UniProtKB - Q12841 (FSTL1_HUMAN)
Protein
Follistatin-related protein 1
Gene
FSTL1
Organism
Homo sapiens (Human)
Status
Functioni
May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).By similarity
GO - Molecular functioni
- calcium ion binding Source: InterPro
- heparin binding Source: ProtInc
GO - Biological processi
- BMP signaling pathway Source: Reactome
- cell differentiation Source: GO_Central
- cellular protein metabolic process Source: Reactome
- multicellular organism development Source: GO_Central
- post-translational protein modification Source: Reactome
- regulation of BMP signaling pathway Source: GO_Central
- response to starvation Source: Ensembl
Keywordsi
Molecular function | Heparin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q12841 |
Reactomei | R-HSA-201451, Signaling by BMP R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Protein family/group databases
MEROPSi | I01.967 |
Names & Taxonomyi
Protein namesi | Recommended name: Follistatin-related protein 1Alternative name(s): Follistatin-like protein 1 |
Gene namesi | Name:FSTL1 Synonyms:FRP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163430.9 |
HGNCi | HGNC:3972, FSTL1 |
MIMi | 605547, gene |
neXtProti | NX_Q12841 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 11167 |
OpenTargetsi | ENSG00000163430 |
PharmGKBi | PA28389 |
Miscellaneous databases
Pharosi | Q12841, Tbio |
Polymorphism and mutation databases
BioMutai | FSTL1 |
DMDMi | 2498390 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000010111 | 21 – 308 | Follistatin-related protein 1Add BLAST | 288 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 54 ↔ 84 | PROSITE-ProRule annotation | ||
Disulfide bondi | 58 ↔ 77 | PROSITE-ProRule annotation | ||
Disulfide bondi | 66 ↔ 98 | PROSITE-ProRule annotation | ||
Glycosylationi | 144 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 165 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 175 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 180 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q12841 |
jPOSTi | Q12841 |
MassIVEi | Q12841 |
MaxQBi | Q12841 |
PaxDbi | Q12841 |
PeptideAtlasi | Q12841 |
PRIDEi | Q12841 |
ProteomicsDBi | 5127 58980 [Q12841-1] |
PTM databases
GlyConnecti | 1252, 9 N-Linked glycans (1 site) |
GlyGeni | Q12841, 4 sites, 2 O-linked glycans (1 site) |
iPTMneti | Q12841 |
PhosphoSitePlusi | Q12841 |
Expressioni
Tissue specificityi
Overexpressed in synovial tissues from rheumatoid arthritis.1 Publication
Gene expression databases
Bgeei | ENSG00000163430, Expressed in connective tissue and 235 other tissues |
ExpressionAtlasi | Q12841, baseline and differential |
Genevisiblei | Q12841, HS |
Organism-specific databases
HPAi | ENSG00000163430, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SCN10A.
Binary interactionsi
Hide detailsQ12841
Protein-protein interaction databases
BioGRIDi | 116338, 42 interactors |
IntActi | Q12841, 42 interactors |
MINTi | Q12841 |
STRINGi | 9606.ENSP00000295633 |
Miscellaneous databases
RNActi | Q12841, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 53 | Follistatin-likeAdd BLAST | 24 | |
Domaini | 48 – 100 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 144 – 178 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 193 – 228 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 233 – 287 | VWFCAdd BLAST | 55 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QQAG, Eukaryota |
GeneTreei | ENSGT00940000157784 |
HOGENOMi | CLU_038229_0_0_1 |
InParanoidi | Q12841 |
OMAi | KGSQTHT |
OrthoDBi | 1079836at2759 |
PhylomeDBi | Q12841 |
TreeFami | TF106409 |
Family and domain databases
Gene3Di | 3.90.290.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR036773, TB_dom_sf |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF07648, Kazal_2, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits PS51465, KAZAL_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q12841-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWKRWLALAL ALVAVAWVRA EEELRSKSKI CANVFCGAGR ECAVTEKGEP
60 70 80 90 100
TCLCIEQCKP HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE
110 120 130 140 150
KKSVSPSASP VVCYQSNRDE LRRRIIQWLE AEIIPDGWFS KGSNYSEILD
160 170 180 190 200
KYFKNFDNGD SRLDSSEFLK FVEQNETAIN ITTYPDQENN KLLRGLCVDA
210 220 230 240 250
LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY ADGAETEVDC
260 270 280 290 300
NRCVCACGNW VCTAMTCDGK NQKGAQTQTE EEMTRYVQEL QKHQETAEKT
KRVSTKEI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J5G4 | C9J5G4_HUMAN | Follistatin-related protein 1 | FSTL1 | 139 | Annotation score: | ||
H7C4W4 | H7C4W4_HUMAN | Follistatin-related protein 1 | FSTL1 | 20 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 221 | C → S in BAF83827 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 226 | F → S in BAF83827 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055075 | 22 – 56 | Missing in isoform 2. 1 PublicationAdd BLAST | 35 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06863 mRNA Translation: AAA66062.1 D89937 mRNA Translation: BAA28707.1 AB119283 Genomic DNA Translation: BAD12167.1 AK289388 mRNA Translation: BAF82077.1 AK291138 mRNA Translation: BAF83827.1 AK300356 mRNA Translation: BAG62097.1 AK312261 mRNA Translation: BAG35192.1 AC063952 Genomic DNA No translation available. AC078982 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79526.1 CH471052 Genomic DNA Translation: EAW79527.1 BC000055 mRNA Translation: AAH00055.1 |
CCDSi | CCDS2998.1 [Q12841-1] |
PIRi | S51362 |
RefSeqi | NP_009016.1, NM_007085.4 [Q12841-1] |
Genome annotation databases
Ensembli | ENST00000295633; ENSP00000295633; ENSG00000163430 [Q12841-1] ENST00000424703; ENSP00000394355; ENSG00000163430 [Q12841-2] |
GeneIDi | 11167 |
KEGGi | hsa:11167 |
UCSCi | uc003eds.4, human [Q12841-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06863 mRNA Translation: AAA66062.1 D89937 mRNA Translation: BAA28707.1 AB119283 Genomic DNA Translation: BAD12167.1 AK289388 mRNA Translation: BAF82077.1 AK291138 mRNA Translation: BAF83827.1 AK300356 mRNA Translation: BAG62097.1 AK312261 mRNA Translation: BAG35192.1 AC063952 Genomic DNA No translation available. AC078982 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79526.1 CH471052 Genomic DNA Translation: EAW79527.1 BC000055 mRNA Translation: AAH00055.1 |
CCDSi | CCDS2998.1 [Q12841-1] |
PIRi | S51362 |
RefSeqi | NP_009016.1, NM_007085.4 [Q12841-1] |
3D structure databases
SMRi | Q12841 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116338, 42 interactors |
IntActi | Q12841, 42 interactors |
MINTi | Q12841 |
STRINGi | 9606.ENSP00000295633 |
Protein family/group databases
MEROPSi | I01.967 |
PTM databases
GlyConnecti | 1252, 9 N-Linked glycans (1 site) |
GlyGeni | Q12841, 4 sites, 2 O-linked glycans (1 site) |
iPTMneti | Q12841 |
PhosphoSitePlusi | Q12841 |
Polymorphism and mutation databases
BioMutai | FSTL1 |
DMDMi | 2498390 |
Proteomic databases
EPDi | Q12841 |
jPOSTi | Q12841 |
MassIVEi | Q12841 |
MaxQBi | Q12841 |
PaxDbi | Q12841 |
PeptideAtlasi | Q12841 |
PRIDEi | Q12841 |
ProteomicsDBi | 5127 58980 [Q12841-1] |
Protocols and materials databases
Antibodypediai | 32794, 373 antibodies |
Genome annotation databases
Ensembli | ENST00000295633; ENSP00000295633; ENSG00000163430 [Q12841-1] ENST00000424703; ENSP00000394355; ENSG00000163430 [Q12841-2] |
GeneIDi | 11167 |
KEGGi | hsa:11167 |
UCSCi | uc003eds.4, human [Q12841-1] |
Organism-specific databases
CTDi | 11167 |
DisGeNETi | 11167 |
EuPathDBi | HostDB:ENSG00000163430.9 |
GeneCardsi | FSTL1 |
HGNCi | HGNC:3972, FSTL1 |
HPAi | ENSG00000163430, Low tissue specificity |
MIMi | 605547, gene |
neXtProti | NX_Q12841 |
OpenTargetsi | ENSG00000163430 |
PharmGKBi | PA28389 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQAG, Eukaryota |
GeneTreei | ENSGT00940000157784 |
HOGENOMi | CLU_038229_0_0_1 |
InParanoidi | Q12841 |
OMAi | KGSQTHT |
OrthoDBi | 1079836at2759 |
PhylomeDBi | Q12841 |
TreeFami | TF106409 |
Enzyme and pathway databases
PathwayCommonsi | Q12841 |
Reactomei | R-HSA-201451, Signaling by BMP R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 11167, 1 hit in 844 CRISPR screens |
ChiTaRSi | FSTL1, human |
GeneWikii | FSTL1 |
GenomeRNAii | 11167 |
Pharosi | Q12841, Tbio |
PROi | PR:Q12841 |
RNActi | Q12841, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163430, Expressed in connective tissue and 235 other tissues |
ExpressionAtlasi | Q12841, baseline and differential |
Genevisiblei | Q12841, HS |
Family and domain databases
Gene3Di | 3.90.290.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR036773, TB_dom_sf |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF07648, Kazal_2, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits PS51465, KAZAL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FSTL1_HUMAN | |
Accessioni | Q12841Primary (citable) accession number: Q12841 Secondary accession number(s): A8K523 Q549Z0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot