UniProtKB - Q12926 (ELAV2_HUMAN)
Protein
ELAV-like protein 2
Gene
ELAVL2
Organism
Homo sapiens (Human)
Status
Functioni
RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity).By similarity
GO - Molecular functioni
- mRNA 3'-UTR binding Source: ProtInc
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA splicing, via spliceosome Source: Reactome
- regulation of transcription, DNA-templated Source: ProtInc
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q12926 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: ELAV-like protein 2Alternative name(s): ELAV-like neuronal protein 1 Hu-antigen B Short name: HuB Nervous system-specific RNA-binding protein Hel-N1 |
Gene namesi | Name:ELAVL2 Synonyms:HUB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3313, ELAVL2 |
MIMi | 601673, gene |
neXtProti | NX_Q12926 |
VEuPathDBi | HostDB:ENSG00000107105.14 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
Other locations
- ribonucleoprotein complex Source: InterPro
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1993 |
OpenTargetsi | ENSG00000107105 |
PharmGKBi | PA27741 |
Miscellaneous databases
Pharosi | Q12926, Tbio |
Genetic variation databases
BioMutai | ELAVL2 |
DMDMi | 93141258 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081579 | 1 – 359 | ELAV-like protein 2Add BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 221 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q12926 |
jPOSTi | Q12926 |
MassIVEi | Q12926 |
MaxQBi | Q12926 |
PaxDbi | Q12926 |
PeptideAtlasi | Q12926 |
PRIDEi | Q12926 |
ProteomicsDBi | 59031 [Q12926-1] 59032 [Q12926-2] |
PTM databases
iPTMneti | Q12926 |
PhosphoSitePlusi | Q12926 |
SwissPalmi | Q12926 |
Expressioni
Tissue specificityi
Brain; neural-specific.
Gene expression databases
Bgeei | ENSG00000107105, Expressed in Brodmann (1909) area 23 and 155 other tissues |
ExpressionAtlasi | Q12926, baseline and differential |
Genevisiblei | Q12926, HS |
Organism-specific databases
HPAi | ENSG00000107105, Group enriched (brain, testis) |
Interactioni
Subunit structurei
Interacts with IGF2BP1 (PubMed:17289661).
Interacts with MAP1B light chain LC1 (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsIsoform 2 [Q12926-2]
With | #Exp. | IntAct |
---|---|---|
GEMIN8 [Q9NWZ8] | 3 | EBI-11075944,EBI-2626001 |
TFF2 [Q03403] | 3 | EBI-11075944,EBI-4314702 |
Protein-protein interaction databases
BioGRIDi | 108308, 134 interactors |
IntActi | Q12926, 109 interactors |
STRINGi | 9606.ENSP00000380479 |
Miscellaneous databases
RNActi | Q12926, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 117 | RRM 1PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 125 – 205 | RRM 2PROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 276 – 354 | RRM 3PROSITE-ProRule annotationAdd BLAST | 79 |
Sequence similaritiesi
Belongs to the RRM elav family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0145, Eukaryota |
GeneTreei | ENSGT00940000156823 |
HOGENOMi | CLU_026186_2_2_1 |
InParanoidi | Q12926 |
OrthoDBi | 775799at2759 |
PhylomeDBi | Q12926 |
TreeFami | TF313377 |
Family and domain databases
CDDi | cd12650, RRM1_Hu, 1 hit cd12775, RRM2_HuB, 1 hit cd12654, RRM3_HuB, 1 hit |
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR006548, ELAD_HU_SF IPR034775, ELAV/Hu_RRM1 IPR034999, HuB_RRM2 IPR034914, HuB_RRM3 IPR002343, Hud_Sxl_RNA IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits |
PRINTSi | PR00961, HUDSXLRNA |
SMARTi | View protein in SMART SM00360, RRM, 3 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
TIGRFAMsi | TIGR01661, ELAV_HUD_SF, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q12926-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM
60 70 80 90 100
TQEELKSLFG SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL
110 120 130 140 150
NGLRLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMTQKE LEQLFSQYGR
160 170 180 190 200
IITSRILVDQ VTGISRGVGF IRFDKRIEAE EAIKGLNGQK PPGATEPITV
210 220 230 240 250
KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD NLLNMAYGVK
260 270 280 290 300
RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG
310 320 330 340 350
AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS
FKTNKTHKA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AM48 | B1AM48_HUMAN | ELAV-like protein | ELAVL2 | 189 | Annotation score: | ||
A0A0A0MRX1 | A0A0A0MRX1_HUMAN | ELAV-like protein | ELAVL2 | 389 | Annotation score: | ||
C9JB16 | C9JB16_HUMAN | ELAV-like protein 2 | ELAVL2 | 90 | Annotation score: |
Sequence cautioni
The sequence BAD92531 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 335 | A → R (PubMed:8158249).Curated | 1 | |
Sequence conflicti | 335 | A → R (PubMed:7972035).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005788 | 239 – 251 | Missing in isoform 2. 2 PublicationsAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12431 mRNA Translation: AAA69698.1 U29943 mRNA Translation: AAA70417.1 AB209294 mRNA Translation: BAD92531.1 Different initiation. AL161628 Genomic DNA No translation available. AL445623 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58581.1 CH471071 Genomic DNA Translation: EAW58582.1 BC030692 mRNA Translation: AAH30692.1 |
CCDSi | CCDS55298.1 [Q12926-2] CCDS6515.1 [Q12926-1] |
PIRi | I38726 I39077 |
RefSeqi | NP_001164666.1, NM_001171195.1 [Q12926-2] NP_001164668.1, NM_001171197.1 [Q12926-2] NP_004423.2, NM_004432.3 [Q12926-1] XP_016869908.1, XM_017014419.1 XP_016869909.1, XM_017014420.1 XP_016869910.1, XM_017014421.1 XP_016869911.1, XM_017014422.1 XP_016869912.1, XM_017014423.1 XP_016869913.1, XM_017014424.1 XP_016869914.1, XM_017014425.1 |
Genome annotation databases
Ensembli | ENST00000223951; ENSP00000223951; ENSG00000107105 [Q12926-2] ENST00000380117; ENSP00000369460; ENSG00000107105 [Q12926-1] ENST00000397312; ENSP00000380479; ENSG00000107105 [Q12926-1] ENST00000544538; ENSP00000440998; ENSG00000107105 [Q12926-1] |
GeneIDi | 1993 |
KEGGi | hsa:1993 |
UCSCi | uc003zps.4, human [Q12926-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12431 mRNA Translation: AAA69698.1 U29943 mRNA Translation: AAA70417.1 AB209294 mRNA Translation: BAD92531.1 Different initiation. AL161628 Genomic DNA No translation available. AL445623 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58581.1 CH471071 Genomic DNA Translation: EAW58582.1 BC030692 mRNA Translation: AAH30692.1 |
CCDSi | CCDS55298.1 [Q12926-2] CCDS6515.1 [Q12926-1] |
PIRi | I38726 I39077 |
RefSeqi | NP_001164666.1, NM_001171195.1 [Q12926-2] NP_001164668.1, NM_001171197.1 [Q12926-2] NP_004423.2, NM_004432.3 [Q12926-1] XP_016869908.1, XM_017014419.1 XP_016869909.1, XM_017014420.1 XP_016869910.1, XM_017014421.1 XP_016869911.1, XM_017014422.1 XP_016869912.1, XM_017014423.1 XP_016869913.1, XM_017014424.1 XP_016869914.1, XM_017014425.1 |
3D structure databases
SMRi | Q12926 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108308, 134 interactors |
IntActi | Q12926, 109 interactors |
STRINGi | 9606.ENSP00000380479 |
PTM databases
iPTMneti | Q12926 |
PhosphoSitePlusi | Q12926 |
SwissPalmi | Q12926 |
Genetic variation databases
BioMutai | ELAVL2 |
DMDMi | 93141258 |
Proteomic databases
EPDi | Q12926 |
jPOSTi | Q12926 |
MassIVEi | Q12926 |
MaxQBi | Q12926 |
PaxDbi | Q12926 |
PeptideAtlasi | Q12926 |
PRIDEi | Q12926 |
ProteomicsDBi | 59031 [Q12926-1] 59032 [Q12926-2] |
Protocols and materials databases
Antibodypediai | 10496, 322 antibodies |
DNASUi | 1993 |
Genome annotation databases
Ensembli | ENST00000223951; ENSP00000223951; ENSG00000107105 [Q12926-2] ENST00000380117; ENSP00000369460; ENSG00000107105 [Q12926-1] ENST00000397312; ENSP00000380479; ENSG00000107105 [Q12926-1] ENST00000544538; ENSP00000440998; ENSG00000107105 [Q12926-1] |
GeneIDi | 1993 |
KEGGi | hsa:1993 |
UCSCi | uc003zps.4, human [Q12926-1] |
Organism-specific databases
CTDi | 1993 |
DisGeNETi | 1993 |
GeneCardsi | ELAVL2 |
HGNCi | HGNC:3313, ELAVL2 |
HPAi | ENSG00000107105, Group enriched (brain, testis) |
MIMi | 601673, gene |
neXtProti | NX_Q12926 |
OpenTargetsi | ENSG00000107105 |
PharmGKBi | PA27741 |
VEuPathDBi | HostDB:ENSG00000107105.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0145, Eukaryota |
GeneTreei | ENSGT00940000156823 |
HOGENOMi | CLU_026186_2_2_1 |
InParanoidi | Q12926 |
OrthoDBi | 775799at2759 |
PhylomeDBi | Q12926 |
TreeFami | TF313377 |
Enzyme and pathway databases
PathwayCommonsi | Q12926 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 1993, 6 hits in 873 CRISPR screens |
ChiTaRSi | ELAVL2, human |
GeneWikii | ELAVL2 |
GenomeRNAii | 1993 |
Pharosi | Q12926, Tbio |
PROi | PR:Q12926 |
RNActi | Q12926, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107105, Expressed in Brodmann (1909) area 23 and 155 other tissues |
ExpressionAtlasi | Q12926, baseline and differential |
Genevisiblei | Q12926, HS |
Family and domain databases
CDDi | cd12650, RRM1_Hu, 1 hit cd12775, RRM2_HuB, 1 hit cd12654, RRM3_HuB, 1 hit |
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR006548, ELAD_HU_SF IPR034775, ELAV/Hu_RRM1 IPR034999, HuB_RRM2 IPR034914, HuB_RRM3 IPR002343, Hud_Sxl_RNA IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits |
PRINTSi | PR00961, HUDSXLRNA |
SMARTi | View protein in SMART SM00360, RRM, 3 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
TIGRFAMsi | TIGR01661, ELAV_HUD_SF, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELAV2_HUMAN | |
Accessioni | Q12926Primary (citable) accession number: Q12926 Secondary accession number(s): D3DRK3 Q9H1Q8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | April 18, 2006 | |
Last modified: | February 10, 2021 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM