Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dihydropyrimidine dehydrogenase [NADP(+)]

Gene

DPYD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:
  • FADNote: Binds 2 FAD.
  • FMNNote: Binds 2 FMN.
  • [4Fe-4S] clusterBy similarityNote: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: beta-alanine biosynthesis

This protein is involved in the pathway beta-alanine biosynthesis, which is part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi79Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi82Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi87Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi91Iron-sulfur 2 (4Fe-4S)By similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei129FAD; via carbonyl oxygenBy similarity1
Metal bindingi130Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi136Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi140Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi156Iron-sulfur 2 (4Fe-4S)By similarity1
Binding sitei235FADBy similarity1
Binding sitei261FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei371NADPBy similarity1
Binding sitei550FMNBy similarity1
Binding sitei609SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei671Proton acceptorBy similarity1
Binding sitei709FMNBy similarity1
Binding sitei767FMN; via amide nitrogenBy similarity1
Metal bindingi953Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi956Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi959Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi963Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi986Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi989Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi992Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi996Iron-sulfur 4 (4Fe-4S)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi194 – 198FADBy similarity5
Nucleotide bindingi218 – 226FADBy similarity9
Nucleotide bindingi340 – 343NADPBy similarity4
Nucleotide bindingi364 – 365NADPBy similarity2
Nucleotide bindingi437 – 439NADPBy similarity3
Nucleotide bindingi480 – 489FADBy similarity10
Nucleotide bindingi481 – 487NADPBy similarity7
Nucleotide bindingi574 – 575FMNBy similarity2
Nucleotide bindingi793 – 795FMNBy similarity3
Nucleotide bindingi816 – 817FMNBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, FAD, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06975-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.3.1.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-73621 Pyrimidine catabolism

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q12882

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00131

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dihydropyrimidine dehydrogenase [NADP(+)] (EC:1.3.1.2)
Short name:
DHPDHase
Short name:
DPD
Alternative name(s):
Dihydrothymine dehydrogenase
Dihydrouracil dehydrogenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPYD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188641.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3012 DPYD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612779 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12882

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dihydropyrimidine dehydrogenase deficiency (DPYDD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder with large phenotypic variability, ranging from no symptoms to a convulsive disorder with motor and mental retardation. It is characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil.
See also OMIM:274270
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00517329C → R in DPYDD; allele DPYD*9A and allele DPYD*9B; loss of activity. 5 PublicationsCorresponds to variant dbSNP:rs1801265EnsemblClinVar.1
Natural variantiVAR_005174235R → W in DPYDD; allele DPYD*8; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs1801266EnsemblClinVar.1
Natural variantiVAR_005177886R → H in DPYDD; allele DPYD*9B; 25% of activity. 2 PublicationsCorresponds to variant dbSNP:rs1801267EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1806

MalaCards human disease database

More...
MalaCardsi
DPYD
MIMi274270 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000188641

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
293948 1p21.3 microdeletion syndrome
240839 5-fluorouracil toxicity
1675 Dihydropyrimidine dehydrogenase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3172

Drug and drug target database

More...
DrugBanki
DB03554 5-Iodouracil
DB03048 6-Carboxymethyluracil
DB01101 Capecitabine
DB03516 Eniluracil
DB03147 Flavin adenine dinucleotide
DB00544 Fluorouracil
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB03247 Riboflavin Monophosphate
DB03419 Uracil

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DPYD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160332325

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000211141 – 33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000211154 – 1025Dihydropyrimidine dehydrogenase [NADP(+)]Add BLAST1022

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei384N6-acetyllysineCombined sources1
Modified residuei905PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12882

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12882

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12882

PeptideAtlas

More...
PeptideAtlasi
Q12882

PRoteomics IDEntifications database

More...
PRIDEi
Q12882

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58999

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q12882

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12882

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12882

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188641 Expressed in 219 organ(s), highest expression level in germinal epithelium of ovary

