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Entry version 156 (17 Jun 2020)
Sequence version 3 (05 Apr 2011)
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Protein

Interferon-related developmental regulator 2

Gene

IFRD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-65 is the initiator.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon-related developmental regulator 2
Alternative name(s):
Protein SKMC15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFRD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000214706.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5457 IFRD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602725 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12894

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7866

Open Targets

More...
OpenTargetsi
ENSG00000214706

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29692

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12894 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFRD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478577

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001532891 – 506Interferon-related developmental regulator 2Add BLAST506

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12894

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q12894

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q12894

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12894

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12894

PeptideAtlas

More...
PeptideAtlasi
Q12894

PRoteomics IDEntifications database

More...
PRIDEi
Q12894

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
59008 [Q12894-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12894

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12894

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a variety of tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000214706 Expressed in body of stomach and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12894 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12894 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000214706 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
113616, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q12894, 22 interactors

Molecular INTeraction database

More...
MINTi
Q12894

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000392316

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12894 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12894

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IFRD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2842 Eukaryota
ENOG410XSIZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013347

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_031384_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12894

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARAKCCT

Database of Orthologous Groups

More...
OrthoDBi
1153292at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12894

TreeFam database of animal gene trees

More...
TreeFami
TF313638

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039777 IFRD
IPR006921 Interferon-rel_develop_reg_C
IPR007701 Interferon-rel_develop_reg_N

The PANTHER Classification System

More...
PANTHERi
PTHR12354 PTHR12354, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05004 IFRD, 1 hit
PF04836 IFRD_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12894-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWNSPSRRP VWQGGAPRED GGARGVWLPS SGQVSAQRTG RRLVGLEPTP
60 70 80 90 100
TGSLTPRPPR PVPGMPRARK GNTLRKGGQR RGGGARSSAQ ADSGSSDDEA
110 120 130 140 150
ASEARSTASE CPSLLSTTAE DSLGGDVVDE QGQQEDLEEK LKEYVDCLTD
160 170 180 190 200
KSAKTRQGAL ESLRLALASR LLPDFLLERR LTLADALEKC LKKGKGEEQA
210 220 230 240 250
LAAAVLGLLC VQLGPGPKGE ELFHSLQPLL VSVLSDSTAS PAARLHCASA
260 270 280 290 300
LGLGCYVAAA DIQDLVSCLA CLESVFSRFY GLGGSSTSPV VPASLHGLLS
310 320 330 340 350
AALQAWALLL TICPSTQISH ILDRQLPRLP QLLSSESVNL RIAAGETIAL
360 370 380 390 400
LFELARDLEE EFVYEDMEAL CSVLRTLATD SNKYRAKADR RRQRSTFRAV
410 420 430 440 450
LHSVEGGECE EEIVRFGFEV LYMDSWARHR IYAAFKEVLG SGMHHHLQNN
460 470 480 490 500
ELLRDIFGLG PVLLLDATAL KACKVPRFEK HLYNAAAFKA RTKARSRVRD

KRADIL
Length:506
Mass (Da):54,814
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07E026CEADF973E8
GO
Isoform 2 (identifier: Q12894-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MAWNSPSRRPVWQ → MGPKKSWRSH...SGISSFSLVD

Show »
Length:608
Mass (Da):65,598
Checksum:i6277F0358CBF3C2D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEI6F8WEI6_HUMAN
Interferon-related developmental re...
IFRD2
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J2F6A0A0R4J2F6_HUMAN
Interferon-related developmental re...
IFRD2
442Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C444H7C444_HUMAN
Interferon-related developmental re...
IFRD2
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2Z4H7C2Z4_HUMAN
Interferon-related developmental re...
IFRD2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH01327 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH01676 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH07265 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH07437 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029302502R → Q1 PublicationCorresponds to variant dbSNP:rs2229648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0570331 – 13MAWNS…RPVWQ → MGPKKSWRSHFFPLPEVWLL LLLSQALSPSHGPQTQAGVG LVWSVPLPSALRSQSCLGAP LRDASELTTVHLFPTRGWGA RRALWVHSSASASSAASRRR LRAQASGISSFSLVD in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y12395 mRNA Translation: CAA73027.1
U73167 Genomic DNA Translation: AAC02728.1
CH471055 Genomic DNA Translation: EAW65070.1
BC001327 mRNA Translation: AAH01327.1 Different initiation.
BC001676 mRNA Translation: AAH01676.1 Different initiation.
BC007265 mRNA Translation: AAH07265.1 Different initiation.
BC007437 mRNA Translation: AAH07437.3 Different initiation.
BI826806 mRNA No translation available.
U09585 mRNA Translation: AAC16924.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS77746.1 [Q12894-1]

NCBI Reference Sequences

More...
RefSeqi
NP_006755.4, NM_006764.4 [Q12894-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000417626; ENSP00000402849; ENSG00000214706 [Q12894-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7866

UCSC genome browser

More...
UCSCi
uc011bdp.2 human [Q12894-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12395 mRNA Translation: CAA73027.1
U73167 Genomic DNA Translation: AAC02728.1
CH471055 Genomic DNA Translation: EAW65070.1
BC001327 mRNA Translation: AAH01327.1 Different initiation.
BC001676 mRNA Translation: AAH01676.1 Different initiation.
BC007265 mRNA Translation: AAH07265.1 Different initiation.
BC007437 mRNA Translation: AAH07437.3 Different initiation.
BI826806 mRNA No translation available.
U09585 mRNA Translation: AAC16924.1
CCDSiCCDS77746.1 [Q12894-1]
RefSeqiNP_006755.4, NM_006764.4 [Q12894-1]

3D structure databases

SMRiQ12894
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113616, 22 interactors
IntActiQ12894, 22 interactors
MINTiQ12894
STRINGi9606.ENSP00000392316

PTM databases

iPTMnetiQ12894
PhosphoSitePlusiQ12894

Polymorphism and mutation databases

BioMutaiIFRD2
DMDMi327478577

Proteomic databases

EPDiQ12894
jPOSTiQ12894
MassIVEiQ12894
MaxQBiQ12894
PaxDbiQ12894
PeptideAtlasiQ12894
PRIDEiQ12894
ProteomicsDBi59008 [Q12894-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
7285 151 antibodies

The DNASU plasmid repository

More...
DNASUi
7866

Genome annotation databases

EnsembliENST00000417626; ENSP00000402849; ENSG00000214706 [Q12894-1]
GeneIDi7866
KEGGihsa:7866
UCSCiuc011bdp.2 human [Q12894-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7866
DisGeNETi7866
EuPathDBiHostDB:ENSG00000214706.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IFRD2
HGNCiHGNC:5457 IFRD2
HPAiENSG00000214706 Low tissue specificity
MIMi602725 gene
neXtProtiNX_Q12894
OpenTargetsiENSG00000214706
PharmGKBiPA29692

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2842 Eukaryota
ENOG410XSIZ LUCA
GeneTreeiENSGT00390000013347
HOGENOMiCLU_031384_1_1_1
InParanoidiQ12894
OMAiARAKCCT
OrthoDBi1153292at2759
PhylomeDBiQ12894
TreeFamiTF313638

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7866 2 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IFRD2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7866
PharosiQ12894 Tbio

Protein Ontology

More...
PROi
PR:Q12894
RNActiQ12894 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000214706 Expressed in body of stomach and 221 other tissues
ExpressionAtlasiQ12894 baseline and differential
GenevisibleiQ12894 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039777 IFRD
IPR006921 Interferon-rel_develop_reg_C
IPR007701 Interferon-rel_develop_reg_N
PANTHERiPTHR12354 PTHR12354, 1 hit
PfamiView protein in Pfam
PF05004 IFRD, 1 hit
PF04836 IFRD_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFRD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12894
Secondary accession number(s): Q9BVB4, Q9UJ88
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 5, 2011
Last modified: June 17, 2020
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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