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Entry version 160 (17 Jun 2020)
Sequence version 3 (10 Jul 2007)
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Protein

Trophinin

Gene

TRO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trophinin
Alternative name(s):
MAGE-D3 antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRO
Synonyms:KIAA1114, MAGED3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000067445.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12326 TRO

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300132 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12816

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7216

Open Targets

More...
OpenTargetsi
ENSG00000067445

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37002

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12816 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
152031714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001567421 – 1431TrophininAdd BLAST1431

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12816

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q12816

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q12816

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12816

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12816

PeptideAtlas

More...
PeptideAtlasi
Q12816

PRoteomics IDEntifications database

More...
PRIDEi
Q12816

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
24606
3053
3054
58968 [Q12816-1]
58969 [Q12816-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12816

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12816

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi. Also found in macrophages.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000067445 Expressed in adenohypophysis and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12816 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q12816 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000067445 Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly binds bystin, and indirectly tastin.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
113067, 31 interactors

Protein interaction database and analysis system

More...
IntActi
Q12816, 26 interactors

Molecular INTeraction database

More...
MINTi
Q12816

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000173898

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12816 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12816

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini444 – 642MAGEPROSITE-ProRule annotationAdd BLAST199
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati751 – 760110
Repeati769 – 778210
Repeati779 – 7863; approximate8
Repeati787 – 796410
Repeati805 – 814510
Repeati823 – 8336; approximateAdd BLAST11
Repeati841 – 850710
Repeati859 – 8708; approximateAdd BLAST12
Repeati879 – 8909; approximateAdd BLAST12
Repeati901 – 9101010
Repeati911 – 9201110
Repeati921 – 9301210
Repeati931 – 9401310
Repeati941 – 9501410
Repeati951 – 96015; approximate10
Repeati961 – 9701610
Repeati971 – 9801710
Repeati981 – 9901810
Repeati991 – 10001910
Repeati1001 – 10102010
Repeati1011 – 10202110
Repeati1021 – 103022; approximate10
Repeati1031 – 10402310
Repeati1041 – 10502410
Repeati1051 – 10602510
Repeati1061 – 10702610
Repeati1071 – 108027; approximate10
Repeati1081 – 109028; approximate10
Repeati1091 – 11002910
Repeati1101 – 11103010
Repeati1111 – 11203110
Repeati1121 – 11303210
Repeati1131 – 11403310
Repeati1141 – 11503410
Repeati1151 – 11603510
Repeati1161 – 11703610
Repeati1171 – 118037; approximate10
Repeati1181 – 119038; approximate10
Repeati1191 – 12003910
Repeati1201 – 12104010
Repeati1211 – 12204110
Repeati1221 – 123042; approximate10
Repeati1231 – 124043; approximate10
Repeati1241 – 12504410
Repeati1251 – 12604510
Repeati1261 – 127046; approximate10
Repeati1271 – 12804710
Repeati1281 – 12904810
Repeati1291 – 13004910
Repeati1301 – 131050; approximate10
Repeati1311 – 13205110
Repeati1321 – 133052; approximate10
Repeati1331 – 134053; approximate10
Repeati1341 – 135054; approximate10
Repeati1351 – 136055; approximate10
Repeati1361 – 137056; approximate10
Repeati1371 – 138057; approximate10
Repeati1381 – 139058; approximate10
Repeati1391 – 140059; approximate10
Repeati1401 – 141060; approximate10
Repeati1411 – 142061; approximate10
Repeati1421 – 143062; approximate10

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni751 – 143062 X 10 AA approximate tandem repeatsAdd BLAST680

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4562 Eukaryota
ENOG4111S70 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162763

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001549_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12816

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDEFVRQ

Database of Orthologous Groups

More...
OrthoDBi
1195799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12816

