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UniProtKB - Q12899 (TRI26_HUMAN)

Entry version 197 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Tripartite motif-containing protein 26

Gene

TRIM26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi102ZincPROSITE-ProRule annotation1
Metal bindingi105ZincPROSITE-ProRule annotation1
Metal bindingi124ZincPROSITE-ProRule annotation1
Metal bindingi130ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri97 – 138B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processImmunity, Innate immunity
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q12899

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-877300, Interferon gamma signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 26 (EC:2.3.2.271 Publication)
Alternative name(s):
Acid finger protein
Short name:
AFP
RING finger protein 95
Zinc finger protein 173
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM26
Synonyms:RNF95, ZNF173
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12962, TRIM26

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600830, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q12899

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000234127

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7726

Open Targets

More...OpenTargetsi		ENSG00000234127

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37544

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q12899, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIM26

Domain mapping of disease mutations (DMDM)

More...DMDMi		17380344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562351 – 539Tripartite motif-containing protein 26Add BLAST539

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q12899

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q12899

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q12899

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q12899

PeptideAtlas

More...PeptideAtlasi		Q12899

PRoteomics IDEntifications database

More...PRIDEi		Q12899

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59009

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q12899

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q12899

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000234127, Expressed in saliva-secreting gland and 232 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q12899, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q12899, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000234127, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TBK1; this interaction bridges together TBK1 and NEMO in order to activate TBK1 (PubMed:26611359).

Interacts with INCA1 (PubMed:21750715).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113515, 102 interactors

Database of interacting proteins

More...DIPi		DIP-52853N

Protein interaction database and analysis system

More...IntActi		Q12899, 73 interactors

Molecular INTeraction database

More...MINTi		Q12899

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000410446

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q12899, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini295 – 539B30.2/SPRYPROSITE-ProRule annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni376 – 437DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili188 – 227Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi376 – 435Acidic residuesSequence analysisAdd BLAST60

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 57RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri97 – 138B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158668

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013137_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q12899

Identification of Orthologs from Complete Genome Data

More...OMAi		PFFWLNW

Database of Orthologous Groups

More...OrthoDBi		542578at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q12899

TreeFam database of animal gene trees

More...TreeFami		TF342569

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR003877, SPRY_dom
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13765, PRY, 1 hit
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01407, BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00336, BBOX, 1 hit
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50119, ZF_BBOX, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q12899-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR 
        60         70         80         90        100
PVCPLCKKPF KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK 
       110        120        130        140        150
LCERHREKLH YYCEDDGKLL CVMCRESREH RPHTAVLMEK AAQPHREKIL 
       160        170        180        190        200
NHLSTLRRDR DKIQGFQAKG EADILAALKK LQDQRQYIVA EFEQGHQFLR 
       210        220        230        240        250
EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS ELEGKAQQPA 
       260        270        280        290        300
AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF 
       310        320        330        340        350
QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ 
       360        370        380        390        400
FDCEPGVLGS KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE 
       410        420        430        440        450
AGYGDGYDDW ETDEDEESLG DEEEEEEEEE EEVLESCMVG VARDSVKRKG 
       460        470        480        490        500
DLSLRPEDGV WALRLSSSGI WANTSPEAEL FPALRPRRVG IALDYEGGTV 
       510        520        530 
TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP
Length:539
Mass (Da):62,166
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i842A71C41F2E2348
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AE48A2AE48_HUMAN
Tripartite motif-containing protein...
TRIM26
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SPU2Q5SPU2_HUMAN
Tripartite motif-containing protein...
TRIM26
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JIW2A0A0G2JIW2_HUMAN
Tripartite motif-containing protein...
TRIM26
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AE50A2AE50_HUMAN
Tripartite motif-containing protein...
TRIM26
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052138197Q → H. Corresponds to variant dbSNP:rs17194565Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U09825 mRNA Translation: AAA93131.1
BA000025 Genomic DNA Translation: BAB63330.1
AB088090 Genomic DNA Translation: BAC54923.1
AB202086 Genomic DNA Translation: BAE78607.1
AB103596 Genomic DNA Translation: BAF31258.1
AL844220 Genomic DNA No translation available.
BX248419 Genomic DNA No translation available.
CR788282 Genomic DNA No translation available.
CR388382 Genomic DNA No translation available.
BX927189 Genomic DNA No translation available.
BX927221 Genomic DNA No translation available.
CR759838 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03272.1
BC024039 mRNA Translation: AAH24039.1
BC032297 mRNA Translation: AAH32297.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4678.1

NCBI Reference Sequences

More...RefSeqi		NP_001229712.1, NM_001242783.1
NP_003440.1, NM_003449.4
XP_005249431.1, XM_005249374.2
XP_005249432.1, XM_005249375.2
XP_005249433.1, XM_005249376.2
XP_005249434.1, XM_005249377.2
XP_005249435.1, XM_005249378.2
XP_006715243.1, XM_006715180.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327357; ENSP00000331131; ENSG00000137313
ENST00000383607; ENSP00000373102; ENSG00000137313
ENST00000396558; ENSP00000379806; ENSG00000137313
ENST00000415923; ENSP00000415755; ENSG00000231002
ENST00000422349; ENSP00000396188; ENSG00000234046
ENST00000425523; ENSP00000393011; ENSG00000228881
ENST00000425831; ENSP00000394371; ENSG00000231641
ENST00000427535; ENSP00000398545; ENSG00000234046
ENST00000428486; ENSP00000414248; ENSG00000231002
ENST00000432326; ENSP00000407876; ENSG00000231641
ENST00000433314; ENSP00000402395; ENSG00000226060
ENST00000436219; ENSP00000390258; ENSG00000230230
ENST00000437089; ENSP00000395491; ENSG00000234127
ENST00000438384; ENSP00000416737; ENSG00000231641
ENST00000438908; ENSP00000409182; ENSG00000230230
ENST00000439094; ENSP00000389203; ENSG00000228881
ENST00000445259; ENSP00000407294; ENSG00000234046
ENST00000447711; ENSP00000408233; ENSG00000226060
ENST00000450392; ENSP00000394421; ENSG00000231002
ENST00000453195; ENSP00000391879; ENSG00000234127
ENST00000454678; ENSP00000410446; ENSG00000234127
ENST00000455000; ENSP00000392805; ENSG00000230230
ENST00000456093; ENSP00000406707; ENSG00000226060
ENST00000456770; ENSP00000415328; ENSG00000228881

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7726

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7726

UCSC genome browser

More...UCSCi		uc003npr.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09825 mRNA Translation: AAA93131.1
BA000025 Genomic DNA Translation: BAB63330.1
AB088090 Genomic DNA Translation: BAC54923.1
AB202086 Genomic DNA Translation: BAE78607.1
AB103596 Genomic DNA Translation: BAF31258.1
AL844220 Genomic DNA No translation available.
BX248419 Genomic DNA No translation available.
CR788282 Genomic DNA No translation available.
CR388382 Genomic DNA No translation available.
BX927189 Genomic DNA No translation available.
BX927221 Genomic DNA No translation available.
CR759838 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03272.1
BC024039 mRNA Translation: AAH24039.1
BC032297 mRNA Translation: AAH32297.1
CCDSiCCDS4678.1
RefSeqiNP_001229712.1, NM_001242783.1
NP_003440.1, NM_003449.4
XP_005249431.1, XM_005249374.2
XP_005249432.1, XM_005249375.2
XP_005249433.1, XM_005249376.2
XP_005249434.1, XM_005249377.2
XP_005249435.1, XM_005249378.2
XP_006715243.1, XM_006715180.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi113515, 102 interactors
DIPiDIP-52853N
IntActiQ12899, 73 interactors
MINTiQ12899
STRINGi9606.ENSP00000410446

PTM databases

iPTMnetiQ12899
PhosphoSitePlusiQ12899

Genetic variation databases

BioMutaiTRIM26
DMDMi17380344

Proteomic databases

EPDiQ12899
jPOSTiQ12899
MassIVEiQ12899
PaxDbiQ12899
PeptideAtlasiQ12899
PRIDEiQ12899
ProteomicsDBi59009

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26253, 137 antibodies

The DNASU plasmid repository

More...DNASUi		7726

Genome annotation databases

EnsembliENST00000327357; ENSP00000331131; ENSG00000137313
ENST00000383607; ENSP00000373102; ENSG00000137313
ENST00000396558; ENSP00000379806; ENSG00000137313
ENST00000415923; ENSP00000415755; ENSG00000231002
ENST00000422349; ENSP00000396188; ENSG00000234046
ENST00000425523; ENSP00000393011; ENSG00000228881
ENST00000425831; ENSP00000394371; ENSG00000231641
ENST00000427535; ENSP00000398545; ENSG00000234046
ENST00000428486; ENSP00000414248; ENSG00000231002
ENST00000432326; ENSP00000407876; ENSG00000231641
ENST00000433314; ENSP00000402395; ENSG00000226060
ENST00000436219; ENSP00000390258; ENSG00000230230
ENST00000437089; ENSP00000395491; ENSG00000234127
ENST00000438384; ENSP00000416737; ENSG00000231641
ENST00000438908; ENSP00000409182; ENSG00000230230
ENST00000439094; ENSP00000389203; ENSG00000228881
ENST00000445259; ENSP00000407294; ENSG00000234046
ENST00000447711; ENSP00000408233; ENSG00000226060
ENST00000450392; ENSP00000394421; ENSG00000231002
ENST00000453195; ENSP00000391879; ENSG00000234127
ENST00000454678; ENSP00000410446; ENSG00000234127
ENST00000455000; ENSP00000392805; ENSG00000230230
ENST00000456093; ENSP00000406707; ENSG00000226060
ENST00000456770; ENSP00000415328; ENSG00000228881
GeneIDi7726
KEGGihsa:7726
UCSCiuc003npr.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7726
DisGeNETi7726

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIM26
HGNCiHGNC:12962, TRIM26
HPAiENSG00000234127, Low tissue specificity
MIMi600830, gene
neXtProtiNX_Q12899
OpenTargetsiENSG00000234127
PharmGKBiPA37544
VEuPathDBiHostDB:ENSG00000234127

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000158668
HOGENOMiCLU_013137_0_3_1
InParanoidiQ12899
OMAiPFFWLNW
OrthoDBi542578at2759
PhylomeDBiQ12899
TreeFamiTF342569

Enzyme and pathway databases

PathwayCommonsiQ12899
ReactomeiR-HSA-877300, Interferon gamma signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7726, 3 hits in 1043 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIM26, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7726
PharosiQ12899, Tbio

Protein Ontology

More...PROi		PR:Q12899
RNActiQ12899, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000234127, Expressed in saliva-secreting gland and 232 other tissues
ExpressionAtlasiQ12899, baseline and differential
GenevisibleiQ12899, HS

Family and domain databases

Gene3Di2.60.120.920, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR003879, Butyrophylin_SPRY
IPR013320, ConA-like_dom_sf
IPR006574, PRY
IPR003877, SPRY_dom
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13765, PRY, 1 hit
PF00622, SPRY, 1 hit
PF00643, zf-B_box, 1 hit
PRINTSiPR01407, BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336, BBOX, 1 hit
SM00589, PRY, 1 hit
SM00184, RING, 1 hit
SM00449, SPRY, 1 hit
SUPFAMiSSF49899, SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 1 hit
PS50119, ZF_BBOX, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI26_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12899
Secondary accession number(s): A6NG96, Q5SRL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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