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Protein

Contactin-1

Gene

CNTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Notch signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-373760 L1CAM interactions
R-HSA-447043 Neurofascin interactions

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q12860

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Contactin-1
Alternative name(s):
Glycoprotein gp135
Neural cell surface protein F3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000018236.14

Human Gene Nomenclature Database

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HGNCi
HGNC:2171 CNTN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600016 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12860

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopathy, congenital, Compton-North (MYPCN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA lethal, autosomal recessive, congenital myopathy characterized by fetal akinesia, neonatal hypotonia, severe muscle weakness, loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma and disruption of sarcomeres with disorganization of the Z band.
See also OMIM:612540

Organism-specific databases

DisGeNET

More...
DisGeNETi
1272

MalaCards human disease database

More...
MalaCardsi
CNTN1
MIMi612540 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000018236

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
210163 Congenital lethal myopathy, Compton-North type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26685

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNTN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2497301

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Add BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001468521 – ?993Contactin-1Add BLAST973
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000014686?994 – 1018Removed in mature formAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi65 ↔ 114PROSITE-ProRule annotation
Disulfide bondi158 ↔ 211PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi263 ↔ 310PROSITE-ProRule annotation
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi352 ↔ 391PROSITE-ProRule annotation
Disulfide bondi436 ↔ 484PROSITE-ProRule annotation
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi494N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi521N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi526 ↔ 583PROSITE-ProRule annotation
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi933N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi993GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12860

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q12860

MaxQB - The MaxQuant DataBase

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MaxQBi
Q12860

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q12860

PeptideAtlas

More...
PeptideAtlasi
Q12860

PRoteomics IDEntifications database

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PRIDEi
Q12860

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58988
58989 [Q12860-2]
58990 [Q12860-3]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q12860-3 [Q12860-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1930

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12860

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12860

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q12860

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000018236 Expressed in 178 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...
CleanExi
HS_CNTN1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q12860 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q12860 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025200
HPA070467

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with CNTNAP1 in cis form (By similarity). Binds to the carbonic-anhydrase like domain of PTPRZ1 (PubMed:20133774). Interacts with NOTCH1 and TNR. Detected in a complex with NRCAM and PTPRB (By similarity).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107672, 26 interactors

Database of interacting proteins

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DIPi
DIP-59714N

Protein interaction database and analysis system

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IntActi
Q12860, 8 interactors

Molecular INTeraction database

More...
MINTi
Q12860

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325660

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11018
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EE2NMR-A798-903[»]
3S97X-ray2.30C/D133-329[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q12860

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q12860

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q12860

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 131Ig-like C2-type 1Add BLAST91
Domaini137 – 223Ig-like C2-type 2Add BLAST87
Domaini241 – 326Ig-like C2-type 3Add BLAST86
Domaini331 – 407Ig-like C2-type 4Add BLAST77
Domaini413 – 500Ig-like C2-type 5Add BLAST88
Domaini504 – 601Ig-like C2-type 6Add BLAST98
Domaini606 – 704Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini709 – 806Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini811 – 906Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini907 – 1000Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi602 – 609Gly/Pro-rich8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3513 Eukaryota
ENOG410XSVG LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155915

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051047

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q12860

KEGG Orthology (KO)

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KOi
K06759

Identification of Orthologs from Complete Genome Data

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OMAi
MNNGDID

Database of Orthologous Groups

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OrthoDBi
655902at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q12860

TreeFam database of animal gene trees

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TreeFami
TF351103

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036992 Contactin-1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

