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Protein

Killer cell lectin-like receptor subfamily B member 1

Gene

KLRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.3 Publications

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily B member 1
Alternative name(s):
C-type lectin domain family 5 member B
HNKR-P1a
Short name:
NKR-P1A
Natural killer cell surface protein P1A
CD_antigen: CD161
Gene namesi
Name:KLRB1
Synonyms:CLEC5B, NKRP1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111796.3
HGNCiHGNC:6373 KLRB1
MIMi602890 gene
neXtProtiNX_Q12918

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini67 – 225ExtracellularSequence analysisAdd BLAST159

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3820
OpenTargetsiENSG00000111796
PharmGKBiPA30162

Polymorphism and mutation databases

BioMutaiKLRB1
DMDMi74722301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600001 – 225Killer cell lectin-like receptor subfamily B member 1Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 105PROSITE-ProRule annotation
Disulfide bondi122 ↔ 210PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi189 ↔ 202PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated. Contains sialic acid residues.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ12918
PeptideAtlasiQ12918
PRIDEiQ12918
ProteomicsDBi59026

Expressioni

Tissue specificityi

Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype.2 Publications

Inductioni

By IL12/interleukin-12 in NK cells.1 Publication

Gene expression databases

BgeeiENSG00000111796 Expressed in 130 organ(s), highest expression level in mononuclear cell
CleanExiHS_KLRB1
GenevisibleiQ12918 HS

Organism-specific databases

HPAiHPA039113

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with acid sphingomyelinase/SMPD1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CLEC2DQ9UHP7-12EBI-2805465,EBI-13640978

Protein-protein interaction databases

IntActiQ12918, 2 interactors
STRINGi9606.ENSP00000229402

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ12918
SMRiQ12918
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 211C-type lectinPROSITE-ProRule annotationAdd BLAST111

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00730000110837
HOGENOMiHOG000074586
HOVERGENiHBG052267
InParanoidiQ12918
KOiK06543
OMAiNNSLADC
OrthoDBiEOG091G0QVA
PhylomeDBiQ12918
TreeFamiTF337735

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q12918-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQQAIYAEL NLPTDSGPES SSPSSLPRDV CQGSPWHQFA LKLSCAGIIL
60 70 80 90 100
LVLVVTGLSV SVTSLIQKSS IEKCSVDIQQ SRNKTTERPG LLNCPIYWQQ
110 120 130 140 150
LREKCLLFSH TVNPWNNSLA DCSTKESSLL LIRDKDELIH TQNLIRDKAI
160 170 180 190 200
LFWIGLNFSL SEKNWKWING SFLNSNDLEI RGDAKENSCI SISQTSVYSE
210 220
YCSTEIRWIC QKELTPVRNK VYPDS
Length:225
Mass (Da):25,415
Last modified:November 1, 1996 - v1
Checksum:i01BFA925445B83B0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028981168I → T1 PublicationCorresponds to variant dbSNP:rs1135816Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11276 mRNA Translation: AAA21605.1
BC113997 mRNA Translation: AAI13998.1
BC114516 mRNA Translation: AAI14517.1
CCDSiCCDS8601.1
PIRiI38700
RefSeqiNP_002249.1, NM_002258.2
UniGeneiHs.169824

Genome annotation databases

EnsembliENST00000229402; ENSP00000229402; ENSG00000111796
GeneIDi3820
KEGGihsa:3820
UCSCiuc010sgt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

NKRP1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11276 mRNA Translation: AAA21605.1
BC113997 mRNA Translation: AAI13998.1
BC114516 mRNA Translation: AAI14517.1
CCDSiCCDS8601.1
PIRiI38700
RefSeqiNP_002249.1, NM_002258.2
UniGeneiHs.169824

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MGRX-ray1.80A/B90-225[»]
5MGSX-ray1.90A/B/C/D/E/F/G/H90-225[»]
5MGTX-ray1.90C/D/E/F90-225[»]
ProteinModelPortaliQ12918
SMRiQ12918
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ12918, 2 interactors
STRINGi9606.ENSP00000229402

Polymorphism and mutation databases

BioMutaiKLRB1
DMDMi74722301

Proteomic databases

PaxDbiQ12918
PeptideAtlasiQ12918
PRIDEiQ12918
ProteomicsDBi59026

Protocols and materials databases

DNASUi3820
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229402; ENSP00000229402; ENSG00000111796
GeneIDi3820
KEGGihsa:3820
UCSCiuc010sgt.3 human

Organism-specific databases

CTDi3820
DisGeNETi3820
EuPathDBiHostDB:ENSG00000111796.3
GeneCardsiKLRB1
HGNCiHGNC:6373 KLRB1
HPAiHPA039113
MIMi602890 gene
neXtProtiNX_Q12918
OpenTargetsiENSG00000111796
PharmGKBiPA30162
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00730000110837
HOGENOMiHOG000074586
HOVERGENiHBG052267
InParanoidiQ12918
KOiK06543
OMAiNNSLADC
OrthoDBiEOG091G0QVA
PhylomeDBiQ12918
TreeFamiTF337735

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

GeneWikiiKLRB1
GenomeRNAii3820
PROiPR:Q12918
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111796 Expressed in 130 organ(s), highest expression level in mononuclear cell
CleanExiHS_KLRB1
GenevisibleiQ12918 HS

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLRB1_HUMAN
AccessioniPrimary (citable) accession number: Q12918
Secondary accession number(s): Q24K24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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