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Entry version 169 (16 Oct 2019)
Sequence version 2 (08 Feb 2011)
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Protein

Ileal sodium/bile acid cotransporter

Gene

SLC10A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-159418 Recycling of bile acids and salts

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.28.1.2 the bile acid:na(+) symporter (bass) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ileal sodium/bile acid cotransporter
Alternative name(s):
Apical sodium-dependent bile acid transporter
Short name:
ASBT
Ileal Na(+)/bile acid cotransporter
Ileal sodium-dependent bile acid transporter
Short name:
IBAT
Short name:
ISBT
Na(+)-dependent ileal bile acid transporter
Sodium/taurocholate cotransporting polypeptide, ileal
Solute carrier family 10 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC10A2
Synonyms:ASBT, ISBT, NTCP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10906 SLC10A2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601295 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12908

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 82CytoplasmicSequence analysisAdd BLAST33
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 126ExtracellularSequence analysisAdd BLAST23
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 157CytoplasmicSequence analysis10
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 195ExtracellularSequence analysisAdd BLAST17
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 224CytoplasmicSequence analysis8
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 284ExtracellularSequence analysisAdd BLAST39
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 348CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Primary bile acid malabsorption (PBAM)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn intestinal disorder associated with chronic watery diarrhea, excess fecal bile acids, steatorrhea and interruption of the enterohepatic circulation of bile acids.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_004614243L → P in PBAM; abolishes taurocholate transport. 1 PublicationCorresponds to variant dbSNP:rs121917848EnsemblClinVar.1
Natural variantiVAR_004615262T → M in PBAM; abolishes taurocholate transport. 1 PublicationCorresponds to variant dbSNP:rs72547505EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi10N → D: Abolishes glycosylation. 1 Publication1
Mutagenesisi328N → D: No effect on glycosylation. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6555

MalaCards human disease database

More...
MalaCardsi
SLC10A2
MIMi613291 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000125255

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
449262 NON RARE IN EUROPE: Primary bile acid malabsorption

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA318

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12908

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2778

Drug and drug target database

More...
DrugBanki
DB00787 Acyclovir
DB02659 Cholic Acid
DB00091 Ciclosporin
DB03619 Deoxycholic Acid
DB02123 Glycochenodeoxycholic Acid
DB04348 Taurocholic Acid
DB01586 Ursodeoxycholic acid
DB00577 Valaciclovir
DB13914 Volixibat

DrugCentral

More...
DrugCentrali
Q12908

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
960

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC10A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
322510055

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523391 – 348Ileal sodium/bile acid cotransporterAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi10N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei335PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei328Not glycosylated1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12908

PeptideAtlas

More...
PeptideAtlasi
Q12908

PRoteomics IDEntifications database

More...
PRIDEi
Q12908

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59021

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12908

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12908

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125255 Expressed in 29 organ(s), highest expression level in small intestine Peyer's patch

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12908 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004795

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112444, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q12908, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000245312

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q12908

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2718 Eukaryota
COG0385 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182808

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234524

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12908

KEGG Orthology (KO)

More...
KOi
K14342

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMTIRRF

Database of Orthologous Groups

More...
OrthoDBi
1098342at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12908

