CDC20

Functionⁱ

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.3 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

anaphase-promoting complex binding Source: InterPro
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17443180
histone deacetylase binding Source: Ensembl
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10700282
ubiquitin-protein transferase activator activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anaphase-promoting complex-dependent catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 17443180
cell division Source: UniProtKB-KW
mitotic sister chromatid cohesion Source: Ensembl
mitotic spindle assembly Source: Ensembl
mitotic spindle assembly checkpoint Source: Reactome
positive regulation of cell proliferation Source: Ensembl
positive regulation of synapse maturation Source: UniProtKB
positive regulation of synaptic plasticity Source: UniProtKB
positive regulation of ubiquitin protein ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11459826
protein deubiquitination Source: Reactome
protein ubiquitination Source: UniProtKB-UniPathway
regulation of dendrite development Source: Ensembl
regulation of meiotic nuclear division Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis, Ubl conjugation pathway

Biological process

Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis, Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176417 Phosphorylation of Emi1 R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5663220 RHO GTPases Activate Formins R-HSA-5689880 Ub-specific processing proteases R-HSA-68877 Mitotic Prometaphase R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q12834
SIGNORⁱ	Q12834
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division cycle protein 20 homolog Alternative name(s): p55CDC
Gene namesⁱ	Name:CDC20
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117399.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1723 CDC20
MIMⁱ	603618 gene
neXtProtⁱ	NX_Q12834

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	41	S → A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-72; A-92; A-153; A-157 and A-161. 1 Publication	1
Mutagenesisⁱ	72	S → A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-41; A-92; A-153; A-157 and A-161. 1 Publication	1
Mutagenesisⁱ	92	S → A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-41; A-72; A-153; A-157 and A-161. 1 Publication	1
Mutagenesisⁱ	132	R → A: Loss of interaction with MAD2L1. 1 Publication	1
Mutagenesisⁱ	153	S → A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-42; A-72; A-92; A-157 and A-161. 1 Publication	1
Mutagenesisⁱ	157	T → A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-42; A-72; A-92; A-153 and A-161. 1 Publication	1
Mutagenesisⁱ	161	S → A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-72; A-92; A-153; A-157 and A-161. 1 Publication	1
Mutagenesisⁱ	485	K → R: Does not affect its ability to bind the APC/C complex; when associated with R-490. 1 Publication	1
Mutagenesisⁱ	490	K → R: Does not affect its ability to bind the APC/C complex; when associated with R-485. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	991
Open Targets More...OpenTargetsⁱ	ENSG00000117399
PharmGKBⁱ	PA26257

Polymorphism and mutation databases

BioMutaⁱ	CDC20
DMDMⁱ	37537762

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050900	1 – 499	Cell division cycle protein 20 homologAdd BLAST		499

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	41	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	66	N6-acetyllysine1 Publication	1
Modified residueⁱ	70	PhosphothreonineCombined sources1 Publication	1
Modified residueⁱ	72	Phosphoserine1 Publication	1
Modified residueⁱ	92	Phosphoserine1 Publication	1
Modified residueⁱ	106	Phosphothreonine1 Publication	1
Modified residueⁱ	153	Phosphoserine1 Publication	1
Modified residueⁱ	157	Phosphothreonine1 Publication	1
Modified residueⁱ	161	Phosphoserine1 Publication	1
Cross-linkⁱ	485	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	490	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationⁱ

Phosphorylated during mitosis, probably by maturation promoting factor (MPF). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161. Phosphorylated by NEK2.4 Publications

Dephosphorylated by CTDP1.

Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint. Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C. Ubiquitinated at Lys-490 during prometaphase. Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex.4 Publications

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q12834
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q12834
PaxDbⁱ	Q12834
PeptideAtlas More...PeptideAtlasⁱ	Q12834
PRIDEⁱ	Q12834
ProteomicsDBⁱ	58976

PTM databases

iPTMnetⁱ	Q12834
PhosphoSitePlusⁱ	Q12834

Miscellaneous databases

PMAP-CutDBⁱ	Q12834

PMAP-CutDBⁱ

Q12834

Expressionⁱ

Developmental stageⁱ

Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly degraded at M/G1 transition.

Gene expression databases

Bgeeⁱ	ENSG00000117399 Expressed in 150 organ(s), highest expression level in oocyte
CleanExⁱ	HS_CDC20
Genevisibleⁱ	Q12834 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004525 HPA045842 HPA055288

HPAⁱ

CAB004525
HPA045842
HPA055288

Interactionⁱ

Subunit structureⁱ

Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with NEUROD2 and SPATC1 (By similarity). Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2 and SIRT2. Interacts with isoform 1 of NEK2. Interacts with HSF1 (via phosphorylated form); this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex (PubMed:18794143). Interacts (via the N-terminal substrate-binding domain) with FBXO5 (By similarity).By similarity12 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ANAPC4	Q9UJX5	9	EBI-367462,EBI-2554854
Axin2	O88566	2	EBI-367462,EBI-7690990	From Mus musculus.
BUB1B	O60566	30	EBI-367462,EBI-1001438
CDC27	P30260	12	EBI-367462,EBI-994813
MAD2L1	Q13257	33	EBI-367462,EBI-78203
MAD2L2	Q9UI95	2	EBI-367462,EBI-77889
RASSF1	Q9NS23-2	2	EBI-367462,EBI-438698
SIRT2	Q8IXJ6-2	2	EBI-367462,EBI-5240785

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17443180
histone deacetylase binding Source: Ensembl
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10700282

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107427, 180 interactors
CORUMⁱ	Q12834
Database of interacting proteins More...DIPⁱ	DIP-29655N
ELMⁱ	Q12834
IntActⁱ	Q12834, 57 interactors
Molecular INTeraction database More...MINTⁱ	Q12834
STRINGⁱ	9606.ENSP00000308450

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	173 – 177	Combined sources	5
Beta strandⁱ	190 – 192	Combined sources	3
Beta strandⁱ	196 – 202	Combined sources	7
Beta strandⁱ	205 – 210	Combined sources	6
Turnⁱ	211 – 213	Combined sources	3
Beta strandⁱ	216 – 221	Combined sources	6
Beta strandⁱ	229 – 234	Combined sources	6
Beta strandⁱ	238 – 245	Combined sources	8
Beta strandⁱ	248 – 254	Combined sources	7
Turnⁱ	255 – 258	Combined sources	4
Beta strandⁱ	259 – 265	Combined sources	7
Beta strandⁱ	271 – 277	Combined sources	7
Beta strandⁱ	280 – 285	Combined sources	6
Beta strandⁱ	288 – 294	Combined sources	7
Beta strandⁱ	297 – 299	Combined sources	3
Beta strandⁱ	301 – 306	Combined sources	6
Beta strandⁱ	312 – 317	Combined sources	6
Beta strandⁱ	321 – 328	Combined sources	8
Beta strandⁱ	333 – 339	Combined sources	7
Beta strandⁱ	348 – 351	Combined sources	4
Beta strandⁱ	358 – 363	Combined sources	6
Beta strandⁱ	370 – 375	Combined sources	6
Turnⁱ	377 – 379	Combined sources	3
Beta strandⁱ	381 – 386	Combined sources	6
Turnⁱ	387 – 389	Combined sources	3
Beta strandⁱ	392 – 397	Combined sources	6
Beta strandⁱ	402 – 408	Combined sources	7
Turnⁱ	409 – 412	Combined sources	4
Beta strandⁱ	413 – 418	Combined sources	6
Turnⁱ	420 – 422	Combined sources	3
Beta strandⁱ	425 – 429	Combined sources	5
Turnⁱ	430 – 432	Combined sources	3
Beta strandⁱ	435 – 439	Combined sources	5
Beta strandⁱ	446 – 451	Combined sources	6
Beta strandⁱ	458 – 462	Combined sources	5
Turnⁱ	463 – 465	Combined sources	3
Beta strandⁱ	466 – 470	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q12834
SMRⁱ	Q12834
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	182 – 221	WD 1Add BLAST	40
Repeatⁱ	224 – 263	WD 2Add BLAST	40
Repeatⁱ	266 – 303	WD 3Add BLAST	38
Repeatⁱ	307 – 346	WD 4Add BLAST	40
Repeatⁱ	353 – 395	WD 5Add BLAST	43
Repeatⁱ	397 – 438	WD 6Add BLAST	42
Repeatⁱ	441 – 480	WD 7Add BLAST	40

Sequence similaritiesⁱ

Belongs to the WD repeat CDC20/Fizzy family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0305 Eukaryota ENOG410XQ8I LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136444
HOGENOMⁱ	HOG000195514
HOVERGENⁱ	HBG001024
InParanoidⁱ	Q12834
KEGG Orthology (KO) More...KOⁱ	K03363
OMAⁱ	WQSNILA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FJ
PhylomeDBⁱ	Q12834
TreeFamⁱ	TF101065

