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Protein

Interleukin enhancer-binding factor 3

Gene

ILF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).4 Publications

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB
  • DNA binding Source: UniProtKB
  • double-stranded RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • single-stranded RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processAntiviral defense, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ12906

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin enhancer-binding factor 3
Alternative name(s):
Double-stranded RNA-binding protein 76
Short name:
DRBP76
M-phase phosphoprotein 4
Short name:
MPP4
Nuclear factor associated with dsRNA
Short name:
NFAR
Nuclear factor of activated T-cells 90 kDa
Short name:
NF-AT-90
Translational control protein 80
Short name:
TCP80
Gene namesi
Name:ILF3
Synonyms:DRBF, MPHOSPH4, NF90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000129351.17
HGNCiHGNC:6038 ILF3
MIMi603182 gene
neXtProtiNX_Q12906

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3609
OpenTargetsiENSG00000129351
PharmGKBiPA29853

Polymorphism and mutation databases

BioMutaiILF3
DMDMi62512150

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260701 – 894Interleukin enhancer-binding factor 3Add BLAST894

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineCombined sources1
Modified residuei100N6-acetyllysineCombined sources1
Modified residuei188Phosphothreonine; by PKR1 Publication1
Modified residuei190PhosphoserineCombined sources1
Modified residuei315Phosphothreonine; by PKR1 Publication1
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei382PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Cross-linki396Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei460N6-acetyllysineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei482PhosphoserineCombined sources1
Cross-linki489Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei592PhosphothreonineCombined sources1
Modified residuei792PhosphoserineCombined sources1
Modified residuei810PhosphoserineCombined sources1
Modified residuei812PhosphoserineCombined sources1
Modified residuei816PhosphoserineCombined sources1
Isoform 4 (identifier: Q12906-4)
Modified residuei482PhosphoserineCombined sources1
Isoform 6 (identifier: Q12906-6)
Modified residuei482PhosphoserineCombined sources1
Isoform 7 (identifier: Q12906-7)
Modified residuei482PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.1 Publication
Methylated by protein arginine N-methyltransferase 1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ12906
MaxQBiQ12906
PaxDbiQ12906
PeptideAtlasiQ12906
PRIDEiQ12906
ProteomicsDBi59014
59015 [Q12906-2]
59016 [Q12906-3]
59017 [Q12906-4]
59018 [Q12906-5]
59019 [Q12906-6]
TopDownProteomicsiQ12906-1 [Q12906-1]

2D gel databases

SWISS-2DPAGEiQ12906

PTM databases

iPTMnetiQ12906
PhosphoSitePlusiQ12906
SwissPalmiQ12906

Miscellaneous databases

PMAP-CutDBiQ12906

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000129351 Expressed in 236 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ12906 baseline and differential
GenevisibleiQ12906 HS

Organism-specific databases

HPAiHPA001897

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with FUS and SMN. Interacts (via C-terminus) with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2. Interacts with DHX36; this interaction occurs in a RNA-dependent manner (PubMed:14731398). Interacts with ELAVL1; this interaction occurs in a RNA-dependent manner (PubMed:14731398).14 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi109822, 357 interactors
CORUMiQ12906
DIPiDIP-29853N
IntActiQ12906, 101 interactors
MINTiQ12906
STRINGi9606.ENSP00000404121

Structurei

Secondary structure

1894
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ12906
SMRiQ12906
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12906

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 378DZFPROSITE-ProRule annotationAdd BLAST374
Domaini398 – 467DRBM 1PROSITE-ProRule annotationAdd BLAST70
Domaini524 – 590DRBM 2PROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni609 – 894Interaction with PRMT11 PublicationAdd BLAST286

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi371 – 389Bipartite nuclear localization signalSequence analysisAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi385 – 389Poly-Lys5
Compositional biasi634 – 637Poly-Pro4
Compositional biasi640 – 659Arg/Gly-richAdd BLAST20
Compositional biasi701 – 709Poly-Gly9
Compositional biasi794 – 798Poly-Gly5

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3792 Eukaryota
ENOG410XPBY LUCA
GeneTreeiENSGT00550000074528
HOVERGENiHBG069915
InParanoidiQ12906
KOiK13090
OMAiGQGNYSS
OrthoDBiEOG091G022L
PhylomeDBiQ12906
TreeFamiTF320194

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR006561 DZF_dom
IPR033099 ILF3/NF90
PANTHERiPTHR10910:SF34 PTHR10910:SF34, 1 hit
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF07528 DZF, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
SM00572 DZF, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits
PS51703 DZF, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12906-1) [UniParc]FASTAAdd to basket
Also known as: NFAR-2, ILF3-E

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPMRIFVND DRHVMAKHSS VYPTQEELEA VQNMVSHTER ALKAVSDWID
60 70 80 90 100
EQEKGSSEQA ESDNMDVPPE DDSKEGAGEQ KTEHMTRTLR GVMRVGLVAK
110 120 130 140 150
GLLLKGDLDL ELVLLCKEKP TTALLDKVAD NLAIQLAAVT EDKYEILQSV
160 170 180 190 200
DDAAIVIKNT KEPPLSLTIH LTSPVVREEM EKVLAGETLS VNDPPDVLDR
210 220 230 240 250
QKCLAALASL RHAKWFQARA NGLKSCVIVI RVLRDLCTRV PTWGPLRGWP
260 270 280 290 300
LELLCEKSIG TANRPMGAGE ALRRVLECLA SGIVMPDGSG IYDPCEKEAT
310 320 330 340 350
DAIGHLDRQQ REDITQSAQH ALRLAAFGQL HKVLGMDPLP SKMPKKPKNE
360 370 380 390 400
NPVDYTVQIP PSTTYAITPM KRPMEEDGEE KSPSKKKKKI QKKEEKAEPP
410 420 430 440 450
QAMNALMRLN QLKPGLQYKL VSQTGPVHAP IFTMSVEVDG NSFEASGPSK
460 470 480 490 500
KTAKLHVAVK VLQDMGLPTG AEGRDSSKGE DSAEETEAKP AVVAPAPVVE
510 520 530 540 550
AVSTPSAAFP SDATAEQGPI LTKHGKNPVM ELNEKRRGLK YELISETGGS
560 570 580 590 600
HDKRFVMEVE VDGQKFQGAG SNKKVAKAYA ALAALEKLFP DTPLALDANK
610 620 630 640 650
KKRAPVPVRG GPKFAAKPHN PGFGMGGPMH NEVPPPPNLR GRGRGGSIRG
660 670 680 690 700
RGRGRGFGGA NHGGYMNAGA GYGSYGYGGN SATAGYSQFY SNGGHSGNAS
710 720 730 740 750
GGGGGGGGGS SGYGSYYQGD NYNSPVPPKH AGKKQPHGGQ QKPSYGSGYQ
760 770 780 790 800
SHQGQQQSYN QSPYSNYGPP QGKQKGYNHG QGSYSYSNSY NSPGGGGGSD
810 820 830 840 850
YNYESKFNYS GSGGRSGGNS YGSGGASYNP GSHGGYGGGS GGGSSYQGKQ
860 870 880 890
GGYSQSNYNS PGSGQNYSGP PSSYQSSQGG YGRNADHSMN YQYR
Length:894
Mass (Da):95,338
Last modified:April 12, 2005 - v3
Checksum:i20903ABD0331F370
GO
Isoform 2 (identifier: Q12906-2) [UniParc]FASTAAdd to basket
Also known as: NFAR-1, DRBP76

The sequence of this isoform differs from the canonical sequence as follows:
     688-702: QFYSNGGHSGNASGG → DFFTDCYGYHDFGSS
     703-894: Missing.

Show »
Length:702
Mass (Da):76,033
Checksum:i3DDE63929988DED4
GO
Isoform 3 (identifier: Q12906-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     690-764: YSNGGHSGNA...QQQSYNQSPY → SRPPPPSRPR...LRVSGNSVCL
     765-894: Missing.

Note: Dubious isoform produced through aberrant splice sites.
Show »
Length:764
Mass (Da):82,802
Checksum:i3C7C7565F5980B1E
GO
Isoform 4 (identifier: Q12906-4) [UniParc]FASTAAdd to basket
Also known as: DRBP76 Alpha, ILF3-A

The sequence of this isoform differs from the canonical sequence as follows:
     516-516: E → ENVKQ
     688-694: QFYSNGG → KCAFLSV
     695-894: Missing.

Show »
Length:698
Mass (Da):75,508
Checksum:iF4ECBD8A7C428905
GO
Isoform 5 (identifier: Q12906-5) [UniParc]FASTAAdd to basket
Also known as: DRBP76 Delta, Gamma, ILF3-C

The sequence of this isoform differs from the canonical sequence as follows:
     687-690: SQFY → TGFV
     691-894: Missing.

Show »
Length:690
Mass (Da):74,607
Checksum:i8DEC4DC15E80A8C5
GO
Isoform 6 (identifier: Q12906-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-516: E → ENVKQ
     688-702: QFYSNGGHSGNASGG → DFFTDCYGYHDFGSS
     703-894: Missing.

Show »
Length:706
Mass (Da):76,502
Checksum:iBC0B5D61BC51129C
GO
Isoform 7 (identifier: Q12906-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-516: E → ENVKQ

Note: Gene prediction based on EST data.Combined sources
Show »
Length:898
Mass (Da):95,808
Checksum:i83A1755F05408949
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKJ9K7EKJ9_HUMAN
Interleukin enhancer-binding factor...
ILF3
254Annotation score:
K7ER69K7ER69_HUMAN
Interleukin enhancer-binding factor...
ILF3
161Annotation score:
K7ELV3K7ELV3_HUMAN
Interleukin enhancer-binding factor...
ILF3
116Annotation score:
K7EMZ8K7EMZ8_HUMAN
Interleukin enhancer-binding factor...
ILF3
113Annotation score:
K7EQR9K7EQR9_HUMAN
Interleukin enhancer-binding factor...
ILF3
180Annotation score:
K7EKY0K7EKY0_HUMAN
Interleukin enhancer-binding factor...
ILF3
158Annotation score:
K7EJ09K7EJ09_HUMAN
Interleukin enhancer-binding factor...
ILF3
122Annotation score:
K7EQ75K7EQ75_HUMAN
Interleukin enhancer-binding factor...
ILF3
55Annotation score:
K7EM82K7EM82_HUMAN
Interleukin enhancer-binding factor...
ILF3
99Annotation score:
K7EPG3K7EPG3_HUMAN
Interleukin enhancer-binding factor...
ILF3
73Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAA20994 differs from that shown. Sequencing errors.Curated
The sequence AAH48314 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101G → C in AAD51098 (PubMed:11438536).Curated1
Sequence conflicti101G → C in AAD51099 (PubMed:11438536).Curated1
Sequence conflicti101G → C in AAK07424 (PubMed:11161820).Curated1
Sequence conflicti101G → C in AAK07425 (PubMed:11161820).Curated1
Sequence conflicti260G → V in AAD33966 (PubMed:10400669).Curated1
Sequence conflicti260G → V in CAA66918 (PubMed:8885239).Curated1
Sequence conflicti647S → T in AAD33966 (PubMed:10400669).Curated1
Sequence conflicti647S → T in AAK07424 (PubMed:11161820).Curated1
Sequence conflicti647S → T in AAK07425 (PubMed:11161820).Curated1
Sequence conflicti688 – 689QF → N in AAF82687 (Ref. 13) Curated2
Sequence conflicti763P → L in CAC01407 (PubMed:11167023).Curated1
Sequence conflicti797G → R in CAC01124 (PubMed:11167023).Curated1
Sequence conflicti797G → R in AAK07425 (PubMed:11161820).Curated1
Sequence conflicti799S → SGS in AAF82685 (Ref. 13) Curated1
Sequence conflicti813G → E in AAK07425 (PubMed:11161820).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02215950D → H1 PublicationCorresponds to variant dbSNP:rs1064493Ensembl.1
Natural variantiVAR_048906501A → S. Corresponds to variant dbSNP:rs34520379Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003883516E → ENVKQ in isoform 4, isoform 6 and isoform 7. 3 Publications1
Alternative sequenceiVSP_003886687 – 690SQFY → TGFV in isoform 5. 1 Publication4
Alternative sequenceiVSP_003888688 – 702QFYSN…NASGG → DFFTDCYGYHDFGSS in isoform 2 and isoform 6. 7 PublicationsAdd BLAST15
Alternative sequenceiVSP_003884688 – 694QFYSNGG → KCAFLSV in isoform 4. 1 Publication7
Alternative sequenceiVSP_003890690 – 764YSNGG…NQSPY → SRPPPPSRPRCCVVRCSGSP CGPSCDPYLAVFGTPCLQWF VSCHYNFVWVEFLSFCSSVS LCLFTLRVSGNSVCL in isoform 3. 2 PublicationsAdd BLAST75
Alternative sequenceiVSP_003887691 – 894Missing in isoform 5. 1 PublicationAdd BLAST204
Alternative sequenceiVSP_003885695 – 894Missing in isoform 4. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_003889703 – 894Missing in isoform 2 and isoform 6. 7 PublicationsAdd BLAST192
Alternative sequenceiVSP_003891765 – 894Missing in isoform 3. 2 PublicationsAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10324 mRNA Translation: AAA20994.1 Sequence problems.
AF147209 mRNA Translation: AAD33966.1
AF141870 mRNA Translation: AAD37575.1
AJ271741 Genomic DNA Translation: CAC01121.1
AJ271741 Genomic DNA Translation: CAC01122.1
AJ271741 Genomic DNA Translation: CAC01123.1
AJ271741 Genomic DNA Translation: CAC01124.1
AJ271744 mRNA Translation: CAC01404.1
AJ271745 mRNA Translation: CAC01405.1
AJ271746 mRNA Translation: CAC01406.1
AJ271747 mRNA Translation: CAC01407.1
AF167569 mRNA Translation: AAD51098.1
AF167570 mRNA Translation: AAD51099.1
AF320244
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243 Genomic DNA Translation: AAK07424.1
AF320247
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243, AF320245, AF320246 Genomic DNA Translation: AAK07425.1
AK291617 mRNA Translation: BAF84306.1
AC011475 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84132.1
BC048314 mRNA Translation: AAH48314.1 Sequence problems.
BC064836 mRNA Translation: AAH64836.1
X98264 mRNA Translation: CAA66917.1
X98265 mRNA Translation: CAA66918.1
AF202445 Genomic DNA Translation: AAF82685.1
AF202445 Genomic DNA Translation: AAF82686.1
AF202445 Genomic DNA Translation: AAF82687.1
AF007140 mRNA Translation: AAC19152.1
CCDSiCCDS12246.1 [Q12906-1]
CCDS12247.1 [Q12906-2]
CCDS45965.1 [Q12906-7]
CCDS45966.1 [Q12906-5]
CCDS45967.1 [Q12906-6]
PIRiB54857
RefSeqiNP_001131145.1, NM_001137673.1 [Q12906-6]
NP_004507.2, NM_004516.3 [Q12906-2]
NP_036350.2, NM_012218.3 [Q12906-1]
NP_060090.2, NM_017620.2 [Q12906-7]
NP_703194.1, NM_153464.2 [Q12906-5]
XP_011526286.2, XM_011527984.2 [Q12906-7]
XP_016882252.1, XM_017026763.1 [Q12906-7]
UniGeneiHs.465885

