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Entry version 143 (18 Sep 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Transmembrane protein 115

Gene

TMEM115

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807878 COPI-mediated anterograde transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 115Curated
Alternative name(s):
Placental protein 6Curated
Protein PL6Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM115Imported
Synonyms:PL6Imported
ORF Names:LUCA11.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30055 TMEM115

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607069 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12893

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19CytoplasmicCuratedAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 97LumenalCuratedAdd BLAST57
Transmembranei98 – 118Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini119 – 126CytoplasmicCurated8
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 165LumenalCuratedAdd BLAST18
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 351Cytoplasmic1 PublicationAdd BLAST165

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11070

Open Targets

More...
OpenTargetsi
ENSG00000126062

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485636

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM115

Domain mapping of disease mutations (DMDM)

More...
DMDMi
24638130

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000584511 – 351Transmembrane protein 115Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei329PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12893

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q12893

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q12893

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12893

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12893

PeptideAtlas

More...
PeptideAtlasi
Q12893

PRoteomics IDEntifications database

More...
PRIDEi
Q12893

ProteomicsDB human proteome resource

More...
ProteomicsDBi
59007

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12893

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12893

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q12893

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain (PubMed:11085536). Widely expressed with ubiquitous expression in epithelial tissues (at protein level) (PubMed:17973242).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126062 Expressed in 212 organ(s), highest expression level in body of stomach

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12893 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12893 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB006319
HPA015497

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (PubMed:24806965).

Interacts with COPB1 (PubMed:24806965). May interact with LMAN1 (PubMed:24806965).

Interacts with the COG complex; probably through COG3 (PubMed:24806965).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-8633987,EBI-7131783

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116254, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q12893, 16 interactors

Molecular INTeraction database

More...
MINTi
Q12893

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000266025

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 205Mediates homooligomerization1 PublicationAdd BLAST205
Regioni206 – 229Mediates localization to the Golgi1 PublicationAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM115 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2890 Eukaryota
ENOG410XQM0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002470

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007827

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12893

Identification of Orthologs from Complete Genome Data

More...
OMAi
EIHFWEV

Database of Orthologous Groups

More...
OrthoDBi
1156492at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12893

TreeFam database of animal gene trees

More...
TreeFami
TF315100

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013861 TMEM115/Pdh1/Rbl19

The PANTHER Classification System

More...
PANTHERi
PTHR13377 PTHR13377, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08551 DUF1751, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q12893-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRALPGARQ HLGAILASAS VVVKALCAAV LFLYLLSFAV DTGCLAVTPG
60 70 80 90 100
YLFPPNFWIW TLATHGLMEQ HVWDVAISLT TVVVAGRLLE PLWGALELLI
110 120 130 140 150
FFSVVNVSVG LLGAFAYLLT YMASFNLVYL FTVRIHGALG FLGGVLVALK
160 170 180 190 200
QTMGDCVVLR VPQVRVSVMP MLLLALLLLL RLATLLQSPA LASYGFGLLS
210 220 230 240 250
SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA NLVHSLLVKV
260 270 280 290 300
KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED
310 320 330 340 350
QSIWPSMDDD EEESGAKVDS PLPSDKAPTP PGKGAAPESS LITFEAAPPT

L
Length:351
Mass (Da):38,197
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CFBF66322FDEEFC
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB67308 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09584 mRNA Translation: AAA92281.1
CR457020 mRNA Translation: CAG33301.1
AC002481 Genomic DNA Translation: AAB67308.1 Sequence problems.
Z84492 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65115.1
BC011948 mRNA Translation: AAH11948.1
BC017367 mRNA Translation: AAH17367.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2828.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G01430

NCBI Reference Sequences

More...
RefSeqi
NP_008955.1, NM_007024.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000266025; ENSP00000266025; ENSG00000126062

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11070

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11070

UCSC genome browser

More...
UCSCi
uc003dan.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09584 mRNA Translation: AAA92281.1
CR457020 mRNA Translation: CAG33301.1
AC002481 Genomic DNA Translation: AAB67308.1 Sequence problems.
Z84492 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65115.1
BC011948 mRNA Translation: AAH11948.1
BC017367 mRNA Translation: AAH17367.1
CCDSiCCDS2828.1
PIRiG01430
RefSeqiNP_008955.1, NM_007024.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116254, 8 interactors
IntActiQ12893, 16 interactors
MINTiQ12893
STRINGi9606.ENSP00000266025

PTM databases

iPTMnetiQ12893
PhosphoSitePlusiQ12893
SwissPalmiQ12893

Polymorphism and mutation databases

BioMutaiTMEM115
DMDMi24638130

Proteomic databases

EPDiQ12893
jPOSTiQ12893
MassIVEiQ12893
MaxQBiQ12893
PaxDbiQ12893
PeptideAtlasiQ12893
PRIDEiQ12893
ProteomicsDBi59007

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11070
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266025; ENSP00000266025; ENSG00000126062
GeneIDi11070
KEGGihsa:11070
UCSCiuc003dan.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11070
DisGeNETi11070

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM115
HGNCiHGNC:30055 TMEM115
HPAiCAB006319
HPA015497
MIMi607069 gene
neXtProtiNX_Q12893
OpenTargetsiENSG00000126062
PharmGKBiPA143485636

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2890 Eukaryota
ENOG410XQM0 LUCA
GeneTreeiENSGT00390000002470
HOGENOMiHOG000007827
InParanoidiQ12893
OMAiEIHFWEV
OrthoDBi1156492at2759
PhylomeDBiQ12893
TreeFamiTF315100

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11070

Pharos

More...
Pharosi
Q12893

Protein Ontology

More...
PROi
PR:Q12893

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126062 Expressed in 212 organ(s), highest expression level in body of stomach
ExpressionAtlasiQ12893 baseline and differential
GenevisibleiQ12893 HS

Family and domain databases

InterProiView protein in InterPro
IPR013861 TMEM115/Pdh1/Rbl19
PANTHERiPTHR13377 PTHR13377, 1 hit
PfamiView protein in Pfam
PF08551 DUF1751, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM115_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12893
Secondary accession number(s): A2IDB7
, O14568, Q6IAY4, Q9UIX3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1996
Last modified: September 18, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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