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Protein

Oviduct-specific glycoprotein

Gene

OVGP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.

GO - Molecular functioni

  • chitinase activity Source: GO_Central
  • chitin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processFertilization

Enzyme and pathway databases

ReactomeiR-HSA-1300644 Interaction With The Zona Pellucida

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Oviduct-specific glycoprotein
Alternative name(s):
Estrogen-dependent oviduct protein
Mucin-9
Oviductal glycoprotein
Oviductin
Gene namesi
Name:OVGP1
Synonyms:MUC9, OGP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000085465.12
HGNCiHGNC:8524 OVGP1
MIMi603578 gene
neXtProtiNX_Q12889

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi5016
OpenTargetsiENSG00000085465
PharmGKBiPA32852

Polymorphism and mutation databases

BioMutaiOVGP1
DMDMi2493676

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001197322 – 678Oviduct-specific glycoproteinAdd BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi580N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi648N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ12889
PeptideAtlasiQ12889
PRIDEiQ12889
ProteomicsDBi59005

PTM databases

iPTMnetiQ12889
PhosphoSitePlusiQ12889

Expressioni

Tissue specificityi

Oviduct.

Gene expression databases

BgeeiENSG00000085465 Expressed in 185 organ(s), highest expression level in right uterine tube
CleanExiHS_OVGP1
GenevisibleiQ12889 HS

Organism-specific databases

HPAiHPA062205

Interactioni

Protein-protein interaction databases

BioGridi111056, 6 interactors
IntActiQ12889, 2 interactors
STRINGi9606.ENSP00000358747

Structurei

3D structure databases

ProteinModelPortaliQ12889
SMRiQ12889
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
GeneTreeiENSGT00550000074323
HOGENOMiHOG000111109
HOVERGENiHBG011684
InParanoidiQ12889
KOiK17526
OMAiGVPHIVQ
OrthoDBiEOG091G014W
PhylomeDBiQ12889
TreeFamiTF315610

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF54556 SSF54556, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12889-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWKLLLWVGL VLVLKHHDGA AHKLVCYFTN WAHSRPGPAS ILPHDLDPFL
60 70 80 90 100
CTHLIFAFAS MNNNQIVAKD LQDEKILYPE FNKLKERNRE LKTLLSIGGW
110 120 130 140 150
NFGTSRFTTM LSTFANREKF IASVISLLRT HDFDGLDLFF LYPGLRGSPM
160 170 180 190 200
HDRWTFLFLI EELLFAFRKE ALLTMRPRLL LSAAVSGVPH IVQTSYDVRF
210 220 230 240 250
LGRLLDFINV LSYDLHGSWE RFTGHNSPLF SLPEDPKSSA YAMNYWRKLG
260 270 280 290 300
APSEKLIMGI PTYGRTFRLL KASKNGLQAR AIGPASPGKY TKQEGFLAYF
310 320 330 340 350
EICSFVWGAK KHWIDYQYVP YANKGKEWVG YDNAISFSYK AWFIRREHFG
360 370 380 390 400
GAMVWTLDMD DVRGTFCGTG PFPLVYVLND ILVRAEFSST SLPQFWLSSA
410 420 430 440 450
VNSSSTDPER LAVTTAWTTD SKILPPGGEA GVTEIHGKCE NMTITPRGTT
460 470 480 490 500
VTPTKETVSL GKHTVALGEK TEITGAMTMT SVGHQSMTPG EKALTPVGHQ
510 520 530 540 550
SVTTGQKTLT SVGYQSVTPG EKTLTPVGHQ SVTPVSHQSV SPGGTTMTPV
560 570 580 590 600
HFQTETLRQN TVAPRRKAVA REKVTVPSRN ISVTPEGQTM PLRGENLTSE
610 620 630 640 650
VGTHPRMGNL GLQMEAENRM MLSSSPVIQL PEQTPLAFDN RFVPIYGNHS
660 670
SVNSVTPQTS PLSLKKEIPE NSAVDEEA
Length:678
Mass (Da):75,421
Last modified:November 1, 1997 - v1
Checksum:i245F2CEDCE92768B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti511S → P in AAB04126 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049199332D → E. Corresponds to variant dbSNP:rs17027633Ensembl.1
Natural variantiVAR_024459477M → T1 PublicationCorresponds to variant dbSNP:rs2485319Ensembl.1
Natural variantiVAR_049200479M → V. Corresponds to variant dbSNP:rs3767607Ensembl.1
Natural variantiVAR_049201514Y → H1 PublicationCorresponds to variant dbSNP:rs1126656Ensembl.1
Natural variantiVAR_061190526P → S. Corresponds to variant dbSNP:rs12096782Ensembl.1
Natural variantiVAR_049202536S → G. Corresponds to variant dbSNP:rs3767609Ensembl.1
Natural variantiVAR_024460604H → Q. Corresponds to variant dbSNP:rs10067Ensembl.1
Natural variantiVAR_035752662L → H in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_016109676E → Q1 PublicationCorresponds to variant dbSNP:rs7825Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09550 mRNA Translation: AAA86946.1
U58010
, U58001, U58002, U58003, U58004, U58005, U58006, U58007, U58008, U58009 Genomic DNA Translation: AAB04126.1
AL390195 Genomic DNA No translation available.
BC126177 mRNA Translation: AAI26178.1
BC136406 mRNA Translation: AAI36407.1
CCDSiCCDS834.1
RefSeqiNP_002548.3, NM_002557.3
UniGeneiHs.1154

