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Entry version 214 (16 Oct 2019)
Sequence version 3 (12 Apr 2005)
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Protein

Interleukin enhancer-binding factor 3

Gene

ILF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processAntiviral defense, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q12906

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin enhancer-binding factor 3
Alternative name(s):
Double-stranded RNA-binding protein 76
Short name:
DRBP76
M-phase phosphoprotein 4
Short name:
MPP4
Nuclear factor associated with dsRNA
Short name:
NFAR
Nuclear factor of activated T-cells 90 kDa
Short name:
NF-AT-90
Translational control protein 80
Short name:
TCP80
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ILF3
Synonyms:DRBF, MPHOSPH4, NF90
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6038 ILF3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603182 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12906

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3609

Open Targets

More...
OpenTargetsi
ENSG00000129351

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29853

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12906

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ILF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62512150

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001260701 – 894Interleukin enhancer-binding factor 3Add BLAST894

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei62PhosphoserineCombined sources1
Modified residuei100N6-acetyllysineCombined sources1
Modified residuei188Phosphothreonine; by PKR1 Publication1
Modified residuei190PhosphoserineCombined sources1
Modified residuei315Phosphothreonine; by PKR1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei382PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Cross-linki396Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei460N6-acetyllysineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei482PhosphoserineCombined sources1
Cross-linki489Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei592PhosphothreonineCombined sources1
Modified residuei792PhosphoserineCombined sources1
Modified residuei810PhosphoserineCombined sources1
Modified residuei812PhosphoserineCombined sources1
Modified residuei816PhosphoserineCombined sources1
Isoform 4 (identifier: Q12906-4)
Modified residuei482PhosphoserineCombined sources1
Isoform 6 (identifier: Q12906-6)
Modified residuei482PhosphoserineCombined sources1
Isoform 7 (identifier: Q12906-7)
Modified residuei482PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.1 Publication
Methylated by protein arginine N-methyltransferase 1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-395
CPTAC-396

Encyclopedia of Proteome Dynamics

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EPDi
Q12906

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q12906

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q12906

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12906

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12906

PeptideAtlas

More...
PeptideAtlasi
Q12906

PRoteomics IDEntifications database

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PRIDEi
Q12906

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
33984
59014 [Q12906-1]
59015 [Q12906-2]
59016 [Q12906-3]
59017 [Q12906-4]
59018 [Q12906-5]
59019 [Q12906-6]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q12906-1 [Q12906-1]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
Q12906

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12906

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12906

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q12906

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q12906

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000129351 Expressed in 236 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q12906 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q12906 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA001897

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

Interacts with FUS and SMN.

Interacts (via C-terminus) with PRMT1.

Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80.

Forms a heteromeric complex with ZNF346 and ILF3.

Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA.

Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA.

Interacts with XPO5 and ZNF346.

Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA.

Interacts with AGO1 and AGO2.

Interacts with DHX36; this interaction occurs in a RNA-dependent manner (PubMed:14731398).

Interacts with ELAVL1; this interaction occurs in a RNA-dependent manner (PubMed:14731398).

14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109822, 391 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q12906

Database of interacting proteins

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DIPi
DIP-29853N

Protein interaction database and analysis system

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IntActi
Q12906, 109 interactors

Molecular INTeraction database

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MINTi
Q12906

STRING: functional protein association networks

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STRINGi
9606.ENSP00000404121

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1894
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q12906

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q12906

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 378DZFPROSITE-ProRule annotationAdd BLAST374
Domaini398 – 467DRBM 1PROSITE-ProRule annotationAdd BLAST70
Domaini524 – 590DRBM 2PROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni609 – 894Interaction with PRMT11 PublicationAdd BLAST286

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi371 – 389Bipartite nuclear localization signalSequence analysisAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi385 – 389Poly-Lys5
Compositional biasi634 – 637Poly-Pro4
Compositional biasi640 – 659Arg/Gly-richAdd BLAST20
Compositional biasi701 – 709Poly-Gly9
Compositional biasi794 – 798Poly-Gly5

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3792 Eukaryota
ENOG410XPBY LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156719

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q12906

KEGG Orthology (KO)

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KOi
K13090

Identification of Orthologs from Complete Genome Data

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OMAi
QSQYSNY

Database of Orthologous Groups

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OrthoDBi
612611at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q12906

TreeFam database of animal gene trees

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TreeFami
TF320194

Family and domain databases

Conserved Domains Database

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CDDi
cd00048 DSRM, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014720 dsRBD_dom
IPR006561 DZF_dom
IPR033099 ILF3/NF90

The PANTHER Classification System

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PANTHERi
PTHR45762:SF4 PTHR45762:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00035 dsrm, 2 hits
PF07528 DZF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00358 DSRM, 2 hits
SM00572 DZF, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50137 DS_RBD, 2 hits
PS51703 DZF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12906-1) [UniParc]FASTAAdd to basket
Also known as: NFAR-2, ILF3-E

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPMRIFVND DRHVMAKHSS VYPTQEELEA VQNMVSHTER ALKAVSDWID
60 70 80 90 100
EQEKGSSEQA ESDNMDVPPE DDSKEGAGEQ KTEHMTRTLR GVMRVGLVAK
110 120 130 140 150
GLLLKGDLDL ELVLLCKEKP TTALLDKVAD NLAIQLAAVT EDKYEILQSV
160 170 180 190 200
DDAAIVIKNT KEPPLSLTIH LTSPVVREEM EKVLAGETLS VNDPPDVLDR
210 220 230 240 250
QKCLAALASL RHAKWFQARA NGLKSCVIVI RVLRDLCTRV PTWGPLRGWP
260 270 280 290 300
LELLCEKSIG TANRPMGAGE ALRRVLECLA SGIVMPDGSG IYDPCEKEAT
310 320 330 340 350
DAIGHLDRQQ REDITQSAQH ALRLAAFGQL HKVLGMDPLP SKMPKKPKNE
360 370 380 390 400
NPVDYTVQIP PSTTYAITPM KRPMEEDGEE KSPSKKKKKI QKKEEKAEPP
410 420 430 440 450
QAMNALMRLN QLKPGLQYKL VSQTGPVHAP IFTMSVEVDG NSFEASGPSK
460 470 480 490 500
KTAKLHVAVK VLQDMGLPTG AEGRDSSKGE DSAEETEAKP AVVAPAPVVE
510 520 530 540 550
AVSTPSAAFP SDATAEQGPI LTKHGKNPVM ELNEKRRGLK YELISETGGS
560 570 580 590 600
HDKRFVMEVE VDGQKFQGAG SNKKVAKAYA ALAALEKLFP DTPLALDANK
610 620 630 640 650
KKRAPVPVRG GPKFAAKPHN PGFGMGGPMH NEVPPPPNLR GRGRGGSIRG
660 670 680 690 700
RGRGRGFGGA NHGGYMNAGA GYGSYGYGGN SATAGYSQFY SNGGHSGNAS
710 720 730 740 750
GGGGGGGGGS SGYGSYYQGD NYNSPVPPKH AGKKQPHGGQ QKPSYGSGYQ
760 770 780 790 800
SHQGQQQSYN QSPYSNYGPP QGKQKGYNHG QGSYSYSNSY NSPGGGGGSD
810 820 830 840 850
YNYESKFNYS GSGGRSGGNS YGSGGASYNP GSHGGYGGGS GGGSSYQGKQ
860 870 880 890
GGYSQSNYNS PGSGQNYSGP PSSYQSSQGG YGRNADHSMN YQYR
Length:894
Mass (Da):95,338
Last modified:April 12, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20903ABD0331F370
GO
Isoform 2 (identifier: Q12906-2) [UniParc]FASTAAdd to basket
Also known as: NFAR-1, DRBP76

The sequence of this isoform differs from the canonical sequence as follows:
     688-702: QFYSNGGHSGNASGG → DFFTDCYGYHDFGSS
     703-894: Missing.

Show »
Length:702
Mass (Da):76,033
Checksum:i3DDE63929988DED4
GO
Isoform 3 (identifier: Q12906-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     690-764: YSNGGHSGNA...QQQSYNQSPY → SRPPPPSRPR...LRVSGNSVCL
     765-894: Missing.

Note: Dubious isoform produced through aberrant splice sites.
Show »
Length:764
Mass (Da):82,802
Checksum:i3C7C7565F5980B1E
GO
Isoform 4 (identifier: Q12906-4) [UniParc]FASTAAdd to basket
Also known as: DRBP76 Alpha, ILF3-A

The sequence of this isoform differs from the canonical sequence as follows:
     516-516: E → ENVKQ
     688-694: QFYSNGG → KCAFLSV
     695-894: Missing.

