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Protein

Transmembrane protein 115

Gene

TMEM115

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: Reactome
  • negative regulation of cell proliferation Source: UniProtKB
  • protein glycosylation Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 115Curated
Alternative name(s):
Placental protein 6Curated
Protein PL6Curated
Gene namesi
Name:TMEM115Imported
Synonyms:PL6Imported
ORF Names:LUCA11.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000126062.3
HGNCiHGNC:30055 TMEM115
MIMi607069 gene
neXtProtiNX_Q12893

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicCuratedAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 97LumenalCuratedAdd BLAST57
Transmembranei98 – 118Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini119 – 126CytoplasmicCurated8
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 165LumenalCuratedAdd BLAST18
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 351Cytoplasmic1 PublicationAdd BLAST165

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11070
OpenTargetsiENSG00000126062
PharmGKBiPA143485636

Polymorphism and mutation databases

BioMutaiTMEM115
DMDMi24638130

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584511 – 351Transmembrane protein 115Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei329PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ12893
MaxQBiQ12893
PaxDbiQ12893
PeptideAtlasiQ12893
PRIDEiQ12893
ProteomicsDBi59007

PTM databases

iPTMnetiQ12893
PhosphoSitePlusiQ12893
SwissPalmiQ12893

Expressioni

Tissue specificityi

Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain (PubMed:11085536). Widely expressed with ubiquitous expression in epithelial tissues (at protein level) (PubMed:17973242).2 Publications

Gene expression databases

BgeeiENSG00000126062 Expressed in 212 organ(s), highest expression level in body of stomach
CleanExiHS_TMEM115
ExpressionAtlasiQ12893 baseline and differential
GenevisibleiQ12893 HS

Organism-specific databases

HPAiCAB006319
HPA015497

Interactioni

Subunit structurei

Homooligomer (PubMed:24806965). Interacts with COPB1 (PubMed:24806965). May interact with LMAN1 (PubMed:24806965). Interacts with the COG complex; probably through COG3 (PubMed:24806965).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-8633987,EBI-7131783

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116254, 8 interactors
IntActiQ12893, 14 interactors
MINTiQ12893
STRINGi9606.ENSP00000266025

Structurei

3D structure databases

ProteinModelPortaliQ12893
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 205Mediates homooligomerization1 PublicationAdd BLAST205
Regioni206 – 229Mediates localization to the Golgi1 PublicationAdd BLAST24

Sequence similaritiesi

Belongs to the TMEM115 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2890 Eukaryota
ENOG410XQM0 LUCA
GeneTreeiENSGT00390000002470
HOGENOMiHOG000007827
HOVERGENiHBG027575
InParanoidiQ12893
OMAiEIHFWEV
OrthoDBiEOG091G0B9B
PhylomeDBiQ12893
TreeFamiTF315100

Family and domain databases

InterProiView protein in InterPro
IPR013861 DUF1751_Mem_euk
PANTHERiPTHR13377 PTHR13377, 1 hit
PfamiView protein in Pfam
PF08551 DUF1751, 1 hit

Sequencei

Sequence statusi: Complete.

Q12893-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRALPGARQ HLGAILASAS VVVKALCAAV LFLYLLSFAV DTGCLAVTPG
60 70 80 90 100
YLFPPNFWIW TLATHGLMEQ HVWDVAISLT TVVVAGRLLE PLWGALELLI
110 120 130 140 150
FFSVVNVSVG LLGAFAYLLT YMASFNLVYL FTVRIHGALG FLGGVLVALK
160 170 180 190 200
QTMGDCVVLR VPQVRVSVMP MLLLALLLLL RLATLLQSPA LASYGFGLLS
210 220 230 240 250
SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA NLVHSLLVKV
260 270 280 290 300
KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED
310 320 330 340 350
QSIWPSMDDD EEESGAKVDS PLPSDKAPTP PGKGAAPESS LITFEAAPPT

L
Length:351
Mass (Da):38,197
Last modified:November 1, 1996 - v1
Checksum:i8CFBF66322FDEEFC
GO

Sequence cautioni

The sequence AAB67308 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09584 mRNA Translation: AAA92281.1
CR457020 mRNA Translation: CAG33301.1
AC002481 Genomic DNA Translation: AAB67308.1 Sequence problems.
Z84492 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65115.1
BC011948 mRNA Translation: AAH11948.1
BC017367 mRNA Translation: AAH17367.1
CCDSiCCDS2828.1
PIRiG01430
RefSeqiNP_008955.1, NM_007024.4
UniGeneiHs.91566

Genome annotation databases

EnsembliENST00000266025; ENSP00000266025; ENSG00000126062
GeneIDi11070
KEGGihsa:11070
UCSCiuc003dan.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09584 mRNA Translation: AAA92281.1
CR457020 mRNA Translation: CAG33301.1
AC002481 Genomic DNA Translation: AAB67308.1 Sequence problems.
Z84492 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65115.1
BC011948 mRNA Translation: AAH11948.1
BC017367 mRNA Translation: AAH17367.1
CCDSiCCDS2828.1
PIRiG01430
RefSeqiNP_008955.1, NM_007024.4
UniGeneiHs.91566

3D structure databases

ProteinModelPortaliQ12893
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116254, 8 interactors
IntActiQ12893, 14 interactors
MINTiQ12893
STRINGi9606.ENSP00000266025

PTM databases

iPTMnetiQ12893
PhosphoSitePlusiQ12893
SwissPalmiQ12893

Polymorphism and mutation databases

BioMutaiTMEM115
DMDMi24638130

Proteomic databases

EPDiQ12893
MaxQBiQ12893
PaxDbiQ12893
PeptideAtlasiQ12893
PRIDEiQ12893
ProteomicsDBi59007

Protocols and materials databases

DNASUi11070
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266025; ENSP00000266025; ENSG00000126062
GeneIDi11070
KEGGihsa:11070
UCSCiuc003dan.2 human

Organism-specific databases

CTDi11070
DisGeNETi11070
EuPathDBiHostDB:ENSG00000126062.3
GeneCardsiTMEM115
HGNCiHGNC:30055 TMEM115
HPAiCAB006319
HPA015497
MIMi607069 gene
neXtProtiNX_Q12893
OpenTargetsiENSG00000126062
PharmGKBiPA143485636
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2890 Eukaryota
ENOG410XQM0 LUCA
GeneTreeiENSGT00390000002470
HOGENOMiHOG000007827
HOVERGENiHBG027575
InParanoidiQ12893
OMAiEIHFWEV
OrthoDBiEOG091G0B9B
PhylomeDBiQ12893
TreeFamiTF315100

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport

Miscellaneous databases

GenomeRNAii11070
PROiPR:Q12893
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126062 Expressed in 212 organ(s), highest expression level in body of stomach
CleanExiHS_TMEM115
ExpressionAtlasiQ12893 baseline and differential
GenevisibleiQ12893 HS

Family and domain databases

InterProiView protein in InterPro
IPR013861 DUF1751_Mem_euk
PANTHERiPTHR13377 PTHR13377, 1 hit
PfamiView protein in Pfam
PF08551 DUF1751, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM115_HUMAN
AccessioniPrimary (citable) accession number: Q12893
Secondary accession number(s): A2IDB7
, O14568, Q6IAY4, Q9UIX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1996
Last modified: October 10, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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