Genome annotation databases

EnsembliENST00000369732; ENSP00000358747; ENSG00000085465
GeneIDi5016
KEGGihsa:5016
UCSCiuc001eba.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09550 mRNA Translation: AAA86946.1
U58010
, U58001, U58002, U58003, U58004, U58005, U58006, U58007, U58008, U58009 Genomic DNA Translation: AAB04126.1
AL390195 Genomic DNA No translation available.
BC126177 mRNA Translation: AAI26178.1
BC136406 mRNA Translation: AAI36407.1
CCDSiCCDS834.1
RefSeqiNP_002548.3, NM_002557.3
UniGeneiHs.1154

3D structure databases

ProteinModelPortaliQ12889
SMRiQ12889
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111056, 6 interactors
IntActiQ12889, 2 interactors
STRINGi9606.ENSP00000358747

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

PTM databases

iPTMnetiQ12889
PhosphoSitePlusiQ12889

Polymorphism and mutation databases

BioMutaiOVGP1
DMDMi2493676

Proteomic databases

PaxDbiQ12889
PeptideAtlasiQ12889
PRIDEiQ12889
ProteomicsDBi59005

Protocols and materials databases

DNASUi5016
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369732; ENSP00000358747; ENSG00000085465
GeneIDi5016
KEGGihsa:5016
UCSCiuc001eba.4 human

Organism-specific databases

CTDi5016
DisGeNETi5016
EuPathDBiHostDB:ENSG00000085465.12
GeneCardsiOVGP1
HGNCiHGNC:8524 OVGP1
HPAiHPA062205
MIMi603578 gene
neXtProtiNX_Q12889
OpenTargetsiENSG00000085465
PharmGKBiPA32852
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
GeneTreeiENSGT00550000074323
HOGENOMiHOG000111109
HOVERGENiHBG011684
InParanoidiQ12889
KOiK17526
OMAiGVPHIVQ
OrthoDBiEOG091G014W
PhylomeDBiQ12889
TreeFamiTF315610

Enzyme and pathway databases

ReactomeiR-HSA-1300644 Interaction With The Zona Pellucida

Miscellaneous databases

GeneWikiiOVGP1
GenomeRNAii5016
PROiPR:Q12889
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000085465 Expressed in 185 organ(s), highest expression level in right uterine tube
CleanExiHS_OVGP1
GenevisibleiQ12889 HS

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF54556 SSF54556, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOVGP1_HUMAN
AccessioniPrimary (citable) accession number: Q12889
Secondary accession number(s): A0AV19, B9EGE1, Q15841
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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