UniProtKB - Q12840 (KIF5A_HUMAN)
Kinesin heavy chain isoform 5A
KIF5A
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 86 – 93 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
- kinesin binding Source: Ensembl
- microtubule binding Source: GO_Central
- microtubule motor activity Source: GO_Central
- motor activity Source: ProtInc
GO - Biological processi
- anterograde axonal protein transport Source: UniProtKB
- anterograde dendritic transport of neurotransmitter receptor complex Source: GO_Central
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- axon guidance Source: GO_Central
- chemical synaptic transmission Source: ProtInc
- cytoskeleton-dependent intracellular transport Source: GO_Central
- microtubule-based movement Source: GO_Central
- retrograde neuronal dense core vesicle transport Source: ARUK-UCL
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: Reactome
- synaptic vesicle transport Source: GO_Central
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q12840 |
Reactomei | R-HSA-2132295, MHC class II antigen presentation R-HSA-264876, Insulin processing R-HSA-5625970, RHO GTPases activate KTN1 R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
SignaLinki | Q12840 |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin heavy chain isoform 5AAlternative name(s): Kinesin heavy chain neuron-specific 1 Neuronal kinesin heavy chain Short name: NKHC |
Gene namesi | Name:KIF5A Synonyms:NKHC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000155980.11 |
HGNCi | HGNC:6323, KIF5A |
MIMi | 602821, gene |
neXtProti | NX_Q12840 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- perinuclear region By similarity
- Perikaryon By similarity
Note: Concentrated in the cell body of the neurons, particularly in the perinuclear region.By similarity
Cytoskeleton
- ciliary rootlet Source: Ensembl
- kinesin complex Source: GO_Central
- microtubule Source: GO_Central
Cytosol
- cytosol Source: Reactome
Other locations
- axon cytoplasm Source: GOC
- dendrite cytoplasm Source: GOC
- membrane Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- synapse Source: GOC
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Involvement in diseasei
Spastic paraplegia 10, autosomal dominant (SPG10)8 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058741 | 63 | Y → C in SPG10; complicated form. 1 Publication | 1 | |
Natural variantiVAR_058742 | 198 | M → T in SPG10; complicated form. 1 Publication | 1 | |
Natural variantiVAR_066616 | 203 | S → C in SPG10. 1 Publication | 1 | |
Natural variantiVAR_058743 | 204 | R → Q in SPG10; complicated form. 1 PublicationCorresponds to variant dbSNP:rs387907287EnsemblClinVar. | 1 | |
Natural variantiVAR_058744 | 251 | E → K in SPG10; complicated form. 1 PublicationCorresponds to variant dbSNP:rs387907285EnsemblClinVar. | 1 | |
Natural variantiVAR_046744 | 253 | K → N in SPG10; decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 Publications | 1 | |
Natural variantiVAR_032842 | 256 | N → S in SPG10; slightly decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 PublicationsCorresponds to variant dbSNP:rs121434441EnsemblClinVar. | 1 | |
Natural variantiVAR_058745 | 256 | Missing in SPG10. 1 Publication | 1 | |
Natural variantiVAR_058746 | 257 | K → N in SPG10; complicated form. 1 Publication | 1 | |
Natural variantiVAR_033108 | 276 | Y → C in SPG10. 1 PublicationCorresponds to variant dbSNP:rs121434443EnsemblClinVar. | 1 | |
Natural variantiVAR_032843 | 280 | R → C in SPG10. 2 PublicationsCorresponds to variant dbSNP:rs121434442EnsemblClinVar. | 1 | |
Natural variantiVAR_058747 | 280 | R → H in SPG10; complicated form. 1 PublicationCorresponds to variant dbSNP:rs387907288EnsemblClinVar. | 1 | |
Natural variantiVAR_058748 | 280 | R → L in SPG10; pure form. 1 Publication | 1 | |
Natural variantiVAR_032844 | 361 | A → V in SPG10; does not affect microtubule affinity; does not affect gliding velocity; does not affect microtubule-dependent ATP turnover. 2 PublicationsCorresponds to variant dbSNP:rs121434444EnsemblClinVar. | 1 |
Myoclonus, intractable, neonatal (NEIMY)3 Publications
Amyotrophic lateral sclerosis 25 (ALS25)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080647 | 413 | E → G in ALS25; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1399145820Ensembl. | 1 | |
Natural variantiVAR_080648 | 474 | Q → H in ALS25; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1373971092Ensembl. | 1 | |
Natural variantiVAR_080649 | 544 – 1032 | Missing in ALS25. 1 PublicationAdd BLAST | 489 | |
Natural variantiVAR_080650 | 577 | S → G in ALS25; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754373609Ensembl. | 1 | |
Natural variantiVAR_080651 | 986 | P → L in ALS25; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs113247976EnsemblClinVar. | 1 | |
Natural variantiVAR_080652 | 1007 | R → G in ALS25. 2 PublicationsCorresponds to variant dbSNP:rs1555179087EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 280 | R → S: Strongly reduces microtubule affinity; slightly reduces gliding velocity. 1 Publication | 1 |
Keywords - Diseasei
Amyotrophic lateral sclerosis, Disease mutation, Epilepsy, Hereditary spastic paraplegia, NeurodegenerationOrganism-specific databases
DisGeNETi | 3798 |
GeneReviewsi | KIF5A |
MalaCardsi | KIF5A |
MIMi | 604187, phenotype 617235, phenotype 617921, phenotype |
OpenTargetsi | ENSG00000155980 |
Orphaneti | 324611, Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation 100991, Autosomal dominant spastic paraplegia type 10 |
PharmGKBi | PA30107 |
Miscellaneous databases
Pharosi | Q12840, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5295 |
Polymorphism and mutation databases
BioMutai | KIF5A |
DMDMi | 143811412 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000125353 | 2 – 1032 | Kinesin heavy chain isoform 5AAdd BLAST | 1031 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 397 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q12840 |
jPOSTi | Q12840 |
MassIVEi | Q12840 |
MaxQBi | Q12840 |
PaxDbi | Q12840 |
PeptideAtlasi | Q12840 |
PRIDEi | Q12840 |
ProteomicsDBi | 58979 |
PTM databases
iPTMneti | Q12840 |
PhosphoSitePlusi | Q12840 |
SwissPalmi | Q12840 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000155980, Expressed in right frontal lobe and 142 other tissues |
ExpressionAtlasi | Q12840, baseline and differential |
Genevisiblei | Q12840, HS |
Organism-specific databases
HPAi | ENSG00000155980, Tissue enriched (brain) |
Interactioni
Subunit structurei
Oligomer composed of two heavy chains and two light chains.
Interacts with GRIP1.
Interacts with FMR1 (via C-terminus); this interaction is increased in a mGluR-dependent manner.
Interacts with ZFYVE27.
Interacts with VAPA, VAPB, SURF4, RAB11A (GDP-bound form), RAB11B (GDP-bound form) and RTN3 in a ZFYVE27-dependent manner (By similarity).
Interacts with BORCS5 (PubMed:25898167).
Interacts with BICD2 (PubMed:20386726).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ12840
With | #Exp. | IntAct |
---|---|---|
ANKRD27 [Q96NW4] | 4 | EBI-713468,EBI-6125599 |
Trak2 [Q8R2H7] from Rattus norvegicus. | 2 | EBI-713468,EBI-1396483 |
GO - Molecular functioni
- kinesin binding Source: Ensembl
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109999, 36 interactors |
CORUMi | Q12840 |
DIPi | DIP-37584N |
IntActi | Q12840, 42 interactors |
MINTi | Q12840 |
STRINGi | 9606.ENSP00000408979 |
Chemistry databases
BindingDBi | Q12840 |
Miscellaneous databases
RNActi | Q12840, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 327 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 319 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 174 – 315 | Microtubule-bindingAdd BLAST | 142 | |
Regioni | 271 – 361 | Necessary for interaction with ZFYVE27By similarityAdd BLAST | 91 | |
Regioni | 353 – 1032 | Interaction with BICD21 PublicationAdd BLAST | 680 | |
Regioni | 907 – 1032 | GlobularAdd BLAST | 126 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 331 – 906 | Add BLAST | 576 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0240, Eukaryota |
GeneTreei | ENSGT00940000159439 |
HOGENOMi | CLU_001485_11_1_1 |
InParanoidi | Q12840 |
OMAi | RVNMELT |
OrthoDBi | 1334528at2759 |
PhylomeDBi | Q12840 |
TreeFami | TF105225 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 18 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAETNNECSI KVLCRFRPLN QAEILRGDKF IPIFQGDDSV VIGGKPYVFD
60 70 80 90 100
RVFPPNTTQE QVYHACAMQI VKDVLAGYNG TIFAYGQTSS GKTHTMEGKL
110 120 130 140 150
HDPQLMGIIP RIARDIFNHI YSMDENLEFH IKVSYFEIYL DKIRDLLDVT
160 170 180 190 200
KTNLSVHEDK NRVPFVKGCT ERFVSSPEEI LDVIDEGKSN RHVAVTNMNE
210 220 230 240 250
HSSRSHSIFL INIKQENMET EQKLSGKLYL VDLAGSEKVS KTGAEGAVLD
260 270 280 290 300
EAKNINKSLS ALGNVISALA EGTKSYVPYR DSKMTRILQD SLGGNCRTTM
310 320 330 340 350
FICCSPSSYN DAETKSTLMF GQRAKTIKNT ASVNLELTAE QWKKKYEKEK
360 370 380 390 400
EKTKAQKETI AKLEAELSRW RNGENVPETE RLAGEEAALG AELCEETPVN
410 420 430 440 450
DNSSIVVRIA PEERQKYEEE IRRLYKQLDD KDDEINQQSQ LIEKLKQQML
460 470 480 490 500
DQEELLVSTR GDNEKVQREL SHLQSENDAA KDEVKEVLQA LEELAVNYDQ
510 520 530 540 550
KSQEVEEKSQ QNQLLVDELS QKVATMLSLE SELQRLQEVS GHQRKRIAEV
560 570 580 590 600
LNGLMKDLSE FSVIVGNGEI KLPVEISGAI EEEFTVARLY ISKIKSEVKS
610 620 630 640 650
VVKRCRQLEN LQVECHRKME VTGRELSSCQ LLISQHEAKI RSLTEYMQSV
660 670 680 690 700
ELKKRHLEES YDSLSDELAK LQAQETVHEV ALKDKEPDTQ DADEVKKALE
710 720 730 740 750
LQMESHREAH HRQLARLRDE INEKQKTIDE LKDLNQKLQL ELEKLQADYE
760 770 780 790 800
KLKSEEHEKS TKLQELTFLY ERHEQSKQDL KGLEETVARE LQTLHNLRKL
810 820 830 840 850
FVQDVTTRVK KSAEMEPEDS GGIHSQKQKI SFLENNLEQL TKVHKQLVRD
860 870 880 890 900
NADLRCELPK LEKRLRATAE RVKALEGALK EAKEGAMKDK RRYQQEVDRI
910 920 930 940 950
KEAVRYKSSG KRGHSAQIAK PVRPGHYPAS SPTNPYGTRS PECISYTNSL
960 970 980 990 1000
FQNYQNLYLQ ATPSSTSDMY FANSCTSSGA TSSGGPLASY QKANMDNGNA
1010 1020 1030
TDINDNRSDL PCGYEAEDQA KLFPLHQETA AS
Computationally mapped potential isoform sequencesi
There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KNA1 | J3KNA1_HUMAN | Kinesin-like protein | KIF5A | 943 | Annotation score: | ||
A0A6Q8PEZ8 | A0A6Q8PEZ8_HUMAN | Kinesin heavy chain isoform 5A | KIF5A | 997 | Annotation score: | ||
A0A6Q8PFB8 | A0A6Q8PFB8_HUMAN | Kinesin heavy chain isoform 5A | KIF5A | 33 | Annotation score: | ||
A0A6Q8PFD6 | A0A6Q8PFD6_HUMAN | Kinesin heavy chain isoform 5A | KIF5A | 27 | Annotation score: | ||
A0A6Q8PFG5 | A0A6Q8PFG5_HUMAN | Kinesin heavy chain isoform 5A | KIF5A | 68 | Annotation score: | ||
A0A6Q8PFQ3 | A0A6Q8PFQ3_HUMAN | Kinesin heavy chain isoform 5A | KIF5A | 66 | Annotation score: | ||
A0A6Q8PFR6 | A0A6Q8PFR6_HUMAN | Kinesin heavy chain isoform 5A | KIF5A | 26 | Annotation score: | ||
A0A6Q8PFV6 | A0A6Q8PFV6_HUMAN | Kinesin heavy chain isoform 5A | KIF5A | 132 | Annotation score: | ||
A0A6Q8PGG7 | A0A6Q8PGG7_HUMAN | Kinesin heavy chain isoform 5A | KIF5A | 134 | Annotation score: | ||
A0A6Q8PGJ3 | A0A6Q8PGJ3_HUMAN | Kinesin heavy chain isoform 5A | KIF5A | 1,039 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 490 | A → V in BAE06127 (Ref. 2) Curated | 1 | |
Sequence conflicti | 913 | G → A in AAA20231 (PubMed:7514426).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058741 | 63 | Y → C in SPG10; complicated form. 1 Publication | 1 | |
Natural variantiVAR_058742 | 198 | M → T in SPG10; complicated form. 1 Publication | 1 | |
Natural variantiVAR_066616 | 203 | S → C in SPG10. 1 Publication | 1 | |
Natural variantiVAR_058743 | 204 | R → Q in SPG10; complicated form. 1 PublicationCorresponds to variant dbSNP:rs387907287EnsemblClinVar. | 1 | |
Natural variantiVAR_058744 | 251 | E → K in SPG10; complicated form. 1 PublicationCorresponds to variant dbSNP:rs387907285EnsemblClinVar. | 1 | |
Natural variantiVAR_046744 | 253 | K → N in SPG10; decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 Publications | 1 | |
Natural variantiVAR_032842 | 256 | N → S in SPG10; slightly decreases microtubule affinity; reduces gliding velocity; reduces microtubule-dependent ATP turnover. 2 PublicationsCorresponds to variant dbSNP:rs121434441EnsemblClinVar. | 1 | |
Natural variantiVAR_058745 | 256 | Missing in SPG10. 1 Publication | 1 | |
Natural variantiVAR_058746 | 257 | K → N in SPG10; complicated form. 1 Publication | 1 | |
Natural variantiVAR_033108 | 276 | Y → C in SPG10. 1 PublicationCorresponds to variant dbSNP:rs121434443EnsemblClinVar. | 1 | |
Natural variantiVAR_032843 | 280 | R → C in SPG10. 2 PublicationsCorresponds to variant dbSNP:rs121434442EnsemblClinVar. | 1 | |
Natural variantiVAR_058747 | 280 | R → H in SPG10; complicated form. 1 PublicationCorresponds to variant dbSNP:rs387907288EnsemblClinVar. | 1 | |
Natural variantiVAR_058748 | 280 | R → L in SPG10; pure form. 1 Publication | 1 | |
Natural variantiVAR_032844 | 361 | A → V in SPG10; does not affect microtubule affinity; does not affect gliding velocity; does not affect microtubule-dependent ATP turnover. 2 PublicationsCorresponds to variant dbSNP:rs121434444EnsemblClinVar. | 1 | |
Natural variantiVAR_080647 | 413 | E → G in ALS25; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1399145820Ensembl. | 1 | |
Natural variantiVAR_080648 | 474 | Q → H in ALS25; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1373971092Ensembl. | 1 | |
Natural variantiVAR_080649 | 544 – 1032 | Missing in ALS25. 1 PublicationAdd BLAST | 489 | |
Natural variantiVAR_080650 | 577 | S → G in ALS25; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754373609Ensembl. | 1 | |
Natural variantiVAR_080651 | 986 | P → L in ALS25; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs113247976EnsemblClinVar. | 1 | |
Natural variantiVAR_080652 | 1007 | R → G in ALS25. 2 PublicationsCorresponds to variant dbSNP:rs1555179087EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06698 mRNA Translation: AAA20231.1 AB210045 mRNA Translation: BAE06127.1 Different initiation. CH471054 Genomic DNA Translation: EAW97030.1 BC146670 mRNA Translation: AAI46671.1 BC150208 mRNA Translation: AAI50209.1 |
CCDSi | CCDS8945.1 |
PIRi | I38510 |
RefSeqi | NP_004975.2, NM_004984.2 |
Genome annotation databases
Ensembli | ENST00000455537; ENSP00000408979; ENSG00000155980 |
GeneIDi | 3798 |
KEGGi | hsa:3798 |
UCSCi | uc001sor.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06698 mRNA Translation: AAA20231.1 AB210045 mRNA Translation: BAE06127.1 Different initiation. CH471054 Genomic DNA Translation: EAW97030.1 BC146670 mRNA Translation: AAI46671.1 BC150208 mRNA Translation: AAI50209.1 |
CCDSi | CCDS8945.1 |
PIRi | I38510 |
RefSeqi | NP_004975.2, NM_004984.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UXT | electron microscopy | 7.40 | C | 1-340 | [»] | |
4UXY | electron microscopy | 6.50 | C | 1-340 | [»] | |
4UY0 | electron microscopy | 7.70 | C | 1-340 | [»] | |
SMRi | Q12840 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109999, 36 interactors |
CORUMi | Q12840 |
DIPi | DIP-37584N |
IntActi | Q12840, 42 interactors |
MINTi | Q12840 |
STRINGi | 9606.ENSP00000408979 |
Chemistry databases
BindingDBi | Q12840 |
ChEMBLi | CHEMBL5295 |
PTM databases
iPTMneti | Q12840 |
PhosphoSitePlusi | Q12840 |
SwissPalmi | Q12840 |
Polymorphism and mutation databases
BioMutai | KIF5A |
DMDMi | 143811412 |
Proteomic databases
EPDi | Q12840 |
jPOSTi | Q12840 |
MassIVEi | Q12840 |
MaxQBi | Q12840 |
PaxDbi | Q12840 |
PeptideAtlasi | Q12840 |
PRIDEi | Q12840 |
ProteomicsDBi | 58979 |
Protocols and materials databases
Antibodypediai | 1390, 258 antibodies |
Genome annotation databases
Ensembli | ENST00000455537; ENSP00000408979; ENSG00000155980 |
GeneIDi | 3798 |
KEGGi | hsa:3798 |
UCSCi | uc001sor.2, human |
Organism-specific databases
CTDi | 3798 |
DisGeNETi | 3798 |
EuPathDBi | HostDB:ENSG00000155980.11 |
GeneCardsi | KIF5A |
GeneReviewsi | KIF5A |
HGNCi | HGNC:6323, KIF5A |
HPAi | ENSG00000155980, Tissue enriched (brain) |
MalaCardsi | KIF5A |
MIMi | 602821, gene 604187, phenotype 617235, phenotype 617921, phenotype |
neXtProti | NX_Q12840 |
OpenTargetsi | ENSG00000155980 |
Orphaneti | 324611, Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation 100991, Autosomal dominant spastic paraplegia type 10 |
PharmGKBi | PA30107 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0240, Eukaryota |
GeneTreei | ENSGT00940000159439 |
HOGENOMi | CLU_001485_11_1_1 |
InParanoidi | Q12840 |
OMAi | RVNMELT |
OrthoDBi | 1334528at2759 |
PhylomeDBi | Q12840 |
TreeFami | TF105225 |
Enzyme and pathway databases
PathwayCommonsi | Q12840 |
Reactomei | R-HSA-2132295, MHC class II antigen presentation R-HSA-264876, Insulin processing R-HSA-5625970, RHO GTPases activate KTN1 R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
SignaLinki | Q12840 |
Miscellaneous databases
BioGRID-ORCSi | 3798, 11 hits in 843 CRISPR screens |
ChiTaRSi | KIF5A, human |
GeneWikii | KIF5A |
GenomeRNAii | 3798 |
Pharosi | Q12840, Tbio |
PROi | PR:Q12840 |
RNActi | Q12840, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155980, Expressed in right frontal lobe and 142 other tissues |
ExpressionAtlasi | Q12840, baseline and differential |
Genevisiblei | Q12840, HS |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KIF5A_HUMAN | |
Accessioni | Q12840Primary (citable) accession number: Q12840 Secondary accession number(s): A6H8M5, Q4LE26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 3, 2007 | |
Last modified: | December 2, 2020 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations