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Protein

Dihydropyrimidine dehydrogenase [NADP(+)]

Gene

DPYD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

Catalytic activityi

5,6-dihydrouracil + NADP+ = uracil + NADPH.

Cofactori

Protein has several cofactor binding sites:
  • FADNote: Binds 2 FAD.
  • FMNNote: Binds 2 FMN.
  • [4Fe-4S] clusterBy similarityNote: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.By similarity

Pathwayi: beta-alanine biosynthesis

This protein is involved in the pathway beta-alanine biosynthesis, which is part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi82Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi87Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi91Iron-sulfur 2 (4Fe-4S)By similarity1
Binding sitei129FAD; via carbonyl oxygenBy similarity1
Metal bindingi130Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi136Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi140Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi156Iron-sulfur 2 (4Fe-4S)By similarity1
Binding sitei235FADBy similarity1
Binding sitei261FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei371NADPBy similarity1
Binding sitei550FMNBy similarity1
Binding sitei609SubstrateBy similarity1
Active sitei671Proton acceptorBy similarity1
Binding sitei709FMNBy similarity1
Binding sitei767FMN; via amide nitrogenBy similarity1
Metal bindingi953Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi956Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi959Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi963Iron-sulfur 3 (4Fe-4S)By similarity1
Metal bindingi986Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi989Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi992Iron-sulfur 4 (4Fe-4S)By similarity1
Metal bindingi996Iron-sulfur 4 (4Fe-4S)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 198FADBy similarity5
Nucleotide bindingi218 – 226FADBy similarity9
Nucleotide bindingi340 – 343NADPBy similarity4
Nucleotide bindingi364 – 365NADPBy similarity2
Nucleotide bindingi437 – 439NADPBy similarity3
Nucleotide bindingi480 – 489FADBy similarity10
Nucleotide bindingi481 – 487NADPBy similarity7
Nucleotide bindingi574 – 575FMNBy similarity2
Nucleotide bindingi793 – 795FMNBy similarity3
Nucleotide bindingi816 – 817FMNBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, FAD, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06975-MONOMER
BRENDAi1.3.1.2 2681
ReactomeiR-HSA-73621 Pyrimidine catabolism
SIGNORiQ12882
UniPathwayi
UPA00131

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidine dehydrogenase [NADP(+)] (EC:1.3.1.2)
Short name:
DHPDHase
Short name:
DPD
Alternative name(s):
Dihydrothymine dehydrogenase
Dihydrouracil dehydrogenase
Gene namesi
Name:DPYD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188641.12
HGNCiHGNC:3012 DPYD
MIMi612779 gene
neXtProtiNX_Q12882

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Dihydropyrimidine dehydrogenase deficiency (DPYDD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder with large phenotypic variability, ranging from no symptoms to a convulsive disorder with motor and mental retardation. It is characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil.
See also OMIM:274270
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00517329C → R in DPYDD; allele DPYD*9A and allele DPYD*9B; loss of activity. 5 PublicationsCorresponds to variant dbSNP:rs1801265EnsemblClinVar.1
Natural variantiVAR_005174235R → W in DPYDD; allele DPYD*8; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs1801266EnsemblClinVar.1
Natural variantiVAR_005177886R → H in DPYDD; allele DPYD*9B; 25% of activity. 2 PublicationsCorresponds to variant dbSNP:rs1801267EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1806
MalaCardsiDPYD
MIMi274270 phenotype
OpenTargetsiENSG00000188641
Orphaneti293948 1p21.3 microdeletion syndrome
240839 5-fluorouracil toxicity
1675 Dihydropyrimidine dehydrogenase deficiency
PharmGKBiPA145

Chemistry databases

ChEMBLiCHEMBL3172
DrugBankiDB03554 5-Iodouracil
DB03048 6-Carboxymethyluracil
DB01101 Capecitabine
DB03516 Eniluracil
DB03147 Flavin adenine dinucleotide
DB00544 Fluorouracil
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB03247 Riboflavin Monophosphate
DB03419 Uracil

Polymorphism and mutation databases

BioMutaiDPYD
DMDMi160332325

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000211141 – 33
ChainiPRO_00000211154 – 1025Dihydropyrimidine dehydrogenase [NADP(+)]Add BLAST1022

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei384N6-acetyllysineCombined sources1
Modified residuei905PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ12882
MaxQBiQ12882
PaxDbiQ12882
PeptideAtlasiQ12882
PRIDEiQ12882
ProteomicsDBi58999

PTM databases

CarbonylDBiQ12882
iPTMnetiQ12882
PhosphoSitePlusiQ12882

Expressioni

Tissue specificityi

Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.

