HYAL2

Functionⁱ

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.3 Publications

Caution

Was originally thought to be lysosomal.Curated

Catalytic activityⁱ

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	135	Proton donorBy similarity		1

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro
cartilage development
Source: UniProtKB
Inferred from expression patternⁱ
- 11944887
cellular response to fibroblast growth factor stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 19577615
cellular response to interleukin-1
Source: UniProtKB
Inferred from direct assayⁱ
- 18390475
cellular response to transforming growth factor beta stimulus
Source: BHF-UCL
Inferred from direct assayⁱ
- 19366691
cellular response to tumor necrosis factor
Source: UniProtKB
Inferred from expression patternⁱ
- 18390475
cellular response to UV-B
Source: UniProtKB
Inferred from direct assayⁱ
- 21699545
defense response to virus Source: Ensembl
fusion of virus membrane with host plasma membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 11296287
glycosaminoglycan catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 9712871
hematopoietic progenitor cell differentiation Source: Ensembl
hyaluronan catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
kidney development Source: UniProtKB
monocyte activation
Source: UniProtKB
Inferred from direct assayⁱ
- 19443707
multicellular organism aging Source: Ensembl
multicellular organismal iron ion homeostasis Source: Ensembl
negative regulation of cell growth
Source: UniProtKB
Inferred from direct assayⁱ
- 18725949
negative regulation of fibroblast migration
Source: UniProtKB
Inferred from direct assayⁱ
- 19577615
negative regulation of MAP kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12676986
negative regulation of protein kinase B signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 12676986
negative regulation of protein tyrosine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12676986
positive regulation of extrinsic apoptotic signaling pathway
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 19366691
positive regulation of inflammatory response
Source: UniProtKB
Inferred from direct assayⁱ
- 19443707
positive regulation of interleukin-6 secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 19443707
positive regulation of interleukin-8 secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 19443707
positive regulation of protein import into nucleus Source: BHF-UCL
positive regulation of transcription by RNA polymerase II Source: BHF-UCL
positive regulation of urine volume Source: UniProtKB
renal water absorption Source: UniProtKB
response to antibiotic
Source: UniProtKB
Inferred from expression patternⁱ
- 11944887
response to reactive oxygen species
Source: UniProtKB
Inferred from direct assayⁱ
- 20554532
response to virus
Source: UniProtKB
Inferred from direct assayⁱ
- 11296287
- 12676986
skeletal system morphogenesis Source: Ensembl
transformation of host cell by virus
Source: UniProtKB
Inferred from direct assayⁱ
- 11296287
viral entry into host cell Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase, Receptor

Molecular function

Glycosidase, Hydrolase, Receptor

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00926-MONOMER
BRENDAⁱ	3.2.1.35 2681 4.2.2.1 2681
Reactomeⁱ	R-HSA-2160916 Hyaluronan uptake and degradation
SignaLinkⁱ	Q12891

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH56 Glycoside Hydrolase Family 56

CAZyⁱ

GH56 Glycoside Hydrolase Family 56

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hyaluronidase-2 (EC:3.2.1.35) Short name: Hyal-2 Alternative name(s): Hyaluronoglucosaminidase-2 Lung carcinoma protein 2 Short name: LuCa-2
Gene namesⁱ	Name:HYAL2 Synonyms:LUCA2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000068001.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5321 HYAL2
MIMⁱ	603551 gene
neXtProtⁱ	NX_Q12891

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8692
Open Targets More...OpenTargetsⁱ	ENSG00000068001
PharmGKBⁱ	PA29572

Polymorphism and mutation databases

BioMutaⁱ	HYAL2
DMDMⁱ	311033483

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST	20
ChainⁱPRO_0000012099	21 – 448	Hyaluronidase-2Add BLAST	428
PropeptideⁱPRO_0000012100	449 – 473	Removed in mature formSequence analysisAdd BLAST	25

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	47 ↔ 340	By similarity
Glycosylationⁱ	74	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	103	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	211 ↔ 227	By similarity
Glycosylationⁱ	357	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	365 ↔ 376	By similarity
Disulfide bondⁱ	370 ↔ 427	By similarity
Disulfide bondⁱ	429 ↔ 438	By similarity
Lipidationⁱ	448	GPI-anchor amidated glycineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDⁱ	Q12891
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q12891
PaxDbⁱ	Q12891
PeptideAtlas More...PeptideAtlasⁱ	Q12891
PRIDEⁱ	Q12891
ProteomicsDBⁱ	59006

PTM databases

iPTMnetⁱ	Q12891
PhosphoSitePlusⁱ	Q12891

Expressionⁱ

Tissue specificityⁱ

Widely expressed. No expression detected in adult brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000068001
CleanExⁱ	HS_HYAL2
ExpressionAtlasⁱ	Q12891 baseline and differential
Genevisibleⁱ	Q12891 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036436

HPAⁱ

HPA036436

Interactionⁱ

Subunit structureⁱ

Interacts with MST1R.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FHL3	Q13643	3	EBI-2806068,EBI-741101
KRTAP3-2	Q9BYR7	3	EBI-2806068,EBI-751260

