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UniProtKB - Q12836 (ZP4_HUMAN)

Entry version 142 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Zona pellucida sperm-binding protein 4

Gene

ZP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • acrosin binding Source: UniProtKB
  • identical protein binding Source: IntAct
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processFertilization

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1300644 Interaction With The Zona Pellucida

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zona pellucida sperm-binding protein 4
Alternative name(s):
Zona pellucida glycoprotein 4
Short name:
Zp-4
Zona pellucida protein B
Cleaved into the following chain:
Processed zona pellucida sperm-binding protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZP4
Synonyms:ZPB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000116996.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:15770 ZP4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613514 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q12836

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 505ExtracellularSequence analysisAdd BLAST487
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 540CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57829

Open Targets

More...OpenTargetsi		ENSG00000116996

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38036

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZP4

Domain mapping of disease mutations (DMDM)

More...DMDMi		46397080

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004172719 – 462Zona pellucida sperm-binding protein 4Add BLAST444
ChainiPRO_000030457819 – ?Processed zona pellucida sperm-binding protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000041728463 – 540Removed in mature formBy similarityAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi219N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302O-linked (GalNAc...) threonineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi367 ↔ 442PROSITE-ProRule annotation
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q12836

PeptideAtlas

More...PeptideAtlasi		Q12836

PRoteomics IDEntifications database

More...PRIDEi		Q12836

ProteomicsDB human proteome resource

More...ProteomicsDBi		58977

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q12836

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q12836

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Oocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116996 Expressed in 8 organ(s), highest expression level in oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q12836 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA008547

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-11783805,EBI-11783805

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Molecular INTeraction database

More...MINTi		Q12836

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355529

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q12836

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q12836

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 183P-typePROSITE-ProRule annotationAdd BLAST43
Domaini188 – 466ZPPROSITE-ProRule annotationAdd BLAST279

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZP domain family. ZPB subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IE4J Eukaryota
ENOG4111H75 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161324

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000059607

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG050410

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q12836

Identification of Orthologs from Complete Genome Data

More...OMAi		SCYYGNT

Database of Orthologous Groups

More...OrthoDBi		586615at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q12836

TreeFam database of animal gene trees

More...TreeFami		TF332794

Family and domain databases

Conserved Domains Database

More...CDDi		cd00111 Trefoil, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
IPR001507 ZP_dom
IPR017977 ZP_dom_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00088 Trefoil, 1 hit
PF00100 Zona_pellucida, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00023 ZPELLUCIDA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00018 PD, 1 hit
SM00241 ZP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 1 hit
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q12836-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLLRCVLLC VSLSLAVSGQ HKPEAPDYSS VLHCGPWSFQ FAVNLNQEAT 
        60         70         80         90        100
SPPVLIAWDN QGLLHELQND SDCGTWIRKG PGSSVVLEAT YSSCYVTEWD 
       110        120        130        140        150
SHYIMPVGVE GAGAAEHKVV TERKLLKCPM DLLARDAPDT DWCDSIPARD 
       160        170        180        190        200
RLPCAPSPIS RGDCEGLGCC YSSEEVNSCY YGNTVTLHCT REGHFSIAVS 
       210        220        230        240        250
RNVTSPPLLL DSVRLALRND SACNPVMATQ AFVLFQFPFT SCGTTRQITG 
       260        270        280        290        300
DRAVYENELV ATRDVKNGSR GSVTRDSIFR LHVSCSYSVS SNSLPINVQV 
       310        320        330        340        350
FTLPPPFPET QPGPLTLELQ IAKDKNYGSY YGVGDYPVVK LLRDPIYVEV 
       360        370        380        390        400
SILHRTDPYL GLLLQQCWAT PSTDPLSQPQ WPILVKGCPY IGDNYQTQLI 
       410        420        430        440        450
PVQKALDLPF PSHHQRFSIF TFSFVNPTVE KQALRGPVHL HCSVSVCQPA 
       460        470        480        490        500
ETPSCVVTCP DLSRRRNFDN SSQNTTASVS SKGPMILLQA TKDPPEKLRV 
       510        520        530        540
PVDSKVLWVA GLSGTLILGA LLVSYLAVKK QKSCPDQMCQ
Length:540
Mass (Da):59,400
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DAC310D808E1AC3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052997114A → V. Corresponds to variant dbSNP:rs34370253Ensembl.1
Natural variantiVAR_052998295P → S. Corresponds to variant dbSNP:rs34811980Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U05781 Genomic DNA Translation: AAA74391.1
AK314151 mRNA Translation: BAG36838.1
AL359924 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW70072.1
BC069521 mRNA Translation: AAH69521.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1615.1

Protein sequence database of the Protein Information Resource

More...PIRi		S70403

NCBI Reference Sequences

More...RefSeqi		NP_067009.1, NM_021186.4

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.136241

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000366570; ENSP00000355529; ENSG00000116996
ENST00000611898; ENSP00000482304; ENSG00000116996

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57829

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57829

UCSC genome browser

More...UCSCi		uc001hym.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05781 Genomic DNA Translation: AAA74391.1
AK314151 mRNA Translation: BAG36838.1
AL359924 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW70072.1
BC069521 mRNA Translation: AAH69521.1
CCDSiCCDS1615.1
PIRiS70403
RefSeqiNP_067009.1, NM_021186.4
UniGeneiHs.136241

3D structure databases

ProteinModelPortaliQ12836
SMRiQ12836
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiQ12836
STRINGi9606.ENSP00000355529

PTM databases

iPTMnetiQ12836
PhosphoSitePlusiQ12836

Polymorphism and mutation databases

BioMutaiZP4
DMDMi46397080

Proteomic databases

PaxDbiQ12836
PeptideAtlasiQ12836
PRIDEiQ12836
ProteomicsDBi58977

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366570; ENSP00000355529; ENSG00000116996
ENST00000611898; ENSP00000482304; ENSG00000116996
GeneIDi57829
KEGGihsa:57829
UCSCiuc001hym.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57829
DisGeNETi57829
EuPathDBiHostDB:ENSG00000116996.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZP4
HGNCiHGNC:15770 ZP4
HPAiHPA008547
MIMi613514 gene
neXtProtiNX_Q12836
OpenTargetsiENSG00000116996
PharmGKBiPA38036

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IE4J Eukaryota
ENOG4111H75 LUCA
GeneTreeiENSGT00940000161324
HOGENOMiHOG000059607
HOVERGENiHBG050410
InParanoidiQ12836
OMAiSCYYGNT
OrthoDBi586615at2759
PhylomeDBiQ12836
TreeFamiTF332794

Enzyme and pathway databases

ReactomeiR-HSA-1300644 Interaction With The Zona Pellucida

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57829

Protein Ontology

More...PROi		PR:Q12836

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116996 Expressed in 8 organ(s), highest expression level in oocyte
GenevisibleiQ12836 HS

Family and domain databases

CDDicd00111 Trefoil, 1 hit
InterProiView protein in InterPro
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00088 Trefoil, 1 hit
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00018 PD, 1 hit
SM00241 ZP, 1 hit
PROSITEiView protein in PROSITE
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 1 hit
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12836
Secondary accession number(s): B2RAE1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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