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Entry version 173 (12 Aug 2020)
Sequence version 2 (26 May 2009)
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Protein

Forkhead box protein F1

Gene

FOXF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcription activator for a number of lung-specific genes.

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi47 – 138Fork-headPROSITE-ProRule annotationAdd BLAST92

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q12946

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q12946

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q12946

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Forkhead box protein F1
Alternative name(s):
Forkhead-related activator 1
Short name:
FREAC-1
Forkhead-related protein FKHL5
Forkhead-related transcription factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FOXF1
Synonyms:FKHL5, FREAC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103241.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3809, FOXF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601089, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12946

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare developmental disorder characterized by abnormal development of the capillary vascular system in the lungs. Histological features include failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07101649P → Q in ACDMPV. 1 Publication1
Natural variantiVAR_07101749P → S in ACDMPV. 1 Publication1
Natural variantiVAR_07101852S → F in ACDMPV. 1 Publication1
Natural variantiVAR_07101953Y → C in ACDMPV. 1 Publication1
Natural variantiVAR_07102074I → N in ACDMPV. 1 Publication1
Natural variantiVAR_07659277F → L in ACDMPV. 1 Publication1
Natural variantiVAR_07102185F → I in ACDMPV. 1 Publication1
Natural variantiVAR_07102285F → L in ACDMPV. 1 Publication1
Natural variantiVAR_07102385F → S in ACDMPV. 1 Publication1
Natural variantiVAR_07102486R → W in ACDMPV. 1 Publication1
Natural variantiVAR_07102591G → E in ACDMPV. 1 Publication1
Natural variantiVAR_07102691G → V in ACDMPV. 1 Publication1
Natural variantiVAR_07102796V → M in ACDMPV. 1 Publication1
Natural variantiVAR_07102897R → H in ACDMPV. 1 Publication1
Natural variantiVAR_07102998H → Q in ACDMPV. 1 Publication1
Natural variantiVAR_071030101S → L in ACDMPV. 1 Publication1
Natural variantiVAR_071031106F → L in ACDMPV. 1 Publication1
Natural variantiVAR_071032113 – 119Missing in ACDMPV. 1 Publication7
Natural variantiVAR_071033119G → D in ACDMPV. 1 Publication1
Natural variantiVAR_071034126P → L in ACDMPV. 1 Publication1
Natural variantiVAR_071035139R → L in ACDMPV. 1 Publication1
Natural variantiVAR_071036330R → W in ACDMPV; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs761162914Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2294

MalaCards human disease database

More...
MalaCardsi
FOXF1
MIMi265380, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000103241

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
210122, Congenital alveolar capillary dysplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28226

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12946, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FOXF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
238054293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000918321 – 379Forkhead box protein F1Add BLAST379

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q12946

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q12946

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12946

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12946

PeptideAtlas

More...
PeptideAtlasi
Q12946

PRoteomics IDEntifications database

More...
PRIDEi
Q12946

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59041

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12946

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12946

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung and placenta.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103241, Expressed in esophagogastric junction muscularis propria and 168 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12946, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000103241, Tissue enhanced (smooth muscle, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
108583, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q12946, 15 interactors

Molecular INTeraction database

More...
MINTi
Q12946

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262426

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12946, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q12946

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2294, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161035

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039845_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12946

KEGG Orthology (KO)

More...
KOi
K09399

Identification of Orthologs from Complete Genome Data

More...
OMAi
SGVMEPH

Database of Orthologous Groups

More...
OrthoDBi
1120805at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12946

TreeFam database of animal gene trees

More...
TreeFami
TF351598

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00059, FH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001766, Fork_head_dom
IPR018122, TF_fork_head_CS_1
IPR030456, TF_fork_head_CS_2
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00250, Forkhead, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00053, FORKHEAD