TreeFam database of animal gene trees

More...
TreeFami
TF352132

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1200, 1 hit
1.10.10.1210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037445 MAGE
IPR041898 MAGE_WH1
IPR041899 MAGE_WH2
IPR002190 MHD_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11736 PTHR11736, 7 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01454 MAGE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01373 MAGE, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50838 MAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12816-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRRNDYGYR VPLFQGPLPP PGSLGLPFPP DIQTETTEED SVLLMHTLLA
60 70 80 90 100
ATKDSLAMDP PVVNRPKKSK TKKAPIKTIT KAAPAAPPVP AANEIATNKP
110 120 130 140 150
KITWQALNLP VITQISQALP TTEVTNTQAS SVTAQPKKAN KMKRVTAKAA
160 170 180 190 200
QGSQSPTGHE GGTIQLKSPL QVLKLPVISQ NIHAPIANES ASSQALITSI
210 220 230 240 250
KPKKASKAKK AANKAIASAT EVSLAATATH TATTQGQITN ETASIHTTAA
260 270 280 290 300
SIRTKKASKA RKTIAKVINT DTEHIEALNV TDAATRQIEA SVVAIRPKKS
310 320 330 340 350
KGKKAASRGP NSVSEISEAP LATQIVTNQA LAATLRVKRG SRARKAATKA
360 370 380 390 400
RATESQTPNA DQGAQAKIAS AQTNVSALET QVAAAVQALA DDYLAQLSLE
410 420 430 440 450
PTTRTRGKRN RKSKHLNGDE RSGSNYRRIP WGRRPAPPRD VAILQERANK
460 470 480 490 500
LVKYLLVKDQ TKIPIKRSDM LRDVIQEYDE YFPEIIERAS YTLEKMFRVN
510 520 530 540 550
LKEIDKQSSL YILISTQESS AGILGTTKDT PKLGLLMVIL SVIFMNGNKA
560 570 580 590 600
SEAVIWEVLR KLGLRPGVRH SLFGEVRKLI TDEFVKQKYL EYKRVPNSRP
610 620 630 640 650
PEYEFFWGLR SYHETSKMKV LKFACRVQKK DPKDWAVQYR EAVEMEVQAA
660 670 680 690 700
AVAVAEAEAR AEARAQMGIG EEAVAGPWNW DDMDIDCLTR EELGDDAQAW
710 720 730 740 750
SRFSFEIEAR AQENADASTN VNFSRGASTR AGFSDGASIS FNGAPSSSGG
760 770 780 790 800
FSGGPGITFG VAPSTSASFS NTASISFGGT LSTSSSFSSA ASISFGCAHS
810 820 830 840 850
TSTSFSSEAS ISFGGMPCTS ASFSGGVSSS FSGPLSTSAT FSGGASSGFG
860 870 880 890 900
GTLSTTAGFS GVLSTSTSFG SAPTTSTVFS SALSTSTGFG GILSTSVCFG
910 920 930 940 950
GSPSSSGSFG GTLSTSICFG GSPCTSTGFG GTLSTSVSFG GSSSTSANFG
960 970 980 990 1000
GTLSTSICFD GSPSTGAGFG GALNTSASFG SVLNTSTGFG GAMSTSADFG
1010 1020 1030 1040 1050
GTLSTSVCFG GSPGTSVSFG SALNTNAGYG GAVSTNTDFG GTLSTSVCFG
1060 1070 1080 1090 1100
GSPSTSAGFG GALNTNASFG CAVSTSASFS GAVSTSACFS GAPITNPGFG
1110 1120 1130 1140 1150
GAFSTSAGFG GALSTAADFG GTPSNSIGFG AAPSTSVSFG GAHGTSLCFG
1160 1170 1180 1190 1200
GAPSTSLCFG SASNTNLCFG GPPSTSACFS GATSPSFCDG PSTSTGFSFG
1210 1220 1230 1240 1250
NGLSTNAGFG GGLNTSAGFG GGLGTSAGFS GGLSTSSGFD GGLGTSAGFG
1260 1270 1280 1290 1300
GGPGTSTGFG GGLGTSAGFS GGLGTSAGFG GGLVTSDGFG GGLGTNASFG
1310 1320 1330 1340 1350
STLGTSAGFS GGLSTSDGFG SRPNASFDRG LSTIIGFGSG SNTSTGFTGE
1360 1370 1380 1390 1400
PSTSTGFSSG PSSIVGFSGG PSTGVGFCSG PSTSGFSGGP STGAGFGGGP
1410 1420 1430
NTGAGFGGGP STSAGFGSGA ASLGACGFSY G
Length:1,431
Mass (Da):143,716
Last modified:July 10, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00FB9BFAC34A1699
GO
Isoform 2 (identifier: Q12816-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     663-705: ARAQMGIGEE...DAQAWSRFSF → IYSPCLQIPL...SYGQSAEGVM
     706-1431: Missing.

Show »
Length:706
Mass (Da):77,025
Checksum:i0F4A0E6B2F33B8FA
GO
Isoform 3 (identifier: Q12816-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-469: Missing.

Show »
Length:962
Mass (Da):93,745
Checksum:iC70C6D46F1D5FFB5
GO
Isoform 4 (identifier: Q12816-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-412: Missing.

Show »
Length:1,034
Mass (Da):102,278
Checksum:i5DA3F570544D2A00
GO
Isoform 5 (identifier: Q12816-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-412: Missing.
     663-705: ARAQMGIGEE...DAQAWSRFSF → IYSPCLQIPL...SYGQSAEGVM
     706-1431: Missing.

Show »
Length:309
Mass (Da):35,586
Checksum:i75B892ABEED362F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9N2G5E9N2_HUMAN
Trophinin
TRO hCG_18641
681Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKE7B1AKE7_HUMAN
Trophinin
TRO
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKF4B1AKF4_HUMAN
Trophinin
TRO
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERU6E7ERU6_HUMAN
Trophinin
TRO
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKE6B1AKE6_HUMAN
Trophinin
TRO
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKF3B1AKF3_HUMAN
Trophinin
TRO
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKF6B1AKF6_HUMAN
Trophinin
TRO
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKF2B1AKF2_HUMAN
Trophinin
TRO
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKF5B1AKF5_HUMAN
Trophinin
TRO
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKE8B1AKE8_HUMAN
Trophinin
TRO
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA79334 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA83066 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti747S → T in AAA79334 (PubMed:7758945).Curated1
Sequence conflicti768S → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti812S → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti824S → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti1026N → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti1056S → G in BAA83066 (PubMed:10470851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06212265R → W. Corresponds to variant dbSNP:rs60674633Ensembl.1
Natural variantiVAR_053510738S → G1 PublicationCorresponds to variant dbSNP:rs17297490Ensembl.1
Natural variantiVAR_076264951G → S1 PublicationCorresponds to variant dbSNP:rs1211752617Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0539371 – 469Missing in isoform 3. CuratedAdd BLAST469
Alternative sequenceiVSP_05393816 – 412Missing in isoform 4 and isoform 5. CuratedAdd BLAST397
Alternative sequenceiVSP_043513663 – 705ARAQM…SRFSF → IYSPCLQIPLINCSSPSHGA KVHPWNLCPHSSQGSYGQSA EGVM in isoform 2 and isoform 5. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_043514706 – 1431Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST726

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029037 mRNA Translation: BAA83066.3 Different initiation.
AK027489 mRNA Translation: BAB55149.1
AL049732 Genomic DNA No translation available.
CH471154 Genomic DNA Translation: EAW93200.1
CH471154 Genomic DNA Translation: EAW93205.1
U04811 mRNA Translation: AAA79334.2 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43958.1 [Q12816-2]
CCDS43959.1 [Q12816-1]
CCDS59527.1 [Q12816-5]
CCDS59528.1 [Q12816-4]
CCDS59529.1 [Q12816-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38488

NCBI Reference Sequences

More...
RefSeqi
NP_001034794.1, NM_001039705.2 [Q12816-1]
NP_001258112.1, NM_001271183.1 [Q12816-3]
NP_057241.2, NM_016157.3 [Q12816-2]
NP_808224.1, NM_177556.2 [Q12816-2]
NP_808225.1, NM_177557.2 [Q12816-5]
XP_006724663.1, XM_006724600.2 [Q12816-1]
XP_011529110.1, XM_011530808.1 [Q12816-1]
XP_011529111.1, XM_011530809.1 [Q12816-1]
XP_011529113.1, XM_011530811.2 [Q12816-1]
XP_011529114.1, XM_011530812.1 [Q12816-1]
XP_011529115.1, XM_011530813.1 [Q12816-1]
XP_016885256.1, XM_017029767.1 [Q12816-1]
XP_016885258.1, XM_017029769.1 [Q12816-2]
XP_016885259.1, XM_017029770.1 [Q12816-2]
XP_016885260.1, XM_017029771.1 [Q12816-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000173898; ENSP00000173898; ENSG00000067445 [Q12816-1]
ENST00000319167; ENSP00000318278; ENSG00000067445 [Q12816-2]
ENST00000375022; ENSP00000364162; ENSG00000067445 [Q12816-2]
ENST00000375041; ENSP00000364181; ENSG00000067445 [Q12816-4]
ENST00000399736; ENSP00000382641; ENSG00000067445 [Q12816-5]
ENST00000420798; ENSP00000405126; ENSG00000067445 [Q12816-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7216

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7216

UCSC genome browser

More...
UCSCi
uc004dtq.6 human [Q12816-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029037 mRNA Translation: BAA83066.3 Different initiation.
AK027489 mRNA Translation: BAB55149.1
AL049732 Genomic DNA No translation available.
CH471154 Genomic DNA Translation: EAW93200.1
CH471154 Genomic DNA Translation: EAW93205.1
U04811 mRNA Translation: AAA79334.2 Different initiation.
CCDSiCCDS43958.1 [Q12816-2]
CCDS43959.1 [Q12816-1]
CCDS59527.1 [Q12816-5]
CCDS59528.1 [Q12816-4]
CCDS59529.1 [Q12816-3]
PIRiI38488
RefSeqiNP_001034794.1, NM_001039705.2 [Q12816-1]
NP_001258112.1, NM_001271183.1 [Q12816-3]
NP_057241.2, NM_016157.3 [Q12816-2]
NP_808224.1, NM_177556.2 [Q12816-2]
NP_808225.1, NM_177557.2 [Q12816-5]
XP_006724663.1, XM_006724600.2 [Q12816-1]
XP_011529110.1, XM_011530808.1 [Q12816-1]
XP_011529111.1, XM_011530809.1 [Q12816-1]
XP_011529113.1, XM_011530811.2 [Q12816-1]
XP_011529114.1, XM_011530812.1 [Q12816-1]
XP_011529115.1, XM_011530813.1 [Q12816-1]
XP_016885256.1, XM_017029767.1 [Q12816-1]
XP_016885258.1, XM_017029769.1 [Q12816-2]
XP_016885259.1, XM_017029770.1 [Q12816-2]
XP_016885260.1, XM_017029771.1 [Q12816-2]

3D structure databases

SMRiQ12816
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113067, 31 interactors
IntActiQ12816, 26 interactors
MINTiQ12816
STRINGi9606.ENSP00000173898

PTM databases

iPTMnetiQ12816
PhosphoSitePlusiQ12816

Polymorphism and mutation databases

BioMutaiTRO
DMDMi152031714

Proteomic databases

EPDiQ12816
jPOSTiQ12816
MassIVEiQ12816
MaxQBiQ12816
PaxDbiQ12816
PeptideAtlasiQ12816
PRIDEiQ12816
ProteomicsDBi24606
3053
3054
58968 [Q12816-1]
58969 [Q12816-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
62228 53 antibodies

The DNASU plasmid repository

More...
DNASUi
7216

Genome annotation databases

EnsembliENST00000173898; ENSP00000173898; ENSG00000067445 [Q12816-1]
ENST00000319167; ENSP00000318278; ENSG00000067445 [Q12816-2]
ENST00000375022; ENSP00000364162; ENSG00000067445 [Q12816-2]
ENST00000375041; ENSP00000364181; ENSG00000067445 [Q12816-4]
ENST00000399736; ENSP00000382641; ENSG00000067445 [Q12816-5]
ENST00000420798; ENSP00000405126; ENSG00000067445 [Q12816-3]
GeneIDi7216
KEGGihsa:7216
UCSCiuc004dtq.6 human [Q12816-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7216
DisGeNETi7216
EuPathDBiHostDB:ENSG00000067445.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRO
HGNCiHGNC:12326 TRO
HPAiENSG00000067445 Tissue enhanced (skeletal)
MIMi300132 gene
neXtProtiNX_Q12816
OpenTargetsiENSG00000067445
PharmGKBiPA37002

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00940000162763
HOGENOMiCLU_001549_0_0_1
InParanoidiQ12816
OMAiKDEFVRQ
OrthoDBi1195799at2759
PhylomeDBiQ12816
TreeFamiTF352132

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7216 0 hits in 411 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRO human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRO_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7216
PharosiQ12816 Tbio

Protein Ontology

More...
PROi
PR:Q12816
RNActiQ12816 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000067445 Expressed in adenohypophysis and 199 other tissues
ExpressionAtlasiQ12816 baseline and differential
GenevisibleiQ12816 HS

Family and domain databases

Gene3Di1.10.10.1200, 1 hit
1.10.10.1210, 1 hit
InterProiView protein in InterPro
IPR037445 MAGE
IPR041898 MAGE_WH1
IPR041899 MAGE_WH2
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 7 hits
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTROP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12816
Secondary accession number(s): B1AKE9
, B1AKF1, F5GY27, Q96SX2, Q9NU89, Q9UPN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 10, 2007
Last modified: June 17, 2020
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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