Genome annotation databases

EnsembliENST00000250241; ENSP00000250241; ENSG00000129351 [Q12906-5]
ENST00000407004; ENSP00000384660; ENSG00000129351 [Q12906-6]
ENST00000449870; ENSP00000404121; ENSG00000129351 [Q12906-7]
ENST00000588657; ENSP00000468181; ENSG00000129351 [Q12906-7]
ENST00000589998; ENSP00000465219; ENSG00000129351 [Q12906-2]
ENST00000590261; ENSP00000468156; ENSG00000129351 [Q12906-1]
ENST00000592763; ENSP00000465515; ENSG00000129351 [Q12906-4]
GeneIDi3609
KEGGihsa:3609
UCSCiuc002mpl.3 human [Q12906-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10324 mRNA Translation: AAA20994.1 Sequence problems.
AF147209 mRNA Translation: AAD33966.1
AF141870 mRNA Translation: AAD37575.1
AJ271741 Genomic DNA Translation: CAC01121.1
AJ271741 Genomic DNA Translation: CAC01122.1
AJ271741 Genomic DNA Translation: CAC01123.1
AJ271741 Genomic DNA Translation: CAC01124.1
AJ271744 mRNA Translation: CAC01404.1
AJ271745 mRNA Translation: CAC01405.1
AJ271746 mRNA Translation: CAC01406.1
AJ271747 mRNA Translation: CAC01407.1
AF167569 mRNA Translation: AAD51098.1
AF167570 mRNA Translation: AAD51099.1
AF320244
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243 Genomic DNA Translation: AAK07424.1
AF320247
, AF320228, AF320229, AF320230, AF320231, AF320232, AF320233, AF320234, AF320235, AF320236, AF320237, AF320238, AF320239, AF320240, AF320241, AF320242, AF320243, AF320245, AF320246 Genomic DNA Translation: AAK07425.1
AK291617 mRNA Translation: BAF84306.1
AC011475 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84132.1
BC048314 mRNA Translation: AAH48314.1 Sequence problems.
BC064836 mRNA Translation: AAH64836.1
X98264 mRNA Translation: CAA66917.1
X98265 mRNA Translation: CAA66918.1
AF202445 Genomic DNA Translation: AAF82685.1
AF202445 Genomic DNA Translation: AAF82686.1
AF202445 Genomic DNA Translation: AAF82687.1
AF007140 mRNA Translation: AAC19152.1
CCDSiCCDS12246.1 [Q12906-1]
CCDS12247.1 [Q12906-2]
CCDS45965.1 [Q12906-7]
CCDS45966.1 [Q12906-5]
CCDS45967.1 [Q12906-6]
PIRiB54857
RefSeqiNP_001131145.1, NM_001137673.1 [Q12906-6]
NP_004507.2, NM_004516.3 [Q12906-2]
NP_036350.2, NM_012218.3 [Q12906-1]
NP_060090.2, NM_017620.2 [Q12906-7]
NP_703194.1, NM_153464.2 [Q12906-5]
XP_011526286.2, XM_011527984.2 [Q12906-7]
XP_016882252.1, XM_017026763.1 [Q12906-7]
UniGeneiHs.465885

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L33NMR-A521-600[»]
3P1XX-ray1.90A/B520-594[»]
ProteinModelPortaliQ12906
SMRiQ12906
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109822, 357 interactors
CORUMiQ12906
DIPiDIP-29853N
IntActiQ12906, 101 interactors
MINTiQ12906
STRINGi9606.ENSP00000404121

PTM databases

iPTMnetiQ12906
PhosphoSitePlusiQ12906
SwissPalmiQ12906

Polymorphism and mutation databases

BioMutaiILF3
DMDMi62512150

2D gel databases

SWISS-2DPAGEiQ12906

Proteomic databases

EPDiQ12906
MaxQBiQ12906
PaxDbiQ12906
PeptideAtlasiQ12906
PRIDEiQ12906
ProteomicsDBi59014
59015 [Q12906-2]
59016 [Q12906-3]
59017 [Q12906-4]
59018 [Q12906-5]
59019 [Q12906-6]
TopDownProteomicsiQ12906-1 [Q12906-1]

Protocols and materials databases

DNASUi3609
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250241; ENSP00000250241; ENSG00000129351 [Q12906-5]
ENST00000407004; ENSP00000384660; ENSG00000129351 [Q12906-6]
ENST00000449870; ENSP00000404121; ENSG00000129351 [Q12906-7]
ENST00000588657; ENSP00000468181; ENSG00000129351 [Q12906-7]
ENST00000589998; ENSP00000465219; ENSG00000129351 [Q12906-2]
ENST00000590261; ENSP00000468156; ENSG00000129351 [Q12906-1]
ENST00000592763; ENSP00000465515; ENSG00000129351 [Q12906-4]
GeneIDi3609
KEGGihsa:3609
UCSCiuc002mpl.3 human [Q12906-1]

Organism-specific databases

CTDi3609
DisGeNETi3609
EuPathDBiHostDB:ENSG00000129351.17
GeneCardsiILF3
H-InvDBiHIX0014753
HGNCiHGNC:6038 ILF3
HPAiHPA001897
MIMi603182 gene
neXtProtiNX_Q12906
OpenTargetsiENSG00000129351
PharmGKBiPA29853
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3792 Eukaryota
ENOG410XPBY LUCA
GeneTreeiENSGT00550000074528
HOVERGENiHBG069915
InParanoidiQ12906
KOiK13090
OMAiGQGNYSS
OrthoDBiEOG091G022L
PhylomeDBiQ12906
TreeFamiTF320194

Enzyme and pathway databases

SIGNORiQ12906

Miscellaneous databases

ChiTaRSiILF3 human
EvolutionaryTraceiQ12906
GeneWikiiILF3
GenomeRNAii3609
PMAP-CutDBiQ12906
PROiPR:Q12906
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129351 Expressed in 236 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ12906 baseline and differential
GenevisibleiQ12906 HS

Family and domain databases

CDDicd00048 DSRM, 2 hits
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR006561 DZF_dom
IPR033099 ILF3/NF90
PANTHERiPTHR10910:SF34 PTHR10910:SF34, 1 hit
PfamiView protein in Pfam
PF00035 dsrm, 2 hits
PF07528 DZF, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 2 hits
SM00572 DZF, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 2 hits
PS51703 DZF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiILF3_HUMAN
AccessioniPrimary (citable) accession number: Q12906
Secondary accession number(s): A8K6F2
, G5E9M5, O43409, Q6P1X1, Q86XY7, Q99544, Q99545, Q9BZH4, Q9BZH5, Q9NQ95, Q9NQ96, Q9NQ97, Q9NQ98, Q9NQ99, Q9NQA0, Q9NQA1, Q9NQA2, Q9NRN2, Q9NRN3, Q9NRN4, Q9UMZ9, Q9UN00, Q9UN84, Q9UNA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 12, 2005
Last modified: November 7, 2018
This is version 205 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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