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00339, FH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00657, FORK_HEAD_1, 1 hit
PS00658, FORK_HEAD_2, 1 hit
PS50039, FORK_HEAD_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12946-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAPEKQQP PHGGGGGGGG GGGAAMDPAS SGPSKAKKTN AGIRRPEKPP
60 70 80 90 100
YSYIALIVMA IQSSPTKRLT LSEIYQFLQS RFPFFRGSYQ GWKNSVRHNL
110 120 130 140 150
SLNECFIKLP KGLGRPGKGH YWTIDPASEF MFEEGSFRRR PRGFRRKCQA
160 170 180 190 200
LKPMYSMMNG LGFNHLPDTY GFQGSAGGLS CPPNSLALEG GLGMMNGHLP
210 220 230 240 250
GNVDGMALPS HSVPHLPSNG GHSYMGGCGG AAAGEYPHHD SSVPASPLLP
260 270 280 290 300
TGAGGVMEPH AVYSGSAAAW PPSASAALNS GASYIKQQPL SPCNPAANPL
310 320 330 340 350
SGSLSTHSLE QPYLHQNSHN APAELQGIPR YHSQSPSMCD RKEFVFSFNA
360 370
MASSSMHSAG GGSYYHQQVT YQDIKPCVM
Length:379
Mass (Da):40,122
Last modified:May 26, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA3DE3CEFB94FC3E
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50399 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC61576 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH89442 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG36851 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07101649P → Q in ACDMPV. 1 Publication1
Natural variantiVAR_07101749P → S in ACDMPV. 1 Publication1
Natural variantiVAR_07101852S → F in ACDMPV. 1 Publication1
Natural variantiVAR_07101953Y → C in ACDMPV. 1 Publication1
Natural variantiVAR_07102074I → N in ACDMPV. 1 Publication1
Natural variantiVAR_07659277F → L in ACDMPV. 1 Publication1
Natural variantiVAR_07102185F → I in ACDMPV. 1 Publication1
Natural variantiVAR_07102285F → L in ACDMPV. 1 Publication1
Natural variantiVAR_07102385F → S in ACDMPV. 1 Publication1
Natural variantiVAR_07102486R → W in ACDMPV. 1 Publication1
Natural variantiVAR_07102591G → E in ACDMPV. 1 Publication1
Natural variantiVAR_07102691G → V in ACDMPV. 1 Publication1
Natural variantiVAR_07102796V → M in ACDMPV. 1 Publication1
Natural variantiVAR_07102897R → H in ACDMPV. 1 Publication1
Natural variantiVAR_07102998H → Q in ACDMPV. 1 Publication1
Natural variantiVAR_071030101S → L in ACDMPV. 1 Publication1
Natural variantiVAR_071031106F → L in ACDMPV. 1 Publication1
Natural variantiVAR_071032113 – 119Missing in ACDMPV. 1 Publication7
Natural variantiVAR_071033119G → D in ACDMPV. 1 Publication1
Natural variantiVAR_071034126P → L in ACDMPV. 1 Publication1
Natural variantiVAR_071035139R → L in ACDMPV. 1 Publication1
Natural variantiVAR_071036330R → W in ACDMPV; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs761162914Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U13219 mRNA Translation: AAC50399.1 Different initiation.
AF085343, AF085342 Genomic DNA Translation: AAC61576.1 Different initiation.
AK314167 mRNA Translation: BAG36851.1 Frameshift.
AC009108 Genomic DNA No translation available.
BC089442 mRNA Translation: AAH89442.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10957.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S51624

NCBI Reference Sequences

More...
RefSeqi
NP_001442.2, NM_001451.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262426; ENSP00000262426; ENSG00000103241

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2294

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2294

UCSC genome browser

More...
UCSCi
uc002fjl.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13219 mRNA Translation: AAC50399.1 Different initiation.
AF085343, AF085342 Genomic DNA Translation: AAC61576.1 Different initiation.
AK314167 mRNA Translation: BAG36851.1 Frameshift.
AC009108 Genomic DNA No translation available.
BC089442 mRNA Translation: AAH89442.1 Different initiation.
CCDSiCCDS10957.2
PIRiS51624
RefSeqiNP_001442.2, NM_001451.2

3D structure databases

SMRiQ12946
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108583, 24 interactors
IntActiQ12946, 15 interactors
MINTiQ12946
STRINGi9606.ENSP00000262426

PTM databases

iPTMnetiQ12946
PhosphoSitePlusiQ12946

Polymorphism and mutation databases

BioMutaiFOXF1
DMDMi238054293

Proteomic databases

jPOSTiQ12946
MassIVEiQ12946
MaxQBiQ12946
PaxDbiQ12946
PeptideAtlasiQ12946
PRIDEiQ12946
ProteomicsDBi59041

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17194, 244 antibodies

The DNASU plasmid repository

More...
DNASUi
2294

Genome annotation databases

EnsembliENST00000262426; ENSP00000262426; ENSG00000103241
GeneIDi2294
KEGGihsa:2294
UCSCiuc002fjl.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2294
DisGeNETi2294
EuPathDBiHostDB:ENSG00000103241.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FOXF1
HGNCiHGNC:3809, FOXF1
HPAiENSG00000103241, Tissue enhanced (smooth muscle, urinary bladder)
MalaCardsiFOXF1
MIMi265380, phenotype
601089, gene
neXtProtiNX_Q12946
OpenTargetsiENSG00000103241
Orphaneti210122, Congenital alveolar capillary dysplasia
PharmGKBiPA28226

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2294, Eukaryota
GeneTreeiENSGT00940000161035
HOGENOMiCLU_039845_1_0_1
InParanoidiQ12946
KOiK09399
OMAiSGVMEPH
OrthoDBi1120805at2759
PhylomeDBiQ12946
TreeFamiTF351598

Enzyme and pathway databases

PathwayCommonsiQ12946
SignaLinkiQ12946
SIGNORiQ12946

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
2294, 18 hits in 895 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FOXF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2294
PharosiQ12946, Tbio

Protein Ontology

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PROi
PR:Q12946
RNActiQ12946, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000103241, Expressed in esophagogastric junction muscularis propria and 168 other tissues
GenevisibleiQ12946, HS

Family and domain databases

CDDicd00059, FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766, Fork_head_dom
IPR018122, TF_fork_head_CS_1
IPR030456, TF_fork_head_CS_2
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250, Forkhead, 1 hit
PRINTSiPR00053, FORKHEAD
SMARTiView protein in SMART
SM00339, FH, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657, FORK_HEAD_1, 1 hit
PS00658, FORK_HEAD_2, 1 hit
PS50039, FORK_HEAD_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOXF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12946
Secondary accession number(s): B2RAF4, Q5FWE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 26, 2009
Last modified: August 12, 2020
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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