CleanEx database of gene expression profiles

More...
CleanExi
HS_DPYD

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12882 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033241
HPA045210

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108140, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q12882, 20 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359211

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q12882

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q12882

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12882

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini69 – 1004Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST32
Domaini944 – 9764Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST33
Domaini978 – 10074Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni668 – 670Substrate bindingBy similarity3
Regioni736 – 737Substrate bindingBy similarity2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0399 Eukaryota
COG0167 LUCA
COG0493 LUCA
COG1146 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044896

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169491

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG074715

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12882

KEGG Orthology (KO)

More...
KOi
K00207

Identification of Orthologs from Complete Genome Data

More...
OMAi
HWKRNAD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00YL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12882

TreeFam database of animal gene trees

More...
TreeFami
TF105791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1060.10, 1 hit
3.20.20.70, 1 hit
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR013785 Aldolase_TIM
IPR005720 Dihydroorotate_DH
IPR028261 DPD_II
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR009051 Helical_ferredxn

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01180 DHO_dh, 1 hit
PF14691 Fer4_20, 1 hit
PF07992 Pyr_redox_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46548 SSF46548, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01037 pyrD_sub1_fam, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q12882-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPVLSKDSA DIESILALNP RTQTHATLCS TSAKKLDKKH WKRNPDKNCF
60 70 80 90 100
NCEKLENNFD DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF
110 120 130 140 150
ITSIANKNYY GAAKMIFSDN PLGLTCGMVC PTSDLCVGGC NLYATEEGPI
160 170 180 190 200
NIGGLQQFAT EVFKAMSIPQ IRNPSLPPPE KMSEAYSAKI ALFGAGPASI
210 220 230 240 250
SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDV VNFEIELMKD
260 270 280 290 300
LGVKIICGKS LSVNEMTLST LKEKGYKAAF IGIGLPEPNK DAIFQGLTQD
310 320 330 340 350
QGFYTSKDFL PLVAKGSKAG MCACHSPLPS IRGVVIVLGA GDTAFDCATS
360 370 380 390 400
ALRCGARRVF IVFRKGFVNI RAVPEEMELA KEEKCEFLPF LSPRKVIVKG
410 420 430 440 450
GRIVAMQFVR TEQDETGKWN EDEDQMVHLK ADVVISAFGS VLSDPKVKEA
460 470 480 490 500
LSPIKFNRWG LPEVDPETMQ TSEAWVFAGG DVVGLANTTV ESVNDGKQAS
510 520 530 540 550
WYIHKYVQSQ YGASVSAKPE LPLFYTPIDL VDISVEMAGL KFINPFGLAS
560 570 580 590 600
ATPATSTSMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPMY
610 620 630 640 650
GPGQSSFLNI ELISEKTAAY WCQSVTELKA DFPDNIVIAS IMCSYNKNDW
660 670 680 690 700
TELAKKSEDS GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ
710 720 730 740 750
AVQIPFFAKL TPNVTDIVSI ARAAKEGGAN GVTATNTVSG LMGLKSDGTP
760 770 780 790 800
WPAVGIAKRT TYGGVSGTAI RPIALRAVTS IARALPGFPI LATGGIDSAE
810 820 830 840 850
SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL KSIEELQDWD
860 870 880 890 900
GQSPATVSHQ KGKPVPRIAE LMDKKLPSFG PYLEQRKKII AENKIRLKEQ
910 920 930 940 950
NVAFSPLKRN CFIPKRPIPT IKDVIGKALQ YLGTFGELSN VEQVVAMIDE
960 970 980 990 1000
EMCINCGKCY MTCNDSGYQA IQFDPETHLP TITDTCTGCT LCLSVCPIVD
1010 1020
CIKMVSRTTP YEPKRGVPLS VNPVC
Length:1,025
Mass (Da):111,401
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0201943955AB2C21
GO
Isoform 2 (identifier: Q12882-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-173: VFKAMSIPQIRN → TLILAFSLMNHL
     174-1025: Missing.

