UniProtKB - Q12955 (ANK3_HUMAN)
Ankyrin-3
ANK3
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- cytoskeletal anchor activity Source: GO_Central
- cytoskeletal protein binding Source: BHF-UCL
- ion channel binding Source: BHF-UCL
- protein-macromolecule adaptor activity Source: BHF-UCL
- spectrin binding Source: BHF-UCL
- structural constituent of cytoskeleton Source: BHF-UCL
GO - Biological processi
- axonogenesis Source: BHF-UCL
- cellular response to magnesium ion Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- establishment of protein localization Source: UniProtKB
- Golgi to plasma membrane protein transport Source: BHF-UCL
- magnesium ion homeostasis Source: UniProtKB
- maintenance of protein location in plasma membrane Source: BHF-UCL
- membrane assembly Source: BHF-UCL
- mitotic cytokinesis Source: BHF-UCL
- negative regulation of delayed rectifier potassium channel activity Source: UniProtKB
- neuromuscular junction development Source: BHF-UCL
- neuronal action potential Source: BHF-UCL
- plasma membrane organization Source: BHF-UCL
- positive regulation of cation channel activity Source: BHF-UCL
- positive regulation of cell communication by electrical coupling Source: BHF-UCL
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of homotypic cell-cell adhesion Source: BHF-UCL
- positive regulation of membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
- positive regulation of membrane potential Source: BHF-UCL
- positive regulation of protein targeting to membrane Source: BHF-UCL
- positive regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
- positive regulation of sodium ion transport Source: BHF-UCL
- protein localization to axon Source: UniProtKB
- protein localization to plasma membrane Source: BHF-UCL
- regulation of potassium ion transport Source: BHF-UCL
- signal transduction Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q12955 |
Reactomei | R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-6807878, COPI-mediated anterograde transport |
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin-31 PublicationShort name: ANK-31 Publication Alternative name(s): Ankyrin-G1 Publication |
Gene namesi | Name:ANK3Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:494, ANK3 |
MIMi | 600465, gene |
neXtProti | NX_Q12955 |
VEuPathDBi | HostDB:ENSG00000151150.20 |
Subcellular locationi
Plasma membrane
- sarcolemma 1 Publication
- postsynaptic cell membrane By similarity
- T-tubule By similarity
Lysosome
- Lysosome By similarity
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- axon By similarity
Note: In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes.By similarity
Golgi apparatus
- Golgi apparatus 1 Publication
Cytoskeleton
- cytoskeleton 1 Publication
Cytoskeleton
- spectrin-associated cytoskeleton Source: BHF-UCL
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: ProtInc
- sarcoplasmic reticulum Source: BHF-UCL
Golgi apparatus
- Golgi apparatus Source: ProtInc
Lysosome
- lysosome Source: UniProtKB-SubCell
Plasma Membrane
- basal plasma membrane Source: BHF-UCL
- basolateral plasma membrane Source: UniProtKB
- lateral plasma membrane Source: BHF-UCL
- plasma membrane Source: HPA
- postsynaptic membrane Source: BHF-UCL
- sarcolemma Source: BHF-UCL
- T-tubule Source: BHF-UCL
Other locations
- axon initial segment Source: CAFA
- cell surface Source: BHF-UCL
- costamere Source: BHF-UCL
- dendrite Source: BHF-UCL
- intercalated disc Source: BHF-UCL
- neuromuscular junction Source: BHF-UCL
- neuron projection Source: BHF-UCL
- node of Ranvier Source: ARUK-UCL
- Z disc Source: BHF-UCL
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Lysosome, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Involvement in diseasei
Mental retardation, autosomal recessive 37 (MRT37)
Keywords - Diseasei
Autism spectrum disorder, Mental retardationOrganism-specific databases
DisGeNETi | 288 |
MalaCardsi | ANK3 |
MIMi | 615493, phenotype |
OpenTargetsi | ENSG00000151150 |
Orphaneti | 356996, ANK3-related intellectual disability-sleep disturbance syndrome |
PharmGKBi | PA24800 |
Miscellaneous databases
Pharosi | Q12955, Tbio |
Genetic variation databases
BioMutai | ANK3 |
DMDMi | 257051061 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066886 | 1 – 4377 | Ankyrin-3Add BLAST | 4377 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 39 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 623 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 847 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 861 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 867 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 913 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 916 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 922 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 957 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 959 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1113 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1445 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1459 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1470 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1622 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1625 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1984 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 2111 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 2123 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 2126 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 4211 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 4229 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 4290 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 4298 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 4350 | PhosphoserineCombined sources | 1 | ||
Isoform 5 (identifier: Q12955-7) | |||||
Modified residuei | 468 | PhosphoserineCombined sources | 1 | ||
Isoform 4 (identifier: Q12955-6) | |||||
Modified residuei | 765 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 791 | PhosphoserineCombined sources | 1 | ||
Isoform 3 (identifier: Q12955-5) | |||||
Modified residuei | 1625 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1651 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: Q12955-4) | |||||
Modified residuei | 1632 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1658 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q12955 |
jPOSTi | Q12955 |
MassIVEi | Q12955 |
MaxQBi | Q12955 |
PaxDbi | Q12955 |
PeptideAtlasi | Q12955 |
PRIDEi | Q12955 |
ProteomicsDBi | 19802 3339 59048 [Q12955-3] |
PTM databases
iPTMneti | Q12955 |
PhosphoSitePlusi | Q12955 |
SwissPalmi | Q12955 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000151150, Expressed in substantia nigra and 246 other tissues |
ExpressionAtlasi | Q12955, baseline and differential |
Genevisiblei | Q12955, HS |
Organism-specific databases
HPAi | ENSG00000151150, Tissue enhanced (brain, parathyroid gland) |
Interactioni
Subunit structurei
Directly interacts with DMD and betaDAG1. This interaction does not interfere with binding between DMD and betaDAG1. It is also required for DMD and betaDAG1 retention at costameres (By similarity).
Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 5 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). May be a constituent of a NFASC/NRCAM/ankyrin G complex.
Interacts with RHBG (PubMed:15611082).
Interacts with PLEC and FLNC (PubMed:21223964).
Interacts with KCNA1; this inhibits channel activity (PubMed:23903368).
Interacts (via ANK repeats) with IQCJ-SCHIP1; required for IQCJ-SCHIP1 localization at axon initial segments (AIS) and nodes of Ranvier (PubMed:25950943).
Interacts with SCHIP1 (PubMed:25950943).
Interacts with SCN5A (PubMed:15579534).
By similarity5 PublicationsBinary interactionsi
Hide detailsQ12955
With | #Exp. | IntAct |
---|---|---|
AP3B1 - isoform 1 [O00203-1] | 2 | EBI-2691178,EBI-15816315 |
SMAD2 [Q15796] | 2 | EBI-2691178,EBI-1040141 |
Isoform 3 [Q12955-5]
With | #Exp. | IntAct |
---|---|---|
NAB2 [Q15742] | 3 | EBI-12154305,EBI-8641936 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- cytoskeletal protein binding Source: BHF-UCL
- ion channel binding Source: BHF-UCL
- spectrin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 106785, 59 interactors |
CORUMi | Q12955 |
DIPi | DIP-49017N |
ELMi | Q12955 |
IntActi | Q12955, 41 interactors |
MINTi | Q12955 |
STRINGi | 9606.ENSP00000280772 |
Miscellaneous databases
RNActi | Q12955, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q12955 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 73 – 102 | ANK 1Add BLAST | 30 | |
Repeati | 106 – 135 | ANK 2Add BLAST | 30 | |
Repeati | 139 – 168 | ANK 3Add BLAST | 30 | |
Repeati | 172 – 201 | ANK 4Add BLAST | 30 | |
Repeati | 203 – 230 | ANK 5Add BLAST | 28 | |
Repeati | 234 – 263 | ANK 6Add BLAST | 30 | |
Repeati | 267 – 296 | ANK 7Add BLAST | 30 | |
Repeati | 300 – 329 | ANK 8Add BLAST | 30 | |
Repeati | 333 – 362 | ANK 9Add BLAST | 30 | |
Repeati | 366 – 395 | ANK 10Add BLAST | 30 | |
Repeati | 399 – 428 | ANK 11Add BLAST | 30 | |
Repeati | 432 – 461 | ANK 12Add BLAST | 30 | |
Repeati | 465 – 494 | ANK 13Add BLAST | 30 | |
Repeati | 498 – 527 | ANK 14Add BLAST | 30 | |
Repeati | 531 – 560 | ANK 15Add BLAST | 30 | |
Repeati | 564 – 593 | ANK 16Add BLAST | 30 | |
Repeati | 597 – 626 | ANK 17Add BLAST | 30 | |
Repeati | 630 – 659 | ANK 18Add BLAST | 30 | |
Repeati | 663 – 692 | ANK 19Add BLAST | 30 | |
Repeati | 696 – 725 | ANK 20Add BLAST | 30 | |
Repeati | 729 – 758 | ANK 21Add BLAST | 30 | |
Repeati | 762 – 791 | ANK 22Add BLAST | 30 | |
Repeati | 795 – 825 | ANK 23Add BLAST | 31 | |
Domaini | 984 – 1139 | ZU5 1PROSITE-ProRule annotationAdd BLAST | 156 | |
Domaini | 1141 – 1288 | ZU5 2PROSITE-ProRule annotationAdd BLAST | 148 | |
Domaini | 4090 – 4174 | DeathPROSITE-ProRule annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1273 – 1407 | UPA domainBy similarityAdd BLAST | 135 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1519 – 1898 | Ser-richAdd BLAST | 380 | |
Compositional biasi | 2247 – 2250 | Poly-Thr | 4 | |
Compositional biasi | 2393 – 2396 | Poly-Glu | 4 | |
Compositional biasi | 3205 – 3211 | Poly-Glu | 7 | |
Compositional biasi | 3255 – 3259 | Poly-Pro | 5 | |
Compositional biasi | 3482 – 3487 | Poly-Ser | 6 | |
Compositional biasi | 3785 – 3791 | Poly-Asn | 7 | |
Compositional biasi | 3957 – 3981 | Thr-richAdd BLAST | 25 |
Domaini
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG4177, Eukaryota |
GeneTreei | ENSGT00940000154939 |
HOGENOMi | CLU_000134_29_1_1 |
InParanoidi | Q12955 |
OMAi | MPDYFSE |
OrthoDBi | 1011028at2759 |
PhylomeDBi | Q12955 |
TreeFami | TF351263 |
Family and domain databases
CDDi | cd08803, Death_ank3, 1 hit |
Gene3Di | 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR037971, Ank3_Death IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 7 hits PF13606, Ank_3, 1 hit PF00531, Death, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 22 hits SM00005, DEATH, 1 hit SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 21 hits PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAHAASQLKK NRDLEINAEE EPEKKRKHRK RSRDRKKKSD ANASYLRAAR
60 70 80 90 100
AGHLEKALDY IKNGVDINIC NQNGLNALHL ASKEGHVEVV SELLQREANV
110 120 130 140 150
DAATKKGNTA LHIASLAGQA EVVKVLVTNG ANVNAQSQNG FTPLYMAAQE
160 170 180 190 200
NHLEVVKFLL DNGASQSLAT EDGFTPLAVA LQQGHDQVVS LLLENDTKGK
210 220 230 240 250
VRLPALHIAA RKDDTKAAAL LLQNDNNADV ESKSGFTPLH IAAHYGNINV
260 270 280 290 300
ATLLLNRAAA VDFTARNDIT PLHVASKRGN ANMVKLLLDR GAKIDAKTRD
310 320 330 340 350
GLTPLHCGAR SGHEQVVEML LDRAAPILSK TKNGLSPLHM ATQGDHLNCV
360 370 380 390 400
QLLLQHNVPV DDVTNDYLTA LHVAAHCGHY KVAKVLLDKK ANPNAKALNG
410 420 430 440 450
FTPLHIACKK NRIKVMELLL KHGASIQAVT ESGLTPIHVA AFMGHVNIVS
460 470 480 490 500
QLMHHGASPN TTNVRGETAL HMAARSGQAE VVRYLVQDGA QVEAKAKDDQ
510 520 530 540 550
TPLHISARLG KADIVQQLLQ QGASPNAATT SGYTPLHLSA REGHEDVAAF
560 570 580 590 600
LLDHGASLSI TTKKGFTPLH VAAKYGKLEV ANLLLQKSAS PDAAGKSGLT
610 620 630 640 650
PLHVAAHYDN QKVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIATTL
660 670 680 690 700
LEYGADANAV TRQGIASVHL AAQEGHVDMV SLLLGRNANV NLSNKSGLTP
710 720 730 740 750
LHLAAQEDRV NVAEVLVNQG AHVDAQTKMG YTPLHVGCHY GNIKIVNFLL
760 770 780 790 800
QHSAKVNAKT KNGYTPLHQA AQQGHTHIIN VLLQNNASPN ELTVNGNTAL
810 820 830 840 850
GIARRLGYIS VVDTLKIVTE ETMTTTTVTE KHKMNVPETM NEVLDMSDDE
860 870 880 890 900
VRKANAPEML SDGEYISDVE EGEDAMTGDT DKYLGPQDLK ELGDDSLPAE
910 920 930 940 950
GYMGFSLGAR SASLRSFSSD RSYTLNRSSY ARDSMMIEEL LVPSKEQHLT
960 970 980 990 1000
FTREFDSDSL RHYSWAADTL DNVNLVSSPI HSGFLVSFMV DARGGSMRGS
1010 1020 1030 1040 1050
RHHGMRIIIP PRKCTAPTRI TCRLVKRHKL ANPPPMVEGE GLASRLVEMG
1060 1070 1080 1090 1100
PAGAQFLGPV IVEIPHFGSM RGKERELIVL RSENGETWKE HQFDSKNEDL
1110 1120 1130 1140 1150
TELLNGMDEE LDSPEELGKK RICRIITKDF PQYFAVVSRI KQESNQIGPE
1160 1170 1180 1190 1200
GGILSSTTVP LVQASFPEGA LTKRIRVGLQ AQPVPDEIVK KILGNKATFS
1210 1220 1230 1240 1250
PIVTVEPRRR KFHKPITMTI PVPPPSGEGV SNGYKGDTTP NLRLLCSITG
1260 1270 1280 1290 1300
GTSPAQWEDI TGTTPLTFIK DCVSFTTNVS ARFWLADCHQ VLETVGLATQ
1310 1320 1330 1340 1350
LYRELICVPY MAKFVVFAKM NDPVESSLRC FCMTDDKVDK TLEQQENFEE
1360 1370 1380 1390 1400
VARSKDIEVL EGKPIYVDCY GNLAPLTKGG QQLVFNFYSF KENRLPFSIK
1410 1420 1430 1440 1450
IRDTSQEPCG RLSFLKEPKT TKGLPQTAVC NLNITLPAHK KETESDQDDE
1460 1470 1480 1490 1500
IEKTDRRQSF ASLALRKRYS YLTEPGMIER STGATRSLPT TYSYKPFFST
1510 1520 1530 1540 1550
RPYQSWTTAP ITVPGPAKSG FTSLSSSSSN TPSASPLKSI WSVSTPSPIK
1560 1570 1580 1590 1600
STLGASTTSS VKSISDVASP IRSFRTMSSP IKTVVSQSPY NIQVSSGTLA
1610 1620 1630 1640 1650
RAPAVTEATP LKGLASNSTF SSRTSPVTTA GSLLERSSIT MTPPASPKSN
1660 1670 1680 1690 1700
INMYSSSLPF KSIITSAAPL ISSPLKSVVS PVKSAVDVIS SAKITMASSL
1710 1720 1730 1740 1750
SSPVKQMPGH AEVALVNGSI SPLKYPSSST LINGCKATAT LQEKISSATN
1760 1770 1780 1790 1800
SVSSVVSAAT DTVEKVFSTT TAMPFSPLRS YVSAAPSAFQ SLRTPSASAL
1810 1820 1830 1840 1850
YTSLGSSISA TTSSVTSSII TVPVYSVVNV LPEPALKKLP DSNSFTKSAA
1860 1870 1880 1890 1900
ALLSPIKTLT TETHPQPHFS RTSSPVKSSL FLAPSALKLS TPSSLSSSQE
1910 1920 1930 1940 1950
ILKDVAEMKE DLMRMTAILQ TDVPEEKPFQ PELPKEGRID DEEPFKIVEK
1960 1970 1980 1990 2000
VKEDLVKVSE ILKKDVCVDN KGSPKSPKSD KGHSPEDDWI EFSSEEIREA
2010 2020 2030 2040 2050
RQQAAASQSP SLPERVQVKA KAASEKDYNL TKVIDYLTND IGSSSLTNLK
2060 2070 2080 2090 2100
YKFEDAKKDG EERQKRVLKP AIALQEHKLK MPPASMRTST SEKELCKMAD
2110 2120 2130 2140 2150
SFFGTDTILE SPDDFSQHDQ DKSPLSDSGF ETRSEKTPSA PQSAESTGPK
2160 2170 2180 2190 2200
PLFHEVPIPP VITETRTEVV HVIRSYDPSA GDVPQTQPEE PVSPKPSPTF
2210 2220 2230 2240 2250
MELEPKPTTS SIKEKVKAFQ MKASSEEDDH NRVLSKGMRV KEETHITTTT
2260 2270 2280 2290 2300
RMVYHSPPGG EGASERIEET MSVHDIMKAF QSGRDPSKEL AGLFEHKSAV
2310 2320 2330 2340 2350
SPDVHKSAAE TSAQHAEKDN QMKPKLERII EVHIEKGNQA EPTEVIIRET
2360 2370 2380 2390 2400
KKHPEKEMYV YQKDLSRGDI NLKDFLPEKH DAFPCSEEQG QQEEEELTAE
2410 2420 2430 2440 2450
ESLPSYLESS RVNTPVSQEE DSRPSSAQLI SDDSYKTLKL LSQHSIEYHD
2460 2470 2480 2490 2500
DELSELRGES YRFAEKMLLS EKLDVSHSDT EESVTDHAGP PSSELQGSDK
2510 2520 2530 2540 2550
RSREKIATAP KKEILSKIYK DVSENGVGKV SKDEHFDKVT VLHYSGNVSS
2560 2570 2580 2590 2600
PKHAMWMRFT EDRLDRGREK LIYEDRVDRT VKEAEEKLTE VSQFFRDKTE
2610 2620 2630 2640 2650
KLNDELQSPE KKARPKNGKE YSSQSPTSSS PEKVLLTELL ASNDEWVKAR
2660 2670 2680 2690 2700
QHGPDGQGFP KAEEKAPSLP SSPEKMVLSQ QTEDSKSTVE AKGSISQSKA
2710 2720 2730 2740 2750
PDGPQSGFQL KQSKLSSIRL KFEQGTHAKS KDMSQEDRKS DGQSRIPVKK
2760 2770 2780 2790 2800
IQESKLPVYQ VFAREKQQKA IDLPDESVSV QKDFMVLKTK DEHAQSNEIV
2810 2820 2830 2840 2850
VNDSGSDNVK KQRTEMSSKA MPDSFSEQQA KDLACHITSD LATRGPWDKK
2860 2870 2880 2890 2900
VFRTWESSGA TNNKSQKEKL SHVLVHDVRE NHIGHPESKS VDQKNEFMSV
2910 2920 2930 2940 2950
TERERKLLTN GSLSEIKEMT VKSPSKKVLY REYVVKEGDH PGGLLDQPSR
2960 2970 2980 2990 3000
RSESSAVSHI PVRVADERRM LSSNIPDGFC EQSAFPKHEL SQKLSQSSMS
3010 3020 3030 3040 3050
KETVETQHFN SIEDEKVTYS EISKVSKHQS YVGLCPPLEE TETSPTKSPD
3060 3070 3080 3090 3100
SLEFSPGKES PSSDVFDHSP IDGLEKLAPL AQTEGGKEIK TLPVYVSFVQ
3110 3120 3130 3140 3150
VGKQYEKEIQ QGGVKKIISQ ECKTVQETRG TFYTTRQQKQ PPSPQGSPED
3160 3170 3180 3190 3200
DTLEQVSFLD SSGKSPLTPE TPSSEEVSYE FTSKTPDSLI AYIPGKPSPI
3210 3220 3230 3240 3250
PEVSEESEEE EQAKSTSLKQ TTVEETAVER EMPNDVSKDS NQRPKNNRVA
3260 3270 3280 3290 3300
YIEFPPPPPL DADQIESDKK HHYLPEKEVD MIEVNLQDEH DKYQLAEPVI
3310 3320 3330 3340 3350
RVQPPSPVPP GADVSDSSDD ESIYQPVPVK KYTFKLKEVD DEQKEKPKAS
3360 3370 3380 3390 3400
AEKASNQKEL ESNGSGKDNE FGLGLDSPQN EIAQNGNNDQ SITECSIATT
3410 3420 3430 3440 3450
AEFSHDTDAT EIDSLDGYDL QDEDDGLTES DSKLPIQAME IKKDIWNTEG
3460 3470 3480 3490 3500
ILKPADRSFS QSKLEVIEEE GKVGPDEDKP PSKSSSSEKT PDKTDQKSGA
3510 3520 3530 3540 3550
QFFTLEGRHP DRSVFPDTYF SYKVDEEFAT PFKTVATKGL DFDPWSNNRG
3560 3570 3580 3590 3600
DDEVFDSKSR EDETKPFGLA VEDRSPATTP DTTPARTPTD ESTPTSEPNP
3610 3620 3630 3640 3650
FPFHEGKMFE MTRSGAIDMS KRDFVEERLQ FFQIGEHTSE GKSGDQGEGD
3660 3670 3680 3690 3700
KSMVTATPQP QSGDTTVETN LERNVETPTV EPNPSIPTSG ECQEGTSSSG
3710 3720 3730 3740 3750
SLEKSAAATN TSKVDPKLRT PIKMGISAST MTMKKEGPGE ITDKIEAVMT
3760 3770 3780 3790 3800
SCQGLENETI TMISNTANSQ MGVRPHEKHD FQKDNFNNNN NLDSSTIQTD
3810 3820 3830 3840 3850
NIMSNIVLTE HSAPTCTTEK DNPVKVSSGK KTGVLQGHCV RDKQKVLGEQ
3860 3870 3880 3890 3900
QKTKELIGIR QKSKLPIKAT SPKDTFPPNH MSNTKASKMK QVSQSEKTKA
3910 3920 3930 3940 3950
LTTSSCVDVK SRIPVKNTHR DNIIAVRKAC ATQKQGQPEK GKAKQLPSKL
3960 3970 3980 3990 4000
PVKVRSTCVT TTTTTATTTT TTTTTTTTSC TVKVRKSQLK EVCKHSIEYF
4010 4020 4030 4040 4050
KGISGETLKL VDRLSEEEKK MQSELSDEEE STSRNTSLSE TSRGGQPSVT
4060 4070 4080 4090 4100
TKSARDKKTE AAPLKSKSEK AGSEKRSSRR TGPQSPCERT DIRMAIVADH
4110 4120 4130 4140 4150
LGLSWTELAR ELNFSVDEIN QIRVENPNSL ISQSFMLLKK WVTRDGKNAT
4160 4170 4180 4190 4200
TDALTSVLTK INRIDIVTLL EGPIFDYGNI SGTRSFADEN NVFHDPVDGW
4210 4220 4230 4240 4250
QNETSSGNLE SCAQARRVTG GLLDRLDDSP DQCRDSITSY LKGEAGKFEA
4260 4270 4280 4290 4300
NGSHTEITPE AKTKSYFPES QNDVGKQSTK ETLKPKIHGS GHVEEPASPL
4310 4320 4330 4340 4350
AAYQKSLEET SKLIIEETKP CVPVSMKKMS RTSPADGKPR LSLHEEEGSS
4360 4370
GSEQKQGEGF KVKTKKEIRH VEKKSHS
The sequence of this isoform differs from the canonical sequence as follows:
1-36: MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRK → MSEEPKEKNAKPAHRKRKG
872-872: G → GNRCTWYKIPKVQEFTVKS
1442-1450: Missing.
1478-4081: Missing.
4082-4082: G → S
4199-4199: G → GYPSLQVELE...ESQLENVCLS
The sequence of this isoform differs from the canonical sequence as follows:
1-37: MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKK → MASSASSSPAGTEDSAPAQGGFGSDYSRSSR
1442-1450: Missing.
1478-4081: Missing.
4082-4082: G → S
4199-4199: G → GYPSLQVELE...ESQLENVCLS
The sequence of this isoform differs from the canonical sequence as follows:
1-6: MAHAAS → MNLRCD
7-385: Missing.
850-870: Missing.
913-918: Missing.
1036-1043: MVEGEGLA → HGERRGIS
1442-1450: Missing.
1478-1880: IERSTGATRS...RTSSPVKSSL → TSCTVKVRKS...IRHVEKKSHS
1881-4377: Missing.
Computationally mapped potential isoform sequencesi
There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZ65 | A0A087WZ65_HUMAN | Ankyrin-3 | ANK3 | 973 | Annotation score: | ||
H0Y3A4 | H0Y3A4_HUMAN | Ankyrin-3 | ANK3 | 459 | Annotation score: | ||
A0A087WTF3 | A0A087WTF3_HUMAN | Ankyrin-3 | ANK3 | 1,643 | Annotation score: | ||
A0A087WY90 | A0A087WY90_HUMAN | Ankyrin-3 | ANK3 | 178 | Annotation score: | ||
H0YAH5 | H0YAH5_HUMAN | Ankyrin-3 | ANK3 | 217 | Annotation score: | ||
A0A087WTE8 | A0A087WTE8_HUMAN | Ankyrin-3 | ANK3 | 241 | Annotation score: | ||
A0A087WVC2 | A0A087WVC2_HUMAN | Ankyrin-3 | ANK3 | 322 | Annotation score: | ||
A0A087X0B4 | A0A087X0B4_HUMAN | Ankyrin-3 | ANK3 | 450 | Annotation score: | ||
H0Y951 | H0Y951_HUMAN | Ankyrin-3 | ANK3 | 166 | Annotation score: | ||
A0A087WX55 | A0A087WX55_HUMAN | Ankyrin-3 | ANK3 | 175 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 197 | T → A in CAI56716 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 222 | L → P in CAD97900 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 327 | I → V in CAD97900 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 338 | L → W in BAG58523 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 523 | A → T in CAD97900 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 578 | L → P in CAI56716 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 921 | R → G in CAB66645 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 977 | S → P in CAB66645 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 1237 | D → G in CAI56716 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1418 | P → R in AAA64834 (PubMed:7836469).Curated | 1 | |
Sequence conflicti | 1455 | D → E in BAG58523 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1574 | F → L in AAA64834 (PubMed:7836469).Curated | 1 | |
Sequence conflicti | 1685 | A → R in AAA64834 (PubMed:7836469).Curated | 1 | |
Sequence conflicti | 1726 | P → A in AAA64834 (PubMed:7836469).Curated | 1 | |
Sequence conflicti | 2062 – 2063 | ER → GG in AAA64834 (PubMed:7836469).Curated | 2 | |
Sequence conflicti | 2146 | S → T in AAA64834 (PubMed:7836469).Curated | 1 | |
Sequence conflicti | 3919 | H → P in AAA64834 (PubMed:7836469).Curated | 1 | |
Sequence conflicti | 4137 | L → F in CAB66645 (PubMed:11230166).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077912 | 968 | D → H Found in a patient with Gillessen-Kaesbach-Nishimura syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs730882195EnsemblClinVar. | 1 | |
Natural variantiVAR_068702 | 1569 | S → A Found in a patient with autism; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs375050420EnsemblClinVar. | 1 | |
Natural variantiVAR_061013 | 2318 | K → R. Corresponds to variant dbSNP:rs59021407EnsemblClinVar. | 1 | |
Natural variantiVAR_059115 | 2885 | H → Q. Corresponds to variant dbSNP:rs11599164Ensembl. | 1 | |
Natural variantiVAR_061014 | 2996 | Q → H. Corresponds to variant dbSNP:rs41274672EnsemblClinVar. | 1 | |
Natural variantiVAR_059116 | 3117 | I → V. Corresponds to variant dbSNP:rs28932171Ensembl. | 1 | |
Natural variantiVAR_059117 | 3123 | K → R. Corresponds to variant dbSNP:rs10821668Ensembl. | 1 | |
Natural variantiVAR_068703 | 3720 | T → M Found in a patient with autism; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201547988Ensembl. | 1 | |