TreeFam database of animal gene trees

More...
TreeFami
TF315811

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030207 SLC10A2

The PANTHER Classification System

More...
PANTHERi
PTHR10361 PTHR10361, 1 hit
PTHR10361:SF19 PTHR10361:SF19, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01758 SBF, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00841 bass, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12908-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDPNSCVDN ATVCSGASCV VPESNFNNIL SVVLSTVLTI LLALVMFSMG
60 70 80 90 100
CNVEIKKFLG HIKRPWGICV GFLCQFGIMP LTGFILSVAF DILPLQAVVV
110 120 130 140 150
LIIGCCPGGT ASNILAYWVD GDMDLSVSMT TCSTLLALGM MPLCLLIYTK
160 170 180 190 200
MWVDSGSIVI PYDNIGTSLV SLVVPVSIGM FVNHKWPQKA KIILKIGSIA
210 220 230 240 250
GAILIVLIAV VGGILYQSAW IIAPKLWIIG TIFPVAGYSL GFLLARIAGL
260 270 280 290 300
PWYRCRTVAF ETGMQNTQLC STIVQLSFTP EELNVVFTFP LIYSIFQLAF
310 320 330 340
AAIFLGFYVA YKKCHGKNKA EIPESKENGT EPESSFYKAN GGFQPDEK
Length:348
Mass (Da):37,714
Last modified:February 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9794EAA77C3EC4F9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02483798V → I2 PublicationsCorresponds to variant dbSNP:rs55971546Ensembl.1
Natural variantiVAR_024838159V → I1 PublicationCorresponds to variant dbSNP:rs60380298Ensembl.1
Natural variantiVAR_004613171S → A7 PublicationsCorresponds to variant dbSNP:rs188096EnsemblClinVar.1
Natural variantiVAR_004614243L → P in PBAM; abolishes taurocholate transport. 1 PublicationCorresponds to variant dbSNP:rs121917848EnsemblClinVar.1
Natural variantiVAR_004615262T → M in PBAM; abolishes taurocholate transport. 1 PublicationCorresponds to variant dbSNP:rs72547505EnsemblClinVar.1
Natural variantiVAR_004616290P → S in a patient with Crohn disease; abolishes taurocholate transport. 1 PublicationCorresponds to variant dbSNP:rs56398830EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U10417 mRNA Translation: AAC51870.1
U67674
, U67669, U67670, U67671, U67672, U67673 Genomic DNA Translation: AAC95398.1
AE014294 Genomic DNA Translation: AAN16026.1
AL161771 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09074.1
BC130521 mRNA Translation: AAI30522.1
BC130523 mRNA Translation: AAI30524.1
Z54350 Genomic DNA Translation: CAA91161.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9506.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38655

NCBI Reference Sequences

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RefSeqi
NP_000443.1, NM_000452.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000245312; ENSP00000245312; ENSG00000125255

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6555

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6555

UCSC genome browser

More...
UCSCi
uc001vpy.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10417 mRNA Translation: AAC51870.1
U67674
, U67669, U67670, U67671, U67672, U67673 Genomic DNA Translation: AAC95398.1
AE014294 Genomic DNA Translation: AAN16026.1
AL161771 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09074.1
BC130521 mRNA Translation: AAI30522.1
BC130523 mRNA Translation: AAI30524.1
Z54350 Genomic DNA Translation: CAA91161.1
CCDSiCCDS9506.1
PIRiI38655
RefSeqiNP_000443.1, NM_000452.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112444, 1 interactor
IntActiQ12908, 11 interactors
STRINGi9606.ENSP00000245312

Chemistry databases

BindingDBiQ12908
ChEMBLiCHEMBL2778
DrugBankiDB00787 Acyclovir
DB02659 Cholic Acid
DB00091 Ciclosporin
DB03619 Deoxycholic Acid
DB02123 Glycochenodeoxycholic Acid
DB04348 Taurocholic Acid
DB01586 Ursodeoxycholic acid
DB00577 Valaciclovir
DB13914 Volixibat
DrugCentraliQ12908
GuidetoPHARMACOLOGYi960

Protein family/group databases

TCDBi2.A.28.1.2 the bile acid:na(+) symporter (bass) family

PTM databases

iPTMnetiQ12908
PhosphoSitePlusiQ12908

Polymorphism and mutation databases

BioMutaiSLC10A2
DMDMi322510055

Proteomic databases

PaxDbiQ12908
PeptideAtlasiQ12908
PRIDEiQ12908
ProteomicsDBi59021

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6555

Genome annotation databases

EnsembliENST00000245312; ENSP00000245312; ENSG00000125255
GeneIDi6555
KEGGihsa:6555
UCSCiuc001vpy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6555
DisGeNETi6555

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC10A2
HGNCiHGNC:10906 SLC10A2
HPAiHPA004795
MalaCardsiSLC10A2
MIMi601295 gene
613291 phenotype
neXtProtiNX_Q12908
OpenTargetsiENSG00000125255
Orphaneti449262 NON RARE IN EUROPE: Primary bile acid malabsorption
PharmGKBiPA318

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00950000182808
HOGENOMiHOG000234524
InParanoidiQ12908
KOiK14342
OMAiGMTIRRF
OrthoDBi1098342at2759
PhylomeDBiQ12908
TreeFamiTF315811

Enzyme and pathway databases

ReactomeiR-HSA-159418 Recycling of bile acids and salts

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC10A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6555
PharosiQ12908

Protein Ontology

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PROi
PR:Q12908

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125255 Expressed in 29 organ(s), highest expression level in small intestine Peyer's patch
GenevisibleiQ12908 HS

Family and domain databases

Gene3Di1.20.1530.20, 1 hit
InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR038770 Na+/solute_symporter_sf
IPR030207 SLC10A2
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF19 PTHR10361:SF19, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTCP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12908
Secondary accession number(s): A1L4F4, Q13839
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 8, 2011
Last modified: October 16, 2019
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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