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UniProtKB - Q12837 (PO4F2_HUMAN)

Entry version 180 (22 Apr 2020)
Sequence version 2 (02 Mar 2010)
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Protein

POU domain, class 4, transcription factor 2

Gene

POU4F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044). Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi345 – 404HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processApoptosis, Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q12837

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q12837

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POU domain, class 4, transcription factor 2Curated
Alternative name(s):
Brain-specific homeobox/POU domain protein 3B
Short name:
Brain-3B
Short name:
Brn-3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POU4F2Imported
Synonyms:BRN3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9219 POU4F2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		113725 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q12837

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi171 – 185Missing : Absent from nuclear speckle; no change in transcriptional activity. 1 PublicationAdd BLAST15

Organism-specific databases

DisGeNET

More...DisGeNETi		5458

Open Targets

More...OpenTargetsi		ENSG00000151615

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33543

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q12837 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POU4F2

Domain mapping of disease mutations (DMDM)

More...DMDMi		290457652

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001007401 – 409POU domain, class 4, transcription factor 2Add BLAST409

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q12837

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q12837

PeptideAtlas

More...PeptideAtlasi		Q12837

PRoteomics IDEntifications database

More...PRIDEi		Q12837

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58978

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q12837

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q12837

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain (PubMed:7691107). Expressed in the ganglion cell layer of the retina (PubMed:7691107).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151615 Expressed in secondary oocyte and 26 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q12837 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151615 Group enriched (brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POU4F1; this interaction inhibits both POU4F1 DNA-binding and transcriptional activities.

Interacts (C-terminus) with ESR1 (via DNA-binding domain); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner.

Interacts (via C-terminus) with TP53 (via N-terminus).

Interacts with DLX1 (via homeobox DNA-binding domain); this interaction suppresses DLX1-mediated transcriptional activity in postnatal retina enhancing retinal ganglion cell (RGC) differentiation.

Interacts with DLX2 (via homeobox DNA-binding domain); this interaction enhances RGC differentiation.

Interacts (via C-terminus) with ISL1 (via C-terminus).

Interacts with ISL2.

Interacts with LHX2.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q12837
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-17236143,EBI-10173507
ALPP [P05187]3EBI-17236143,EBI-1211484
CCN3 [P48745]3EBI-17236143,EBI-3904822
CD46 - isoform D [P15529-3]3EBI-17236143,EBI-13046140
CERCAM [Q5T4B2]3EBI-17236143,EBI-12261896
CHIC2 [Q9UKJ5]3EBI-17236143,EBI-741528
CHRD [Q9H2X0]3EBI-17236143,EBI-947551
CHRDL2 - isoform 2 [Q6WN34-2]3EBI-17236143,EBI-12593838
COL8A1 [P27658]5EBI-17236143,EBI-747133
CYP21A2 [Q08AG9]3EBI-17236143,EBI-14156412
CYSRT1 [A8MQ03]3EBI-17236143,EBI-3867333
DLX3 [O60479]3EBI-17236143,EBI-3908248
FAM86C1 - isoform 2 [Q9NVL1-2]5EBI-17236143,EBI-12845222
GRN [P28799]6EBI-17236143,EBI-747754
HDHD3 [Q9BSH5]3EBI-17236143,EBI-745201
HIGD2B [Q4VC39]3EBI-17236143,EBI-12881610
IGFBP6 [P24592]3EBI-17236143,EBI-947015
IGFL1 [Q6UW32]3EBI-17236143,EBI-3870426
INCA1 [Q0VD86]3EBI-17236143,EBI-6509505
KPRP [Q5T749]5EBI-17236143,EBI-10981970
KRT31 [Q15323]3EBI-17236143,EBI-948001
KRT35 [Q92764]3EBI-17236143,EBI-1058674
KRT38 [O76015]3EBI-17236143,EBI-1047263
KRT83 [P78385]3EBI-17236143,EBI-10221390
KRTAP10-11 [P60412]3EBI-17236143,EBI-10217483
KRTAP10-5 [P60370]3EBI-17236143,EBI-10172150
KRTAP10-8 [P60410]3EBI-17236143,EBI-10171774
KRTAP10-9 [P60411]6EBI-17236143,EBI-10172052
KRTAP12-1 [P59990]3EBI-17236143,EBI-10210845
KRTAP12-2 [P59991]3EBI-17236143,EBI-10176379
KRTAP12-3 [P60328]3EBI-17236143,EBI-11953334
KRTAP12-4 [P60329]3EBI-17236143,EBI-10176396
KRTAP13-3 [Q3SY46]3EBI-17236143,EBI-10241252
KRTAP19-2 [Q3LHN2]3EBI-17236143,EBI-12196745
KRTAP19-6 [Q3LI70]3EBI-17236143,EBI-12805508
KRTAP19-7 [Q3SYF9]3EBI-17236143,EBI-10241353
KRTAP21-2 [Q3LI59]3EBI-17236143,EBI-18395721
KRTAP3-2 [Q9BYR7]5EBI-17236143,EBI-751260
KRTAP4-11 [Q9BYQ6]3EBI-17236143,EBI-10302392
KRTAP4-12 [Q9BQ66]3EBI-17236143,EBI-739863
KRTAP4-2 [Q9BYR5]3EBI-17236143,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-17236143,EBI-11958132
KRTAP4-5 [Q9BYR2]3EBI-17236143,EBI-11993254
KRTAP5-11 [Q6L8G4]3EBI-17236143,EBI-11993296
KRTAP5-3 [Q6L8H2]3EBI-17236143,EBI-11974251
KRTAP5-4 [Q6L8H1]3EBI-17236143,EBI-11963072
KRTAP5-6 [Q6L8G9]3EBI-17236143,EBI-10250562
KRTAP5-9 [P26371]3EBI-17236143,EBI-3958099
KRTAP6-1 [Q3LI64]3EBI-17236143,EBI-12111050
KRTAP9-2 [Q9BYQ4]6EBI-17236143,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-17236143,EBI-1043191
KRTAP9-8 [Q9BYQ0]3EBI-17236143,EBI-11958364
LCE1C [Q5T751]3EBI-17236143,EBI-12224199
LCE1F [Q5T754]3EBI-17236143,EBI-11958008
LCE5A [Q5TCM9]3EBI-17236143,EBI-11955689
LCN2 [P80188]3EBI-17236143,EBI-11911016
LGALS13 [Q9UHV8]3EBI-17236143,EBI-3957707
LHX2 [P50458]3EBI-17236143,EBI-12179869
LYPD2 [Q6UXB3]3EBI-17236143,EBI-18270828
MMADHC [Q9H3L0]3EBI-17236143,EBI-11111575
NFKBID [Q8NI38]3EBI-17236143,EBI-10271199
NOTO [A8MTQ0]3EBI-17236143,EBI-17490746
PCSK5 - isoform PC6A [Q92824-2]6EBI-17236143,EBI-11956269
PLSCR2 [Q9NRY7]5EBI-17236143,EBI-3937430
RBP3 [P10745]3EBI-17236143,EBI-12806054
RBPMS - isoform C [Q93062-3]3EBI-17236143,EBI-740343
RGS19 [P49795]3EBI-17236143,EBI-874907
SPRY4 [Q9C004]3EBI-17236143,EBI-354861
TGFB1 [P01137]3EBI-17236143,EBI-779636
TRIM42 [Q8IWZ5]5EBI-17236143,EBI-5235829
VWC2 [Q2TAL6]3EBI-17236143,EBI-11957238

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111454, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q12837, 71 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000281321

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q12837 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q12837

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini250 – 327POU-specificPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni91 – 237Required for transcriptional activationBy similarityAdd BLAST147
Regioni238 – 409Required for DNA-binding and transcriptional repressionBy similarityAdd BLAST172

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi110 – 119POU-IV box10
Motifi171 – 185Nuclear speckle targeting signal1 PublicationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 79Ser-richPROSITE-ProRule annotationAdd BLAST53
Compositional biasi54 – 83Gly-richPROSITE-ProRule annotationAdd BLAST30
Compositional biasi126 – 185His-richPROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal transcriptional activation region is sufficient to induce transcriptional activity.By similarity
The POU-specific domain and POU homeodomain regions are necessary for DNA-binding activity and transcriptional repression.By similarity
The polyhistidine motif acts as a targeting signal to nuclear speckles.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the POU transcription factor family. Class-4 subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1168 Eukaryota
ENOG410XPNX LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160339

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013065_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q12837

KEGG Orthology (KO)

More...KOi		K09366

Identification of Orthologs from Complete Genome Data

More...OMAi		HMGMNDV

Database of Orthologous Groups

More...OrthoDBi		929123at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q12837

TreeFam database of animal gene trees

More...TreeFami		TF316413

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046 Homeodomain, 1 hit
PF00157 Pou, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00028 POUDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q12837-1) [UniParc]FASTAAdd to basket
Also known as: Brn-3b long1 Publication, Brn-3b-l1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MMMMSLNSKQ AFSMPHGGSL HVEPKYSALH STSPGSSAPI APSASSPSSS 
        60         70         80         90        100
SNAGGGGGGG GGGGGGGGRS SSSSSSGSSG GGGSEAMRRA CLPTPPSNIF 
       110        120        130        140        150
GGLDESLLAR AEALAAVDIV SQSKSHHHHP PHHSPFKPDA TYHTMNTIPC 
       160        170        180        190        200
TSAASSSSVP ISHPSALAGT HHHHHHHHHH HHQPHQALEG ELLEHLSPGL 
       210        220        230        240        250
ALGAMAGPDG AVVSTPAHAP HMATMNPMHQ AALSMAHAHG LPSHMGCMSD 
       260        270        280        290        300
VDADPRDLEA FAERFKQRRI KLGVTQADVG SALANLKIPG VGSLSQSTIC 
       310        320        330        340        350
RFESLTLSHN NMIALKPILQ AWLEEAEKSH REKLTKPELF NGAEKKRKRT 
       360        370        380        390        400
SIAAPEKRSL EAYFAIQPRP SSEKIAAIAE KLDLKKNVVR VWFCNQRQKQ 

KRMKYSAGI
Length:409
Mass (Da):43,087
Last modified:March 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42E2C174674E8DFC
GO
Isoform 2 (identifier: Q12837-2) [UniParc]FASTAAdd to basket
Also known as: Brn-3b short1 Publication, Brn-3b-s1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Show »
Length:265
Mass (Da):29,042
Checksum:iA31096BF6445757A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54G → GG in AAA16509 (PubMed:7691107).Curated1
Sequence conflicti54G → GG in BAG37481 (PubMed:14702039).Curated1
Sequence conflicti54G → GG in AAI36345 (PubMed:14702039).Curated1
Sequence conflicti54G → GG in AAI36346 (PubMed:14702039).Curated1
Sequence conflicti165S → C in AAA16509 (PubMed:7691107).Curated1
Sequence conflicti182Missing in CAA50589 (PubMed:8332509).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05932140I → T. Corresponds to variant dbSNP:rs13152799Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0588371 – 144Missing in isoform 2. Add BLAST144

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U06233 mRNA Translation: AAA16509.1
AK314982 mRNA Translation: BAG37481.1
AC093887 Genomic DNA No translation available.
BC136344 mRNA Translation: AAI36345.1
BC136345 mRNA Translation: AAI36346.1
EU439706 mRNA Translation: ACA49233.1
X71488 mRNA Translation: CAA50589.1
L20434 mRNA Translation: AAA36393.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34074.1 [Q12837-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I38502

NCBI Reference Sequences

More...RefSeqi		NP_004566.2, NM_004575.2 [Q12837-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000281321; ENSP00000281321; ENSG00000151615 [Q12837-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5458

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5458

UCSC genome browser

More...UCSCi		uc003ikv.4 human [Q12837-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06233 mRNA Translation: AAA16509.1
AK314982 mRNA Translation: BAG37481.1
AC093887 Genomic DNA No translation available.
BC136344 mRNA Translation: AAI36345.1
BC136345 mRNA Translation: AAI36346.1
EU439706 mRNA Translation: ACA49233.1
X71488 mRNA Translation: CAA50589.1
L20434 mRNA Translation: AAA36393.1
CCDSiCCDS34074.1 [Q12837-1]
PIRiI38502
RefSeqiNP_004566.2, NM_004575.2 [Q12837-1]

3D structure databases

SMRiQ12837
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111454, 1 interactor
IntActiQ12837, 71 interactors
STRINGi9606.ENSP00000281321

PTM databases

iPTMnetiQ12837
PhosphoSitePlusiQ12837

Polymorphism and mutation databases

BioMutaiPOU4F2
DMDMi290457652

Proteomic databases

MassIVEiQ12837
PaxDbiQ12837
PeptideAtlasiQ12837
PRIDEiQ12837
ProteomicsDBi58978

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16443 162 antibodies

Genome annotation databases

EnsembliENST00000281321; ENSP00000281321; ENSG00000151615 [Q12837-1]
GeneIDi5458
KEGGihsa:5458
UCSCiuc003ikv.4 human [Q12837-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5458
DisGeNETi5458

GeneCards: human genes, protein and diseases

More...GeneCardsi		POU4F2
HGNCiHGNC:9219 POU4F2
HPAiENSG00000151615 Group enriched (brain, testis)
MIMi113725 gene
neXtProtiNX_Q12837
OpenTargetsiENSG00000151615
PharmGKBiPA33543

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1168 Eukaryota
ENOG410XPNX LUCA
GeneTreeiENSGT00940000160339
HOGENOMiCLU_013065_0_0_1
InParanoidiQ12837
KOiK09366
OMAiHMGMNDV
OrthoDBi929123at2759
PhylomeDBiQ12837
TreeFamiTF316413

Enzyme and pathway databases

ReactomeiR-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors
SignaLinkiQ12837
SIGNORiQ12837

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		POU4F2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5458
PharosiQ12837 Tbio

Protein Ontology

More...PROi		PR:Q12837
RNActiQ12837 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151615 Expressed in secondary oocyte and 26 other tissues
GenevisibleiQ12837 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00093 HTH_XRE, 1 hit
Gene3Di1.10.260.40, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PF00157 Pou, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPO4F2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12837
Secondary accession number(s): B1PJR6
, B2RC84, Q13883, Q14987
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 2, 2010
Last modified: April 22, 2020
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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