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Protein

Vesicular integral-membrane protein VIP36

Gene

LMAN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96CarbohydratePROSITE-ProRule annotation1
Binding sitei131CarbohydratePROSITE-ProRule annotation1
Metal bindingi162CalciumPROSITE-ProRule annotation1
Metal bindingi164Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi166CalciumPROSITE-ProRule annotation1
Binding sitei190CarbohydratePROSITE-ProRule annotation1
Metal bindingi193CalciumPROSITE-ProRule annotation1

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • heat shock protein binding Source: UniProtKB
  • mannose binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • positive regulation of phagocytosis Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-5694530 Cargo concentration in the ER

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular integral-membrane protein VIP36
Alternative name(s):
Glycoprotein GP36b
Lectin mannose-binding 2
Vesicular integral-membrane protein 36
Short name:
VIP36
Gene namesi
Name:LMAN2
Synonyms:C5orf8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169223.14
HGNCiHGNC:16986 LMAN2
MIMi609551 gene
neXtProtiNX_Q12907

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 322LumenalSequence analysisAdd BLAST278
Transmembranei323 – 345HelicalSequence analysisAdd BLAST23
Topological domaini346 – 356CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169223
PharmGKBiPA25919

Polymorphism and mutation databases

BioMutaiLMAN2
DMDMi21264108

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisCombined sourcesAdd BLAST44
ChainiPRO_000001766645 – 356Vesicular integral-membrane protein VIP36Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi183N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi202 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ12907
MaxQBiQ12907
PaxDbiQ12907
PeptideAtlasiQ12907
PRIDEiQ12907
ProteomicsDBi59020
TopDownProteomicsiQ12907

PTM databases

iPTMnetiQ12907
PhosphoSitePlusiQ12907
SwissPalmiQ12907

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000169223
CleanExiHS_LMAN2
ExpressionAtlasiQ12907 baseline and differential
GenevisibleiQ12907 HS

Organism-specific databases

HPAiHPA003927

Interactioni

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116159, 30 interactors
IntActiQ12907, 9 interactors
STRINGi9606.ENSP00000303366

Structurei

3D structure databases

ProteinModelPortaliQ12907
SMRiQ12907
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 276L-type lectin-likePROSITE-ProRule annotationAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 166Carbohydrate bindingPROSITE-ProRule annotation3
Regioni260 – 262Carbohydrate bindingPROSITE-ProRule annotation3

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3839 Eukaryota
ENOG410YH8V LUCA
GeneTreeiENSGT00530000062977
HOGENOMiHOG000164540
HOVERGENiHBG052334
InParanoidiQ12907
KOiK10082
OMAiDNFEGLG
OrthoDBiEOG091G0AZ1
PhylomeDBiQ12907
TreeFamiTF313311

Family and domain databases

CDDicd06901 lectin_VIP36_VIPL, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR005052 Lectin_leg
IPR035664 VIP36_lectin
PfamiView protein in Pfam
PF03388 Lectin_leg-like, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51328 L_LECTIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEGWIWRW GWGRRCLGRP GLLGPGPGPT TPLFLLLLLG SVTADITDGN
60 70 80 90 100
SEHLKREHSL IKPYQGVGSS SMPLWDFQGS TMLTSQYVRL TPDERSKEGS
110 120 130 140 150
IWNHQPCFLK DWEMHVHFKV HGTGKKNLHG DGIALWYTRD RLVPGPVFGS
160 170 180 190 200
KDNFHGLAIF LDTYPNDETT ERVFPYISVM VNNGSLSYDH SKDGRWTELA
210 220 230 240 250
GCTADFRNRD HDTFLAVRYS RGRLTVMTDL EDKNEWKNCI DITGVRLPTG
260 270 280 290 300
YYFGASAGTG DLSDNHDIIS MKLFQLMVEH TPDEESIDWT KIEPSVNFLK
310 320 330 340 350
SPKDNVDDPT GNFRSGPLTG WRVFLLLLCA LLGIVVCAVV GAVVFQKRQE

RNKRFY
Length:356
Mass (Da):40,229
Last modified:November 1, 1996 - v1
Checksum:i196193C8E655141C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266H → R in BAD96329 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10362 mRNA Translation: AAA19572.1
AK222609 mRNA Translation: BAD96329.1
BC017263 mRNA Translation: AAH17263.1
CCDSiCCDS4417.1
PIRiG01447
RefSeqiNP_006807.1, NM_006816.2
UniGeneiHs.75864

Genome annotation databases

EnsembliENST00000303127; ENSP00000303366; ENSG00000169223
GeneIDi10960
KEGGihsa:10960
UCSCiuc003mge.4 human

Similar proteinsi

Entry informationi

Entry nameiLMAN2_HUMAN
AccessioniPrimary (citable) accession number: Q12907
Secondary accession number(s): Q53HH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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