FOXF1

Functionⁱ

Probable transcription activator for a number of lung-specific genes.

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	47 – 138	Fork-headPROSITE-ProRule annotationAdd BLAST		92

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9769171
DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 8626802
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 8626802
sequence-specific DNA binding
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 7957066
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood vessel development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
cardiac left ventricle morphogenesis
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
cell-cell adhesion Source: Ensembl
cellular response to cytokine stimulus Source: Ensembl
cellular response to organic cyclic compound Source: Ensembl
detection of wounding Source: Ensembl
determination of left/right symmetry Source: Ensembl
digestive tract development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
ductus arteriosus closure
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
embryonic digestive tract morphogenesis
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
embryonic ectodermal digestive tract morphogenesis
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
embryonic foregut morphogenesis Source: Ensembl
endocardial cushion development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
epithelial cell differentiation involved in mammary gland alveolus development Source: Ensembl
epithelial tube branching involved in lung morphogenesis Source: Ensembl
establishment of epithelial cell apical/basal polarity Source: Ensembl
extracellular matrix organization Source: Ensembl
heart development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
in utero embryonic development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
lateral mesodermal cell differentiation Source: Ensembl
lung alveolus development Source: Ensembl
lung development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
lung lobe morphogenesis Source: Ensembl
lung vasculature development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
mesenchyme migration Source: Ensembl
midgut development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
morphogenesis of a branching structure
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
negative regulation of inflammatory response Source: Ensembl
negative regulation of mast cell degranulation Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
pancreas development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
positive regulation of cell migration Source: Ensembl
positive regulation of cell-substrate adhesion Source: Ensembl
positive regulation of mesenchymal cell proliferation Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 8626802
- 9769171
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 8626802
regulation of smooth muscle cell differentiation Source: Ensembl
renal system development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
respiratory tube development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
right lung morphogenesis Source: Ensembl
smoothened signaling pathway Source: Ensembl
smooth muscle cell differentiation Source: Ensembl
somitogenesis Source: Ensembl
trachea development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
ureter development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772
vasculogenesis Source: Ensembl
venous blood vessel development
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19500772

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkⁱ	Q12946
SIGNORⁱ	Q12946

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Forkhead box protein F1 Alternative name(s): Forkhead-related activator 1 Short name: FREAC-1 Forkhead-related protein FKHL5 Forkhead-related transcription factor 1
Gene namesⁱ	Name:FOXF1 Synonyms:FKHL5, FREAC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103241.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3809 FOXF1
MIMⁱ	601089 gene
neXtProtⁱ	NX_Q12946

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare developmental disorder characterized by abnormal development of the capillary vascular system in the lungs. Histological features include failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2294
MalaCards human disease database More...MalaCardsⁱ	FOXF1
MIMⁱ	265380 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000103241
Orphanetⁱ	210122 Congenital alveolar capillary dysplasia
PharmGKBⁱ	PA28226

Polymorphism and mutation databases

BioMutaⁱ	FOXF1
DMDMⁱ	238054293

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000091832	1 – 379	Forkhead box protein F1Add BLAST		379

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q12946
PaxDbⁱ	Q12946
PeptideAtlas More...PeptideAtlasⁱ	Q12946
PRIDEⁱ	Q12946
ProteomicsDBⁱ	59041

PTM databases

iPTMnetⁱ	Q12946
PhosphoSitePlusⁱ	Q12946

Expressionⁱ

Tissue specificityⁱ

Expressed in lung and placenta.1 Publication

Developmental stageⁱ

Expressed in fetal lung.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000103241 Expressed in 155 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExⁱ	HS_FOXF1
Genevisibleⁱ	Q12946 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028886

HPAⁱ

HPA028886

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	108583, 23 interactors
IntActⁱ	Q12946, 13 interactors
Molecular INTeraction database More...MINTⁱ	Q12946
STRINGⁱ	9606.ENSP00000262426

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q12946
SMRⁱ	Q12946
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150834
HOGENOMⁱ	HOG000060124
HOVERGENⁱ	HBG051644
InParanoidⁱ	Q12946
KEGG Orthology (KO) More...KOⁱ	K09399
OMAⁱ	DQSYLHQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11UK
PhylomeDBⁱ	Q12946
TreeFamⁱ	TF351598

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001766 Fork_head_dom IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q12946-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSAPEKQQP PHGGGGGGGG GGGAAMDPAS SGPSKAKKTN AGIRRPEKPP 
        60         70         80         90        100
YSYIALIVMA IQSSPTKRLT LSEIYQFLQS RFPFFRGSYQ GWKNSVRHNL 
       110        120        130        140        150
SLNECFIKLP KGLGRPGKGH YWTIDPASEF MFEEGSFRRR PRGFRRKCQA 
       160        170        180        190        200
LKPMYSMMNG LGFNHLPDTY GFQGSAGGLS CPPNSLALEG GLGMMNGHLP 
       210        220        230        240        250
GNVDGMALPS HSVPHLPSNG GHSYMGGCGG AAAGEYPHHD SSVPASPLLP 
       260        270        280        290        300
TGAGGVMEPH AVYSGSAAAW PPSASAALNS GASYIKQQPL SPCNPAANPL 
       310        320        330        340        350
SGSLSTHSLE QPYLHQNSHN APAELQGIPR YHSQSPSMCD RKEFVFSFNA 
       360        370 
MASSSMHSAG GGSYYHQQVT YQDIKPCVM