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):18,936
Checksum:i94D241E912F29B6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti131P → S in AAI08743 (PubMed:16710414).Curated1
Sequence conflicti845E → G in BAF83906 (PubMed:14702039).Curated1
Sequence conflicti910N → S in AAA57474 (PubMed:8083224).Curated1
Sequence conflicti1024V → G in AAI31779 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00517329C → R in DPYDD; allele DPYD*9A and allele DPYD*9B; loss of activity. 5 PublicationsCorresponds to variant dbSNP:rs1801265EnsemblClinVar.1
Natural variantiVAR_054034166M → V. Corresponds to variant dbSNP:rs2297595EnsemblClinVar.1
Natural variantiVAR_005174235R → W in DPYDD; allele DPYD*8; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs1801266EnsemblClinVar.1
Natural variantiVAR_005175534S → N in allele DPYD*4. 2 PublicationsCorresponds to variant dbSNP:rs1801158EnsemblClinVar.1
Natural variantiVAR_005176543I → V in allele DPYD*5. 3 PublicationsCorresponds to variant dbSNP:rs1801159EnsemblClinVar.1
Natural variantiVAR_014760732V → I2 PublicationsCorresponds to variant dbSNP:rs1801160EnsemblClinVar.1
Natural variantiVAR_005177886R → H in DPYDD; allele DPYD*9B; 25% of activity. 2 PublicationsCorresponds to variant dbSNP:rs1801267EnsemblClinVar.1
Natural variantiVAR_005178995V → F in allele DPYD*10; low activity. Corresponds to variant dbSNP:rs1801268Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044929162 – 173VFKAM…PQIRN → TLILAFSLMNHL in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_044930174 – 1025Missing in isoform 2. 2 PublicationsAdd BLAST852

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09178 mRNA Translation: AAA57474.1
U20938 mRNA Translation: AAB51366.1
AB003063 mRNA Translation: BAA89789.1
BT006740 mRNA Translation: AAP35386.1
AK291217 mRNA Translation: BAF83906.1
AC091608 Genomic DNA No translation available.
AC093576 Genomic DNA No translation available.
AC099787 Genomic DNA No translation available.
AC114878 Genomic DNA No translation available.
AC138135 Genomic DNA No translation available.
AL356457 Genomic DNA No translation available.
BX908805 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73002.1
BC008379 mRNA Translation: AAH08379.1
BC064027 mRNA Translation: AAH64027.1
BC108742 mRNA Translation: AAI08743.1
BC131777 mRNA Translation: AAI31778.1
BC131778 mRNA Translation: AAI31779.1
X95670 Genomic DNA Translation: CAA64973.1
U57655 Genomic DNA Translation: AAB07049.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30777.1 [Q12882-1]
CCDS53346.1 [Q12882-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A54718

NCBI Reference Sequences

More...
RefSeqi
NP_000101.2, NM_000110.3 [Q12882-1]
NP_001153773.1, NM_001160301.1 [Q12882-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.335034

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306031; ENSP00000307107; ENSG00000188641 [Q12882-2]
ENST00000370192; ENSP00000359211; ENSG00000188641 [Q12882-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1806

