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UniProtKB - Q12912 (IRAG2_HUMAN)

Entry version 153 (29 Sep 2021)
Sequence version 3 (11 Jan 2011)
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Protein

Inositol 1,4,5-triphosphate receptor associated 2

Gene

IRAG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules.

By similarity

Caution

It is uncertain whether Met-1 or Met-57 is the initiator methionine. However, according to PubMed:8021504, the initiator methionine is coded by a non-canonical CTG leucine codon; This leucine codon is in an excellent Kozak consensus located 39 bp upstream of the corresponding first mouse ATG.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFertilization, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q12912

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695, Neutrophil degranulation

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.140.1.1, the lymphoid-restricted membrane protein (lrmp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol 1,4,5-triphosphate receptor associated 2Curated
Alternative name(s):
Lymphoid-restricted membrane protein
Protein Jaw1
Cleaved into the following chain:
Processed inositol 1,4,5-triphosphate receptor associated 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRAG2Imported
Synonyms:JAW1, LRMP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6690, IRAG2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602003, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q12912

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000118308

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 495CytoplasmicSequence analysisAdd BLAST495
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei496 – 516Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini517 – 555LumenalSequence analysisAdd BLAST39

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4033

Open Targets

More...OpenTargetsi		ENSG00000118308

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30450

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q12912, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRMP

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373427

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000844831 – 555Inositol 1,4,5-triphosphate receptor associated 2Add BLAST555
ChainiPRO_00002962441 – ?Processed inositol 1,4,5-triphosphate receptor associated 2

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei91PhosphothreonineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei424PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The removal of the C-terminal lumenal domain occurs by proteolytic processing.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q12912

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q12912

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q12912

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q12912

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q12912

PeptideAtlas

More...PeptideAtlasi		Q12912

PRoteomics IDEntifications database

More...PRIDEi		Q12912

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59022 [Q12912-1]
59023 [Q12912-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q12912

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q12912

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q12912

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000118308, Expressed in tonsil and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q12912, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q12912, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000118308, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via coiled-coil domain) with ITPR3.

Interacts with SUN1 and SUN2.

Interacts with microtubules.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110213, 9 interactors

Protein interaction database and analysis system

More...IntActi		Q12912, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346442

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q12912, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q12912

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 103DisorderedSequence analysisAdd BLAST20
Regioni128 – 147DisorderedSequence analysisAdd BLAST20
Regioni437 – 469DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili227 – 341Sequence analysisAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi131 – 147Polar residuesSequence analysisAdd BLAST17
Compositional biasi437 – 464Basic and acidic residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IRAG2 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTH4, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063722

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q12912

Identification of Orthologs from Complete Genome Data

More...OMAi		SINRACE

Database of Orthologous Groups

More...OrthoDBi		560334at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q12912

TreeFam database of animal gene trees

More...TreeFami		TF331789

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008677, MRVI1

The PANTHER Classification System

More...PANTHERi		PTHR15352, PTHR15352, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05781, MRVI1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESTPFSGVA NQIHTLCERP TYGEVKDGAL DVKRQHKCPG PTSGPSPGTN 
        60         70         80         90        100
LSGCIRMNDD PSMEENGVER VCPESLLQSR EYSSLPLPRH TSSTDGTITS 
       110        120        130        140        150
SDPGLEILNM ASCDLDRNSL CKKEEDTRSA SPTIEAQGTS PAHDNIAFQD 
       160        170        180        190        200
STSKDKTILN LEAKEEPETI EEHKKEHASG DSVVSPLPVT TVKSVNLRQS 
       210        220        230        240        250
ENTSANEKEV EAEFLRLSLG FKCDWFTLEK RVKLEERSRD LAEENLKKEI 
       260        270        280        290        300
TNCLKLLESL TPLCEDDNQA QEIIKKLEKS IKFLSQCAAR VASRAEMLGA 
       310        320        330        340        350
INQESRVSKA VEVMIQHVEN LKRMYAKEHA ELEELKQVLL QNERSFNPLE 
       360        370        380        390        400
DDDDCQIKKR SASLNSKPSS LRRVTIASLP RNIGNAGMVA GMENNDRFSR 
       410        420        430        440        450
RSSSWRILGS KQSEHRPSLP RFISTYSWAD AEEEKCELKT KDDSEPSGEE 
       460        470        480        490        500
TVERTRKPSL SEKKNNPSKW DVSSVYDTIA SWATNLKSSI RKANKALWLS 
       510        520        530        540        550
IAFIVLFAAL MSFLTGQLFQ KSVDAAPTQQ EDSWTSLEHI LWPFTRLRHN 

GPPPV
Length:555
Mass (Da):62,122
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAFA4B94DCEB1A42
GO
Isoform 2 (identifier: Q12912-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:499
Mass (Da):56,213
Checksum:i4AAED58CD8C43B9E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H006F5H006_HUMAN
Inositol 1,4,5-triphosphate recepto...
IRAG2
446Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GU45A0A1B0GU45_HUMAN
Inositol 1,4,5-triphosphate recepto...
IRAG2
1,454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9L6F8W9L6_HUMAN
Inositol 1,4,5-triphosphate recepto...
IRAG2
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V513G3V513_HUMAN
Inositol 1,4,5-triphosphate recepto...
IRAG2
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRE4F8VRE4_HUMAN
Inositol 1,4,5-triphosphate recepto...
IRAG2
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2F6G3V2F6_HUMAN
Inositol 1,4,5-triphosphate recepto...
IRAG2
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3C2G3V3C2_HUMAN
Inositol 1,4,5-triphosphate recepto...
IRAG2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJC6H0YJC6_HUMAN
Inositol 1,4,5-triphosphate recepto...
IRAG2
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ39H0YJ39_HUMAN
Inositol 1,4,5-triphosphate recepto...
IRAG2
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JL87A0A0G2JL87_HUMAN
Inositol 1,4,5-triphosphate recepto...
IRAG2
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH29391 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAI26418 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81E → G in AAA21604 (PubMed:8021504).Curated1
Sequence conflicti113C → R in BAG64339 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05454594T → A. Corresponds to variant dbSNP:rs6487451Ensembl.1
Natural variantiVAR_054546197L → V3 PublicationsCorresponds to variant dbSNP:rs7969931Ensembl.1
Natural variantiVAR_054547241L → W1 PublicationCorresponds to variant dbSNP:rs1063159Ensembl.1
Natural variantiVAR_054548253C → S2 PublicationsCorresponds to variant dbSNP:rs1908946Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0364711 – 56Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U10485 mRNA Translation: AAA21604.1
AK303256 mRNA Translation: BAG64339.1
AC023510 Genomic DNA No translation available.
BC029391 mRNA Translation: AAH29391.1 Sequence problems.
BC126417 mRNA Translation: AAI26418.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8701.1 [Q12912-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I38656

NCBI Reference Sequences

More...RefSeqi		NP_001191055.1, NM_001204126.1 [Q12912-2]
NP_001191056.1, NM_001204127.1 [Q12912-2]
NP_006143.2, NM_006152.3 [Q12912-2]
XP_005253427.1, XM_005253370.3
XP_005253429.1, XM_005253372.2
XP_005253431.1, XM_005253374.3
XP_006719139.1, XM_006719076.2
XP_011518969.1, XM_011520667.1
XP_016874789.1, XM_017019300.1
XP_016874790.1, XM_017019301.1
XP_016874791.1, XM_017019302.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354454; ENSP00000346442; ENSG00000118308 [Q12912-2]
ENST00000547044; ENSP00000450246; ENSG00000118308 [Q12912-2]
ENST00000548766; ENSP00000446496; ENSG00000118308 [Q12912-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4033

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4033

UCSC genome browser

More...UCSCi		uc001rgh.4, human [Q12912-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10485 mRNA Translation: AAA21604.1
AK303256 mRNA Translation: BAG64339.1
AC023510 Genomic DNA No translation available.
BC029391 mRNA Translation: AAH29391.1 Sequence problems.
BC126417 mRNA Translation: AAI26418.1 Different initiation.
CCDSiCCDS8701.1 [Q12912-2]
PIRiI38656
RefSeqiNP_001191055.1, NM_001204126.1 [Q12912-2]
NP_001191056.1, NM_001204127.1 [Q12912-2]
NP_006143.2, NM_006152.3 [Q12912-2]
XP_005253427.1, XM_005253370.3
XP_005253429.1, XM_005253372.2
XP_005253431.1, XM_005253374.3
XP_006719139.1, XM_006719076.2
XP_011518969.1, XM_011520667.1
XP_016874789.1, XM_017019300.1
XP_016874790.1, XM_017019301.1
XP_016874791.1, XM_017019302.1

3D structure databases

SMRiQ12912
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110213, 9 interactors
IntActiQ12912, 7 interactors
STRINGi9606.ENSP00000346442

Protein family/group databases

TCDBi8.A.140.1.1, the lymphoid-restricted membrane protein (lrmp) family

PTM databases

iPTMnetiQ12912
MetOSiteiQ12912
PhosphoSitePlusiQ12912

Genetic variation databases

BioMutaiLRMP
DMDMi317373427

Proteomic databases

EPDiQ12912
jPOSTiQ12912
MassIVEiQ12912
MaxQBiQ12912
PaxDbiQ12912
PeptideAtlasiQ12912
PRIDEiQ12912
ProteomicsDBi59022 [Q12912-1]
59023 [Q12912-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1183, 88 antibodies

The DNASU plasmid repository

More...DNASUi		4033

Genome annotation databases

EnsembliENST00000354454; ENSP00000346442; ENSG00000118308 [Q12912-2]
ENST00000547044; ENSP00000450246; ENSG00000118308 [Q12912-2]
ENST00000548766; ENSP00000446496; ENSG00000118308 [Q12912-2]
GeneIDi4033
KEGGihsa:4033
UCSCiuc001rgh.4, human [Q12912-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4033
DisGeNETi4033

GeneCards: human genes, protein and diseases

More...GeneCardsi		IRAG2
HGNCiHGNC:6690, IRAG2
HPAiENSG00000118308, Tissue enhanced (blood, lymphoid tissue)
MIMi602003, gene
neXtProtiNX_Q12912
OpenTargetsiENSG00000118308
PharmGKBiPA30450
VEuPathDBiHostDB:ENSG00000118308

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTH4, Eukaryota
GeneTreeiENSGT00530000063722
InParanoidiQ12912
OMAiSINRACE
OrthoDBi560334at2759
PhylomeDBiQ12912
TreeFamiTF331789

Enzyme and pathway databases

PathwayCommonsiQ12912
ReactomeiR-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4033, 12 hits in 1015 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRMP, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4033
PharosiQ12912, Tbio

Protein Ontology

More...PROi		PR:Q12912
RNActiQ12912, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000118308, Expressed in tonsil and 199 other tissues
ExpressionAtlasiQ12912, baseline and differential
GenevisibleiQ12912, HS

Family and domain databases

InterProiView protein in InterPro
IPR008677, MRVI1
PANTHERiPTHR15352, PTHR15352, 1 hit
PfamiView protein in Pfam
PF05781, MRVI1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRAG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12912
Secondary accession number(s): A0AVM2, B4E077, Q8N301
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 11, 2011
Last modified: September 29, 2021
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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