cd08803, Death_ank3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037971, Ank3_Death
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13606, Ank_3, 1 hit
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 21 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12955-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHAASQLKK NRDLEINAEE EPEKKRKHRK RSRDRKKKSD ANASYLRAAR 
        60         70         80         90        100
AGHLEKALDY IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV 
       110        120        130        140        150
DAATKKGNTA LHIASLAGQA EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE 
       160        170        180        190        200
NHLEVVKFLL DNGASQSLAT EDGFTPLAVA LQQGHDQVVS LLLENDTKGK 
       210        220        230        240        250
VRLPALHIAA RKDDTKAAAL LLQNDNNADV ESKSGFTPLH IAAHYGNINV 
       260        270        280        290        300
ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD 
       310        320        330        340        350
GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV 
       360        370        380        390        400
QLLLQHNVPV DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG 
       410        420        430        440        450
FTPLHIACKK NRIKVMELLL KHGASIQAVT ESGLTPIHVA AFMGHVNIVS 
       460        470        480        490        500
QLMHHGASPN TTNVRGETAL HMAARSGQAE VVRYLVQDGA QVEAKAKDDQ 
       510        520        530        540        550
TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA REGHEDVAAF 
       560        570        580        590        600
LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ANLLLQKSAS PDAAGKSGLT 
       610        620        630        640        650
PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATTL 
       660        670        680        690        700
LEYGADANAV TRQGIASVHL AAQEGHVDMV SLLLGRNANV NLSNKSGLTP 
       710        720        730        740        750
LHLAAQEDRV NVAEVLVNQG AHVDAQTKMG YTPLHVGCHY GNIKIVNFLL 
       760        770        780        790        800
QHSAKVNAKT KNGYTPLHQA AQQGHTHIIN VLLQNNASPN ELTVNGNTAL 
       810        820        830        840        850
GIARRLGYIS VVDTLKIVTE ETMTTTTVTE KHKMNVPETM NEVLDMSDDE 
       860        870        880        890        900
VRKANAPEML SDGEYISDVE EGEDAMTGDT DKYLGPQDLK ELGDDSLPAE 
       910        920        930        940        950
GYMGFSLGAR SASLRSFSSD RSYTLNRSSY ARDSMMIEEL LVPSKEQHLT 
       960        970        980        990       1000
FTREFDSDSL RHYSWAADTL DNVNLVSSPI HSGFLVSFMV DARGGSMRGS 
      1010       1020       1030       1040       1050
RHHGMRIIIP PRKCTAPTRI TCRLVKRHKL ANPPPMVEGE GLASRLVEMG 
      1060       1070       1080       1090       1100
PAGAQFLGPV IVEIPHFGSM RGKERELIVL RSENGETWKE HQFDSKNEDL 
      1110       1120       1130       1140       1150
TELLNGMDEE LDSPEELGKK RICRIITKDF PQYFAVVSRI KQESNQIGPE 
      1160       1170       1180       1190       1200
GGILSSTTVP LVQASFPEGA LTKRIRVGLQ AQPVPDEIVK KILGNKATFS 
      1210       1220       1230       1240       1250
PIVTVEPRRR KFHKPITMTI PVPPPSGEGV SNGYKGDTTP NLRLLCSITG 
      1260       1270       1280       1290       1300
GTSPAQWEDI TGTTPLTFIK DCVSFTTNVS ARFWLADCHQ VLETVGLATQ 
      1310       1320       1330       1340       1350
LYRELICVPY MAKFVVFAKM NDPVESSLRC FCMTDDKVDK TLEQQENFEE 
      1360       1370       1380       1390       1400
VARSKDIEVL EGKPIYVDCY GNLAPLTKGG QQLVFNFYSF KENRLPFSIK 
      1410       1420       1430       1440       1450
IRDTSQEPCG RLSFLKEPKT TKGLPQTAVC NLNITLPAHK KETESDQDDE 
      1460       1470       1480       1490       1500
IEKTDRRQSF ASLALRKRYS YLTEPGMIER STGATRSLPT TYSYKPFFST 
      1510       1520       1530       1540       1550
RPYQSWTTAP ITVPGPAKSG FTSLSSSSSN TPSASPLKSI WSVSTPSPIK 
      1560       1570       1580       1590       1600
STLGASTTSS VKSISDVASP IRSFRTMSSP IKTVVSQSPY NIQVSSGTLA 
      1610       1620       1630       1640       1650
RAPAVTEATP LKGLASNSTF SSRTSPVTTA GSLLERSSIT MTPPASPKSN 
      1660       1670       1680       1690       1700
INMYSSSLPF KSIITSAAPL ISSPLKSVVS PVKSAVDVIS SAKITMASSL 
      1710       1720       1730       1740       1750
SSPVKQMPGH AEVALVNGSI SPLKYPSSST LINGCKATAT LQEKISSATN 
      1760       1770       1780       1790       1800
SVSSVVSAAT DTVEKVFSTT TAMPFSPLRS YVSAAPSAFQ SLRTPSASAL 
      1810       1820       1830       1840       1850
YTSLGSSISA TTSSVTSSII TVPVYSVVNV LPEPALKKLP DSNSFTKSAA 
      1860       1870       1880       1890       1900
ALLSPIKTLT TETHPQPHFS RTSSPVKSSL FLAPSALKLS TPSSLSSSQE 
      1910       1920       1930       1940       1950
ILKDVAEMKE DLMRMTAILQ TDVPEEKPFQ PELPKEGRID DEEPFKIVEK 
      1960       1970       1980       1990       2000
VKEDLVKVSE ILKKDVCVDN KGSPKSPKSD KGHSPEDDWI EFSSEEIREA 
      2010       2020       2030       2040       2050
RQQAAASQSP SLPERVQVKA KAASEKDYNL TKVIDYLTND IGSSSLTNLK 
      2060       2070       2080       2090       2100
YKFEDAKKDG EERQKRVLKP AIALQEHKLK MPPASMRTST SEKELCKMAD 
      2110       2120       2130       2140       2150
SFFGTDTILE SPDDFSQHDQ DKSPLSDSGF ETRSEKTPSA PQSAESTGPK 
      2160       2170       2180       2190       2200
PLFHEVPIPP VITETRTEVV HVIRSYDPSA GDVPQTQPEE PVSPKPSPTF 
      2210       2220       2230       2240       2250
MELEPKPTTS SIKEKVKAFQ MKASSEEDDH NRVLSKGMRV KEETHITTTT 
      2260       2270       2280       2290       2300
RMVYHSPPGG EGASERIEET MSVHDIMKAF QSGRDPSKEL AGLFEHKSAV 
      2310       2320       2330       2340       2350
SPDVHKSAAE TSAQHAEKDN QMKPKLERII EVHIEKGNQA EPTEVIIRET 
      2360       2370       2380       2390       2400
KKHPEKEMYV YQKDLSRGDI NLKDFLPEKH DAFPCSEEQG QQEEEELTAE 
      2410       2420       2430       2440       2450
ESLPSYLESS RVNTPVSQEE DSRPSSAQLI SDDSYKTLKL LSQHSIEYHD 
      2460       2470       2480       2490       2500
DELSELRGES YRFAEKMLLS EKLDVSHSDT EESVTDHAGP PSSELQGSDK 
      2510       2520       2530       2540       2550
RSREKIATAP KKEILSKIYK DVSENGVGKV SKDEHFDKVT VLHYSGNVSS 
      2560       2570       2580       2590       2600
PKHAMWMRFT EDRLDRGREK LIYEDRVDRT VKEAEEKLTE VSQFFRDKTE 
      2610       2620       2630       2640       2650
KLNDELQSPE KKARPKNGKE YSSQSPTSSS PEKVLLTELL ASNDEWVKAR 
      2660       2670       2680       2690       2700
QHGPDGQGFP KAEEKAPSLP SSPEKMVLSQ QTEDSKSTVE AKGSISQSKA 
      2710       2720       2730       2740       2750
PDGPQSGFQL KQSKLSSIRL KFEQGTHAKS KDMSQEDRKS DGQSRIPVKK 
      2760       2770       2780       2790       2800
IQESKLPVYQ VFAREKQQKA IDLPDESVSV QKDFMVLKTK DEHAQSNEIV 
      2810       2820       2830       2840       2850
VNDSGSDNVK KQRTEMSSKA MPDSFSEQQA KDLACHITSD LATRGPWDKK 
      2860       2870       2880       2890       2900
VFRTWESSGA TNNKSQKEKL SHVLVHDVRE NHIGHPESKS VDQKNEFMSV 
      2910       2920       2930       2940       2950
TERERKLLTN GSLSEIKEMT VKSPSKKVLY REYVVKEGDH PGGLLDQPSR 
      2960       2970       2980       2990       3000
RSESSAVSHI PVRVADERRM LSSNIPDGFC EQSAFPKHEL SQKLSQSSMS 
      3010       3020       3030       3040       3050
KETVETQHFN SIEDEKVTYS EISKVSKHQS YVGLCPPLEE TETSPTKSPD 
      3060       3070       3080       3090       3100
SLEFSPGKES PSSDVFDHSP IDGLEKLAPL AQTEGGKEIK TLPVYVSFVQ 
      3110       3120       3130       3140       3150
VGKQYEKEIQ QGGVKKIISQ ECKTVQETRG TFYTTRQQKQ PPSPQGSPED 
      3160       3170       3180       3190       3200
DTLEQVSFLD SSGKSPLTPE TPSSEEVSYE FTSKTPDSLI AYIPGKPSPI 
      3210       3220       3230       3240       3250
PEVSEESEEE EQAKSTSLKQ TTVEETAVER EMPNDVSKDS NQRPKNNRVA 
      3260       3270       3280       3290       3300
YIEFPPPPPL DADQIESDKK HHYLPEKEVD MIEVNLQDEH DKYQLAEPVI 
      3310       3320       3330       3340       3350
RVQPPSPVPP GADVSDSSDD ESIYQPVPVK KYTFKLKEVD DEQKEKPKAS 
      3360       3370       3380       3390       3400
AEKASNQKEL ESNGSGKDNE FGLGLDSPQN EIAQNGNNDQ SITECSIATT 
      3410       3420       3430       3440       3450
AEFSHDTDAT EIDSLDGYDL QDEDDGLTES DSKLPIQAME IKKDIWNTEG 
      3460       3470       3480       3490       3500
ILKPADRSFS QSKLEVIEEE GKVGPDEDKP PSKSSSSEKT PDKTDQKSGA 
      3510       3520       3530       3540       3550
QFFTLEGRHP DRSVFPDTYF SYKVDEEFAT PFKTVATKGL DFDPWSNNRG 
      3560       3570       3580       3590       3600
DDEVFDSKSR EDETKPFGLA VEDRSPATTP DTTPARTPTD ESTPTSEPNP 
      3610       3620       3630       3640       3650
FPFHEGKMFE MTRSGAIDMS KRDFVEERLQ FFQIGEHTSE GKSGDQGEGD 
      3660       3670       3680       3690       3700
KSMVTATPQP QSGDTTVETN LERNVETPTV EPNPSIPTSG ECQEGTSSSG 
      3710       3720       3730       3740       3750
SLEKSAAATN TSKVDPKLRT PIKMGISAST MTMKKEGPGE ITDKIEAVMT 
      3760       3770       3780       3790       3800
SCQGLENETI TMISNTANSQ MGVRPHEKHD FQKDNFNNNN NLDSSTIQTD 
      3810       3820       3830       3840       3850
NIMSNIVLTE HSAPTCTTEK DNPVKVSSGK KTGVLQGHCV RDKQKVLGEQ 
      3860       3870       3880       3890       3900
QKTKELIGIR QKSKLPIKAT SPKDTFPPNH MSNTKASKMK QVSQSEKTKA 
      3910       3920       3930       3940       3950
LTTSSCVDVK SRIPVKNTHR DNIIAVRKAC ATQKQGQPEK GKAKQLPSKL 
      3960       3970       3980       3990       4000
PVKVRSTCVT TTTTTATTTT TTTTTTTTSC TVKVRKSQLK EVCKHSIEYF 
      4010       4020       4030       4040       4050
KGISGETLKL VDRLSEEEKK MQSELSDEEE STSRNTSLSE TSRGGQPSVT 
      4060       4070       4080       4090       4100
TKSARDKKTE AAPLKSKSEK AGSEKRSSRR TGPQSPCERT DIRMAIVADH 
      4110       4120       4130       4140       4150
LGLSWTELAR ELNFSVDEIN QIRVENPNSL ISQSFMLLKK WVTRDGKNAT 
      4160       4170       4180       4190       4200
TDALTSVLTK INRIDIVTLL EGPIFDYGNI SGTRSFADEN NVFHDPVDGW 
      4210       4220       4230       4240       4250
QNETSSGNLE SCAQARRVTG GLLDRLDDSP DQCRDSITSY LKGEAGKFEA 
      4260       4270       4280       4290       4300
NGSHTEITPE AKTKSYFPES QNDVGKQSTK ETLKPKIHGS GHVEEPASPL 
      4310       4320       4330       4340       4350
AAYQKSLEET SKLIIEETKP CVPVSMKKMS RTSPADGKPR LSLHEEEGSS 
      4360       4370 
GSEQKQGEGF KVKTKKEIRH VEKKSHS
Length:4,377
Mass (Da):480,410
Last modified:September 1, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6F9FABD09F15C13
GO
Isoform 2 (identifier: Q12955-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRK → MSEEPKEKNAKPAHRKRKG
     872-872: G → GNRCTWYKIPKVQEFTVKS
     1442-1450: Missing.
     1478-4081: Missing.
     4082-4082: G → S
     4199-4199: G → GYPSLQVELE...ESQLENVCLS

Show »
Length:1,868
Mass (Da):204,142
Checksum:iC02C08780B3918ED
GO
Isoform 3 (identifier: Q12955-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKK → MASSASSSPAGTEDSAPAQGGFGSDYSRSSR
     1442-1450: Missing.
     1478-4081: Missing.
     4082-4082: G → S
     4199-4199: G → GYPSLQVELE...ESQLENVCLS

Show »
Length:1,861
Mass (Da):202,592
Checksum:i06C904B8371BB406
GO
Isoform 4 (identifier: Q12955-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-866: Missing.
     867-872: SDVEEG → MALPQS
     1442-1450: Missing.
     1478-4081: Missing.
     4082-4082: G → S
     4199-4199: G → GYPSLQVELE...ESQLENVCLS

Show »
Length:1,001
Mass (Da):111,099
Checksum:iEF695AFF21999D1E
GO
Isoform 5 (identifier: Q12955-7) [UniParc]FASTAAdd to basket
Also known as: AnkG119, Golgi ankyrin

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAHAAS → MNLRCD
     7-385: Missing.
     850-870: Missing.
     913-918: Missing.
     1036-1043: MVEGEGLA → HGERRGIS
     1442-1450: Missing.
     1478-1880: IERSTGATRS...RTSSPVKSSL → TSCTVKVRKS...IRHVEKKSHS
     1881-4377: Missing.