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1806

UCSC genome browser

More...
UCSCi
uc001drv.4 human [Q12882-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09178 mRNA Translation: AAA57474.1
U20938 mRNA Translation: AAB51366.1
AB003063 mRNA Translation: BAA89789.1
BT006740 mRNA Translation: AAP35386.1
AK291217 mRNA Translation: BAF83906.1
AC091608 Genomic DNA No translation available.
AC093576 Genomic DNA No translation available.
AC099787 Genomic DNA No translation available.
AC114878 Genomic DNA No translation available.
AC138135 Genomic DNA No translation available.
AL356457 Genomic DNA No translation available.
BX908805 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73002.1
BC008379 mRNA Translation: AAH08379.1
BC064027 mRNA Translation: AAH64027.1
BC108742 mRNA Translation: AAI08743.1
BC131777 mRNA Translation: AAI31778.1
BC131778 mRNA Translation: AAI31779.1
X95670 Genomic DNA Translation: CAA64973.1
U57655 Genomic DNA Translation: AAB07049.1
CCDSiCCDS30777.1 [Q12882-1]
CCDS53346.1 [Q12882-2]
PIRiA54718
RefSeqiNP_000101.2, NM_000110.3 [Q12882-1]
NP_001153773.1, NM_001160301.1 [Q12882-2]
UniGeneiHs.335034

3D structure databases

ProteinModelPortaliQ12882
SMRiQ12882
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108140, 9 interactors
IntActiQ12882, 20 interactors
STRINGi9606.ENSP00000359211

Chemistry databases

BindingDBiQ12882
ChEMBLiCHEMBL3172
DrugBankiDB03554 5-Iodouracil
DB03048 6-Carboxymethyluracil
DB01101 Capecitabine
DB03516 Eniluracil
DB03147 Flavin adenine dinucleotide
DB00544 Fluorouracil
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB03247 Riboflavin Monophosphate
DB03419 Uracil

PTM databases

CarbonylDBiQ12882
iPTMnetiQ12882
PhosphoSitePlusiQ12882

Polymorphism and mutation databases

BioMutaiDPYD
DMDMi160332325

Proteomic databases

EPDiQ12882
MaxQBiQ12882
PaxDbiQ12882
PeptideAtlasiQ12882
PRIDEiQ12882
ProteomicsDBi58999

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1806
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306031; ENSP00000307107; ENSG00000188641 [Q12882-2]
ENST00000370192; ENSP00000359211; ENSG00000188641 [Q12882-1]
GeneIDi1806
KEGGihsa:1806
UCSCiuc001drv.4 human [Q12882-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1806
DisGeNETi1806
EuPathDBiHostDB:ENSG00000188641.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DPYD

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0000804
HGNCiHGNC:3012 DPYD
HPAiCAB033241
HPA045210
MalaCardsiDPYD
MIMi274270 phenotype
612779 gene
neXtProtiNX_Q12882
OpenTargetsiENSG00000188641
Orphaneti293948 1p21.3 microdeletion syndrome
240839 5-fluorouracil toxicity
1675 Dihydropyrimidine dehydrogenase deficiency
PharmGKBiPA145

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0399 Eukaryota
COG0167 LUCA
COG0493 LUCA
COG1146 LUCA
GeneTreeiENSGT00500000044896
HOGENOMiHOG000169491
HOVERGENiHBG074715
InParanoidiQ12882
KOiK00207
OMAiHWKRNAD
OrthoDBiEOG091G00YL
PhylomeDBiQ12882
TreeFamiTF105791

Enzyme and pathway databases

UniPathwayi
UPA00131

BioCyciMetaCyc:HS06975-MONOMER
BRENDAi1.3.1.2 2681
ReactomeiR-HSA-73621 Pyrimidine catabolism
SIGNORiQ12882

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DPYD human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DPYD

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1806

Protein Ontology

More...
PROi
PR:Q12882

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188641 Expressed in 219 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_DPYD
GenevisibleiQ12882 HS

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
3.20.20.70, 1 hit
3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR013785 Aldolase_TIM
IPR005720 Dihydroorotate_DH
IPR028261 DPD_II
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR009051 Helical_ferredxn
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
PF14691 Fer4_20, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR01037 pyrD_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPYD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12882
Secondary accession number(s): A2RRQ2
, A2RRQ3, A8K5A2, A8MWG9, B1AN21, E9PFN1, Q16694, Q16761, Q32NB0, Q96HL6, Q96TH1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 13, 2007
Last modified: December 5, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again