The PANTHER Classification System

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PANTHERi
PTHR43905:SF2 PTHR43905:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12860-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMWLLVSHL VIISITTCLA EFTWYRRYGH GVSEEDKGFG PIFEEQPINT
60 70 80 90 100
IYPEESLEGK VSLNCRARAS PFPVYKWRMN NGDVDLTSDR YSMVGGNLVI
110 120 130 140 150
NNPDKQKDAG IYYCLASNNY GMVRSTEATL SFGYLDPFPP EERPEVRVKE
160 170 180 190 200
GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF ITMDKRRFVS QTNGNLYIAN
210 220 230 240 250
VEASDKGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY PADIVVQFKD
260 270 280 290 300
VYALMGQNVT LECFALGNPV PDIRWRKVLE PMPSTAEIST SGAVLKIFNI
310 320 330 340 350
QLEDEGIYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW
360 370 380 390 400
PCVATGKPIP TIRWLKNGYA YHKGELRLYD VTFENAGMYQ CIAENTYGAI
410 420 430 440 450
YANAELKILA LAPTFEMNPM KKKILAAKGG RVIIECKPKA APKPKFSWSK
460 470 480 490 500
GTEWLVNSSR ILIWEDGSLE INNITRNDGG IYTCFAENNR GKANSTGTLV
510 520 530 540 550
ITDPTRIILA PINADITVGE NATMQCAASF DPALDLTFVW SFNGYVIDFN
560 570 580 590 600
KENIHYQRNF MLDSNGELLI RNAQLKHAGR YTCTAQTIVD NSSASADLVV
610 620 630 640 650
RGPPGPPGGL RIEDIRATSV ALTWSRGSDN HSPISKYTIQ TKTILSDDWK
660 670 680 690 700
DAKTDPPIIE GNMEAARAVD LIPWMEYEFR VVATNTLGRG EPSIPSNRIK
710 720 730 740 750
TDGAAPNVAP SDVGGGGGRN RELTITWAPL SREYHYGNNF GYIVAFKPFD
760 770 780 790 800
GEEWKKVTVT NPDTGRYVHK DETMSPSTAF QVKVKAFNNK GDGPYSLVAV
810 820 830 840 850
INSAQDAPSE APTEVGVKVL SSSEISVHWE HVLEKIVESY QIRYWAAHDK
860 870 880 890 900
EEAANRVQVT SQEYSARLEN LLPDTQYFIE VGACNSAGCG PPSDMIEAFT
910 920 930 940 950
KKAPPSQPPR IISSVRSGSR YIITWDHVVA LSNESTVTGY KVLYRPDGQH
960 970 980 990 1000
DGKLYSTHKH SIEVPIPRDG EYVVEVRAHS DGGDGVVSQV KISGAPTLSP
1010
SLLGLLLPAF GILVYLEF
Length:1,018
Mass (Da):113,320
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B8FDC5BFD434ED5
GO
Isoform 2 (identifier: Q12860-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-31: Missing.

Show »
Length:1,007
Mass (Da):111,867
Checksum:i0078E9F82F498EE0
GO
Isoform 3 (identifier: Q12860-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     603-627: PPGPPGGLRIEDIRATSVALTWSRG → KNRKGGEKNMVDSFLPVCASLPPTW
     628-1018: Missing.

Show »
Length:627
Mass (Da):70,604
Checksum:i86825008EAAA085A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VUI9F8VUI9_HUMAN
Contactin-1
CNTN1
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VUI8F8VUI8_HUMAN
Contactin-1
CNTN1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQW3F8VQW3_HUMAN
Contactin-1
CNTN1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VX96F8VX96_HUMAN
Contactin-1
CNTN1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIJ1H0YIJ1_HUMAN
Contactin-1
CNTN1
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti682V → I AA sequence (PubMed:2026173).Curated1
Sequence conflicti687L → P AA sequence (PubMed:2026173).Curated1
Sequence conflicti689R → I AA sequence (PubMed:2026173).Curated1
Sequence conflicti692P → F AA sequence (PubMed:2026173).Curated1
Isoform 3 (identifier: Q12860-3)
Sequence conflicti610K → I in BAF82233 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035506794P → H in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_011722798V → L. Corresponds to variant dbSNP:rs1056020Ensembl.1
Natural variantiVAR_049866824E → G. Corresponds to variant dbSNP:rs11553341Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00250021 – 31Missing in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_011959603 – 627PPGPP…TWSRG → KNRKGGEKNMVDSFLPVCAS LPPTW in isoform 3. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_011960628 – 1018Missing in isoform 3. 2 PublicationsAdd BLAST391

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z21488 mRNA Translation: CAA79696.1
U07819 mRNA Translation: AAA67920.1
U07820 mRNA Translation: AAA67921.1
AK289544 mRNA Translation: BAF82233.1
AK289698 mRNA Translation: BAF82387.1
BC036569 mRNA Translation: AAH36569.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS58225.1 [Q12860-3]
CCDS8737.1 [Q12860-1]
CCDS8738.1 [Q12860-2]

Protein sequence database of the Protein Information Resource

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PIRi
A54744
S15394

NCBI Reference Sequences

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RefSeqi
NP_001242992.1, NM_001256063.1 [Q12860-3]
NP_001242993.1, NM_001256064.1 [Q12860-3]
NP_001834.2, NM_001843.3 [Q12860-1]
NP_778203.1, NM_175038.2 [Q12860-2]
XP_005268708.1, XM_005268651.2 [Q12860-1]
XP_006719304.1, XM_006719241.2 [Q12860-1]
XP_011536228.1, XM_011537926.2 [Q12860-1]
XP_011536229.1, XM_011537927.2 [Q12860-1]
XP_016874314.1, XM_017018825.1
XP_016874315.1, XM_017018826.1 [Q12860-3]
XP_016874316.1, XM_017018827.1 [Q12860-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.143434
Hs.739161
Hs.741112

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000347616; ENSP00000325660; ENSG00000018236 [Q12860-1]
ENST00000348761; ENSP00000261160; ENSG00000018236 [Q12860-2]
ENST00000547702; ENSP00000448004; ENSG00000018236 [Q12860-3]
ENST00000547849; ENSP00000448653; ENSG00000018236 [Q12860-3]
ENST00000551295; ENSP00000447006; ENSG00000018236 [Q12860-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1272

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1272

UCSC genome browser

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UCSCi
uc001rmm.3 human [Q12860-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21488 mRNA Translation: CAA79696.1
U07819 mRNA Translation: AAA67920.1
U07820 mRNA Translation: AAA67921.1
AK289544 mRNA Translation: BAF82233.1
AK289698 mRNA Translation: BAF82387.1
BC036569 mRNA Translation: AAH36569.1
CCDSiCCDS58225.1 [Q12860-3]
CCDS8737.1 [Q12860-1]
CCDS8738.1 [Q12860-2]
PIRiA54744
S15394
RefSeqiNP_001242992.1, NM_001256063.1 [Q12860-3]
NP_001242993.1, NM_001256064.1 [Q12860-3]
NP_001834.2, NM_001843.3 [Q12860-1]
NP_778203.1, NM_175038.2 [Q12860-2]
XP_005268708.1, XM_005268651.2 [Q12860-1]
XP_006719304.1, XM_006719241.2 [Q12860-1]
XP_011536228.1, XM_011537926.2 [Q12860-1]
XP_011536229.1, XM_011537927.2 [Q12860-1]
XP_016874314.1, XM_017018825.1
XP_016874315.1, XM_017018826.1 [Q12860-3]
XP_016874316.1, XM_017018827.1 [Q12860-3]
UniGeneiHs.143434
Hs.739161
Hs.741112

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EE2NMR-A798-903[»]
3S97X-ray2.30C/D133-329[»]
ProteinModelPortaliQ12860
SMRiQ12860
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107672, 26 interactors
DIPiDIP-59714N
IntActiQ12860, 8 interactors
MINTiQ12860
STRINGi9606.ENSP00000325660

PTM databases

GlyConnecti1930
iPTMnetiQ12860
PhosphoSitePlusiQ12860
SwissPalmiQ12860

Polymorphism and mutation databases

BioMutaiCNTN1
DMDMi2497301

Proteomic databases

EPDiQ12860
jPOSTiQ12860
MaxQBiQ12860
PaxDbiQ12860
PeptideAtlasiQ12860
PRIDEiQ12860
ProteomicsDBi58988
58989 [Q12860-2]
58990 [Q12860-3]
TopDownProteomicsiQ12860-3 [Q12860-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1272
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347616; ENSP00000325660; ENSG00000018236 [Q12860-1]
ENST00000348761; ENSP00000261160; ENSG00000018236 [Q12860-2]
ENST00000547702; ENSP00000448004; ENSG00000018236 [Q12860-3]
ENST00000547849; ENSP00000448653; ENSG00000018236 [Q12860-3]
ENST00000551295; ENSP00000447006; ENSG00000018236 [Q12860-1]
GeneIDi1272
KEGGihsa:1272
UCSCiuc001rmm.3 human [Q12860-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1272
DisGeNETi1272
EuPathDBiHostDB:ENSG00000018236.14

GeneCards: human genes, protein and diseases

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GeneCardsi
CNTN1
HGNCiHGNC:2171 CNTN1
HPAiCAB025200
HPA070467
MalaCardsiCNTN1
MIMi600016 gene
612540 phenotype
neXtProtiNX_Q12860
OpenTargetsiENSG00000018236
Orphaneti210163 Congenital lethal myopathy, Compton-North type
PharmGKBiPA26685

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00940000155915
HOVERGENiHBG051047
InParanoidiQ12860
KOiK06759
OMAiMNNGDID
OrthoDBi655902at2759
PhylomeDBiQ12860
TreeFamiTF351103

Enzyme and pathway databases

ReactomeiR-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
R-HSA-373760 L1CAM interactions
R-HSA-447043 Neurofascin interactions
SignaLinkiQ12860

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CNTN1 human
EvolutionaryTraceiQ12860

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CNTN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1272

Protein Ontology

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PROi
PR:Q12860

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000018236 Expressed in 178 organ(s), highest expression level in corpus callosum
CleanExiHS_CNTN1
ExpressionAtlasiQ12860 baseline and differential
GenevisibleiQ12860 HS

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR036992 Contactin-1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR43905:SF2 PTHR43905:SF2, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNTN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12860
Secondary accession number(s): A8K0H9
, A8K0Y3, Q12861, Q14030, Q7M4P0, Q8N466
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 16, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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