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Entry version 194 (07 Oct 2020)
Sequence version 2 (15 Jul 1998)
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Protein

Syntaxin-4

Gene

STX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q12846

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114516, Disinhibition of SNARE formation
R-HSA-1236974, ER-Phagosome pathway
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-199992, trans-Golgi Network Vesicle Budding
R-HSA-449836, Other interleukin signaling

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.F.1.1.1, the synaptosomal vesicle fusion pore (svf-pore) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntaxin-4
Alternative name(s):
Renal carcinoma antigen NY-REN-31
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STX4
Synonyms:STX4A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103496.14

Human Gene Nomenclature Database

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HGNCi
HGNC:11439, STX4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
186591, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12846

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 275CytoplasmicSequence analysisAdd BLAST275
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei276 – 296Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini297ExtracellularSequence analysis1

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6810

Open Targets

More...
OpenTargetsi
ENSG00000103496

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36236

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12846, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STX4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3041737

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002102021 – 297Syntaxin-4Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei31PhosphothreonineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei208PhosphoserineBy similarity1
Modified residuei248PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12846

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q12846

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q12846

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12846

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12846

PeptideAtlas

More...
PeptideAtlasi
Q12846

PRoteomics IDEntifications database

More...
PRIDEi
Q12846

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
2361
58981 [Q12846-1]

2D gel databases

USC-OGP 2-DE database

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OGPi
Q12846

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q12846

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12846

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q12846

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103496, Expressed in C1 segment of cervical spinal cord and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12846, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12846, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000103496, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis.

Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4.

Interacts with VAMP2.

Interacts with SNAP23 and SNAPIN.

Interacts with LLGL1.

Interacts (via C-terminus) with CENPF.

Interacts with DOC2B.

Interacts with STXBP6.

Interacts with STXBP3; excludes interaction with DOC2B and SNAP25.

Interacts with STXBP4; excludes interaction with VAMP2 (By similarity).

Interacts with STXBP5L (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q12846
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-744942,EBI-11096309
ANKRD46 - isoform 1 [Q86W74-2]3EBI-744942,EBI-12109402
BET1 [O15155]6EBI-744942,EBI-749204
CYBRD1 [Q53TN4]7EBI-744942,EBI-8637742
EMD [P50402]3EBI-744942,EBI-489887
FAXDC2 [Q96IV6]3EBI-744942,EBI-12142299
GIMAP5 [Q96F15]3EBI-744942,EBI-6166686
GOSR2 [O14653]6EBI-744942,EBI-4401517
GPR152 [Q8TDT2]3EBI-744942,EBI-13345167
NAPA [P54920]3EBI-744942,EBI-749652
NAPB [Q9H115]6EBI-744942,EBI-3921185
PLP1 - isoform DM-20 [P60201-2]3EBI-744942,EBI-12188331
PSMA3 [P25788]3EBI-744942,EBI-348380
RNF4 [P78317]3EBI-744942,EBI-2340927
SEC22A [Q96IW7]6EBI-744942,EBI-8652744
SEC22B [O75396]4EBI-744942,EBI-1058865
SERP1 [Q9Y6X1]3EBI-744942,EBI-10329948
SGPL1 [O95470]3EBI-744942,EBI-1046170
SNAP47 [Q5SQN1]3EBI-744942,EBI-10244848
STX10 - isoform 2 [O60499-2]3EBI-744942,EBI-12094584
STX11 [O75558]3EBI-744942,EBI-714135
STX12 [Q86Y82]8EBI-744942,EBI-2691717
STX16 [O14662]3EBI-744942,EBI-2853548
STX16 - isoform E [O14662-5]3EBI-744942,EBI-9089968
STX1A [Q16623]3EBI-744942,EBI-712466
STX1B [P61266]3EBI-744942,EBI-9071709
STX2 - isoform 1 [P32856-2]4EBI-744942,EBI-11956649
STX3 [Q13277]8EBI-744942,EBI-1394295
STX5 [Q13190]6EBI-744942,EBI-714206
STX6 [O43752]8EBI-744942,EBI-2695795
STX7 [O15400]7EBI-744942,EBI-3221827
STX8 [Q9UNK0]6EBI-744942,EBI-727240
TCEANC - isoform 2 [Q8N8B7-2]3EBI-744942,EBI-11955057
TMEM199 [Q8N511]3EBI-744942,EBI-10265825
TMEM203 [Q969S6]3EBI-744942,EBI-12274070
TRAF3IP3 [Q9Y228]3EBI-744942,EBI-765817
USE1 [Q9NZ43]3EBI-744942,EBI-742842
VAMP1 [P23763]3EBI-744942,EBI-10201335
VAMP1 - isoform 2 [P23763-3]3EBI-744942,EBI-12097582
VAMP2 [P63027]6EBI-744942,EBI-520113
VAMP3 [Q15836]9EBI-744942,EBI-722343
VAMP4 [O75379]7EBI-744942,EBI-744953
VAMP4 - isoform 2 [O75379-2]4EBI-744942,EBI-10187996
VAMP5 [O95183]7EBI-744942,EBI-10191195
VTI1B [Q9UEU0]6EBI-744942,EBI-723716
ZFPL1 [O95159]3EBI-744942,EBI-718439