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR024977 Apc4_WD40_dom IPR033187 CDC20 IPR033010 Cdc20/Fizzy IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR19918 PTHR19918, 1 hit PTHR19918:SF3 PTHR19918:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12894 ANAPC4_WD40, 1 hit PF00400 WD40, 4 hits
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 3 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q12834-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQFAFESDL HSLLQLDAPI PNAPPARWQR KAKEAAGPAP SPMRAANRSH 
        60         70         80         90        100
SAGRTPGRTP GKSSSKVQTT PSKPGGDRYI PHRSAAQMEV ASFLLSKENQ 
       110        120        130        140        150
PENSQTPTKK EHQKAWALNL NGFDVEEAKI LRLSGKPQNA PEGYQNRLKV 
       160        170        180        190        200
LYSQKATPGS SRKTCRYIPS LPDRILDAPE IRNDYYLNLV DWSSGNVLAV 
       210        220        230        240        250
ALDNSVYLWS ASSGDILQLL QMEQPGEYIS SVAWIKEGNY LAVGTSSAEV 
       260        270        280        290        300
QLWDVQQQKR LRNMTSHSAR VGSLSWNSYI LSSGSRSGHI HHHDVRVAEH 
       310        320        330        340        350
HVATLSGHSQ EVCGLRWAPD GRHLASGGND NLVNVWPSAP GEGGWVPLQT 
       360        370        380        390        400
FTQHQGAVKA VAWCPWQSNV LATGGGTSDR HIRIWNVCSG ACLSAVDAHS 
       410        420        430        440        450
QVCSILWSPH YKELISGHGF AQNQLVIWKY PTMAKVAELK GHTSRVLSLT 
       460        470        480        490 
MSPDGATVAS AAADETLRLW RCFELDPARR REREKASAAK SSLIHQGIR

Length:499

Mass (Da):54,723

Last modified:October 3, 2003 - v2

Checksum:ⁱFD5C967AF84089E8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	101	P → S in AAA19017 (PubMed:7513050).Curated		1
Sequence conflictⁱ	117	A → V in AAH00624 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030368	402	V → M1 PublicationCorresponds to variant dbSNP:rs45443196Ensembl.		1
Natural variantⁱVAR_030369	479	R → Q1 PublicationCorresponds to variant dbSNP:rs45461499Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U05340 mRNA Translation: AAA19017.1 AF099644 mRNA Translation: AAD16405.1 AK312780 mRNA Translation: BAG35643.1 BT007388 mRNA Translation: AAP36052.1 DQ473545 Genomic DNA Translation: ABE96834.1 AL139289 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07101.1 CH471059 Genomic DNA Translation: EAX07102.1 BC000624 mRNA Translation: AAH00624.1 BC001088 mRNA Translation: AAH01088.1 BC006272 mRNA Translation: AAH06272.1 BC009425 mRNA Translation: AAH09425.1 BC009426 mRNA Translation: AAH09426.1 BC010044 mRNA Translation: AAH10044.1 BC012803 mRNA Translation: AAH12803.1 BC012827 mRNA Translation: AAH12827.1 BC013303 mRNA Translation: AAH13303.1 BC015998 mRNA Translation: AAH15998.1 BC024257 mRNA Translation: AAH24257.1 BC031294 mRNA Translation: AAH31294.1 BC110321 mRNA Translation: AAI10322.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS484.1
PIRⁱ	A56021
NCBI Reference Sequences More...RefSeqⁱ	NP_001246.2, NM_001255.2
UniGeneⁱ	Hs.524947

Genome annotation databases

Ensemblⁱ	ENST00000310955; ENSP00000308450; ENSG00000117399 ENST00000372462; ENSP00000361540; ENSG00000117399
GeneIDⁱ	991
KEGGⁱ	hsa:991
UCSC genome browser More...UCSCⁱ	uc001cix.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q12834	CDC20 isoform 1		PANTR		499	UniRef100_Q12834
Uncharacterized protein		PANPA		499
Cell division cycle 20		GORGO		499
UPI000818CC42		HUMAN		374

Protein	Similar proteins		Species	Score	Length	Source
Q12834	Cell division cycle protein 20 homolog		MOUSE		499	UniRef90_Q12834
Cell division cycle protein 20 homolog		RAT		499
Cell division cycle protein 20 homolog		PIG		499
CDC20 isoform 1		PANTR		499
Uncharacterized protein		PANPA		499
+109

Protein	Similar proteins		Species	Score	Length	Source
Q12834	Cell division cycle protein 20 homolog		MOUSE		499	UniRef50_Q12834
Cell division cycle protein 20 homolog		RAT		499
Cell division cycle protein 20 homolog		PIG		499
CDC20 isoform 1		PANTR		499
Uncharacterized protein		PANPA		499
+221

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U05340 mRNA Translation: AAA19017.1 AF099644 mRNA Translation: AAD16405.1 AK312780 mRNA Translation: BAG35643.1 BT007388 mRNA Translation: AAP36052.1 DQ473545 Genomic DNA Translation: ABE96834.1 AL139289 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07101.1 CH471059 Genomic DNA Translation: EAX07102.1 BC000624 mRNA Translation: AAH00624.1 BC001088 mRNA Translation: AAH01088.1 BC006272 mRNA Translation: AAH06272.1 BC009425 mRNA Translation: AAH09425.1 BC009426 mRNA Translation: AAH09426.1 BC010044 mRNA Translation: AAH10044.1 BC012803 mRNA Translation: AAH12803.1 BC012827 mRNA Translation: AAH12827.1 BC013303 mRNA Translation: AAH13303.1 BC015998 mRNA Translation: AAH15998.1 BC024257 mRNA Translation: AAH24257.1 BC031294 mRNA Translation: AAH31294.1 BC110321 mRNA Translation: AAI10322.1
CCDSⁱ	CCDS484.1
PIRⁱ	A56021
RefSeqⁱ	NP_001246.2, NM_001255.2
UniGeneⁱ	Hs.524947

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4GGA	X-ray	2.04	A	81-499	[»]
	4GGC	X-ray	1.35	A	161-477	[»]
	4GGD	X-ray	2.44	A/B	71-499	[»]
	4N14	X-ray	2.10	A	165-477	[»]
	5G04	electron microscopy	4.00	R	1-499	[»]
	5KHR	electron microscopy	6.10	R	1-499	[»]
	5KHU	electron microscopy	4.80	R/S	1-499	[»]
	5LCW	electron microscopy	4.00	Q	126-499	[»]
				R	1-499	[»]
	6F0X	electron microscopy	4.60	Q	1-499	[»]
ProteinModelPortalⁱ	Q12834
SMRⁱ	Q12834
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107427, 180 interactors
CORUMⁱ	Q12834
DIPⁱ	DIP-29655N
ELMⁱ	Q12834
IntActⁱ	Q12834, 57 interactors
MINTⁱ	Q12834
STRINGⁱ	9606.ENSP00000308450

PTM databases

iPTMnetⁱ	Q12834
PhosphoSitePlusⁱ	Q12834

Polymorphism and mutation databases

BioMutaⁱ	CDC20
DMDMⁱ	37537762

Proteomic databases

EPDⁱ	Q12834
MaxQBⁱ	Q12834
PaxDbⁱ	Q12834
PeptideAtlasⁱ	Q12834
PRIDEⁱ	Q12834
ProteomicsDBⁱ	58976

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	991
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000310955; ENSP00000308450; ENSG00000117399 ENST00000372462; ENSP00000361540; ENSG00000117399
GeneIDⁱ	991
KEGGⁱ	hsa:991
UCSCⁱ	uc001cix.4 human

Organism-specific databases

CTDⁱ	991
DisGeNETⁱ	991
EuPathDBⁱ	HostDB:ENSG00000117399.13
GeneCardsⁱ	CDC20
H-InvDBⁱ	HIX0034879
HGNCⁱ	HGNC:1723 CDC20
HPAⁱ	CAB004525 HPA045842 HPA055288
MIMⁱ	603618 gene
neXtProtⁱ	NX_Q12834
OpenTargetsⁱ	ENSG00000117399
PharmGKBⁱ	PA26257
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0305 Eukaryota ENOG410XQ8I LUCA
GeneTreeⁱ	ENSGT00870000136444
HOGENOMⁱ	HOG000195514
HOVERGENⁱ	HBG001024
InParanoidⁱ	Q12834
KOⁱ	K03363
OMAⁱ	WQSNILA
OrthoDBⁱ	EOG091G06FJ
PhylomeDBⁱ	Q12834
TreeFamⁱ	TF101065

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176417 Phosphorylation of Emi1 R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5663220 RHO GTPases Activate Formins R-HSA-5689880 Ub-specific processing proteases R-HSA-68877 Mitotic Prometaphase R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	Q12834
SIGNORⁱ	Q12834

Miscellaneous databases

ChiTaRSⁱ	CDC20 human
GeneWikiⁱ	CDC20
GenomeRNAiⁱ	991
PMAP-CutDBⁱ	Q12834
Protein Ontology More...PROⁱ	PR:Q12834
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117399 Expressed in 150 organ(s), highest expression level in oocyte
CleanExⁱ	HS_CDC20
Genevisibleⁱ	Q12834 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR024977 Apc4_WD40_dom IPR033187 CDC20 IPR033010 Cdc20/Fizzy IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR19918 PTHR19918, 1 hit PTHR19918:SF3 PTHR19918:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF12894 ANAPC4_WD40, 1 hit PF00400 WD40, 4 hits
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 3 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDC20_HUMAN
Accessionⁱ	Q12834Primary (citable) accession number: Q12834 Secondary accession number(s): B2R6Z6 , D3DPJ1, Q5JUY4, Q9BW56, Q9UQI9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
	Last sequence update:	October 3, 2003
	Last modified:	October 10, 2018
	This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PATHWAY comments
Index of metabolic and biosynthesis pathways
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q12834 (CDC20_HUMAN)

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Cell division cycle protein 20 homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

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Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