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Protein

ELAV-like protein 2

Gene

ELAVL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 2
Alternative name(s):
ELAV-like neuronal protein 1
Hu-antigen B
Short name:
HuB
Nervous system-specific RNA-binding protein Hel-N1
Gene namesi
Name:ELAVL2
Synonyms:HUB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107105.14
HGNCiHGNC:3313 ELAVL2
MIMi601673 gene
neXtProtiNX_Q12926

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1993
OpenTargetsiENSG00000107105
PharmGKBiPA27741

Polymorphism and mutation databases

BioMutaiELAVL2
DMDMi93141258

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815791 – 359ELAV-like protein 2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei221PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ12926
MaxQBiQ12926
PaxDbiQ12926
PeptideAtlasiQ12926
PRIDEiQ12926
ProteomicsDBi59031
59032 [Q12926-2]

PTM databases

iPTMnetiQ12926
PhosphoSitePlusiQ12926

Expressioni

Tissue specificityi

Brain; neural-specific.

Gene expression databases

BgeeiENSG00000107105 Expressed in 132 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_ELAVL2
ExpressionAtlasiQ12926 baseline and differential
GenevisibleiQ12926 HS

Organism-specific databases

HPAiCAB022222

Interactioni

Subunit structurei

Interacts with IGF2BP1.1 Publication

Protein-protein interaction databases

BioGridi108308, 131 interactors
IntActiQ12926, 6 interactors
STRINGi9606.ENSP00000369460

Structurei

3D structure databases

ProteinModelPortaliQ12926
SMRiQ12926
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 117RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini125 – 205RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini276 – 354RRM 3PROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000231162
HOVERGENiHBG002295
InParanoidiQ12926
KOiK13208
PhylomeDBiQ12926
TreeFamiTF313377

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12775 RRM2_HuB, 1 hit
cd12654 RRM3_HuB, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034999 HuB_RRM2
IPR034914 HuB_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12926-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METQLSNGPT CNNTANGPTT INNNCSSPVD SGNTEDSKTN LIVNYLPQNM
60 70 80 90 100
TQEELKSLFG SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL
110 120 130 140 150
NGLRLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMTQKE LEQLFSQYGR
160 170 180 190 200
IITSRILVDQ VTGISRGVGF IRFDKRIEAE EAIKGLNGQK PPGATEPITV
210 220 230 240 250
KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD NLLNMAYGVK
260 270 280 290 300
RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG
310 320 330 340 350
AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS

FKTNKTHKA
Length:359
Mass (Da):39,504
Last modified:April 18, 2006 - v2
Checksum:i15E87088FC546DDC
GO
Isoform 2 (identifier: Q12926-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-251: Missing.

Show »
Length:346
Mass (Da):38,015
Checksum:iF1EC0F69EE5D15DD
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRX1A0A0A0MRX1_HUMAN
ELAV-like protein
ELAVL2
389Annotation score:
B1AM48B1AM48_HUMAN
ELAV-like protein
ELAVL2
189Annotation score:
C9JB16C9JB16_HUMAN
ELAV-like protein 2
ELAVL2
90Annotation score:

Sequence cautioni

The sequence BAD92531 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335A → R (PubMed:8158249).Curated1
Sequence conflicti335A → R (PubMed:7972035).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005788239 – 251Missing in isoform 2. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12431 mRNA Translation: AAA69698.1
U29943 mRNA Translation: AAA70417.1
AB209294 mRNA Translation: BAD92531.1 Different initiation.
AL161628 Genomic DNA No translation available.
AL445623 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58581.1
CH471071 Genomic DNA Translation: EAW58582.1
BC030692 mRNA Translation: AAH30692.1
CCDSiCCDS55298.1 [Q12926-2]
CCDS6515.1 [Q12926-1]
PIRiI38726
I39077
RefSeqiNP_001164666.1, NM_001171195.1 [Q12926-2]
NP_001164668.1, NM_001171197.1 [Q12926-2]
NP_004423.2, NM_004432.3 [Q12926-1]
XP_016869908.1, XM_017014419.1
XP_016869909.1, XM_017014420.1
XP_016869910.1, XM_017014421.1
XP_016869911.1, XM_017014422.1
XP_016869912.1, XM_017014423.1
XP_016869913.1, XM_017014424.1
XP_016869914.1, XM_017014425.1
UniGeneiHs.166109

Genome annotation databases

EnsembliENST00000223951; ENSP00000223951; ENSG00000107105 [Q12926-2]
ENST00000380117; ENSP00000369460; ENSG00000107105 [Q12926-1]
ENST00000397312; ENSP00000380479; ENSG00000107105 [Q12926-1]
ENST00000544538; ENSP00000440998; ENSG00000107105 [Q12926-1]
GeneIDi1993
KEGGihsa:1993
UCSCiuc003zps.4 human [Q12926-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12431 mRNA Translation: AAA69698.1
U29943 mRNA Translation: AAA70417.1
AB209294 mRNA Translation: BAD92531.1 Different initiation.
AL161628 Genomic DNA No translation available.
AL445623 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58581.1
CH471071 Genomic DNA Translation: EAW58582.1
BC030692 mRNA Translation: AAH30692.1
CCDSiCCDS55298.1 [Q12926-2]
CCDS6515.1 [Q12926-1]
PIRiI38726
I39077
RefSeqiNP_001164666.1, NM_001171195.1 [Q12926-2]
NP_001164668.1, NM_001171197.1 [Q12926-2]
NP_004423.2, NM_004432.3 [Q12926-1]
XP_016869908.1, XM_017014419.1
XP_016869909.1, XM_017014420.1
XP_016869910.1, XM_017014421.1
XP_016869911.1, XM_017014422.1
XP_016869912.1, XM_017014423.1
XP_016869913.1, XM_017014424.1
XP_016869914.1, XM_017014425.1
UniGeneiHs.166109

3D structure databases

ProteinModelPortaliQ12926
SMRiQ12926
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108308, 131 interactors
IntActiQ12926, 6 interactors
STRINGi9606.ENSP00000369460

PTM databases

iPTMnetiQ12926
PhosphoSitePlusiQ12926

Polymorphism and mutation databases

BioMutaiELAVL2
DMDMi93141258

Proteomic databases

EPDiQ12926
MaxQBiQ12926
PaxDbiQ12926
PeptideAtlasiQ12926
PRIDEiQ12926
ProteomicsDBi59031
59032 [Q12926-2]

Protocols and materials databases

DNASUi1993
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223951; ENSP00000223951; ENSG00000107105 [Q12926-2]
ENST00000380117; ENSP00000369460; ENSG00000107105 [Q12926-1]
ENST00000397312; ENSP00000380479; ENSG00000107105 [Q12926-1]
ENST00000544538; ENSP00000440998; ENSG00000107105 [Q12926-1]
GeneIDi1993
KEGGihsa:1993
UCSCiuc003zps.4 human [Q12926-1]

Organism-specific databases

CTDi1993
DisGeNETi1993
EuPathDBiHostDB:ENSG00000107105.14
GeneCardsiELAVL2
HGNCiHGNC:3313 ELAVL2
HPAiCAB022222
MIMi601673 gene
neXtProtiNX_Q12926
OpenTargetsiENSG00000107105
PharmGKBiPA27741
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000231162
HOVERGENiHBG002295
InParanoidiQ12926
KOiK13208
PhylomeDBiQ12926
TreeFamiTF313377

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

GeneWikiiELAVL2
GenomeRNAii1993
PROiPR:Q12926
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107105 Expressed in 132 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_ELAVL2
ExpressionAtlasiQ12926 baseline and differential
GenevisibleiQ12926 HS

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12775 RRM2_HuB, 1 hit
cd12654 RRM3_HuB, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034999 HuB_RRM2
IPR034914 HuB_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiELAV2_HUMAN
AccessioniPrimary (citable) accession number: Q12926
Secondary accession number(s): D3DRK3
, Q13235, Q59G15, Q8NEM4, Q9H1Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 18, 2006
Last modified: September 12, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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