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
112679, 96 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q12846

Protein interaction database and analysis system

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IntActi
Q12846, 78 interactors

Molecular INTeraction database

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MINTi
Q12846

STRING: functional protein association networks

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STRINGi
9606.ENSP00000317714

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q12846, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q12846

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini200 – 262t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni154 – 297Interaction with CENPFBy similarityAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili43 – 163Sequence analysisAdd BLAST121

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0810, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00980000198538

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_042423_2_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q12846

KEGG Orthology (KO)

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KOi
K13502

Identification of Orthologs from Complete Genome Data

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OMAi
EADENCN

Database of Orthologous Groups

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OrthoDBi
1033833at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q12846

TreeFam database of animal gene trees

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TreeFami
TF313763

Family and domain databases

Conserved Domains Database

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CDDi
cd00179, SynN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010989, SNARE
IPR006012, Syntaxin/epimorphin_CS
IPR006011, Syntaxin_N
IPR000727, T_SNARE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05739, SNARE, 1 hit
PF00804, Syntaxin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00503, SynN, 1 hit
SM00397, t_SNARE, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47661, SSF47661, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00914, SYNTAXIN, 1 hit
PS50192, T_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12846-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRDRTHELRQ GDDSSDEEDK ERVALVVHPG TARLGSPDEE FFHKVRTIRQ
60 70 80 90 100
TIVKLGNKVQ ELEKQQVTIL ATPLPEESMK QELQNLRDEI KQLGREIRLQ
110 120 130 140 150
LKAIEPQKEE ADENYNSVNT RMRKTQHGVL SQQFVELINK CNSMQSEYRE
160 170 180 190 200
KNVERIRRQL KITNAGMVSD EELEQMLDSG QSEVFVSNIL KDTQVTRQAL
210 220 230 240 250
NEISARHSEI QQLERSIREL HDIFTFLATE VEMQGEMINR IEKNILSSAD
260 270 280 290
YVERGQEHVK TALENQKKAR KKKVLIAICV SITVVLLAVI IGVTVVG
Length:297
Mass (Da):34,180
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5084FD1C49A86BAA
GO
Isoform 2 (identifier: Q12846-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: MRDRTHELRQ...GSPDEEFFHK → MGMTARTKRT...STSPLGHPPQ

Show »
Length:295
Mass (Da):33,841
Checksum:i0E0B617DAB04A56C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFM5C9JFM5_HUMAN
Syntaxin-4
STX4
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWW0A0A087WWW0_HUMAN
Syntaxin-4
STX4
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMK2H3BMK2_HUMAN
Syntaxin-4
STX4
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti174E → D in AAA20967 (PubMed:8206394).Curated1
Sequence conflicti269A → V in AAA20967 (PubMed:8206394).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0546031 – 44MRDRT…EFFHK → MGMTARTKRTRSGSRWWCTR ARHGWGARTRSSSTSPLGHP PQ in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U07158 mRNA Translation: AAA20967.1
X85784 mRNA Translation: CAA59769.1
AJ000541 mRNA Translation: CAA04174.1
AF026007 mRNA Translation: AAB88810.1
AF318489 Transcribed RNA Translation: AAG40313.1
BT007326 mRNA Translation: AAP35990.1
AK091833 mRNA Translation: BAG52424.1
AK315716 mRNA Translation: BAG38075.1
CR541806 mRNA Translation: CAG46605.1
AC135050 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52176.1
CH471192 Genomic DNA Translation: EAW52177.1
BC002436 mRNA Translation: AAH02436.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10700.1 [Q12846-1]
CCDS61916.1 [Q12846-2]

Protein sequence database of the Protein Information Resource

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PIRi
I38517
S52726

NCBI Reference Sequences

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RefSeqi
NP_001259025.1, NM_001272096.1 [Q12846-2]
NP_004595.2, NM_004604.4 [Q12846-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000313843; ENSP00000317714; ENSG00000103496 [Q12846-1]
ENST00000394998; ENSP00000378447; ENSG00000103496 [Q12846-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6810

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6810

UCSC genome browser

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UCSCi
uc002eak.5, human [Q12846-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07158 mRNA Translation: AAA20967.1
X85784 mRNA Translation: CAA59769.1
AJ000541 mRNA Translation: CAA04174.1
AF026007 mRNA Translation: AAB88810.1
AF318489 Transcribed RNA Translation: AAG40313.1
BT007326 mRNA Translation: AAP35990.1
AK091833 mRNA Translation: BAG52424.1
AK315716 mRNA Translation: BAG38075.1
CR541806 mRNA Translation: CAG46605.1
AC135050 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52176.1
CH471192 Genomic DNA Translation: EAW52177.1
BC002436 mRNA Translation: AAH02436.1
CCDSiCCDS10700.1 [Q12846-1]
CCDS61916.1 [Q12846-2]
PIRiI38517
S52726
RefSeqiNP_001259025.1, NM_001272096.1 [Q12846-2]
NP_004595.2, NM_004604.4 [Q12846-1]

3D structure databases

SMRiQ12846
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112679, 96 interactors
CORUMiQ12846
IntActiQ12846, 78 interactors
MINTiQ12846
STRINGi9606.ENSP00000317714

Protein family/group databases

TCDBi1.F.1.1.1, the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

iPTMnetiQ12846
PhosphoSitePlusiQ12846
SwissPalmiQ12846

Polymorphism and mutation databases

BioMutaiSTX4
DMDMi3041737

2D gel databases

OGPiQ12846

Proteomic databases

EPDiQ12846
jPOSTiQ12846
MassIVEiQ12846
MaxQBiQ12846
PaxDbiQ12846
PeptideAtlasiQ12846
PRIDEiQ12846
ProteomicsDBi2361
58981 [Q12846-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
732, 269 antibodies

The DNASU plasmid repository

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DNASUi
6810

Genome annotation databases

EnsembliENST00000313843; ENSP00000317714; ENSG00000103496 [Q12846-1]
ENST00000394998; ENSP00000378447; ENSG00000103496 [Q12846-2]
GeneIDi6810
KEGGihsa:6810
UCSCiuc002eak.5, human [Q12846-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6810
DisGeNETi6810
EuPathDBiHostDB:ENSG00000103496.14

GeneCards: human genes, protein and diseases

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GeneCardsi
STX4
HGNCiHGNC:11439, STX4
HPAiENSG00000103496, Low tissue specificity
MIMi186591, gene
neXtProtiNX_Q12846
OpenTargetsiENSG00000103496
PharmGKBiPA36236

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0810, Eukaryota
GeneTreeiENSGT00980000198538
HOGENOMiCLU_042423_2_2_1
InParanoidiQ12846
KOiK13502
OMAiEADENCN
OrthoDBi1033833at2759
PhylomeDBiQ12846
TreeFamiTF313763

Enzyme and pathway databases

PathwayCommonsiQ12846
ReactomeiR-HSA-114516, Disinhibition of SNARE formation
R-HSA-1236974, ER-Phagosome pathway
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-199992, trans-Golgi Network Vesicle Budding
R-HSA-449836, Other interleukin signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6810, 195 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STX4, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
STX4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6810
PharosiQ12846, Tbio

Protein Ontology

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PROi
PR:Q12846
RNActiQ12846, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103496, Expressed in C1 segment of cervical spinal cord and 233 other tissues
ExpressionAtlasiQ12846, baseline and differential
GenevisibleiQ12846, HS

Family and domain databases

CDDicd00179, SynN, 1 hit
InterProiView protein in InterPro
IPR010989, SNARE
IPR006012, Syntaxin/epimorphin_CS
IPR006011, Syntaxin_N
IPR000727, T_SNARE_dom
PfamiView protein in Pfam
PF05739, SNARE, 1 hit
PF00804, Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503, SynN, 1 hit
SM00397, t_SNARE, 1 hit
SUPFAMiSSF47661, SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914, SYNTAXIN, 1 hit
PS50192, T_SNARE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12846
Secondary accession number(s): A8MXY0, Q15525, Q6FHE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: October 7, 2020
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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