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UniProtKB - Q12952 (FOXL1_HUMAN)
Protein
Forkhead box protein L1
Gene
FOXL1
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 48 – 139 | Fork-headPROSITE-ProRule annotationAdd BLAST | 92 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA binding, bending Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- heart development Source: DFLAT
- Peyer's patch morphogenesis Source: Ensembl
- proteoglycan biosynthetic process Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of Wnt signaling pathway Source: UniProtKB
- visceral mesoderm-endoderm interaction involved in midgut development Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q12952 |
SignaLinki | Q12952 |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein L1Alternative name(s): Forkhead-related protein FKHL11 Forkhead-related transcription factor 7 Short name: FREAC-7 |
Gene namesi | Name:FOXL1 Synonyms:FKHL11, FREAC7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3817, FOXL1 |
MIMi | 603252, gene |
neXtProti | NX_Q12952 |
VEuPathDBi | HostDB:ENSG00000176678 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 2300 |
OpenTargetsi | ENSG00000176678 |
PharmGKBi | PA28234 |
Miscellaneous databases
Pharosi | Q12952, Tbio |
Genetic variation databases
BioMutai | FOXL1 |
DMDMi | 13638268 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091859 | 1 – 345 | Forkhead box protein L1Add BLAST | 345 |
Proteomic databases
jPOSTi | Q12952 |
MassIVEi | Q12952 |
PaxDbi | Q12952 |
PeptideAtlasi | Q12952 |
PRIDEi | Q12952 |
PTM databases
iPTMneti | Q12952 |
PhosphoSitePlusi | Q12952 |
Expressioni
Gene expression databases
Bgeei | ENSG00000176678, Expressed in left coronary artery and 116 other tissues |
ExpressionAtlasi | Q12952, baseline and differential |
Genevisiblei | Q12952, HS |
Organism-specific databases
HPAi | ENSG00000176678, Tissue enhanced (gallbladder) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 108589, 125 interactors |
IntActi | Q12952, 185 interactors |
MINTi | Q12952 |
STRINGi | 9606.ENSP00000326272 |
Miscellaneous databases
RNActi | Q12952, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 136 – 289 | DisorderedSequence analysisAdd BLAST | 154 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 147 – 165 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 195 – 209 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 247 – 267 | Polar residuesSequence analysisAdd BLAST | 21 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000162251 |
HOGENOMi | CLU_052451_0_0_1 |
InParanoidi | Q12952 |
OMAi | PLHWPGT |
OrthoDBi | 1270467at2759 |
PhylomeDBi | Q12952 |
TreeFami | TF316127 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q12952-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHLFDPRLP ALAASPMLYL YGPERPGLPL AFAPAAALAA SGRAETPQKP
60 70 80 90 100
PYSYIALIAM AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN
110 120 130 140 150
LSLNDCFVKV PREKGRPGKG SYWTLDPRCL DMFENGNYRR RKRKPKPGPG
160 170 180 190 200
APEAKRPRAE THQRSAEAQP EAGSGAGGSG PAISRLQAAP AGPSPLLDGP
210 220 230 240 250
SPPAPLHWPG TASPNEDAGD AAQGAAAVAV GQAARTGDGP GSPLRPASRS
260 270 280 290 300
SPKSSDKSKS FSIDSILAGK QGQKPPSGDE LLGGAKPGPG GRLGASLLAA
310 320 330 340
SSSLRPPFNA SLMLDPHVQG GFYQLGIPFL SYFPLQVPDT VLHFQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R279 | M0R279_HUMAN | Forkhead box protein L1 | FOXL1 | 114 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF315075 Genomic DNA Translation: AAG40312.1 AC009108 Genomic DNA No translation available. BC117226 mRNA Translation: AAI17227.1 U13225 Genomic DNA Translation: AAA92042.1 |
CCDSi | CCDS10959.1 |
PIRi | S51630 |
RefSeqi | NP_005241.1, NM_005250.2 |
Genome annotation databases
Ensembli | ENST00000320241.5; ENSP00000326272.3; ENSG00000176678.6 |
GeneIDi | 2300 |
KEGGi | hsa:2300 |
MANE-Selecti | ENST00000320241.5; ENSP00000326272.3; NM_005250.3; NP_005241.1 |
UCSCi | uc002fjr.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF315075 Genomic DNA Translation: AAG40312.1 AC009108 Genomic DNA No translation available. BC117226 mRNA Translation: AAI17227.1 U13225 Genomic DNA Translation: AAA92042.1 |
CCDSi | CCDS10959.1 |
PIRi | S51630 |
RefSeqi | NP_005241.1, NM_005250.2 |
3D structure databases
AlphaFoldDBi | Q12952 |
SMRi | Q12952 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108589, 125 interactors |
IntActi | Q12952, 185 interactors |
MINTi | Q12952 |
STRINGi | 9606.ENSP00000326272 |
PTM databases
iPTMneti | Q12952 |
PhosphoSitePlusi | Q12952 |
Genetic variation databases
BioMutai | FOXL1 |
DMDMi | 13638268 |
Proteomic databases
jPOSTi | Q12952 |
MassIVEi | Q12952 |
PaxDbi | Q12952 |
PeptideAtlasi | Q12952 |
PRIDEi | Q12952 |
Protocols and materials databases
Antibodypediai | 17198, 465 antibodies from 28 providers |
DNASUi | 2300 |
Genome annotation databases
Ensembli | ENST00000320241.5; ENSP00000326272.3; ENSG00000176678.6 |
GeneIDi | 2300 |
KEGGi | hsa:2300 |
MANE-Selecti | ENST00000320241.5; ENSP00000326272.3; NM_005250.3; NP_005241.1 |
UCSCi | uc002fjr.4, human |
Organism-specific databases
CTDi | 2300 |
DisGeNETi | 2300 |
GeneCardsi | FOXL1 |
HGNCi | HGNC:3817, FOXL1 |
HPAi | ENSG00000176678, Tissue enhanced (gallbladder) |
MIMi | 603252, gene |
neXtProti | NX_Q12952 |
OpenTargetsi | ENSG00000176678 |
PharmGKBi | PA28234 |
VEuPathDBi | HostDB:ENSG00000176678 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000162251 |
HOGENOMi | CLU_052451_0_0_1 |
InParanoidi | Q12952 |
OMAi | PLHWPGT |
OrthoDBi | 1270467at2759 |
PhylomeDBi | Q12952 |
TreeFami | TF316127 |
Enzyme and pathway databases
PathwayCommonsi | Q12952 |
SignaLinki | Q12952 |
Miscellaneous databases
BioGRID-ORCSi | 2300, 11 hits in 1093 CRISPR screens |
GenomeRNAii | 2300 |
Pharosi | Q12952, Tbio |
PROi | PR:Q12952 |
RNActi | Q12952, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176678, Expressed in left coronary artery and 116 other tissues |
ExpressionAtlasi | Q12952, baseline and differential |
Genevisiblei | Q12952, HS |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXL1_HUMAN | |
Accessioni | Q12952Primary (citable) accession number: Q12952 Secondary accession number(s): Q17RR1, Q9H242 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 27, 2001 | |
Last modified: | May 25, 2022 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot