Hyaluronidase-2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. EC:3.2.1.35

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• enzyme binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1."
    Hsu L.-J., Schultz L., Hong Q., Van Moer K., Heath J., Li M.-Y., Lai F.-J., Lin S.-R., Lee M.-H., Lo C.-P., Lin Y.-S., Chen S.-T., Chang N.-S.
    J. Biol. Chem. 284:16049-16059(2009) [PubMed] [Europe PMC] [Abstract]
• hyaluronic acid binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.10

    "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."
    Danilkovitch-Miagkova A., Duh F.-M., Kuzmin I., Angeloni D., Liu S.-L., Miller A.D., Lerman M.I.
    Proc. Natl. Acad. Sci. U.S.A. 100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH MST1R.
  • "Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines."
    de la Motte C., Nigro J., Vasanji A., Rho H., Kessler S., Bandyopadhyay S., Danese S., Fiocchi C., Stern R.
    Am J Pathol 174:2254-2264(2009) [PubMed] [Europe PMC] [Abstract]
• hyaluronoglucuronidase activity Source: UniProtKBInferred from direct assayⁱ
  • "Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes."
    Kurdykowski S., Mine S., Bardey V., Danoux L., Jeanmaire C., Pauly G., Brabencova E., Wegrowski Y., Maquart F.X.
    Photochem. Photobiol. 87:1105-1112(2011) [PubMed] [Europe PMC] [Abstract]
• hyalurononglucosaminidase activity Source: UniProtKBInferred from direct assayⁱ
  • "Hyaluronidases and CD44 undergo differential modulation during chondrogenesis."
    Nicoll S.B., Barak O., Csoka A.B., Bhatnagar R.S., Stern R.
    Biochem Biophys Res Commun 292:819-825(2002) [PubMed] [Europe PMC] [Abstract]
  • "Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell lines."
    Chow G., Knudson C.B., Knudson W.
    Osteoarthritis Cartilage 14:849-858(2006) [PubMed] [Europe PMC] [Abstract]
  • "CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2."
    Harada H., Takahashi M.
    J Biol Chem 282:5597-5607(2007) [PubMed] [Europe PMC] [Abstract]
  • "Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells."
    Monzon M.E., Manzanares D., Schmid N., Casalino-Matsuda S.M., Forteza R.M.
    Am J Respir Cell Mol Biol 39:289-295(2008) [PubMed] [Europe PMC] [Abstract]
  • "Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines."
    de la Motte C., Nigro J., Vasanji A., Rho H., Kessler S., Bandyopadhyay S., Danese S., Fiocchi C., Stern R.
    Am J Pathol 174:2254-2264(2009) [PubMed] [Europe PMC] [Abstract]
  • "Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation."
    Monzon M.E., Fregien N., Schmid N., Falcon N.S., Campos M., Casalino-Matsuda S.M., Forteza R.M.
    J Biol Chem 285:26126-26134(2010) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity."
    Lepperdinger G., Strobl B., Kreil G.
    J. Biol. Chem. 273:22466-22470(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT ALA-18.
• receptor signaling protein tyrosine kinase inhibitor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."
    Danilkovitch-Miagkova A., Duh F.-M., Kuzmin I., Angeloni D., Liu S.-L., Miller A.D., Lerman M.I.
    Proc. Natl. Acad. Sci. U.S.A. 100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH MST1R.
• receptor tyrosine kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.10

    "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."
    Danilkovitch-Miagkova A., Duh F.-M., Kuzmin I., Angeloni D., Liu S.-L., Miller A.D., Lerman M.I.
    Proc. Natl. Acad. Sci. U.S.A. 100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH MST1R.
• transcription coactivator activity Source: Ensembl
• transforming growth factor beta binding Source: BHF-UCL
• virus receptor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation."
    Rai S.K., Duh F.-M., Vigdorovich V., Danilkovitch-Miagkova A., Lerman M.I., Miller A.D.
    Proc. Natl. Acad. Sci. U.S.A. 98:4443-4448(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  • "Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus."
    Duh F.M., Dirks C., Lerman M.I., Miller A.D.
    Retrovirology 2:59-59(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• carbohydrate metabolic process Source: InterPro
• cartilage development Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Hyaluronidases and CD44 undergo differential modulation during chondrogenesis."
    Nicoll S.B., Barak O., Csoka A.B., Bhatnagar R.S., Stern R.
    Biochem Biophys Res Commun 292:819-825(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to fibroblast growth factor stimulus Source: UniProtKBInferred from direct assayⁱ
  • "bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells."
    Berdiaki A., Nikitovic D., Tsatsakis A., Katonis P., Karamanos N.K., Tzanakakis G.N.
    Biochim Biophys Acta 1790:1258-1265(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-1 Source: UniProtKBInferred from direct assayⁱ
  • "Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells."
    Monzon M.E., Manzanares D., Schmid N., Casalino-Matsuda S.M., Forteza R.M.
    Am J Respir Cell Mol Biol 39:289-295(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to transforming growth factor beta stimulus Source: BHF-UCLInferred from direct assayⁱ
  • "Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1."
    Hsu L.-J., Schultz L., Hong Q., Van Moer K., Heath J., Li M.-Y., Lai F.-J., Lin S.-R., Lee M.-H., Lo C.-P., Lin Y.-S., Chen S.-T., Chang N.-S.
    J. Biol. Chem. 284:16049-16059(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to tumor necrosis factor Source: UniProtKBInferred from expression patternⁱ
  • "Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells."
    Monzon M.E., Manzanares D., Schmid N., Casalino-Matsuda S.M., Forteza R.M.
    Am J Respir Cell Mol Biol 39:289-295(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to UV-B Source: UniProtKBInferred from direct assayⁱ
  • "Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes."
    Kurdykowski S., Mine S., Bardey V., Danoux L., Jeanmaire C., Pauly G., Brabencova E., Wegrowski Y., Maquart F.X.
    Photochem. Photobiol. 87:1105-1112(2011) [PubMed] [Europe PMC] [Abstract]
• defense response to virus Source: Ensembl
• fusion of virus membrane with host plasma membrane Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation."
    Rai S.K., Duh F.-M., Vigdorovich V., Danilkovitch-Miagkova A., Lerman M.I., Miller A.D.
    Proc. Natl. Acad. Sci. U.S.A. 98:4443-4448(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• glycosaminoglycan catabolic process Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity."
    Lepperdinger G., Strobl B., Kreil G.
    J. Biol. Chem. 273:22466-22470(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT ALA-18.
• hematopoietic progenitor cell differentiation Source: Ensembl
• hyaluronan catabolic process Source: UniProtKBInferred from direct assayⁱ
  • "CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2."
    Harada H., Takahashi M.
    J Biol Chem 282:5597-5607(2007) [PubMed] [Europe PMC] [Abstract]
  • "Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines."
    de la Motte C., Nigro J., Vasanji A., Rho H., Kessler S., Bandyopadhyay S., Danese S., Fiocchi C., Stern R.
    Am J Pathol 174:2254-2264(2009) [PubMed] [Europe PMC] [Abstract]
  • "Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation."
    Monzon M.E., Fregien N., Schmid N., Falcon N.S., Campos M., Casalino-Matsuda S.M., Forteza R.M.
    J Biol Chem 285:26126-26134(2010) [PubMed] [Europe PMC] [Abstract]
  • "Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes."
    Kurdykowski S., Mine S., Bardey V., Danoux L., Jeanmaire C., Pauly G., Brabencova E., Wegrowski Y., Maquart F.X.
    Photochem. Photobiol. 87:1105-1112(2011) [PubMed] [Europe PMC] [Abstract]
• kidney development Source: UniProtKB
• monocyte activation Source: UniProtKBInferred from direct assayⁱ
  • "Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines."
    de la Motte C., Nigro J., Vasanji A., Rho H., Kessler S., Bandyopadhyay S., Danese S., Fiocchi C., Stern R.
    Am J Pathol 174:2254-2264(2009) [PubMed] [Europe PMC] [Abstract]
• multicellular organism aging Source: Ensembl
• multicellular organismal iron ion homeostasis Source: Ensembl
• negative regulation of cell growth Source: UniProtKBInferred from direct assayⁱ
  • "HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro."
    Wang F., Grigorieva E.V., Li J., Senchenko V.N., Pavlova T.V., Anedchenko E.A., Kudryavtseva A.V., Tsimanis A., Angeloni D., Lerman M.I., Kashuba V.I., Klein G., Zabarovsky E.R.
    PLoS One 3:e3031-e3031(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of fibroblast migration Source: UniProtKBInferred from direct assayⁱ
  • "bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells."
    Berdiaki A., Nikitovic D., Tsatsakis A., Katonis P., Karamanos N.K., Tzanakakis G.N.
    Biochim Biophys Acta 1790:1258-1265(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of MAP kinase activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."
    Danilkovitch-Miagkova A., Duh F.-M., Kuzmin I., Angeloni D., Liu S.-L., Miller A.D., Lerman M.I.
    Proc. Natl. Acad. Sci. U.S.A. 100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH MST1R.
• negative regulation of protein kinase B signaling Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."
    Danilkovitch-Miagkova A., Duh F.-M., Kuzmin I., Angeloni D., Liu S.-L., Miller A.D., Lerman M.I.
    Proc. Natl. Acad. Sci. U.S.A. 100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH MST1R.
• negative regulation of protein tyrosine kinase activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."
    Danilkovitch-Miagkova A., Duh F.-M., Kuzmin I., Angeloni D., Liu S.-L., Miller A.D., Lerman M.I.
    Proc. Natl. Acad. Sci. U.S.A. 100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH MST1R.
• positive regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1."
    Hsu L.-J., Schultz L., Hong Q., Van Moer K., Heath J., Li M.-Y., Lai F.-J., Lin S.-R., Lee M.-H., Lo C.-P., Lin Y.-S., Chen S.-T., Chang N.-S.
    J. Biol. Chem. 284:16049-16059(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inflammatory response Source: UniProtKBInferred from direct assayⁱ
  • "Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines."
    de la Motte C., Nigro J., Vasanji A., Rho H., Kessler S., Bandyopadhyay S., Danese S., Fiocchi C., Stern R.
    Am J Pathol 174:2254-2264(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-6 production Source: UniProtKBInferred from direct assayⁱ
  • "Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines."
    de la Motte C., Nigro J., Vasanji A., Rho H., Kessler S., Bandyopadhyay S., Danese S., Fiocchi C., Stern R.
    Am J Pathol 174:2254-2264(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-8 production Source: UniProtKBInferred from direct assayⁱ
  • "Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines."
    de la Motte C., Nigro J., Vasanji A., Rho H., Kessler S., Bandyopadhyay S., Danese S., Fiocchi C., Stern R.
    Am J Pathol 174:2254-2264(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein import into nucleus Source: BHF-UCL
• positive regulation of transcription by RNA polymerase II Source: BHF-UCL
• positive regulation of urine volume Source: UniProtKB
• renal water absorption Source: UniProtKB
• response to antibiotic Source: UniProtKBInferred from expression patternⁱ
  • "Hyaluronidases and CD44 undergo differential modulation during chondrogenesis."
    Nicoll S.B., Barak O., Csoka A.B., Bhatnagar R.S., Stern R.
    Biochem Biophys Res Commun 292:819-825(2002) [PubMed] [Europe PMC] [Abstract]
• response to reactive oxygen species Source: UniProtKBInferred from direct assayⁱ
  • "Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation."
    Monzon M.E., Fregien N., Schmid N., Falcon N.S., Campos M., Casalino-Matsuda S.M., Forteza R.M.
    J Biol Chem 285:26126-26134(2010) [PubMed] [Europe PMC] [Abstract]
• response to virus Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation."
    Rai S.K., Duh F.-M., Vigdorovich V., Danilkovitch-Miagkova A., Lerman M.I., Miller A.D.
    Proc. Natl. Acad. Sci. U.S.A. 98:4443-4448(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  • Ref.10

    "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."
    Danilkovitch-Miagkova A., Duh F.-M., Kuzmin I., Angeloni D., Liu S.-L., Miller A.D., Lerman M.I.
    Proc. Natl. Acad. Sci. U.S.A. 100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH MST1R.
• skeletal system morphogenesis Source: Ensembl
• viral entry into host cell Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• enzyme binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1."
    Hsu L.-J., Schultz L., Hong Q., Van Moer K., Heath J., Li M.-Y., Lai F.-J., Lin S.-R., Lee M.-H., Lo C.-P., Lin Y.-S., Chen S.-T., Chang N.-S.
    J. Biol. Chem. 284:16049-16059(2009) [PubMed] [Europe PMC] [Abstract]
• receptor tyrosine kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.10

    "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."
    Danilkovitch-Miagkova A., Duh F.-M., Kuzmin I., Angeloni D., Liu S.-L., Miller A.D., Lerman M.I.
    Proc. Natl. Acad. Sci. U.S.A. 100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH MST1R.
• transforming growth factor beta binding Source: BHF-UCL

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MRAGPGPTVT LALVLAVSWA MELKPTAPPI FTGRPFVVAW DVPTQDCGPR 
        60         70         80         90        100
LKVPLDLNAF DVQASPNEGF VNQNITIFYR DRLGLYPRFD SAGRSVHGGV 
       110        120        130        140        150
PQNVSLWAHR KMLQKRVEHY IRTQESAGLA VIDWEDWRPV WVRNWQDKDV 
       160        170        180        190        200
YRRLSRQLVA SRHPDWPPDR IVKQAQYEFE FAAQQFMLET LRYVKAVRPR 
       210        220        230        240        250
HLWGFYLFPD CYNHDYVQNW ESYTGRCPDV EVARNDQLAW LWAESTALFP 
       260        270        280        290        300
SVYLDETLAS SRHGRNFVSF RVQEALRVAR THHANHALPV YVFTRPTYSR 
       310        320        330        340        350
RLTGLSEMDL ISTIGESAAL GAAGVILWGD AGYTTSTETC QYLKDYLTRL 
       360        370        380        390        400
LVPYVVNVSW ATQYCSRAQC HGHGRCVRRN PSASTFLHLS TNSFRLVPGH 
       410        420        430        440        450
APGEPQLRPV GELSWADIDH LQTHFRCQCY LGWSGEQCQW DHRQAAGGAS 
       460        470 
EAWAGSHLTS LLALAALAFT WTL                              

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Glycosyl hydrolases
   Classification of glycosyl hydrolase families and list of entries
2. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
3. Human entries with genetic variants
   List of human entries with genetic variants
4. Human variants curated from literature reports
   Index of human variants curated from literature reports
5. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
6. SIMILARITY comments
   Index of protein domains and families