Length:379

Mass (Da):40,122

Last modified:May 26, 2009 - v2

Checksum:ⁱCA3DE3CEFB94FC3E

GO

Sequence cautionⁱ

The sequence AAC50399 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAC61576 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH89442 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAG36851 differs from that shown. Reason: Frameshift at several positions.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_071016	49	P → Q in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071017	49	P → S in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071018	52	S → F in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071019	53	Y → C in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071020	74	I → N in ACDMPV. 1 Publication	1
Natural variantⁱVAR_076592	77	F → L in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071021	85	F → I in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071022	85	F → L in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071023	85	F → S in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071024	86	R → W in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071025	91	G → E in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071026	91	G → V in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071027	96	V → M in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071028	97	R → H in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071029	98	H → Q in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071030	101	S → L in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071031	106	F → L in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071032	113 – 119	Missing in ACDMPV. 1 Publication	7
Natural variantⁱVAR_071033	119	G → D in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071034	126	P → L in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071035	139	R → L in ACDMPV. 1 Publication	1
Natural variantⁱVAR_071036	330	R → W in ACDMPV; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs761162914Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U13219 mRNA Translation: AAC50399.1 Different initiation. AF085343, AF085342 Genomic DNA Translation: AAC61576.1 Different initiation. AK314167 mRNA Translation: BAG36851.1 Frameshift. AC009108 Genomic DNA No translation available. BC089442 mRNA Translation: AAH89442.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10957.2
PIRⁱ	S51624
NCBI Reference Sequences More...RefSeqⁱ	NP_001442.2, NM_001451.2
UniGeneⁱ	Hs.155591 Hs.690163

Genome annotation databases

Ensemblⁱ	ENST00000262426; ENSP00000262426; ENSG00000103241
GeneIDⁱ	2294
KEGGⁱ	hsa:2294
UCSC genome browser More...UCSCⁱ	uc002fjl.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q12946	Forkhead box protein F1 (Fragment)		HUMAN		29	UniRef100_Q12946

Protein	Similar proteins		Species	Score	Length	Source
Q12946	Forkhead box protein F1 (Fragment)		HUMAN		29	UniRef90_Q12946
Uncharacterized protein		PROCO		381
forkhead box protein F1		ODORO		381
Forkhead box F1		PONAB		380
Uncharacterized protein		CERAT		380
+41

Protein	Similar proteins		Species	Score	Length	Source
Q12946	Forkhead box protein F1		MOUSE		378	UniRef50_Q12946
Forkhead box protein F1 (Fragment)		HUMAN		29
forkhead box protein F1		ODORO		381
Uncharacterized protein		PROCO		381
Uncharacterized protein		RHIBE		380
+205

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U13219 mRNA Translation: AAC50399.1 Different initiation. AF085343, AF085342 Genomic DNA Translation: AAC61576.1 Different initiation. AK314167 mRNA Translation: BAG36851.1 Frameshift. AC009108 Genomic DNA No translation available. BC089442 mRNA Translation: AAH89442.1 Different initiation.
CCDSⁱ	CCDS10957.2
PIRⁱ	S51624
RefSeqⁱ	NP_001442.2, NM_001451.2
UniGeneⁱ	Hs.155591 Hs.690163

3D structure databases

ProteinModelPortalⁱ	Q12946
SMRⁱ	Q12946
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108583, 23 interactors
IntActⁱ	Q12946, 13 interactors
MINTⁱ	Q12946
STRINGⁱ	9606.ENSP00000262426

PTM databases

iPTMnetⁱ	Q12946
PhosphoSitePlusⁱ	Q12946

Polymorphism and mutation databases

BioMutaⁱ	FOXF1
DMDMⁱ	238054293

Proteomic databases

MaxQBⁱ	Q12946
PaxDbⁱ	Q12946
PeptideAtlasⁱ	Q12946
PRIDEⁱ	Q12946
ProteomicsDBⁱ	59041

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2294
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262426; ENSP00000262426; ENSG00000103241
GeneIDⁱ	2294
KEGGⁱ	hsa:2294
UCSCⁱ	uc002fjl.4 human

Organism-specific databases

CTDⁱ	2294
DisGeNETⁱ	2294
EuPathDBⁱ	HostDB:ENSG00000103241.6
GeneCardsⁱ	FOXF1
HGNCⁱ	HGNC:3809 FOXF1
HPAⁱ	HPA028886
MalaCardsⁱ	FOXF1
MIMⁱ	265380 phenotype 601089 gene
neXtProtⁱ	NX_Q12946
OpenTargetsⁱ	ENSG00000103241
Orphanetⁱ	210122 Congenital alveolar capillary dysplasia
PharmGKBⁱ	PA28226
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
GeneTreeⁱ	ENSGT00930000150834
HOGENOMⁱ	HOG000060124
HOVERGENⁱ	HBG051644
InParanoidⁱ	Q12946
KOⁱ	K09399
OMAⁱ	DQSYLHQ
OrthoDBⁱ	EOG091G11UK
PhylomeDBⁱ	Q12946
TreeFamⁱ	TF351598

Enzyme and pathway databases

SignaLinkⁱ	Q12946
SIGNORⁱ	Q12946

Miscellaneous databases

GeneWikiⁱ	FOXF1
GenomeRNAiⁱ	2294
Protein Ontology More...PROⁱ	PR:Q12946
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000103241 Expressed in 155 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExⁱ	HS_FOXF1
Genevisibleⁱ	Q12946 HS

Family and domain databases

CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001766 Fork_head_dom IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOXF1_HUMAN
Accessionⁱ	Q12946Primary (citable) accession number: Q12946 Secondary accession number(s): B2RAF4, Q5FWE5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	May 26, 2009
	Last modified:	November 7, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q12946 (FOXF1_HUMAN)

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Forkhead box protein F1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