POU4F2

Functionⁱ

Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044). Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity).By similarity2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	345 – 404	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 23805044
promoter-specific chromatin binding Source: UniProtKB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: UniProtKB
Inferred from direct assayⁱ
- 21241485
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21241485
transcription coactivator activity Source: UniProtKB
transcription corepressor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon extension Source: Ensembl
axon guidance Source: UniProtKB
cellular response to cytokine stimulus Source: UniProtKB
cellular response to estradiol stimulus Source: UniProtKB
cellular response to oxygen levels Source: Ensembl
dorsal root ganglion development Source: UniProtKB
heart development Source: ARUK-UCL
intracellular estrogen receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 21241485
intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 21241485
negative regulation of adipose tissue development Source: Ensembl
negative regulation of amacrine cell differentiation Source: UniProtKB
negative regulation of cell differentiation Source: UniProtKB
negative regulation of DNA-binding transcription factor activity Source: UniProtKB
negative regulation of transcription by RNA polymerase II
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 23805044
neuromuscular process controlling balance Source: Ensembl
neuron differentiation Source: UniProtKB
positive regulation of axon extension Source: UniProtKB
positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
positive regulation of cell differentiation Source: UniProtKB
positive regulation of glucose import in response to insulin stimulus Source: Ensembl
positive regulation of osteoclast differentiation Source: UniProtKB
positive regulation of programmed cell death Source: UniProtKB
positive regulation of transcription by RNA polymerase II
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 23805044
positive regulation of transcription regulatory region DNA binding Source: UniProtKB
regulation of DNA-binding transcription factor activity Source: UniProtKB
regulation of retinal ganglion cell axon guidance Source: UniProtKB
regulation of signal transduction by p53 class mediator Source: Reactome
retina development in camera-type eye Source: UniProtKB
retinal ganglion cell axon guidance Source: Ensembl
sensory perception of sound Source: Ensembl
spermatogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding, Repressor
Biological process	Apoptosis, Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors
SignaLinkⁱ	Q12837
SIGNORⁱ	Q12837

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POU domain, class 4, transcription factor 2Curated Alternative name(s): Brain-specific homeobox/POU domain protein 3B Short name: Brain-3B Short name: Brn-3B
Gene namesⁱ	Name:POU4F2Imported Synonyms:BRN3B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151615.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9219 POU4F2
MIMⁱ	113725 gene
neXtProtⁱ	NX_Q12837

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	171 – 185	Missing : Absent from nuclear speckle; no change in transcriptional activity. 1 PublicationAdd BLAST		15

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5458
Open Targets More...OpenTargetsⁱ	ENSG00000151615
PharmGKBⁱ	PA33543

Polymorphism and mutation databases

BioMutaⁱ	POU4F2
DMDMⁱ	290457652

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000100740	1 – 409	POU domain, class 4, transcription factor 2Add BLAST		409

Proteomic databases

PaxDbⁱ	Q12837
PeptideAtlas More...PeptideAtlasⁱ	Q12837
PRIDEⁱ	Q12837
ProteomicsDBⁱ	58978

PTM databases

iPTMnetⁱ	Q12837
PhosphoSitePlusⁱ	Q12837

Expressionⁱ

Tissue specificityⁱ

Expressed in the brain (PubMed:7691107). Expressed in the ganglion cell layer of the retina (PubMed:7691107).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000151615 Expressed in 27 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_POU4F2
Genevisibleⁱ	Q12837 HS

Interactionⁱ

Subunit structureⁱ

Interacts with POU4F1; this interaction inhibits both POU4F1 DNA-binding and transcriptional activities. Interacts (C-terminus) with ESR1 (via DNA-binding domain); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner. Interacts (via C-terminus) with TP53 (via N-terminus). Interacts with DLX1 (via homeobox DNA-binding domain); this interaction suppresses DLX1-mediated transcriptional activity in postnatal retina enhancing retinal ganglion cell (RGC) differentiation. Interacts with DLX2 (via homeobox DNA-binding domain); this interaction enhances RGC differentiation. Interacts (via C-terminus) with ISL1 (via C-terminus). Interacts with ISL2. Interacts with LHX2.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
GRN	P28799	4	EBI-17236143,EBI-747754
KPRP	Q5T749	4	EBI-17236143,EBI-10981970
KRTAP10-9	P60411	4	EBI-17236143,EBI-10172052
KRTAP12-1	P59990	4	EBI-17236143,EBI-10210845
KRTAP12-3	P60328	4	EBI-17236143,EBI-11953334
KRTAP4-12	Q9BQ66	4	EBI-17236143,EBI-739863
KRTAP9-2	Q9BYQ4	4	EBI-17236143,EBI-1044640
KRTAP9-8	Q9BYQ0	4	EBI-17236143,EBI-11958364
PCSK5	Q92824-2	4	EBI-17236143,EBI-11956269

Protein-protein interaction databases

BioGridⁱ	111454, 1 interactor
IntActⁱ	Q12837, 74 interactors
STRINGⁱ	9606.ENSP00000281321

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q12837
SMRⁱ	Q12837
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	250 – 327	POU-specificPROSITE-ProRule annotationAdd BLAST		78

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	91 – 237	Required for transcriptional activationBy similarityAdd BLAST		147
Regionⁱ	238 – 409	Required for DNA-binding and transcriptional repressionBy similarityAdd BLAST		172

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	110 – 119	POU-IV box		10
Motifⁱ	171 – 185	Nuclear speckle targeting signal1 PublicationAdd BLAST		15

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	27 – 79	Ser-richPROSITE-ProRule annotationAdd BLAST	53
Compositional biasⁱ	54 – 83	Gly-richPROSITE-ProRule annotationAdd BLAST	30
Compositional biasⁱ	126 – 185	His-richPROSITE-ProRule annotationAdd BLAST	60

Domainⁱ

The N-terminal transcriptional activation region is sufficient to induce transcriptional activity.By similarity

The POU-specific domain and POU homeodomain regions are necessary for DNA-binding activity and transcriptional repression.By similarity

The polyhistidine motif acts as a targeting signal to nuclear speckles.1 Publication

Sequence similaritiesⁱ

Belongs to the POU transcription factor family. Class-4 subfamily.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG1168 Eukaryota ENOG410XPNX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118935
HOGENOMⁱ	HOG000116305
HOVERGENⁱ	HBG031829
InParanoidⁱ	Q12837
KEGG Orthology (KO) More...KOⁱ	K09366
OMAⁱ	THAPHMA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0WBK
PhylomeDBⁱ	Q12837
TreeFamⁱ	TF316413

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit cd00093 HTH_XRE, 1 hit
InterProⁱ	View protein in InterPro IPR001387 Cro/C1-type_HTH IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR000327 POU_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 1 hit
PRINTSⁱ	PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q12837-1) [UniParc]FASTA Add to basket

Also known as: Brn-3b long1 Publication, Brn-3b-l1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMMMSLNSKQ AFSMPHGGSL HVEPKYSALH STSPGSSAPI APSASSPSSS 
        60         70         80         90        100
SNAGGGGGGG GGGGGGGGRS SSSSSSGSSG GGGSEAMRRA CLPTPPSNIF 
       110        120        130        140        150
GGLDESLLAR AEALAAVDIV SQSKSHHHHP PHHSPFKPDA TYHTMNTIPC 
       160        170        180        190        200
TSAASSSSVP ISHPSALAGT HHHHHHHHHH HHQPHQALEG ELLEHLSPGL 
       210        220        230        240        250
ALGAMAGPDG AVVSTPAHAP HMATMNPMHQ AALSMAHAHG LPSHMGCMSD 
       260        270        280        290        300
VDADPRDLEA FAERFKQRRI KLGVTQADVG SALANLKIPG VGSLSQSTIC 
       310        320        330        340        350
RFESLTLSHN NMIALKPILQ AWLEEAEKSH REKLTKPELF NGAEKKRKRT 
       360        370        380        390        400
SIAAPEKRSL EAYFAIQPRP SSEKIAAIAE KLDLKKNVVR VWFCNQRQKQ 

KRMKYSAGI

Length:409

Mass (Da):43,087

Last modified:March 2, 2010 - v2

Checksum:ⁱ42E2C174674E8DFC

GO

Isoform 2 (identifier: Q12837-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-144: Missing.

« Hide

        10         20         30         40         50
MNTIPCTSAA SSSSVPISHP SALAGTHHHH HHHHHHHHQP HQALEGELLE 
        60         70         80         90        100
HLSPGLALGA MAGPDGAVVS TPAHAPHMAT MNPMHQAALS MAHAHGLPSH 
       110        120        130        140        150
MGCMSDVDAD PRDLEAFAER FKQRRIKLGV TQADVGSALA NLKIPGVGSL 
       160        170        180        190        200
SQSTICRFES LTLSHNNMIA LKPILQAWLE EAEKSHREKL TKPELFNGAE 
       210        220        230        240        250
KKRKRTSIAA PEKRSLEAYF AIQPRPSSEK IAAIAEKLDL KKNVVRVWFC 
       260 
NQRQKQKRMK YSAGI

Show »

Length:265

Mass (Da):29,042

Checksum:ⁱA31096BF6445757A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	54	G → GG in AAA16509 (PubMed:7691107).Curated	1
Sequence conflictⁱ	54	G → GG in BAG37481 (PubMed:14702039).Curated	1
Sequence conflictⁱ	54	G → GG in AAI36345 (PubMed:14702039).Curated	1
Sequence conflictⁱ	54	G → GG in AAI36346 (PubMed:14702039).Curated	1
Sequence conflictⁱ	165	S → C in AAA16509 (PubMed:7691107).Curated	1
Sequence conflictⁱ	182	Missing in CAA50589 (PubMed:8332509).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059321	40	I → T. Corresponds to variant dbSNP:rs13152799Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_058837	1 – 144	Missing in isoform 2. Add BLAST		144