Note: Avidly binds beta spectrin.Curated
Show »
Length:1,465
Mass (Da):160,947
Checksum:i7B43551F7DB9691D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZ65A0A087WZ65_HUMAN
Ankyrin-3
ANK3
973Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3A4H0Y3A4_HUMAN
Ankyrin-3
ANK3
459Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTF3A0A087WTF3_HUMAN
Ankyrin-3
ANK3
1,643Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY90A0A087WY90_HUMAN
Ankyrin-3
ANK3
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAH5H0YAH5_HUMAN
Ankyrin-3
ANK3
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTE8A0A087WTE8_HUMAN
Ankyrin-3
ANK3
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVC2A0A087WVC2_HUMAN
Ankyrin-3
ANK3
322Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0B4A0A087X0B4_HUMAN
Ankyrin-3
ANK3
450Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y951H0Y951_HUMAN
Ankyrin-3
ANK3
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX55A0A087WX55_HUMAN
Ankyrin-3
ANK3
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB66645 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti197T → A in CAI56716 (PubMed:17974005).Curated1
Sequence conflicti222L → P in CAD97900 (PubMed:17974005).Curated1
Sequence conflicti327I → V in CAD97900 (PubMed:17974005).Curated1
Sequence conflicti338L → W in BAG58523 (PubMed:14702039).Curated1
Sequence conflicti523A → T in CAD97900 (PubMed:17974005).Curated1
Sequence conflicti578L → P in CAI56716 (PubMed:17974005).Curated1
Sequence conflicti921R → G in CAB66645 (PubMed:11230166).Curated1
Sequence conflicti977S → P in CAB66645 (PubMed:11230166).Curated1
Sequence conflicti1237D → G in CAI56716 (PubMed:17974005).Curated1
Sequence conflicti1418P → R in AAA64834 (PubMed:7836469).Curated1
Sequence conflicti1455D → E in BAG58523 (PubMed:14702039).Curated1
Sequence conflicti1574F → L in AAA64834 (PubMed:7836469).Curated1
Sequence conflicti1685A → R in AAA64834 (PubMed:7836469).Curated1
Sequence conflicti1726P → A in AAA64834 (PubMed:7836469).Curated1
Sequence conflicti2062 – 2063ER → GG in AAA64834 (PubMed:7836469).Curated2
Sequence conflicti2146S → T in AAA64834 (PubMed:7836469).Curated1
Sequence conflicti3919H → P in AAA64834 (PubMed:7836469).Curated1
Sequence conflicti4137L → F in CAB66645 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077912968D → H Found in a patient with Gillessen-Kaesbach-Nishimura syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs730882195EnsemblClinVar.1
Natural variantiVAR_0687021569S → A Found in a patient with autism; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs375050420EnsemblClinVar.1
Natural variantiVAR_0610132318K → R. Corresponds to variant dbSNP:rs59021407EnsemblClinVar.1
Natural variantiVAR_0591152885H → Q. Corresponds to variant dbSNP:rs11599164Ensembl.1
Natural variantiVAR_0610142996Q → H. Corresponds to variant dbSNP:rs41274672EnsemblClinVar.1
Natural variantiVAR_0591163117I → V. Corresponds to variant dbSNP:rs28932171Ensembl.1
Natural variantiVAR_0591173123K → R. Corresponds to variant dbSNP:rs10821668Ensembl.1