Natural variantiVAR_068704 | 4255 | T → P Found in a patient with autism; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs769573528Ensembl. | 1 | |
Natural variantiVAR_054333 | 4257 | I → V. Corresponds to variant dbSNP:rs12261793Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046885 | 1 – 866 | Missing in isoform 4. 1 PublicationAdd BLAST | 866 | |
Alternative sequenceiVSP_044348 | 1 – 37 | MAHAA…RDRKK → MASSASSSPAGTEDSAPAQG GFGSDYSRSSR in isoform 3. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_044349 | 1 – 36 | MAHAA…SRDRK → MSEEPKEKNAKPAHRKRKG in isoform 2. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_053753 | 1 – 6 | MAHAAS → MNLRCD in isoform 5. 1 Publication | 6 | |
Alternative sequenceiVSP_053754 | 7 – 385 | Missing in isoform 5. 1 PublicationAdd BLAST | 379 | |
Alternative sequenceiVSP_053755 | 850 – 870 | Missing in isoform 5. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_046886 | 867 – 872 | SDVEEG → MALPQS in isoform 4. 1 Publication | 6 | |
Alternative sequenceiVSP_044350 | 872 | G → GNRCTWYKIPKVQEFTVKS in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_053756 | 913 – 918 | Missing in isoform 5. 1 Publication | 6 | |
Alternative sequenceiVSP_053757 | 1036 – 1043 | MVEGEGLA → HGERRGIS in isoform 5. 1 Publication | 8 | |
Alternative sequenceiVSP_044351 | 1442 – 1450 | Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 4 Publications | 9 | |
Alternative sequenceiVSP_044352 | 1478 – 4081 | Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST | 2604 | |
Alternative sequenceiVSP_053758 | 1478 – 1880 | IERST…VKSSL → TSCTVKVRKSQLKEVCKHSI EYFKGISGETLKLVDRLSEE EKKMQSELSDEEESTSRNTS LSETSRGGQPSVTTKSARDK KTEAAPLKSKSEKAGSEKRS SRRTGPQSPCERTDIRMAIV ADHLGLSWTELARELNFSVD EINQIRVENPNSLISQSFML LKKWVTRDGKNATTDALTSV LTKINRIDIVTLLEGPIFDY GNISGTRSFADENNVFHDPV DGWQNETSSGNLESCAQARR VTGGLLDRLDDSPDQCRDSI TSYLKGEAGKFEANGSHTEI TPEAKTKSYFPESQNDVGKQ STKETLKPKIHGSGHVEEPA SPLAAYQKSLEETSKLSKLI IEETKPCVPVSMKKMSRTSP ADGKPRLSLHEEEGSSGSEQ KQGEGFKVKTKKEIRHVEKK SHS in isoform 5. 1 PublicationAdd BLAST | 403 | |
Alternative sequenceiVSP_053759 | 1881 – 4377 | Missing in isoform 5. 1 PublicationAdd BLAST | 2497 | |
Alternative sequenceiVSP_044353 | 4082 | G → S in isoform 2, isoform 3 and isoform 4. 3 Publications | 1 | |
Alternative sequenceiVSP_044354 | 4199 | G → GYPSLQVELETPTGLHYTPP TPFQQDDYFSDISSIESPLR TPSRLSDGLVPSQGNIEHSA DGPPVVTAEDASLEDSKLED SVPLTEMPEAVDVDESQLEN VCLS in isoform 2, isoform 3 and isoform 4. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13616 mRNA Translation: AAA64834.1 U43965 mRNA Translation: AAB08437.1 AL136710 mRNA Translation: CAB66645.1 Frameshift. AK295661 mRNA Translation: BAG58523.1 BX537917 mRNA Translation: CAD97900.2 BX648574 mRNA Translation: CAI56716.1 AC022390 Genomic DNA No translation available. AC023904 Genomic DNA No translation available. AL359267 Genomic DNA No translation available. AL359377 Genomic DNA No translation available. AL391707 Genomic DNA No translation available. AL592430 Genomic DNA No translation available. AL607065 Genomic DNA No translation available. |
CCDSi | CCDS55711.1 [Q12955-4] CCDS55712.1 [Q12955-5] CCDS7258.1 [Q12955-3] CCDS7259.1 [Q12955-6] |
PIRi | A55575 |
RefSeqi | NP_001140.2, NM_001149.3 [Q12955-6] NP_001191332.1, NM_001204403.1 [Q12955-5] NP_001191333.1, NM_001204404.1 [Q12955-4] NP_066267.2, NM_020987.4 [Q12955-3] |
Genome annotation databases
Ensembli | ENST00000280772; ENSP00000280772; ENSG00000151150 [Q12955-3] ENST00000355288; ENSP00000347436; ENSG00000151150 [Q12955-6] ENST00000373827; ENSP00000362933; ENSG00000151150 [Q12955-5] ENST00000503366; ENSP00000425236; ENSG00000151150 [Q12955-4] |
GeneIDi | 288 |
KEGGi | hsa:288 |
