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Entry version 170 (16 Oct 2019)
Sequence version 3 (25 Nov 2008)
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Protein

G-rich sequence factor 1

Gene

GRSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381).3 Publications

Miscellaneous

Depletion of GRSF1 by siRNA results in a combined OXPHOS assembly defect, with the prominent loss of complexes I, III, IV, and V. It also leads to altered steady-state levels of mitochondrial rRNAs and mRNAs.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, tRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-192823 Viral mRNA Translation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-rich sequence factor 1
Short name:
GRSF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRSF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4610 GRSF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604851 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12849

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi155Q → A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-159; A-223; A-255; A-259; A-320; A-406; A-410 and A-470. 1
Mutagenesisi159W → A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-223; A-255; A-259; A-320; A-406; A-410 and A-470. 1
Mutagenesisi223E → A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-255; A-259; A-320; A-406; A-410 and A-470. 1
Mutagenesisi255R → A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-259; A-320; A-406; A-410 and A-470. 1
Mutagenesisi259Y → A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-255; A-320; A-406; A-410 and A-470. 1
Mutagenesisi320E → A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-255; A-259; A-406; A-410 and A-470. 1
Mutagenesisi406R → A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-255; A-259; A-320; A-410 and A-470. 1
Mutagenesisi410F → A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-255; A-259; A-320; A-406 and A-470. 1
Mutagenesisi470E → A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-255; A-259; A-320; A-406 and A-410. 1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2926

Open Targets

More...
OpenTargetsi
ENSG00000132463

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29003

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12849

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GRSF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274142

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 117MitochondrionSequence analysisAdd BLAST117
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000081597118 – 480G-rich sequence factor 1Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei244PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12849

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q12849

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q12849

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12849

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12849

PeptideAtlas

More...
PeptideAtlasi
Q12849

PRoteomics IDEntifications database

More...
PRIDEi
Q12849

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58982 [Q12849-1]
58983 [Q12849-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12849

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12849

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q12849

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132463 Expressed in 235 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12849 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12849 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036984
HPA036985

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Found in a complex with DDX28, DHX30, FASTKD2 and FASTKD5 (PubMed:25683715).

Interacts with the mitochondrial RNase P complex subunit TRMT10C/MRPP1 (PubMed:23473034).

Interacts with the 2 components of the mitochondrial degradosome complex, PNPT1 and SUPV3L1, in an RNA-dependent manner (PubMed:29967381).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
O758324EBI-1054150,EBI-752185

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109182, 102 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q12849

Protein interaction database and analysis system

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IntActi
Q12849, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254799

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q12849

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini122 – 246RRM 1PROSITE-ProRule annotationAdd BLAST125
Domaini250 – 326RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini401 – 480RRM 3PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 111Ala-richAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RRM domains mediate RNA-binding.1 Publication

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ3R Eukaryota
ENOG410YEKV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220896

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12849

Database of Orthologous Groups

More...
OrthoDBi
603679at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12849

TreeFam database of animal gene trees

More...
TreeFami
TF316157

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12730 RRM1_GRSF1, 1 hit
cd12505 RRM2_GRSF1, 1 hit
cd12733 RRM3_GRSF1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034424 GRSF-1_RRM2
IPR033106 GRSF1
IPR034425 GRSF1_RRM1
IPR034426 GRSF1_RRM3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

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PANTHERi
PTHR13976:SF42 PTHR13976:SF42, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12849-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGTRWVLGA LLRGCGCNCS SCRRTGAACL PFYSAAGSIP SGVSGRRRLL
60 70 80 90 100
LLLGAAAAAA SQTRGLQTGP VPPGRLAGPP AVATSAAAAA AASYSALRAS
110 120 130 140 150
LLPQSLAAAA AVPTRSYSQE SKTTYLEDLP PPPEYELAPS KLEEEVDDVF
160 170 180 190 200
LIRAQGLPWS CTMEDVLNFF SDCRIRNGEN GIHFLLNRDG KRRGDALIEM
210 220 230 240 250
ESEQDVQKAL EKHRMYMGQR YVEVYEINNE DVDALMKSLQ VKSSPVVNDG
260 270 280 290 300
VVRLRGLPYS CNEKDIVDFF AGLNIVDITF VMDYRGRRKT GEAYVQFEEP
310 320 330 340 350
EMANQALLKH REEIGNRYIE IFPSRRNEVR THVGSYKGKK IASFPTAKYI
360 370 380 390 400
TEPEMVFEEH EVNEDIQPMT AFESEKEIEL PKEVPEKLPE AADFGTTSSL
410 420 430 440 450
HFVHMRGLPF QANAQDIINF FAPLKPVRIT MEYSSSGKAT GEADVHFETH
460 470 480
EDAVAAMLKD RSHVHHRYIE LFLNSCPKGK
Length:480
Mass (Da):53,126
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE09EE4E70212A70F
GO
Isoform 2 (identifier: Q12849-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Note: No experimental confirmation available.
Show »
Length:318
Mass (Da):36,613
Checksum:iF0AB13A4797FFEBD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAK1H0YAK1_HUMAN
G-rich sequence factor 1
GRSF1
453Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8R1H0Y8R1_HUMAN
G-rich sequence factor 1
GRSF1
417Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5I6F5H5I6_HUMAN
G-rich sequence factor 1
GRSF1
424Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAM1H0YAM1_HUMAN
G-rich sequence factor 1
GRSF1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC95399 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated
The sequence AAH40485 differs from that shown. Intron retention.Curated
The sequence AAY40942 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC03513 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated
The sequence BAC86863 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated
The sequence EAX05634 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti264K → E in BAC86863 (PubMed:14702039).Curated1
Sequence conflicti365 – 366DI → VF in AAC95399 (PubMed:8036161).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047537277D → Y1 PublicationCorresponds to variant dbSNP:rs17854012Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0431181 – 162Missing in isoform 2. 1 PublicationAdd BLAST162