Natural variantiVAR_0687033720T → M Found in a patient with autism; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201547988Ensembl.1
Natural variantiVAR_0687044255T → P Found in a patient with autism; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs769573528Ensembl.1
Natural variantiVAR_0543334257I → V. Corresponds to variant dbSNP:rs12261793Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0468851 – 866Missing in isoform 4. 1 PublicationAdd BLAST866
Alternative sequenceiVSP_0443481 – 37MAHAA…RDRKK → MASSASSSPAGTEDSAPAQG GFGSDYSRSSR in isoform 3. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_0443491 – 36MAHAA…SRDRK → MSEEPKEKNAKPAHRKRKG in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0537531 – 6MAHAAS → MNLRCD in isoform 5. 1 Publication6
Alternative sequenceiVSP_0537547 – 385Missing in isoform 5. 1 PublicationAdd BLAST379
Alternative sequenceiVSP_053755850 – 870Missing in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_046886867 – 872SDVEEG → MALPQS in isoform 4. 1 Publication6
Alternative sequenceiVSP_044350872G → GNRCTWYKIPKVQEFTVKS in isoform 2. 1 Publication1
Alternative sequenceiVSP_053756913 – 918Missing in isoform 5. 1 Publication6
Alternative sequenceiVSP_0537571036 – 1043MVEGEGLA → HGERRGIS in isoform 5. 1 Publication8
Alternative sequenceiVSP_0443511442 – 1450Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 4 Publications9
Alternative sequenceiVSP_0443521478 – 4081Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST2604
Alternative sequenceiVSP_0537581478 – 1880IERST…VKSSL → TSCTVKVRKSQLKEVCKHSI EYFKGISGETLKLVDRLSEE EKKMQSELSDEEESTSRNTS LSETSRGGQPSVTTKSARDK KTEAAPLKSKSEKAGSEKRS SRRTGPQSPCERTDIRMAIV ADHLGLSWTELARELNFSVD EINQIRVENPNSLISQSFML LKKWVTRDGKNATTDALTSV LTKINRIDIVTLLEGPIFDY GNISGTRSFADENNVFHDPV DGWQNETSSGNLESCAQARR VTGGLLDRLDDSPDQCRDSI TSYLKGEAGKFEANGSHTEI TPEAKTKSYFPESQNDVGKQ STKETLKPKIHGSGHVEEPA SPLAAYQKSLEETSKLSKLI IEETKPCVPVSMKKMSRTSP ADGKPRLSLHEEEGSSGSEQ KQGEGFKVKTKKEIRHVEKK SHS in isoform 5. 1 PublicationAdd BLAST403
Alternative sequenceiVSP_0537591881 – 4377Missing in isoform 5. 1 PublicationAdd BLAST2497
Alternative sequenceiVSP_0443534082G → S in isoform 2, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_0443544199G → GYPSLQVELETPTGLHYTPP TPFQQDDYFSDISSIESPLR TPSRLSDGLVPSQGNIEHSA DGPPVVTAEDASLEDSKLED SVPLTEMPEAVDVDESQLEN VCLS in isoform 2, isoform 3 and isoform 4. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U13616 mRNA Translation: AAA64834.1
U43965 mRNA Translation: AAB08437.1
AL136710 mRNA Translation: CAB66645.1 Frameshift.
AK295661 mRNA Translation: BAG58523.1
BX537917 mRNA Translation: CAD97900.2
BX648574 mRNA Translation: CAI56716.1
AC022390 Genomic DNA No translation available.
AC023904 Genomic DNA No translation available.
AL359267 Genomic DNA No translation available.
AL359377 Genomic DNA No translation available.
AL391707 Genomic DNA No translation available.
AL592430 Genomic DNA No translation available.
AL607065 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55711.1 [Q12955-4]
CCDS55712.1 [Q12955-5]
CCDS7258.1 [Q12955-3]
CCDS7259.1 [Q12955-6]

Protein sequence database of the Protein Information Resource

More...PIRi		A55575

NCBI Reference Sequences

More...RefSeqi		NP_001140.2, NM_001149.3 [Q12955-6]
NP_001191332.1, NM_001204403.1 [Q12955-5]
NP_001191333.1, NM_001204404.1 [Q12955-4]
NP_066267.2, NM_020987.4 [Q12955-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000280772; ENSP00000280772; ENSG00000151150 [Q12955-3]
ENST00000355288; ENSP00000347436; ENSG00000151150 [Q12955-6]
ENST00000373827; ENSP00000362933; ENSG00000151150 [Q12955-5]
ENST00000503366; ENSP00000425236; ENSG00000151150 [Q12955-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		288

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:288

UCSC genome browser

More...UCSCi		uc001jkw.4, human [Q12955-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Ankyrin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13616 mRNA Translation: AAA64834.1
U43965 mRNA Translation: AAB08437.1
AL136710 mRNA Translation: CAB66645.1 Frameshift.
AK295661 mRNA Translation: BAG58523.1
BX537917 mRNA Translation: CAD97900.2
BX648574 mRNA Translation: CAI56716.1
AC022390 Genomic DNA No translation available.
AC023904 Genomic DNA No translation available.
AL359267 Genomic DNA No translation available.
AL359377 Genomic DNA No translation available.
AL391707 Genomic DNA No translation available.
AL592430 Genomic DNA No translation available.
AL607065 Genomic DNA No translation available.
CCDSiCCDS55711.1 [Q12955-4]
CCDS55712.1 [Q12955-5]
CCDS7258.1 [Q12955-3]
CCDS7259.1 [Q12955-6]
PIRiA55575
RefSeqiNP_001140.2, NM_001149.3 [Q12955-6]
NP_001191332.1, NM_001204403.1 [Q12955-5]
NP_001191333.1, NM_001204404.1 [Q12955-4]
NP_066267.2, NM_020987.4 [Q12955-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4O6XX-ray2.10A/B4088-4199[»]
SMRiQ12955
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106785, 59 interactors
CORUMiQ12955
DIPiDIP-49017N
ELMiQ12955
IntActiQ12955, 41 interactors
MINTiQ12955
STRINGi9606.ENSP00000280772

PTM databases

iPTMnetiQ12955
PhosphoSitePlusiQ12955
SwissPalmiQ12955

Genetic variation databases

BioMutaiANK3
DMDMi257051061

Proteomic databases

EPDiQ12955
jPOSTiQ12955
MassIVEiQ12955
MaxQBiQ12955
PaxDbiQ12955
PeptideAtlasiQ12955
PRIDEiQ12955
ProteomicsDBi19802
3339
59048 [Q12955-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q12955, 6 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4197, 265 antibodies

The DNASU plasmid repository

More...DNASUi		288

Genome annotation databases

EnsembliENST00000280772; ENSP00000280772; ENSG00000151150 [Q12955-3]
ENST00000355288; ENSP00000347436; ENSG00000151150 [Q12955-6]
ENST00000373827; ENSP00000362933; ENSG00000151150 [Q12955-5]
ENST00000503366; ENSP00000425236; ENSG00000151150 [Q12955-4]
GeneIDi288
KEGGihsa:288
UCSCiuc001jkw.4, human [Q12955-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		288
DisGeNETi288

GeneCards: human genes, protein and diseases

More...GeneCardsi		ANK3
HGNCiHGNC:494, ANK3
HPAiENSG00000151150, Tissue enhanced (brain, parathyroid gland)
MalaCardsiANK3
MIMi600465, gene
615493, phenotype
neXtProtiNX_Q12955
OpenTargetsiENSG00000151150
Orphaneti356996, ANK3-related intellectual disability-sleep disturbance syndrome
PharmGKBiPA24800
VEuPathDBiHostDB:ENSG00000151150.20

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4177, Eukaryota
GeneTreeiENSGT00940000154939
HOGENOMiCLU_000134_29_1_1
InParanoidiQ12955
OMAiMPDYFSE
OrthoDBi1011028at2759
PhylomeDBiQ12955
TreeFamiTF351263

Enzyme and pathway databases

PathwayCommonsiQ12955
ReactomeiR-HSA-445095, Interaction between L1 and Ankyrins
R-HSA-6807878, COPI-mediated anterograde transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		288, 4 hits in 886 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ANK3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ANK3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		288
PharosiQ12955, Tbio

Protein Ontology

More...PROi		PR:Q12955
RNActiQ12955, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151150, Expressed in substantia nigra and 246 other tissues
ExpressionAtlasiQ12955, baseline and differential
GenevisibleiQ12955, HS

Family and domain databases

CDDicd08803, Death_ank3, 1 hit
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR037971, Ank3_Death
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13606, Ank_3, 1 hit
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 21 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANK3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12955
Secondary accession number(s): B1AQT2
, B4DIL1, E9PE32, Q13484, Q5CZH9, Q5VXD5, Q7Z3G4, Q9H0P5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: September 1, 2009
Last modified: February 10, 2021
This is version 201 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with genetic variants
    List of human entries with genetic variants
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