UCSCi | uc001jkw.4, human [Q12955-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Ankyrin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13616 mRNA Translation: AAA64834.1 U43965 mRNA Translation: AAB08437.1 AL136710 mRNA Translation: CAB66645.1 Frameshift. AK295661 mRNA Translation: BAG58523.1 BX537917 mRNA Translation: CAD97900.2 BX648574 mRNA Translation: CAI56716.1 AC022390 Genomic DNA No translation available. AC023904 Genomic DNA No translation available. AL359267 Genomic DNA No translation available. AL359377 Genomic DNA No translation available. AL391707 Genomic DNA No translation available. AL592430 Genomic DNA No translation available. AL607065 Genomic DNA No translation available. |
CCDSi | CCDS55711.1 [Q12955-4] CCDS55712.1 [Q12955-5] CCDS7258.1 [Q12955-3] CCDS7259.1 [Q12955-6] |
PIRi | A55575 |
RefSeqi | NP_001140.2, NM_001149.3 [Q12955-6] NP_001191332.1, NM_001204403.1 [Q12955-5] NP_001191333.1, NM_001204404.1 [Q12955-4] NP_066267.2, NM_020987.4 [Q12955-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4O6X | X-ray | 2.10 | A/B | 4088-4199 | [»] | |
SMRi | Q12955 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106785, 59 interactors |
CORUMi | Q12955 |
DIPi | DIP-49017N |
ELMi | Q12955 |
IntActi | Q12955, 41 interactors |
MINTi | Q12955 |
STRINGi | 9606.ENSP00000280772 |
PTM databases
iPTMneti | Q12955 |
PhosphoSitePlusi | Q12955 |
SwissPalmi | Q12955 |
Genetic variation databases
BioMutai | ANK3 |
DMDMi | 257051061 |
Proteomic databases
EPDi | Q12955 |
jPOSTi | Q12955 |
MassIVEi | Q12955 |
MaxQBi | Q12955 |
PaxDbi | Q12955 |
PeptideAtlasi | Q12955 |
PRIDEi | Q12955 |
ProteomicsDBi | 19802 3339 59048 [Q12955-3] |
Protocols and materials databases
ABCDi | Q12955, 6 sequenced antibodies |
Antibodypediai | 4197, 265 antibodies |
DNASUi | 288 |
Genome annotation databases
Ensembli | ENST00000280772; ENSP00000280772; ENSG00000151150 [Q12955-3] ENST00000355288; ENSP00000347436; ENSG00000151150 [Q12955-6] ENST00000373827; ENSP00000362933; ENSG00000151150 [Q12955-5] ENST00000503366; ENSP00000425236; ENSG00000151150 [Q12955-4] |
GeneIDi | 288 |
KEGGi | hsa:288 |
UCSCi | uc001jkw.4, human [Q12955-3] |
Organism-specific databases
CTDi | 288 |
DisGeNETi | 288 |
GeneCardsi | ANK3 |
HGNCi | HGNC:494, ANK3 |
HPAi | ENSG00000151150, Tissue enhanced (brain, parathyroid gland) |
MalaCardsi | ANK3 |
MIMi | 600465, gene 615493, phenotype |
neXtProti | NX_Q12955 |
OpenTargetsi | ENSG00000151150 |
Orphaneti | 356996, ANK3-related intellectual disability-sleep disturbance syndrome |
PharmGKBi | PA24800 |
VEuPathDBi | HostDB:ENSG00000151150.20 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4177, Eukaryota |
GeneTreei | ENSGT00940000154939 |
HOGENOMi | CLU_000134_29_1_1 |
InParanoidi | Q12955 |
OMAi | MPDYFSE |
OrthoDBi | 1011028at2759 |
PhylomeDBi | Q12955 |
TreeFami | TF351263 |
Enzyme and pathway databases
PathwayCommonsi | Q12955 |
Reactomei | R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-6807878, COPI-mediated anterograde transport |
Miscellaneous databases
BioGRID-ORCSi | 288, 4 hits in 886 CRISPR screens |
ChiTaRSi | ANK3, human |
GeneWikii | ANK3 |
GenomeRNAii | 288 |
Pharosi | Q12955, Tbio |
PROi | PR:Q12955 |
RNActi | Q12955, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151150, Expressed in substantia nigra and 246 other tissues |
ExpressionAtlasi | Q12955, baseline and differential |
Genevisiblei | Q12955, HS |
Family and domain databases
CDDi | cd08803, Death_ank3, 1 hit |
Gene3Di | 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR037971, Ank3_Death IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 7 hits PF13606, Ank_3, 1 hit PF00531, Death, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 22 hits SM00005, DEATH, 1 hit SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 21 hits PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANK3_HUMAN | |
Accessioni | Q12955Primary (citable) accession number: Q12955 Secondary accession number(s): B1AQT2 Q9H0P5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2002 |
Last sequence update: | September 1, 2009 | |
Last modified: | February 10, 2021 | |
This is version 201 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with genetic variants
List of human entries with genetic variants