UniProtKB - Q12852 (M3K12_HUMAN)

BLAST

>sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 OS=Homo sapiens OX=9606 GN=MAP3K12 PE=1 SV=2
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP

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History
Entry version 177 (10 Oct 2018)
Sequence version 2 (17 Oct 2006)
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Protein

Mitogen-activated protein kinase kinase kinase 12

Gene

MAP3K12

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	152	ATPPROSITE-ProRule annotation		1
Active siteⁱ	236	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	131 – 139	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
JUN kinase kinase kinase activity Source: ARUK-UCL
protein homodimerization activity Source: UniProtKB
protein kinase activity
Source: ProtInc
Traceable author statementⁱ
- 8637721
- 8663324
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14697235
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 9353328

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of JNKK activity Source: ARUK-UCL
activation of JUN kinase activity Source: ARUK-UCL
histone phosphorylation Source: UniProtKB
intracellular signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7983011
JNK cascade
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 9353328
MAPK cascade Source: GO_Central
negative regulation of motor neuron apoptotic process Source: Ensembl
peptidyl-serine phosphorylation Source: UniProtKB
peptidyl-threonine phosphorylation Source: UniProtKB
protein autophosphorylation
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 9353328
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 14697235

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q12852
SIGNORⁱ	Q12852

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitogen-activated protein kinase kinase kinase 12 (EC:2.7.11.25) Alternative name(s): Dual leucine zipper bearing kinase Short name: DLK Leucine-zipper protein kinase Short name: ZPK MAPK-upstream kinase Short name: MUK Mixed lineage kinase
Gene namesⁱ	Name:MAP3K12 Synonyms:ZPK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139625.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6851 MAP3K12
MIMⁱ	600447 gene
neXtProtⁱ	NX_Q12852

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7786
Open Targets More...OpenTargetsⁱ	ENSG00000139625
PharmGKBⁱ	PA30595

Chemistry databases

ChEMBLⁱ	CHEMBL1908389
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2072

Polymorphism and mutation databases

BioMutaⁱ	MAP3K12
DMDMⁱ	116242624

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086261	1 – 859	Mitogen-activated protein kinase kinase kinase 12Add BLAST		859

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	37	PhosphothreonineBy similarity	1
Modified residueⁱ	43	PhosphothreonineBy similarity	1
Modified residueⁱ	607	PhosphoserineBy similarity	1
Modified residueⁱ	695	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q12852
PeptideAtlas More...PeptideAtlasⁱ	Q12852
PRIDEⁱ	Q12852
ProteomicsDBⁱ	58985

PTM databases

iPTMnetⁱ	Q12852
PhosphoSitePlusⁱ	Q12852

Expressionⁱ

Tissue specificityⁱ

Highly expressed in brain and kidney.

Gene expression databases

Bgeeⁱ	ENSG00000139625 Expressed in 212 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_MAP3K12
ExpressionAtlasⁱ	Q12852 baseline and differential
Genevisibleⁱ	Q12852 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039936 HPA071996

HPAⁱ

HPA039936
HPA071996

Interactionⁱ

Subunit structureⁱ

Interacts with MBIP.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FRA10AC1	Q70Z53	2	EBI-710223,EBI-710176

With

Entry

#Exp.

IntAct

Notes

FRA10AC1

Q70Z53

EBI-710223,EBI-710176

GO - Molecular functionⁱ

protein homodimerization activity Source: UniProtKB
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14697235

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113566, 13 interactors
IntActⁱ	Q12852, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q12852
STRINGⁱ	9606.ENSP00000448689

Chemistry databases

BindingDBⁱ

Q12852

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	122 – 124	Combined sources	3
Beta strandⁱ	126 – 134	Combined sources	9
Beta strandⁱ	137 – 144	Combined sources	8
Beta strandⁱ	147 – 153	Combined sources	7
Helixⁱ	157 – 160	Combined sources	4
Helixⁱ	163 – 165	Combined sources	3
Beta strandⁱ	176 – 180	Combined sources	5
Beta strandⁱ	187 – 191	Combined sources	5
Helixⁱ	198 – 203	Combined sources	6
Helixⁱ	210 – 229	Combined sources	20
Helixⁱ	239 – 241	Combined sources	3
Beta strandⁱ	242 – 244	Combined sources	3
Beta strandⁱ	250 – 252	Combined sources	3
Helixⁱ	264 – 271	Combined sources	8
Helixⁱ	272 – 276	Combined sources	5
Helixⁱ	279 – 282	Combined sources	4
Helixⁱ	290 – 305	Combined sources	16
Turnⁱ	309 – 312	Combined sources	4
Helixⁱ	315 – 323	Combined sources	9
Helixⁱ	337 – 346	Combined sources	10
Helixⁱ	351 – 353	Combined sources	3
Helixⁱ	357 – 372	Combined sources	16
Helixⁱ	376 – 396	Combined sources	21

Show more details

3D structure databases

ProteinModelPortalⁱ	Q12852
SMRⁱ	Q12852
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	125 – 366	Protein kinasePROSITE-ProRule annotationAdd BLAST		242

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	390 – 411	Leucine-zipper 1Add BLAST		22
Regionⁱ	443 – 464	Leucine-zipper 2Add BLAST		22

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	665 – 668	Poly-Pro		4
Compositional biasⁱ	720 – 731	Glu-rich (acidic)Add BLAST		12

Domainⁱ

Interacts with MBIP through the leucine-zipper motif.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG4721 Eukaryota ENOG410YKX2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140790
HOGENOMⁱ	HOG000113435
HOVERGENⁱ	HBG052383
InParanoidⁱ	Q12852
KEGG Orthology (KO) More...KOⁱ	K04423
OMAⁱ	RRGKPRY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0905
PhylomeDBⁱ	Q12852

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR017419 MAP3K12_MAP3K13 IPR027257 MAPKKK12 IPR000719 Prot_kinase_dom IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07714 Pkinase_Tyr, 1 hit
PIRSFⁱ	PIRSF500741 MAPKKK12, 1 hit PIRSF038165 MAPKKK12_MAPKKK13, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q12852-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTHVLQL 
        60         70         80         90        100
HEQDAGGPGG AAGSPESRAS RVRADEVRLQ CQSGSGFLEG LFGCLRPVWT 
       110        120        130        140        150
MIGKAYSTEH KQQQEDLWEV PFEEILDLQW VGSGAQGAVF LGRFHGEEVA 
       160        170        180        190        200
VKKVRDLKET DIKHLRKLKH PNIITFKGVC TQAPCYCILM EFCAQGQLYE 
       210        220        230        240        250
VLRAGRPVTP SLLVDWSMGI AGGMNYLHLH KIIHRDLKSP NMLITYDDVV 
       260        270        280        290        300
KISDFGTSKE LSDKSTKMSF AGTVAWMAPE VIRNEPVSEK VDIWSFGVVL 
       310        320        330        340        350
WELLTGEIPY KDVDSSAIIW GVGSNSLHLP VPSSCPDGFK ILLRQCWNSK 
       360        370        380        390        400
PRNRPSFRQI LLHLDIASAD VLSTPQETYF KSQAEWREEV KLHFEKIKSE 
       410        420        430        440        450
GTCLHRLEEE LVMRRREELR HALDIREHYE RKLERANNLY MELNALMLQL 
       460        470        480        490        500
ELKERELLRR EQALERRCPG LLKPHPSRGL LHGNTMEKLI KKRNVPQKLS 
       510        520        530        540        550
PHSKRPDILK TESLLPKLDA ALSGVGLPGC PKGPPSPGRS RRGKTRHRKA 
       560        570        580        590        600
SAKGSCGDLP GLRTAVPPHE PGGPGSPGGL GGGPSAWEAC PPALRGLHHD 
       610        620        630        640        650
LLLRKMSSSS PDLLSAALGS RGRGATGGAG DPGSPPPARG DTPPSEGSAP 
       660        670        680        690        700
GSTSPDSPGG AKGEPPPPVG PGEGVGLLGT GREGTSGRGG SRAGSQHLTP 
       710        720        730        740        750
AALLYRAAVT RSQKRGISSE EEEGEVDSEV ELTSSQRWPQ SLNMRQSLST 
       760        770        780        790        800
FSSENPSDGE EGTASEPSPS GTPEVGSTNT DERPDERSDD MCSQGSEIPL 
       810        820        830        840        850
DPPPSEVIPG PEPSSLPIPH QELLRERGPP NSEDSDCDST ELDNSNSVDA 

LRPPASLPP

Length:859

Mass (Da):93,219

Last modified:October 17, 2006 - v2

Checksum:ⁱ1E1BCAD2F6DFCFE8

Isoform 2 (identifier: Q12852-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
46-46: H → QCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANS

« Hide

        10         20         30         40         50
MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR 
        60         70         80         90        100
DVVPLGGQGG GGPSPSPGGE PPPEPFANSV LQLHEQDAGG PGGAAGSPES 
       110        120        130        140        150
RASRVRADEV RLQCQSGSGF LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL 
       160        170        180        190        200
WEVPFEEILD LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK 
       210        220        230        240        250
LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS 
       260        270        280        290        300
MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 
       310        320        330        340        350
MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA 
       360        370        380        390        400
IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA 
       410        420        430        440        450
SADVLSTPQE TYFKSQAEWR EEVKLHFEKI KSEGTCLHRL EEELVMRRRE 
       460        470        480        490        500
ELRHALDIRE HYERKLERAN NLYMELNALM LQLELKEREL LRREQALERR 
       510        520        530        540        550
CPGLLKPHPS RGLLHGNTME KLIKKRNVPQ KLSPHSKRPD ILKTESLLPK 
       560        570        580        590        600
LDAALSGVGL PGCPKGPPSP GRSRRGKTRH RKASAKGSCG DLPGLRTAVP 
       610        620        630        640        650
PHEPGGPGSP GGLGGGPSAW EACPPALRGL HHDLLLRKMS SSSPDLLSAA 
       660        670        680        690        700
LGSRGRGATG GAGDPGSPPP ARGDTPPSEG SAPGSTSPDS PGGAKGEPPP 
       710        720        730        740        750
PVGPGEGVGL LGTGREGTSG RGGSRAGSQH LTPAALLYRA AVTRSQKRGI 
       760        770        780        790        800
SSEEEEGEVD SEVELTSSQR WPQSLNMRQS LSTFSSENPS DGEEGTASEP 
       810        820        830        840        850
SPSGTPEVGS TNTDERPDER SDDMCSQGSE IPLDPPPSEV IPGPEPSSLP 
       860        870        880        890 
IPHQELLRER GPPNSEDSDC DSTELDNSNS VDALRPPASL PP

Note: No experimental confirmation available.

Show »

Length:892

Mass (Da):96,322

Checksum:ⁱEA0C10CFE2461876

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VUG4	F8VUG4_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase 12	MAP3K12	393	Annotation score:
H3BMF0	H3BMF0_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase 12	MAP3K12	25	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	355	P → S in BAG52841 (PubMed:14702039).Curated	1
Sequence conflictⁱ	498	K → N in AAA67343 (PubMed:8037767).Curated	1
Sequence conflictⁱ	504	K → Q in AAA67343 (PubMed:8037767).Curated	1
Sequence conflictⁱ	511	T → A in AAA67343 (PubMed:8037767).Curated	1
Sequence conflictⁱ	533	G → A in AAA67343 (PubMed:8037767).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040705	409	E → K in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040706	628	G → R1 PublicationCorresponds to variant dbSNP:rs34366500Ensembl.	1
Natural variantⁱVAR_040707	640	G → S1 PublicationCorresponds to variant dbSNP:rs55794887Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044646	46	H → QCVLRDVVPLGGQGGGGPSP SPGGEPPPEPFANS in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U07358 mRNA Translation: AAA67343.1 AF283475 Genomic DNA Translation: AAL67158.1 AK094195 mRNA Translation: BAG52841.1 AC023509 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96715.1 BC050050 mRNA Translation: AAH50050.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55831.1 [Q12852-2] CCDS8860.1 [Q12852-1]
PIRⁱ	JC2363
NCBI Reference Sequences More...RefSeqⁱ	NP_001180440.1, NM_001193511.1 [Q12852-2] NP_006292.3, NM_006301.3 [Q12852-1] XP_005269195.1, XM_005269138.3 [Q12852-2] XP_006719651.1, XM_006719588.3 [Q12852-2] XP_011537027.1, XM_011538725.2 [Q12852-2] XP_016875445.1, XM_017019956.1 [Q12852-1]
UniGeneⁱ	Hs.713539

Genome annotation databases

Ensemblⁱ	ENST00000267079; ENSP00000267079; ENSG00000139625 [Q12852-1] ENST00000547035; ENSP00000448689; ENSG00000139625 [Q12852-2] ENST00000547488; ENSP00000449038; ENSG00000139625 [Q12852-2]
GeneIDⁱ	7786
KEGGⁱ	hsa:7786
UCSC genome browser More...UCSCⁱ	uc001sdm.3 human [Q12852-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q12852	Mitogen-activated protein kinase kinase kinase 12		HUMAN		859	UniRef100_Q12852
Q12852-2	Mitogen-activated protein kinase kinase kinase 12, isoform CRA_b		HUMAN		670	UniRef100_A0A024RAZ2

Protein	Similar proteins		Species	Score	Length	Source
Q12852	Mitogen-activated protein kinase kinase kinase 12		MOUSE		888	UniRef90_Q60700
Mitogen-activated protein kinase kinase kinase 12		RAT		888
Mitogen-activated protein kinase kinase kinase 12		FUKDA		938
Mitogen-activated protein kinase kinase kinase 12		DELLE		929
Mitogen-activated protein kinase kinase kinase 12		CAMFR		908
+234

Protein	Similar proteins		Species	Score	Length	Source
Q12852	Mitogen-activated protein kinase kinase kinase 12		MOUSE		888	UniRef50_Q60700
Mitogen-activated protein kinase kinase kinase 12		RAT		888
Mitogen-activated protein kinase kinase kinase 12		FUKDA		938
Mitogen-activated protein kinase kinase kinase 12		DELLE		929
Mitogen-activated protein kinase kinase kinase 12		CAMFR		908
+339

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U07358 mRNA Translation: AAA67343.1 AF283475 Genomic DNA Translation: AAL67158.1 AK094195 mRNA Translation: BAG52841.1 AC023509 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96715.1 BC050050 mRNA Translation: AAH50050.1 Sequence problems.
CCDSⁱ	CCDS55831.1 [Q12852-2] CCDS8860.1 [Q12852-1]
PIRⁱ	JC2363
RefSeqⁱ	NP_001180440.1, NM_001193511.1 [Q12852-2] NP_006292.3, NM_006301.3 [Q12852-1] XP_005269195.1, XM_005269138.3 [Q12852-2] XP_006719651.1, XM_006719588.3 [Q12852-2] XP_011537027.1, XM_011538725.2 [Q12852-2] XP_016875445.1, XM_017019956.1 [Q12852-1]
UniGeneⁱ	Hs.713539

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5CEN	X-ray	1.70	A	115-402	[»]
	5CEO	X-ray	2.28	A	115-402	[»]
	5CEP	X-ray	1.99	A	115-402	[»]
	5CEQ	X-ray	1.91	A	115-402	[»]
	5VO1	X-ray	2.45	A	115-402	[»]
	5VO2	X-ray	2.96	A	115-402	[»]
ProteinModelPortalⁱ	Q12852
SMRⁱ	Q12852
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113566, 13 interactors
IntActⁱ	Q12852, 9 interactors
MINTⁱ	Q12852
STRINGⁱ	9606.ENSP00000448689

Chemistry databases

BindingDBⁱ	Q12852
ChEMBLⁱ	CHEMBL1908389
GuidetoPHARMACOLOGYⁱ	2072

PTM databases

iPTMnetⁱ	Q12852
PhosphoSitePlusⁱ	Q12852

Polymorphism and mutation databases

BioMutaⁱ	MAP3K12
DMDMⁱ	116242624

Proteomic databases

PaxDbⁱ	Q12852
PeptideAtlasⁱ	Q12852
PRIDEⁱ	Q12852
ProteomicsDBⁱ	58985

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7786
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000267079; ENSP00000267079; ENSG00000139625 [Q12852-1] ENST00000547035; ENSP00000448689; ENSG00000139625 [Q12852-2] ENST00000547488; ENSP00000449038; ENSG00000139625 [Q12852-2]
GeneIDⁱ	7786
KEGGⁱ	hsa:7786
UCSCⁱ	uc001sdm.3 human [Q12852-1]

Organism-specific databases

CTDⁱ	7786
DisGeNETⁱ	7786
EuPathDBⁱ	HostDB:ENSG00000139625.12
GeneCardsⁱ	MAP3K12
H-InvDBⁱ	HIX0010672
HGNCⁱ	HGNC:6851 MAP3K12
HPAⁱ	HPA039936 HPA071996
MIMⁱ	600447 gene
neXtProtⁱ	NX_Q12852
OpenTargetsⁱ	ENSG00000139625
PharmGKBⁱ	PA30595
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4721 Eukaryota ENOG410YKX2 LUCA
GeneTreeⁱ	ENSGT00900000140790
HOGENOMⁱ	HOG000113435
HOVERGENⁱ	HBG052383
InParanoidⁱ	Q12852
KOⁱ	K04423
OMAⁱ	RRGKPRY
OrthoDBⁱ	EOG091G0905
PhylomeDBⁱ	Q12852

Enzyme and pathway databases

SignaLinkⁱ	Q12852
SIGNORⁱ	Q12852

Miscellaneous databases

ChiTaRSⁱ	MAP3K12 human
GeneWikiⁱ	MAP3K12
GenomeRNAiⁱ	7786
Protein Ontology More...PROⁱ	PR:Q12852
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139625 Expressed in 212 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_MAP3K12
ExpressionAtlasⁱ	Q12852 baseline and differential
Genevisibleⁱ	Q12852 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR017419 MAP3K12_MAP3K13 IPR027257 MAPKKK12 IPR000719 Prot_kinase_dom IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF07714 Pkinase_Tyr, 1 hit
PIRSFⁱ	PIRSF500741 MAPKKK12, 1 hit PIRSF038165 MAPKKK12_MAPKKK13, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M3K12_HUMAN
Accessionⁱ	Q12852Primary (citable) accession number: Q12852 Secondary accession number(s): B3KSS9 , G3V1Y2, Q86VQ5, Q8WY25
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
	Last sequence update:	October 17, 2006
	Last modified:	October 10, 2018
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

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UniProtKB - Q12852 (M3K12_HUMAN)

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Mitogen-activated protein kinase kinase kinase 12

MAP3K12

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

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Keywords - Cellular componenti

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

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GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

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Keywords - Coding sequence diversityi

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Miscellaneous databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