Show »
Length:698
Mass (Da):75,508
Checksum:iF4ECBD8A7C428905
GO
Isoform 5 (identifier: Q12906-5) [UniParc]FASTAAdd to basket
Also known as: DRBP76 Delta, Gamma, ILF3-C

The sequence of this isoform differs from the canonical sequence as follows:
     687-690: SQFY → TGFV
     691-894: Missing.

Show »
Length:690
Mass (Da):74,607
Checksum:i8DEC4DC15E80A8C5
GO
Isoform 6 (identifier: Q12906-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-516: E → ENVKQ
     688-702: QFYSNGGHSGNASGG → DFFTDCYGYHDFGSS
     703-894: Missing.

Show »
Length:706
Mass (Da):76,502
Checksum:iBC0B5D61BC51129C
GO
Isoform 7 (identifier: Q12906-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-516: E → ENVKQ

Note: Gene prediction based on EST data.Combined sources
Show »
Length:898
Mass (Da):95,808
Checksum:i83A1755F05408949
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKJ9K7EKJ9_HUMAN
Interleukin enhancer-binding factor...
ILF3
254Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER69K7ER69_HUMAN
Interleukin enhancer-binding factor...
ILF3
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ09K7EJ09_HUMAN
Interleukin enhancer-binding factor...
ILF3
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM82K7EM82_HUMAN
Interleukin enhancer-binding factor...
ILF3
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELV3K7ELV3_HUMAN
Interleukin enhancer-binding factor...
ILF3
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ75K7EQ75_HUMAN
Interleukin enhancer-binding factor...
ILF3
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENK6K7ENK6_HUMAN
Interleukin enhancer-binding factor...
ILF3
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPG3K7EPG3_HUMAN
Interleukin enhancer-binding factor...
ILF3
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERM6K7ERM6_HUMAN
Interleukin enhancer-binding factor...
ILF3
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQR9K7EQR9_HUMAN
Interleukin enhancer-binding factor...
ILF3
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA20994 differs from that shown. Sequencing errors.Curated
The sequence AAH48314 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101G → C in AAD51098 (PubMed:11438536).Curated1
Sequence conflicti101G → C in AAD51099 (PubMed:11438536).Curated1
Sequence conflicti101G → C in AAK07424 (PubMed:11161820).Curated1
Sequence conflicti101G → C in AAK07425 (PubMed:11161820).Curated1
Sequence conflicti260G → V in AAD33966 (PubMed:10400669).Curated1
Sequence conflicti260G → V in CAA66918 (PubMed:8885239).Curated1
Sequence conflicti647S → T in AAD33966 (PubMed:10400669).Curated1
Sequence conflicti647S → T in AAK07424 (PubMed:11161820).Curated1
Sequence conflicti647S → T in AAK07425 (PubMed:11161820).Curated1
Sequence conflicti688 – 689QF → N in AAF82687 (Ref. 13) Curated2
Sequence conflicti763P → L in CAC01407 (PubMed:11167023).Curated1
Sequence conflicti797G → R in CAC01124 (PubMed:11167023).Curated1
Sequence conflicti797G → R in AAK07425 (PubMed:11161820).Curated1
Sequence conflicti799S → SGS in AAF82685 (Ref. 13) Curated1
Sequence conflicti813G → E in AAK07425 (PubMed:11161820).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02215950D → H1 PublicationCorresponds to variant dbSNP:rs1064493Ensembl.1
Natural variantiVAR_048906501A → S. Corresponds to variant dbSNP:rs34520379Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003883516E → ENVKQ in isoform 4, isoform 6 and isoform 7. 3 Publications1
Alternative sequenceiVSP_003886687 – 690SQFY → TGFV in isoform 5. 1 Publication4
Alternative sequenceiVSP_003888688 – 702QFYSN…NASGG → DFFTDCYGYHDFGSS in isoform 2 and isoform 6. 7 PublicationsAdd BLAST15
Alternative sequenceiVSP_003884688 – 694QFYSNGG → KCAFLSV in isoform 4. 1 Publication7
Alternative sequenceiVSP_003890690 – 764YSNGG…NQSPY → SRPPPPSRPRCCVVRCSGSP CGPSCDPYLAVFGTPCLQWF VSCHYNFVWVEFLSFCSSVS LCLFTLRVSGNSVCL in isoform 3. 2 PublicationsAdd BLAST75
Alternative sequenceiVSP_003887691 – 894Missing in isoform 5. 1 PublicationAdd BLAST204
Alternative sequenceiVSP_003885695 – 894Missing in isoform 4. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_003889703 – 894Missing in isoform 2 and isoform 6. 7 PublicationsAdd BLAST192
Alternative sequenceiVSP_003891765 – 894Missing in isoform 3. 2 PublicationsAdd BLAST130

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U10324 mRNA Translation: AAA20994.1 Sequence problems.
AF147209 mRNA Translation: AAD33966.1
AF141870 mRNA Translation: AAD37575.1
AJ271741 Genomic DNA Translation: CAC01121.1
AJ271741 Genomic DNA Translation: CAC01122.1
AJ271741 Genomic DNA Translation: CAC01123.1
AJ271741 Genomic DNA Translation: CAC01124.1
AJ271744 mRNA Translation: CAC01404.1
AJ271745 mRNA Translation: CAC01405.1
AJ271746 mRNA Translation: CAC01406.1
AJ271747 mRNA Translation: CAC01407.1
AF167569 mRNA Translation: AAD51098.1
AF167570 mRNA Translation: AAD51099.1
AF320244
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243 Genomic DNA Translation: AAK07424.1
AF320247
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243, AF320245, AF320246 Genomic DNA Translation: AAK07425.1
AK291617 mRNA Translation: BAF84306.1
AC011475 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84132.1
BC048314 mRNA Translation: AAH48314.1 Sequence problems.
BC064836 mRNA Translation: AAH64836.1
X98264 mRNA Translation: CAA66917.1
X98265 mRNA Translation: CAA66918.1
AF202445 Genomic DNA Translation: AAF82685.1
AF202445 Genomic DNA Translation: AAF82686.1
AF202445 Genomic DNA Translation: AAF82687.1
AF007140 mRNA Translation: AAC19152.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12246.1 [Q12906-1]
CCDS12247.1 [Q12906-2]
CCDS45965.1 [Q12906-7]
CCDS45966.1 [Q12906-5]
CCDS45967.1 [Q12906-6]

Protein sequence database of the Protein Information Resource

More...
PIRi
B54857

NCBI Reference Sequences

More...
RefSeqi
NP_001131145.1, NM_001137673.1 [Q12906-6]
NP_004507.2, NM_004516.3 [Q12906-2]
NP_036350.2, NM_012218.3 [Q12906-1]
NP_060090.2, NM_017620.2 [Q12906-7]
NP_703194.1, NM_153464.2 [Q12906-5]
XP_011526286.2, XM_011527984.2 [Q12906-7]
XP_016882252.1, XM_017026763.1 [Q12906-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000250241; ENSP00000250241; ENSG00000129351 [Q12906-5]
ENST00000407004; ENSP00000384660; ENSG00000129351 [Q12906-6]
ENST00000449870; ENSP00000404121; ENSG00000129351 [Q12906-7]
ENST00000588657; ENSP00000468181; ENSG00000129351 [Q12906-7]
ENST00000589998; ENSP00000465219; ENSG00000129351 [Q12906-2]
ENST00000590261; ENSP00000468156; ENSG00000129351 [Q12906-1]
ENST00000592763; ENSP00000465515; ENSG00000129351 [Q12906-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3609

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3609

UCSC genome browser

More...
UCSCi
uc002mpl.3 human [Q12906-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10324 mRNA Translation: AAA20994.1 Sequence problems.
AF147209 mRNA Translation: AAD33966.1
AF141870 mRNA Translation: AAD37575.1
AJ271741 Genomic DNA Translation: CAC01121.1
AJ271741 Genomic DNA Translation: CAC01122.1
AJ271741 Genomic DNA Translation: CAC01123.1
AJ271741 Genomic DNA Translation: CAC01124.1
AJ271744 mRNA Translation: CAC01404.1
AJ271745 mRNA Translation: CAC01405.1
AJ271746 mRNA Translation: CAC01406.1
AJ271747 mRNA Translation: CAC01407.1
AF167569 mRNA Translation: AAD51098.1
AF167570 mRNA Translation: AAD51099.1
AF320244
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243 Genomic DNA Translation: AAK07424.1
AF320247
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243, AF320245, AF320246 Genomic DNA Translation: AAK07425.1
AK291617 mRNA Translation: BAF84306.1
AC011475 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84132.1
BC048314 mRNA Translation: AAH48314.1 Sequence problems.
BC064836 mRNA Translation: AAH64836.1
X98264 mRNA Translation: CAA66917.1
X98265 mRNA Translation: CAA66918.1
AF202445 Genomic DNA Translation: AAF82685.1
AF202445 Genomic DNA Translation: AAF82686.1
AF202445 Genomic DNA Translation: AAF82687.1
AF007140 mRNA Translation: AAC19152.1
CCDSiCCDS12246.1 [Q12906-1]
CCDS12247.1 [Q12906-2]
CCDS45965.1 [Q12906-7]
CCDS45966.1 [Q12906-5]
CCDS45967.1 [Q12906-6]
PIRiB54857
RefSeqiNP_001131145.1, NM_001137673.1 [Q12906-6]
NP_004507.2, NM_004516.3 [Q12906-2]
NP_036350.2, NM_012218.3 [Q12906-1]
NP_060090.2, NM_017620.2 [Q12906-7]
NP_703194.1, NM_153464.2 [Q12906-5]
XP_011526286.2, XM_011527984.2 [Q12906-7]
XP_016882252.1, XM_017026763.1 [Q12906-7]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L33NMR-A521-600[»]
3P1XX-ray1.90A/B520-594[»]
SMRiQ12906
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109822, 391 interactors
CORUMiQ12906
DIPiDIP-29853N
IntActiQ12906, 109 interactors
MINTiQ12906
STRINGi9606.ENSP00000404121

PTM databases

iPTMnetiQ12906
PhosphoSitePlusiQ12906
SwissPalmiQ12906

Polymorphism and mutation databases

BioMutaiILF3
DMDMi62512150

2D gel databases

SWISS-2DPAGEiQ12906

Proteomic databases

CPTACiCPTAC-395
CPTAC-396
EPDiQ12906
jPOSTiQ12906
MassIVEiQ12906
MaxQBiQ12906
PaxDbiQ12906
PeptideAtlasiQ12906
PRIDEiQ12906
ProteomicsDBi33984
59014 [Q12906-1]
59015 [Q12906-2]
59016 [Q12906-3]
59017 [Q12906-4]
59018 [Q12906-5]
59019 [Q12906-6]
TopDownProteomicsiQ12906-1 [Q12906-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3609

Genome annotation databases

EnsembliENST00000250241; ENSP00000250241; ENSG00000129351 [Q12906-5]
ENST00000407004; ENSP00000384660; ENSG00000129351 [Q12906-6]
ENST00000449870; ENSP00000404121; ENSG00000129351 [Q12906-7]
ENST00000588657; ENSP00000468181; ENSG00000129351 [Q12906-7]
ENST00000589998; ENSP00000465219; ENSG00000129351 [Q12906-2]
ENST00000590261; ENSP00000468156; ENSG00000129351 [Q12906-1]
ENST00000592763; ENSP00000465515; ENSG00000129351 [Q12906-4]
GeneIDi3609
KEGGihsa:3609
UCSCiuc002mpl.3 human [Q12906-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3609
DisGeNETi3609

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ILF3
HGNCiHGNC:6038 ILF3
HPAiHPA001897
MIMi603182 gene
neXtProtiNX_Q12906
OpenTargetsiENSG00000129351
PharmGKBiPA29853

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3792 Eukaryota
ENOG410XPBY LUCA
GeneTreeiENSGT00940000156719
InParanoidiQ12906
KOiK13090
OMAiQSQYSNY
OrthoDBi612611at2759
PhylomeDBiQ12906
TreeFamiTF320194

Enzyme and pathway databases

SIGNORiQ12906

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ILF3 human
EvolutionaryTraceiQ12906

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ILF3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3609
PharosiQ12906
PMAP-CutDBiQ12906

Protein Ontology

More...
PROi
PR:Q12906

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000129351 Expressed in 236 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ12906 baseline and differential
GenevisibleiQ12906 HS

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR006561 DZF_dom
IPR033099 ILF3/NF90
PANTHERiPTHR45762:SF4 PTHR45762:SF4, 1 hit
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF07528 DZF, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
SM00572 DZF, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits
PS51703 DZF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiILF3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12906
Secondary accession number(s): A8K6F2
, G5E9M5, O43409, Q6P1X1, Q86XY7, Q99544, Q99545, Q9BZH4, Q9BZH5, Q9NQ95, Q9NQ96, Q9NQ97, Q9NQ98, Q9NQ99, Q9NQA0, Q9NQA1, Q9NQA2, Q9NRN2, Q9NRN3, Q9NRN4, Q9UMZ9, Q9UN00, Q9UN84, Q9UNA2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 12, 2005
Last modified: October 16, 2019
This is version 214 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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