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U06233 mRNA Translation: AAA16509.1 AK314982 mRNA Translation: BAG37481.1 AC093887 Genomic DNA No translation available. BC136344 mRNA Translation: AAI36345.1 BC136345 mRNA Translation: AAI36346.1 EU439706 mRNA Translation: ACA49233.1 X71488 mRNA Translation: CAA50589.1 L20434 mRNA Translation: AAA36393.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34074.1 [Q12837-1]
PIRⁱ	I38502
NCBI Reference Sequences More...RefSeqⁱ	NP_004566.2, NM_004575.2 [Q12837-1]
UniGeneⁱ	Hs.266

Genome annotation databases

Ensemblⁱ	ENST00000281321; ENSP00000281321; ENSG00000151615 [Q12837-1]
GeneIDⁱ	5458
KEGGⁱ	hsa:5458
UCSC genome browser More...UCSCⁱ	uc003ikv.4 human [Q12837-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q12837	POU domain, class 4, transcription factor 2		MOUSE		411	UniRef90_Q63934
POU domain, class 4, transcription factor 2		RAT		412
POU domain protein		NEOLE		424
POU domain protein		CRIGR		165
POU domain protein		PELSI		171
+106
Q12837-2	POU domain protein		TUPCH		265	UniRef90_L9L5S4
UPI0003C8FDFF		TUPCH		420

Protein	Similar proteins		Species	Score	Length	Source
Q12837	POU domain, class 4, transcription factor 2		MOUSE		411	UniRef50_Q63934
POU domain, class 4, transcription factor 2		RAT		412
POU domain protein		NEOLE		424
POU domain protein		CRIGR		165
POU domain protein		PELSI		171
+236

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U06233 mRNA Translation: AAA16509.1 AK314982 mRNA Translation: BAG37481.1 AC093887 Genomic DNA No translation available. BC136344 mRNA Translation: AAI36345.1 BC136345 mRNA Translation: AAI36346.1 EU439706 mRNA Translation: ACA49233.1 X71488 mRNA Translation: CAA50589.1 L20434 mRNA Translation: AAA36393.1
CCDSⁱ	CCDS34074.1 [Q12837-1]
PIRⁱ	I38502
RefSeqⁱ	NP_004566.2, NM_004575.2 [Q12837-1]
UniGeneⁱ	Hs.266

3D structure databases

ProteinModelPortalⁱ	Q12837
SMRⁱ	Q12837
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111454, 1 interactor
IntActⁱ	Q12837, 74 interactors
STRINGⁱ	9606.ENSP00000281321

PTM databases

iPTMnetⁱ	Q12837
PhosphoSitePlusⁱ	Q12837

Polymorphism and mutation databases

BioMutaⁱ	POU4F2
DMDMⁱ	290457652

Proteomic databases

PaxDbⁱ	Q12837
PeptideAtlasⁱ	Q12837
PRIDEⁱ	Q12837
ProteomicsDBⁱ	58978

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000281321; ENSP00000281321; ENSG00000151615 [Q12837-1]
GeneIDⁱ	5458
KEGGⁱ	hsa:5458
UCSCⁱ	uc003ikv.4 human [Q12837-1]

Organism-specific databases

CTDⁱ	5458
DisGeNETⁱ	5458
EuPathDBⁱ	HostDB:ENSG00000151615.3
GeneCardsⁱ	POU4F2
H-InvDBⁱ	HIX0031516
HGNCⁱ	HGNC:9219 POU4F2
MIMⁱ	113725 gene
neXtProtⁱ	NX_Q12837
OpenTargetsⁱ	ENSG00000151615
PharmGKBⁱ	PA33543
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1168 Eukaryota ENOG410XPNX LUCA
GeneTreeⁱ	ENSGT00760000118935
HOGENOMⁱ	HOG000116305
HOVERGENⁱ	HBG031829
InParanoidⁱ	Q12837
KOⁱ	K09366
OMAⁱ	THAPHMA
OrthoDBⁱ	EOG091G0WBK
PhylomeDBⁱ	Q12837
TreeFamⁱ	TF316413

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors
SignaLinkⁱ	Q12837
SIGNORⁱ	Q12837

Miscellaneous databases

GeneWikiⁱ	POU4F2
GenomeRNAiⁱ	5458
Protein Ontology More...PROⁱ	PR:Q12837
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151615 Expressed in 27 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_POU4F2
Genevisibleⁱ	Q12837 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit cd00093 HTH_XRE, 1 hit
InterProⁱ	View protein in InterPro IPR001387 Cro/C1-type_HTH IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR000327 POU_dom
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 1 hit
PRINTSⁱ	PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PO4F2_HUMAN
Accessionⁱ	Q12837Primary (citable) accession number: Q12837 Secondary accession number(s): B1PJR6 , B2RC84, Q13883, Q14987
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	March 2, 2010
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q12837 (PO4F2_HUMAN)

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POU domain, class 4, transcription factor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