Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-17

Gene

CDH17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.1 Publication

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • integrin binding Source: UniProtKB
  • proton-dependent oligopeptide secondary active transmembrane transporter activity Source: UniProtKB
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processCell adhesion, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions
SIGNORiQ12864

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-17
Alternative name(s):
Intestinal peptide-associated transporter HPT-1
Liver-intestine cadherin
Short name:
LI-cadherin
Gene namesi
Name:CDH17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000079112.9
HGNCiHGNC:1756 CDH17
MIMi603017 gene
neXtProtiNX_Q12864

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 787ExtracellularSequence analysisAdd BLAST765
Transmembranei788 – 808HelicalSequence analysisAdd BLAST21
Topological domaini809 – 832CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1015
OpenTargetsiENSG00000079112
PharmGKBiPA26290

Polymorphism and mutation databases

BioMutaiCDH17
DMDMi308153624

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000381223 – 832Cadherin-17Add BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi546N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi587N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi722N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ12864
PaxDbiQ12864
PeptideAtlasiQ12864
PRIDEiQ12864
ProteomicsDBi58991

PTM databases

iPTMnetiQ12864
PhosphoSitePlusiQ12864

Expressioni

Tissue specificityi

Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.1 Publication

Gene expression databases

BgeeiENSG00000079112 Expressed in 86 organ(s), highest expression level in colonic mucosa
CleanExiHS_CDH17
ExpressionAtlasiQ12864 baseline and differential
GenevisibleiQ12864 HS

Organism-specific databases

HPAiCAB025143
HPA023614
HPA023616
HPA026556

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ12864, 1 interactor
STRINGi9606.ENSP00000027335

Structurei

3D structure databases

ProteinModelPortaliQ12864
SMRiQ12864
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 128Cadherin 1PROSITE-ProRule annotationAdd BLAST99
Domaini129 – 244Cadherin 2PROSITE-ProRule annotationAdd BLAST116
Domaini245 – 340Cadherin 3PROSITE-ProRule annotationAdd BLAST96
Domaini341 – 449Cadherin 4PROSITE-ProRule annotationAdd BLAST109
Domaini450 – 566Cadherin 5PROSITE-ProRule annotationAdd BLAST117
Domaini567 – 667Cadherin 6PROSITE-ProRule annotationAdd BLAST101
Domaini668 – 777Cadherin 7PROSITE-ProRule annotationAdd BLAST110

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00740000115559
HOGENOMiHOG000231613
HOVERGENiHBG050767
InParanoidiQ12864
KOiK06811
OMAiVIDINDQ
OrthoDBiEOG091G033T
PhylomeDBiQ12864
TreeFamiTF316817

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 7 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q12864-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ
60 70 80 90 100
FKANPPAVTF ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD
110 120 130 140 150
ANGIIVEGPV PITIKVKDIN DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA
160 170 180 190 200
TDLDDPATPN GQLYYQIVIQ LPMINNVMYF QINNKTGAIS LTREGSQELN
210 220 230 240 250
PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK APKPVEMVEN
260 270 280 290 300
STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR
310 320 330 340 350
EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ
360 370 380 390 400
ENERLGNSIG TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA
410 420 430 440 450
GMLQLAKQSL KKQDTPQYNL TIEVSDKDFK TLCFVQINVI DINDQIPIFE
460 470 480 490 500
KSDYGNLTLA EDTNIGSTIL TIQATDADEP FTGSSKILYH IIKGDSEGRL
510 520 530 540 550
GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV FGVKYNASSF
560 570 580 590 600
AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY
610 620 630 640 650
SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV
660 670 680 690 700
SEFHLILMDV NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG
710 720 730 740 750
PHFTFSLGSG SLQNDWEVSK INGTHARLST RHTEFEEREY VVLIRINDGG
760 770 780 790 800
RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT GIPTVGMAVG ILLTTLLVIG
810 820 830
IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS
Length:832
Mass (Da):92,219
Last modified:October 5, 2010 - v3
Checksum:i2707547DD2DB4202
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EN24E7EN24_HUMAN
Cadherin-17
CDH17
580Annotation score:
E5RJT3E5RJT3_HUMAN
Cadherin-17
CDH17
147Annotation score:
H0YBL0H0YBL0_HUMAN
Cadherin-17
CDH17
90Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055567115K → E2 PublicationsCorresponds to variant dbSNP:rs2243518Ensembl.1
Natural variantiVAR_031694446I → T1 PublicationCorresponds to variant dbSNP:rs1131829Ensembl.1
Natural variantiVAR_031695734E → D2 PublicationsCorresponds to variant dbSNP:rs1051623Ensembl.1
Natural variantiVAR_031696739E → A. Corresponds to variant dbSNP:rs1051624Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07969 mRNA Translation: AAA19021.1
X83228 mRNA Translation: CAA58231.1
AP003351 Genomic DNA No translation available.
AP003478 Genomic DNA No translation available.
BC112013 mRNA Translation: AAI12014.1
BC113464 mRNA Translation: AAI13465.1
CCDSiCCDS6260.1
PIRiS55396
RefSeqiNP_001138135.1, NM_001144663.1
NP_004054.3, NM_004063.3
UniGeneiHs.591853

Genome annotation databases

EnsembliENST00000027335; ENSP00000027335; ENSG00000079112
ENST00000450165; ENSP00000401468; ENSG00000079112
GeneIDi1015
KEGGihsa:1015
UCSCiuc003ygh.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07969 mRNA Translation: AAA19021.1
X83228 mRNA Translation: CAA58231.1
AP003351 Genomic DNA No translation available.
AP003478 Genomic DNA No translation available.
BC112013 mRNA Translation: AAI12014.1
BC113464 mRNA Translation: AAI13465.1
CCDSiCCDS6260.1
PIRiS55396
RefSeqiNP_001138135.1, NM_001144663.1
NP_004054.3, NM_004063.3
UniGeneiHs.591853

3D structure databases

ProteinModelPortaliQ12864
SMRiQ12864
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ12864, 1 interactor
STRINGi9606.ENSP00000027335

PTM databases

iPTMnetiQ12864
PhosphoSitePlusiQ12864

Polymorphism and mutation databases

BioMutaiCDH17
DMDMi308153624

Proteomic databases

MaxQBiQ12864
PaxDbiQ12864
PeptideAtlasiQ12864
PRIDEiQ12864
ProteomicsDBi58991

Protocols and materials databases

DNASUi1015
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000027335; ENSP00000027335; ENSG00000079112
ENST00000450165; ENSP00000401468; ENSG00000079112
GeneIDi1015
KEGGihsa:1015
UCSCiuc003ygh.3 human

Organism-specific databases

CTDi1015
DisGeNETi1015
EuPathDBiHostDB:ENSG00000079112.9
GeneCardsiCDH17
H-InvDBiHIX0025563
HGNCiHGNC:1756 CDH17
HPAiCAB025143
HPA023614
HPA023616
HPA026556
MIMi603017 gene
neXtProtiNX_Q12864
OpenTargetsiENSG00000079112
PharmGKBiPA26290
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00740000115559
HOGENOMiHOG000231613
HOVERGENiHBG050767
InParanoidiQ12864
KOiK06811
OMAiVIDINDQ
OrthoDBiEOG091G033T
PhylomeDBiQ12864
TreeFamiTF316817

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions
SIGNORiQ12864

Miscellaneous databases

ChiTaRSiCDH17 human
GeneWikiiCDH17
GenomeRNAii1015
PROiPR:Q12864
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079112 Expressed in 86 organ(s), highest expression level in colonic mucosa
CleanExiHS_CDH17
ExpressionAtlasiQ12864 baseline and differential
GenevisibleiQ12864 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 7 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCAD17_HUMAN
AccessioniPrimary (citable) accession number: Q12864
Secondary accession number(s): Q15336, Q2M2E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 5, 2010
Last modified: September 12, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again