Gene expression databases

BgeeiENSG00000188641 Expressed in 219 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_DPYD
GenevisibleiQ12882 HS

Organism-specific databases

HPAiCAB033241
HPA045210

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108140, 9 interactors
IntActiQ12882, 20 interactors
STRINGi9606.ENSP00000359211

Chemistry databases

BindingDBiQ12882

Structurei

3D structure databases

ProteinModelPortaliQ12882
SMRiQ12882
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 1004Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST32
Domaini944 – 9764Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST33
Domaini978 – 10074Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni668 – 670Substrate bindingBy similarity3
Regioni736 – 737Substrate bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0399 Eukaryota
COG0167 LUCA
COG0493 LUCA
COG1146 LUCA
GeneTreeiENSGT00500000044896
HOGENOMiHOG000169491
HOVERGENiHBG074715
InParanoidiQ12882
KOiK00207
OMAiHWKRNAD
OrthoDBiEOG091G00YL
PhylomeDBiQ12882
TreeFamiTF105791

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
3.20.20.70, 1 hit
3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR013785 Aldolase_TIM
IPR005720 Dihydroorotate_DH
IPR028261 DPD_II
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR009051 Helical_ferredxn
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
PF14691 Fer4_20, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR01037 pyrD_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q12882-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPVLSKDSA DIESILALNP RTQTHATLCS TSAKKLDKKH WKRNPDKNCF
60 70 80 90 100
NCEKLENNFD DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF
110 120 130 140 150
ITSIANKNYY GAAKMIFSDN PLGLTCGMVC PTSDLCVGGC NLYATEEGPI
160 170 180 190 200
NIGGLQQFAT EVFKAMSIPQ IRNPSLPPPE KMSEAYSAKI ALFGAGPASI
210 220 230 240 250
SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDV VNFEIELMKD
260 270 280 290 300
LGVKIICGKS LSVNEMTLST LKEKGYKAAF IGIGLPEPNK DAIFQGLTQD
310 320 330 340 350
QGFYTSKDFL PLVAKGSKAG MCACHSPLPS IRGVVIVLGA GDTAFDCATS
360 370 380 390 400
ALRCGARRVF IVFRKGFVNI RAVPEEMELA KEEKCEFLPF LSPRKVIVKG
410 420 430 440 450
GRIVAMQFVR TEQDETGKWN EDEDQMVHLK ADVVISAFGS VLSDPKVKEA
460 470 480 490 500
LSPIKFNRWG LPEVDPETMQ TSEAWVFAGG DVVGLANTTV ESVNDGKQAS
510 520 530 540 550
WYIHKYVQSQ YGASVSAKPE LPLFYTPIDL VDISVEMAGL KFINPFGLAS
560 570 580 590 600
ATPATSTSMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPMY
610 620 630 640 650
GPGQSSFLNI ELISEKTAAY WCQSVTELKA DFPDNIVIAS IMCSYNKNDW
660 670 680 690 700
TELAKKSEDS GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ
710 720 730 740 750
AVQIPFFAKL TPNVTDIVSI ARAAKEGGAN GVTATNTVSG LMGLKSDGTP
760 770 780 790 800
WPAVGIAKRT TYGGVSGTAI RPIALRAVTS IARALPGFPI LATGGIDSAE
810 820 830 840 850
SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL KSIEELQDWD
860 870 880 890 900
GQSPATVSHQ KGKPVPRIAE LMDKKLPSFG PYLEQRKKII AENKIRLKEQ
910 920 930 940 950
NVAFSPLKRN CFIPKRPIPT IKDVIGKALQ YLGTFGELSN VEQVVAMIDE
960 970 980 990 1000
EMCINCGKCY MTCNDSGYQA IQFDPETHLP TITDTCTGCT LCLSVCPIVD
1010 1020
CIKMVSRTTP YEPKRGVPLS VNPVC
Length:1,025
Mass (Da):111,401
Last modified:November 13, 2007 - v2
Checksum:i0201943955AB2C21
GO
Isoform 2 (identifier: Q12882-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-173: VFKAMSIPQIRN → TLILAFSLMNHL
     174-1025: Missing.

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):18,936
Checksum:i94D241E912F29B6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131P → S in AAI08743 (PubMed:16710414).Curated1
Sequence conflicti845E → G in BAF83906 (PubMed:14702039).Curated1
Sequence conflicti910N → S in AAA57474 (PubMed:8083224).Curated1
Sequence conflicti1024V → G in AAI31779 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00517329C → R in DPYDD; allele DPYD*9A and allele DPYD*9B; loss of activity. 5 PublicationsCorresponds to variant dbSNP:rs1801265EnsemblClinVar.1
Natural variantiVAR_054034166M → V. Corresponds to variant dbSNP:rs2297595EnsemblClinVar.1
Natural variantiVAR_005174235R → W in DPYDD; allele DPYD*8; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs1801266EnsemblClinVar.1
Natural variantiVAR_005175534S → N in allele DPYD*4. 2 PublicationsCorresponds to variant dbSNP:rs1801158EnsemblClinVar.1
Natural variantiVAR_005176543I → V in allele DPYD*5. 3 PublicationsCorresponds to variant dbSNP:rs1801159EnsemblClinVar.1
Natural variantiVAR_014760732V → I2 PublicationsCorresponds to variant dbSNP:rs1801160EnsemblClinVar.1
Natural variantiVAR_005177886R → H in DPYDD; allele DPYD*9B; 25% of activity. 2 PublicationsCorresponds to variant dbSNP:rs1801267EnsemblClinVar.1
Natural variantiVAR_005178995V → F in allele DPYD*10; low activity. Corresponds to variant dbSNP:rs1801268Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044929162 – 173VFKAM…PQIRN → TLILAFSLMNHL in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_044930174 – 1025Missing in isoform 2. 2 PublicationsAdd BLAST852

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09178 mRNA Translation: AAA57474.1
U20938 mRNA Translation: AAB51366.1
AB003063 mRNA Translation: BAA89789.1
BT006740 mRNA Translation: AAP35386.1
AK291217 mRNA Translation: BAF83906.1
AC091608 Genomic DNA No translation available.
AC093576 Genomic DNA No translation available.
AC099787 Genomic DNA No translation available.
AC114878 Genomic DNA No translation available.
AC138135 Genomic DNA No translation available.
AL356457 Genomic DNA No translation available.
BX908805 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73002.1
BC008379 mRNA Translation: AAH08379.1
BC064027 mRNA Translation: AAH64027.1
BC108742 mRNA Translation: AAI08743.1
BC131777 mRNA Translation: AAI31778.1
BC131778 mRNA Translation: AAI31779.1
X95670 Genomic DNA Translation: CAA64973.1
U57655 Genomic DNA Translation: AAB07049.1
CCDSiCCDS30777.1 [Q12882-1]
CCDS53346.1 [Q12882-2]
PIRiA54718
RefSeqiNP_000101.2, NM_000110.3 [Q12882-1]
NP_001153773.1, NM_001160301.1 [Q12882-2]
UniGeneiHs.335034

Genome annotation databases

EnsembliENST00000306031; ENSP00000307107; ENSG00000188641 [Q12882-2]
ENST00000370192; ENSP00000359211; ENSG00000188641 [Q12882-1]
GeneIDi1806
KEGGihsa:1806
UCSCiuc001drv.4 human [Q12882-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09178 mRNA Translation: AAA57474.1
U20938 mRNA Translation: AAB51366.1
AB003063 mRNA Translation: BAA89789.1
BT006740 mRNA Translation: AAP35386.1
AK291217 mRNA Translation: BAF83906.1
AC091608 Genomic DNA No translation available.
AC093576 Genomic DNA No translation available.
AC099787 Genomic DNA No translation available.
AC114878 Genomic DNA No translation available.
AC138135 Genomic DNA No translation available.
AL356457 Genomic DNA No translation available.
BX908805 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73002.1
BC008379 mRNA Translation: AAH08379.1
BC064027 mRNA Translation: AAH64027.1
BC108742 mRNA Translation: AAI08743.1
BC131777 mRNA Translation: AAI31778.1
BC131778 mRNA Translation: AAI31779.1
X95670 Genomic DNA Translation: CAA64973.1
U57655 Genomic DNA Translation: AAB07049.1
CCDSiCCDS30777.1 [Q12882-1]
CCDS53346.1 [Q12882-2]
PIRiA54718
RefSeqiNP_000101.2, NM_000110.3 [Q12882-1]
NP_001153773.1, NM_001160301.1 [Q12882-2]
UniGeneiHs.335034

3D structure databases

ProteinModelPortaliQ12882
SMRiQ12882
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108140, 9 interactors
IntActiQ12882, 20 interactors
STRINGi9606.ENSP00000359211

Chemistry databases

BindingDBiQ12882
ChEMBLiCHEMBL3172
DrugBankiDB03554 5-Iodouracil
DB03048 6-Carboxymethyluracil
DB01101 Capecitabine
DB03516 Eniluracil
DB03147 Flavin adenine dinucleotide
DB00544 Fluorouracil
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB03247 Riboflavin Monophosphate
DB03419 Uracil

PTM databases

CarbonylDBiQ12882
iPTMnetiQ12882
PhosphoSitePlusiQ12882

Polymorphism and mutation databases

BioMutaiDPYD
DMDMi160332325

Proteomic databases

EPDiQ12882
MaxQBiQ12882
PaxDbiQ12882
PeptideAtlasiQ12882
PRIDEiQ12882
ProteomicsDBi58999

Protocols and materials databases

DNASUi1806
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306031; ENSP00000307107; ENSG00000188641 [Q12882-2]
ENST00000370192; ENSP00000359211; ENSG00000188641 [Q12882-1]
GeneIDi1806
KEGGihsa:1806
UCSCiuc001drv.4 human [Q12882-1]

Organism-specific databases

CTDi1806
DisGeNETi1806
EuPathDBiHostDB:ENSG00000188641.12
GeneCardsiDPYD
H-InvDBiHIX0000804
HGNCiHGNC:3012 DPYD
HPAiCAB033241
HPA045210
MalaCardsiDPYD
MIMi274270 phenotype
612779 gene
neXtProtiNX_Q12882
OpenTargetsiENSG00000188641
Orphaneti293948 1p21.3 microdeletion syndrome
240839 5-fluorouracil toxicity
1675 Dihydropyrimidine dehydrogenase deficiency
PharmGKBiPA145
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0399 Eukaryota
COG0167 LUCA
COG0493 LUCA
COG1146 LUCA
GeneTreeiENSGT00500000044896
HOGENOMiHOG000169491
HOVERGENiHBG074715
InParanoidiQ12882
KOiK00207
OMAiHWKRNAD
OrthoDBiEOG091G00YL
PhylomeDBiQ12882
TreeFamiTF105791

Enzyme and pathway databases

UniPathwayi
UPA00131

BioCyciMetaCyc:HS06975-MONOMER
BRENDAi1.3.1.2 2681
ReactomeiR-HSA-73621 Pyrimidine catabolism
SIGNORiQ12882

Miscellaneous databases

ChiTaRSiDPYD human
GeneWikiiDPYD
GenomeRNAii1806
PROiPR:Q12882
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188641 Expressed in 219 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_DPYD
GenevisibleiQ12882 HS

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
3.20.20.70, 1 hit
3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR013785 Aldolase_TIM
IPR005720 Dihydroorotate_DH
IPR028261 DPD_II
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR009051 Helical_ferredxn
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
PF14691 Fer4_20, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR01037 pyrD_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDPYD_HUMAN
AccessioniPrimary (citable) accession number: Q12882
Secondary accession number(s): A2RRQ2
, A2RRQ3, A8K5A2, A8MWG9, B1AN21, E9PFN1, Q16694, Q16761, Q32NB0, Q96HL6, Q96TH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 187 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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