Show more details

GO - Molecular functionⁱ

enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19366691
receptor tyrosine kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12676986
transforming growth factor beta binding Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114239, 15 interactors
IntActⁱ	Q12891, 13 interactors
STRINGⁱ	9606.ENSP00000350387

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q12891
SMRⁱ	Q12891
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	361 – 439	EGF-likeAdd BLAST		79

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 56 family.Curated

Keywords - Domainⁱ

EGF-like domain, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IECJ Eukaryota ENOG410XPZT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074476
HOGENOMⁱ	HOG000015133
HOVERGENⁱ	HBG052053
InParanoidⁱ	Q12891
KEGG Orthology (KO) More...KOⁱ	K01197
OMAⁱ	WGGEQCQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G064G
PhylomeDBⁱ	Q12891
TreeFamⁱ	TF321598

Family and domain databases

Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR017853 Glycoside_hydrolase_SF IPR018155 Hyaluronidase
PANTHERⁱ	PTHR11769 PTHR11769, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01630 Glyco_hydro_56, 1 hit
PIRSFⁱ	PIRSF038193 Hyaluronidase, 1 hit
PRINTSⁱ	PR00846 GLHYDRLASE56
SUPFAMⁱ	SSF51445 SSF51445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 1 hit PS01186 EGF_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q12891-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRAGPGPTVT LALVLAVSWA MELKPTAPPI FTGRPFVVAW DVPTQDCGPR 
        60         70         80         90        100
LKVPLDLNAF DVQASPNEGF VNQNITIFYR DRLGLYPRFD SAGRSVHGGV 
       110        120        130        140        150
PQNVSLWAHR KMLQKRVEHY IRTQESAGLA VIDWEDWRPV WVRNWQDKDV 
       160        170        180        190        200
YRRLSRQLVA SRHPDWPPDR IVKQAQYEFE FAAQQFMLET LRYVKAVRPR 
       210        220        230        240        250
HLWGFYLFPD CYNHDYVQNW ESYTGRCPDV EVARNDQLAW LWAESTALFP 
       260        270        280        290        300
SVYLDETLAS SRHGRNFVSF RVQEALRVAR THHANHALPV YVFTRPTYSR 
       310        320        330        340        350
RLTGLSEMDL ISTIGESAAL GAAGVILWGD AGYTTSTETC QYLKDYLTRL 
       360        370        380        390        400
LVPYVVNVSW ATQYCSRAQC HGHGRCVRRN PSASTFLHLS TNSFRLVPGH 
       410        420        430        440        450
APGEPQLRPV GELSWADIDH LQTHFRCQCY LGWSGEQCQW DHRQAAGGAS 
       460        470 
EAWAGSHLTS LLALAALAFT WTL

Length:473

Mass (Da):53,860

Last modified:November 2, 2010 - v4

Checksum:ⁱA8302738478BFE61

GO

Sequence cautionⁱ

The sequence AAC28656 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	261 – 262	SR → AL in CAA03924 (PubMed:9712871).Curated	2
Sequence conflictⁱ	301 – 302	RL → C in CAA03924 (PubMed:9712871).Curated	2
Sequence conflictⁱ	375	Missing in CAA03924 (PubMed:9712871).Curated	1
Sequence conflictⁱ	378 – 379	RR → PG in CAA03924 (PubMed:9712871).Curated	2
Sequence conflictⁱ	450	S → N in CAA03924 (PubMed:9712871).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_028170	18	S → A5 PublicationsCorresponds to variant dbSNP:rs709210Ensembl.		1
Natural variantⁱVAR_061193	418	I → L. Corresponds to variant dbSNP:rs35455589Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ000099 mRNA Translation: CAA03924.1 U09577 mRNA Translation: AAC62823.1 AK092449 mRNA Translation: BAG52554.1 AK127945 mRNA Translation: BAG54602.1 AC002455 Genomic DNA Translation: AAB67045.1 CH471055 Genomic DNA Translation: EAW65092.1 BC000692 mRNA Translation: AAH00692.1 AF070608 mRNA Translation: AAC28656.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2818.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003764.3, NM_003773.4 NP_149348.2, NM_033158.4 XP_005265581.1, XM_005265524.2 XP_005265582.1, XM_005265525.2
UniGeneⁱ	Hs.76873

Genome annotation databases

Ensemblⁱ	ENST00000357750; ENSP00000350387; ENSG00000068001 ENST00000395139; ENSP00000378571; ENSG00000068001 ENST00000442581; ENSP00000406657; ENSG00000068001 ENST00000447092; ENSP00000401853; ENSG00000068001
GeneIDⁱ	8692
KEGGⁱ	hsa:8692
UCSC genome browser More...UCSCⁱ	uc003czv.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q12891	Hyaluronidase (Fragment)		HUMAN		121
Hyaluronidase (Fragment)		HUMAN		117
Hyaluronidase-2 (Fragment)		HUMAN		47
Hyaluronidase (Fragment)		HUMAN		76
Hyaluronidase (Fragment)		HUMAN		81

Protein	Similar proteins		Species	Score	Length
Q12891	Hyaluronidase (Fragment)		HUMAN		121
Hyaluronidase		TARSY		473
Hyaluronidase		PONAB		473
Hyaluronidase		TUPCH		473
Hyaluronidase		OTOGA		473
+7

Protein	Similar proteins		Species	Score	Length
Q12891	Hyaluronidase (Fragment)		HUMAN		121
Hyaluronidase		TUPCH		473
Hyaluronidase		OTOGA		473
Hyaluronidase		TARSY		473
Hyaluronidase		NOMLE		473
+166

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ000099 mRNA Translation: CAA03924.1 U09577 mRNA Translation: AAC62823.1 AK092449 mRNA Translation: BAG52554.1 AK127945 mRNA Translation: BAG54602.1 AC002455 Genomic DNA Translation: AAB67045.1 CH471055 Genomic DNA Translation: EAW65092.1 BC000692 mRNA Translation: AAH00692.1 AF070608 mRNA Translation: AAC28656.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2818.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003764.3, NM_003773.4 NP_149348.2, NM_033158.4 XP_005265581.1, XM_005265524.2 XP_005265582.1, XM_005265525.2
UniGeneⁱ	Hs.76873

3D structure databases

ProteinModelPortalⁱ	Q12891
SMRⁱ	Q12891
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114239, 15 interactors
IntActⁱ	Q12891, 13 interactors
STRINGⁱ	9606.ENSP00000350387

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH56 Glycoside Hydrolase Family 56

CAZyⁱ

GH56 Glycoside Hydrolase Family 56

PTM databases

iPTMnetⁱ	Q12891
PhosphoSitePlusⁱ	Q12891

Polymorphism and mutation databases

BioMutaⁱ	HYAL2
DMDMⁱ	311033483

Proteomic databases

EPDⁱ	Q12891
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q12891
PaxDbⁱ	Q12891
PeptideAtlas More...PeptideAtlasⁱ	Q12891
PRIDEⁱ	Q12891
ProteomicsDBⁱ	59006

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8692
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000357750; ENSP00000350387; ENSG00000068001 ENST00000395139; ENSP00000378571; ENSG00000068001 ENST00000442581; ENSP00000406657; ENSG00000068001 ENST00000447092; ENSP00000401853; ENSG00000068001
GeneIDⁱ	8692
KEGGⁱ	hsa:8692
UCSC genome browser More...UCSCⁱ	uc003czv.4 human

Organism-specific databases

CTDⁱ	8692
DisGeNET More...DisGeNETⁱ	8692
EuPathDBⁱ	HostDB:ENSG00000068001.13
GeneCardsⁱ	HYAL2
H-InvDBⁱ	HIX0003314
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5321 HYAL2
Human Protein Atlas More...HPAⁱ	HPA036436
MIMⁱ	603551 gene
neXtProtⁱ	NX_Q12891
Open Targets More...OpenTargetsⁱ	ENSG00000068001
PharmGKBⁱ	PA29572
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IECJ Eukaryota ENOG410XPZT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074476
HOGENOMⁱ	HOG000015133
HOVERGENⁱ	HBG052053
InParanoidⁱ	Q12891
KEGG Orthology (KO) More...KOⁱ	K01197
OMAⁱ	WGGEQCQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G064G
PhylomeDBⁱ	Q12891
TreeFamⁱ	TF321598

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00926-MONOMER
BRENDAⁱ	3.2.1.35 2681 4.2.2.1 2681
Reactomeⁱ	R-HSA-2160916 Hyaluronan uptake and degradation
SignaLinkⁱ	Q12891

Miscellaneous databases

ChiTaRSⁱ	HYAL2 human
GeneWikiⁱ	HYAL2
GenomeRNAiⁱ	8692
Protein Ontology More...PROⁱ	PR:Q12891
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000068001
CleanExⁱ	HS_HYAL2
ExpressionAtlasⁱ	Q12891 baseline and differential
Genevisibleⁱ	Q12891 HS

Family and domain databases

Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR017853 Glycoside_hydrolase_SF IPR018155 Hyaluronidase
PANTHERⁱ	PTHR11769 PTHR11769, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01630 Glyco_hydro_56, 1 hit
PIRSFⁱ	PIRSF038193 Hyaluronidase, 1 hit
PRINTSⁱ	PR00846 GLHYDRLASE56
SUPFAMⁱ	SSF51445 SSF51445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 1 hit PS01186 EGF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HYAL2_HUMAN
Accessionⁱ	Q12891Primary (citable) accession number: Q12891 Secondary accession number(s): B3KRZ2, O15177, Q9BW29
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
	Last sequence update:	November 2, 2010
	Last modified:	July 18, 2018
	This is version 168 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q12891 (HYAL2_HUMAN)

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Hyaluronidase-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytosol

Endoplasmic reticulum

Golgi apparatus

Lysosome

Nucleus

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