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U07231 mRNA Translation: AAC95399.1 Sequence problems.
AK056891 mRNA Translation: BAG51822.1
AK090755 mRNA Translation: BAC03513.1 Sequence problems.
AK094806 mRNA Translation: BAG52934.1
AK095799 mRNA Translation: BAG53131.1
AK097055 mRNA Translation: BAG53414.1
AK127161 mRNA Translation: BAC86863.1 Sequence problems.
AC021989 Genomic DNA Translation: AAY40942.1 Sequence problems.
CH471057 Genomic DNA Translation: EAX05631.1
CH471057 Genomic DNA Translation: EAX05634.1 Sequence problems.
BC040485 mRNA Translation: AAH40485.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS47069.1 [Q12849-1]
CCDS47070.1 [Q12849-5]

Protein sequence database of the Protein Information Resource

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PIRi
S48081

NCBI Reference Sequences

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RefSeqi
NP_001091947.1, NM_001098477.1 [Q12849-5]
NP_002083.3, NM_002092.3 [Q12849-1]
XP_011530199.1, XM_011531897.2 [Q12849-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000254799; ENSP00000254799; ENSG00000132463 [Q12849-1]
ENST00000502323; ENSP00000425430; ENSG00000132463 [Q12849-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2926

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2926

UCSC genome browser

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UCSCi
uc010iia.2 human [Q12849-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07231 mRNA Translation: AAC95399.1 Sequence problems.
AK056891 mRNA Translation: BAG51822.1
AK090755 mRNA Translation: BAC03513.1 Sequence problems.
AK094806 mRNA Translation: BAG52934.1
AK095799 mRNA Translation: BAG53131.1
AK097055 mRNA Translation: BAG53414.1
AK127161 mRNA Translation: BAC86863.1 Sequence problems.
AC021989 Genomic DNA Translation: AAY40942.1 Sequence problems.
CH471057 Genomic DNA Translation: EAX05631.1
CH471057 Genomic DNA Translation: EAX05634.1 Sequence problems.
BC040485 mRNA Translation: AAH40485.1 Sequence problems.
CCDSiCCDS47069.1 [Q12849-1]
CCDS47070.1 [Q12849-5]
PIRiS48081
RefSeqiNP_001091947.1, NM_001098477.1 [Q12849-5]
NP_002083.3, NM_002092.3 [Q12849-1]
XP_011530199.1, XM_011531897.2 [Q12849-5]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LMINMR-A140-245[»]
4QU6X-ray1.75A140-245[»]
4QU7X-ray2.50A/B/C/D400-480[»]
SMRiQ12849
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109182, 102 interactors
CORUMiQ12849
IntActiQ12849, 17 interactors
STRINGi9606.ENSP00000254799

PTM databases

iPTMnetiQ12849
PhosphoSitePlusiQ12849
SwissPalmiQ12849

Polymorphism and mutation databases

BioMutaiGRSF1
DMDMi215274142

Proteomic databases

EPDiQ12849
jPOSTiQ12849
MassIVEiQ12849
MaxQBiQ12849
PaxDbiQ12849
PeptideAtlasiQ12849
PRIDEiQ12849
ProteomicsDBi58982 [Q12849-1]
58983 [Q12849-5]

Genome annotation databases

EnsembliENST00000254799; ENSP00000254799; ENSG00000132463 [Q12849-1]
ENST00000502323; ENSP00000425430; ENSG00000132463 [Q12849-5]
GeneIDi2926
KEGGihsa:2926
UCSCiuc010iia.2 human [Q12849-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2926
DisGeNETi2926

GeneCards: human genes, protein and diseases

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GeneCardsi
GRSF1
HGNCiHGNC:4610 GRSF1
HPAiHPA036984
HPA036985
MIMi604851 gene
neXtProtiNX_Q12849
OpenTargetsiENSG00000132463
PharmGKBiPA29003

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IQ3R Eukaryota
ENOG410YEKV LUCA
GeneTreeiENSGT00940000158529
HOGENOMiHOG000220896
InParanoidiQ12849
OrthoDBi603679at2759
PhylomeDBiQ12849
TreeFamiTF316157

Enzyme and pathway databases

ReactomeiR-HSA-192823 Viral mRNA Translation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GRSF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2926
PharosiQ12849

Protein Ontology

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PROi
PR:Q12849

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000132463 Expressed in 235 organ(s), highest expression level in female gonad
ExpressionAtlasiQ12849 baseline and differential
GenevisibleiQ12849 HS

Family and domain databases

CDDicd12730 RRM1_GRSF1, 1 hit
cd12505 RRM2_GRSF1, 1 hit
cd12733 RRM3_GRSF1, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034424 GRSF-1_RRM2
IPR033106 GRSF1
IPR034425 GRSF1_RRM1
IPR034426 GRSF1_RRM3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR13976:SF42 PTHR13976:SF42, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRSF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12849
Secondary accession number(s): B3KPW0
, Q4W5S5, Q6ZST3, Q8IWD6, Q8NBD2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: October 16, 2019
This is version 170 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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