UniProtKB - Q12899 (TRI26_HUMAN)
Protein
Tripartite motif-containing protein 26
Gene
TRIM26
Organism
Homo sapiens (Human)
Status
Functioni
E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.2 Publications
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.27
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 97 – 138 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- metal ion binding Source: UniProtKB
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- innate immune response Source: UniProtKB
- interferon-gamma-mediated signaling pathway Source: Reactome
- negative regulation of viral entry into host cell Source: UniProtKB
- negative regulation of viral release from host cell Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- protein ubiquitination Source: GO_Central
- regulation of gene expression Source: GO_Central
Keywordsi
Molecular function | Transferase |
Biological process | Immunity, Innate immunity |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q12899 |
Reactomei | R-HSA-877300, Interferon gamma signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 26 (EC:2.3.2.271 Publication)Alternative name(s): Acid finger protein Short name: AFP RING finger protein 95 Zinc finger protein 173 |
Gene namesi | Name:TRIM26 Synonyms:RNF95, ZNF173 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000234127.8 |
HGNCi | HGNC:12962, TRIM26 |
MIMi | 600830, gene |
neXtProti | NX_Q12899 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 7726 |
OpenTargetsi | ENSG00000234127 |
PharmGKBi | PA37544 |
Miscellaneous databases
Pharosi | Q12899, Tbio |
Polymorphism and mutation databases
BioMutai | TRIM26 |
DMDMi | 17380344 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056235 | 1 – 539 | Tripartite motif-containing protein 26Add BLAST | 539 |
Post-translational modificationi
Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction.1 Publication
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | Q12899 |
jPOSTi | Q12899 |
MassIVEi | Q12899 |
PaxDbi | Q12899 |
PeptideAtlasi | Q12899 |
PRIDEi | Q12899 |
ProteomicsDBi | 59009 |
PTM databases
iPTMneti | Q12899 |
PhosphoSitePlusi | Q12899 |
Expressioni
Gene expression databases
Bgeei | ENSG00000234127, Expressed in saliva-secreting gland and 231 other tissues |
ExpressionAtlasi | Q12899, baseline and differential |
Genevisiblei | Q12899, HS |
Organism-specific databases
HPAi | ENSG00000234127, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ12899
Protein-protein interaction databases
BioGRIDi | 113515, 88 interactors |
DIPi | DIP-52853N |
IntActi | Q12899, 72 interactors |
MINTi | Q12899 |
STRINGi | 9606.ENSP00000410446 |
Miscellaneous databases
RNActi | Q12899, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 295 – 539 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 245 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 188 – 227 | Sequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 388 – 400 | Poly-GluAdd BLAST | 13 | |
Compositional biasi | 422 – 432 | Poly-GluAdd BLAST | 11 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 57 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 97 – 138 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000158668 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | Q12899 |
OMAi | KYKSRGV |
OrthoDBi | 542578at2759 |
PhylomeDBi | Q12899 |
TreeFami | TF342569 |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 2.60.120.920, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q12899-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR
60 70 80 90 100
PVCPLCKKPF KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK
110 120 130 140 150
LCERHREKLH YYCEDDGKLL CVMCRESREH RPHTAVLMEK AAQPHREKIL
160 170 180 190 200
NHLSTLRRDR DKIQGFQAKG EADILAALKK LQDQRQYIVA EFEQGHQFLR
210 220 230 240 250
EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS ELEGKAQQPA
260 270 280 290 300
AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF
310 320 330 340 350
QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ
360 370 380 390 400
FDCEPGVLGS KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE
410 420 430 440 450
AGYGDGYDDW ETDEDEESLG DEEEEEEEEE EEVLESCMVG VARDSVKRKG
460 470 480 490 500
DLSLRPEDGV WALRLSSSGI WANTSPEAEL FPALRPRRVG IALDYEGGTV
510 520 530
TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AE48 | A2AE48_HUMAN | RING-type E3 ubiquitin transferase | TRIM26 | 248 | Annotation score: | ||
Q5SPU2 | Q5SPU2_HUMAN | RING-type E3 ubiquitin transferase | TRIM26 | 157 | Annotation score: | ||
A0A0G2JIW2 | A0A0G2JIW2_HUMAN | Tripartite motif-containing protein... | TRIM26 | 159 | Annotation score: | ||
A2AE50 | A2AE50_HUMAN | Tripartite motif-containing protein... | TRIM26 | 122 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052138 | 197 | Q → H. Corresponds to variant dbSNP:rs17194565Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09825 mRNA Translation: AAA93131.1 BA000025 Genomic DNA Translation: BAB63330.1 AB088090 Genomic DNA Translation: BAC54923.1 AB202086 Genomic DNA Translation: BAE78607.1 AB103596 Genomic DNA Translation: BAF31258.1 AL844220 Genomic DNA No translation available. BX248419 Genomic DNA No translation available. CR788282 Genomic DNA No translation available. CR388382 Genomic DNA No translation available. BX927189 Genomic DNA No translation available. BX927221 Genomic DNA No translation available. CR759838 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03272.1 BC024039 mRNA Translation: AAH24039.1 BC032297 mRNA Translation: AAH32297.1 |
CCDSi | CCDS4678.1 |
RefSeqi | NP_001229712.1, NM_001242783.1 NP_003440.1, NM_003449.4 XP_005249431.1, XM_005249374.2 XP_005249432.1, XM_005249375.2 XP_005249433.1, XM_005249376.2 XP_005249434.1, XM_005249377.2 XP_005249435.1, XM_005249378.2 XP_006715243.1, XM_006715180.2 |
Genome annotation databases
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09825 mRNA Translation: AAA93131.1 BA000025 Genomic DNA Translation: BAB63330.1 AB088090 Genomic DNA Translation: BAC54923.1 AB202086 Genomic DNA Translation: BAE78607.1 AB103596 Genomic DNA Translation: BAF31258.1 AL844220 Genomic DNA No translation available. BX248419 Genomic DNA No translation available. CR788282 Genomic DNA No translation available. CR388382 Genomic DNA No translation available. BX927189 Genomic DNA No translation available. BX927221 Genomic DNA No translation available. CR759838 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03272.1 BC024039 mRNA Translation: AAH24039.1 BC032297 mRNA Translation: AAH32297.1 |
CCDSi | CCDS4678.1 |
RefSeqi | NP_001229712.1, NM_001242783.1 NP_003440.1, NM_003449.4 XP_005249431.1, XM_005249374.2 XP_005249432.1, XM_005249375.2 XP_005249433.1, XM_005249376.2 XP_005249434.1, XM_005249377.2 XP_005249435.1, XM_005249378.2 XP_006715243.1, XM_006715180.2 |
3D structure databases
SMRi | Q12899 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113515, 88 interactors |
DIPi | DIP-52853N |
IntActi | Q12899, 72 interactors |
MINTi | Q12899 |
STRINGi | 9606.ENSP00000410446 |
PTM databases
iPTMneti | Q12899 |
PhosphoSitePlusi | Q12899 |
Polymorphism and mutation databases
BioMutai | TRIM26 |
DMDMi | 17380344 |
Proteomic databases
EPDi | Q12899 |
jPOSTi | Q12899 |
MassIVEi | Q12899 |
PaxDbi | Q12899 |
PeptideAtlasi | Q12899 |
PRIDEi | Q12899 |
ProteomicsDBi | 59009 |
Protocols and materials databases
Antibodypediai | 26253, 134 antibodies |
DNASUi | 7726 |
Genome annotation databases
Organism-specific databases
CTDi | 7726 |
DisGeNETi | 7726 |
EuPathDBi | HostDB:ENSG00000234127.8 |
GeneCardsi | TRIM26 |
HGNCi | HGNC:12962, TRIM26 |
HPAi | ENSG00000234127, Low tissue specificity |
MIMi | 600830, gene |
neXtProti | NX_Q12899 |
OpenTargetsi | ENSG00000234127 |
PharmGKBi | PA37544 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000158668 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | Q12899 |
OMAi | KYKSRGV |
OrthoDBi | 542578at2759 |
PhylomeDBi | Q12899 |
TreeFami | TF342569 |
Enzyme and pathway databases
PathwayCommonsi | Q12899 |
Reactomei | R-HSA-877300, Interferon gamma signaling |
Miscellaneous databases
BioGRID-ORCSi | 7726, 2 hits in 844 CRISPR screens |
ChiTaRSi | TRIM26, human |
GenomeRNAii | 7726 |
Pharosi | Q12899, Tbio |
PROi | PR:Q12899 |
RNActi | Q12899, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000234127, Expressed in saliva-secreting gland and 231 other tissues |
ExpressionAtlasi | Q12899, baseline and differential |
Genevisiblei | Q12899, HS |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 2.60.120.920, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI26_HUMAN | |
Accessioni | Q12899Primary (citable) accession number: Q12899 Secondary accession number(s): A6NG96, Q5SRL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 193 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations