Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Trophinin

Gene

TRO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.

GO - Biological processi

  • embryo implantation Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Trophinin
Alternative name(s):
MAGE-D3 antigen
Gene namesi
Name:TRO
Synonyms:KIAA1114, MAGED3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000067445.20
HGNCiHGNC:12326 TRO
MIMi300132 gene
neXtProtiNX_Q12816

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7216
OpenTargetsiENSG00000067445
PharmGKBiPA37002

Polymorphism and mutation databases

DMDMi152031714

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567421 – 1431TrophininAdd BLAST1431

Proteomic databases

EPDiQ12816
MaxQBiQ12816
PaxDbiQ12816
PeptideAtlasiQ12816
PRIDEiQ12816
ProteomicsDBi58968
58969 [Q12816-2]

PTM databases

iPTMnetiQ12816
PhosphoSitePlusiQ12816

Expressioni

Tissue specificityi

Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi. Also found in macrophages.

Gene expression databases

BgeeiENSG00000067445 Expressed in 200 organ(s), highest expression level in adenohypophysis
CleanExiHS_TRO
ExpressionAtlasiQ12816 baseline and differential
GenevisibleiQ12816 HS

Organism-specific databases

HPAiHPA053358

Interactioni

Subunit structurei

Directly binds bystin, and indirectly tastin.

Binary interactionsi

WithEntry#Exp.IntActNotes
BYSLQ138954EBI-950001,EBI-358049

Protein-protein interaction databases

BioGridi113067, 28 interactors
IntActiQ12816, 10 interactors
MINTiQ12816
STRINGi9606.ENSP00000173898

Structurei

3D structure databases

ProteinModelPortaliQ12816
SMRiQ12816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini444 – 642MAGEPROSITE-ProRule annotationAdd BLAST199
Repeati751 – 760110
Repeati769 – 778210
Repeati779 – 7863; approximate8
Repeati787 – 796410
Repeati805 – 814510
Repeati823 – 8336; approximateAdd BLAST11
Repeati841 – 850710
Repeati859 – 8708; approximateAdd BLAST12
Repeati879 – 8909; approximateAdd BLAST12
Repeati901 – 9101010
Repeati911 – 9201110
Repeati921 – 9301210
Repeati931 – 9401310
Repeati941 – 9501410
Repeati951 – 96015; approximate10
Repeati961 – 9701610
Repeati971 – 9801710
Repeati981 – 9901810
Repeati991 – 10001910
Repeati1001 – 10102010
Repeati1011 – 10202110
Repeati1021 – 103022; approximate10
Repeati1031 – 10402310
Repeati1041 – 10502410
Repeati1051 – 10602510
Repeati1061 – 10702610
Repeati1071 – 108027; approximate10
Repeati1081 – 109028; approximate10
Repeati1091 – 11002910
Repeati1101 – 11103010
Repeati1111 – 11203110
Repeati1121 – 11303210
Repeati1131 – 11403310
Repeati1141 – 11503410
Repeati1151 – 11603510
Repeati1161 – 11703610
Repeati1171 – 118037; approximate10
Repeati1181 – 119038; approximate10
Repeati1191 – 12003910
Repeati1201 – 12104010
Repeati1211 – 12204110
Repeati1221 – 123042; approximate10
Repeati1231 – 124043; approximate10
Repeati1241 – 12504410
Repeati1251 – 12604510
Repeati1261 – 127046; approximate10
Repeati1271 – 12804710
Repeati1281 – 12904810
Repeati1291 – 13004910
Repeati1301 – 131050; approximate10
Repeati1311 – 13205110
Repeati1321 – 133052; approximate10
Repeati1331 – 134053; approximate10
Repeati1341 – 135054; approximate10
Repeati1351 – 136055; approximate10
Repeati1361 – 137056; approximate10
Repeati1371 – 138057; approximate10
Repeati1381 – 139058; approximate10
Repeati1391 – 140059; approximate10
Repeati1401 – 141060; approximate10
Repeati1411 – 142061; approximate10
Repeati1421 – 143062; approximate10

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni751 – 143062 X 10 AA approximate tandem repeatsAdd BLAST680

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000049038
HOVERGENiHBG003714
InParanoidiQ12816
OMAiALTHIFM
OrthoDBiEOG091G09D3
PhylomeDBiQ12816
TreeFamiTF352132

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12816-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRRNDYGYR VPLFQGPLPP PGSLGLPFPP DIQTETTEED SVLLMHTLLA
60 70 80 90 100
ATKDSLAMDP PVVNRPKKSK TKKAPIKTIT KAAPAAPPVP AANEIATNKP
110 120 130 140 150
KITWQALNLP VITQISQALP TTEVTNTQAS SVTAQPKKAN KMKRVTAKAA
160 170 180 190 200
QGSQSPTGHE GGTIQLKSPL QVLKLPVISQ NIHAPIANES ASSQALITSI
210 220 230 240 250
KPKKASKAKK AANKAIASAT EVSLAATATH TATTQGQITN ETASIHTTAA
260 270 280 290 300
SIRTKKASKA RKTIAKVINT DTEHIEALNV TDAATRQIEA SVVAIRPKKS
310 320 330 340 350
KGKKAASRGP NSVSEISEAP LATQIVTNQA LAATLRVKRG SRARKAATKA
360 370 380 390 400
RATESQTPNA DQGAQAKIAS AQTNVSALET QVAAAVQALA DDYLAQLSLE
410 420 430 440 450
PTTRTRGKRN RKSKHLNGDE RSGSNYRRIP WGRRPAPPRD VAILQERANK
460 470 480 490 500
LVKYLLVKDQ TKIPIKRSDM LRDVIQEYDE YFPEIIERAS YTLEKMFRVN
510 520 530 540 550
LKEIDKQSSL YILISTQESS AGILGTTKDT PKLGLLMVIL SVIFMNGNKA
560 570 580 590 600
SEAVIWEVLR KLGLRPGVRH SLFGEVRKLI TDEFVKQKYL EYKRVPNSRP
610 620 630 640 650
PEYEFFWGLR SYHETSKMKV LKFACRVQKK DPKDWAVQYR EAVEMEVQAA
660 670 680 690 700
AVAVAEAEAR AEARAQMGIG EEAVAGPWNW DDMDIDCLTR EELGDDAQAW
710 720 730 740 750
SRFSFEIEAR AQENADASTN VNFSRGASTR AGFSDGASIS FNGAPSSSGG
760 770 780 790 800
FSGGPGITFG VAPSTSASFS NTASISFGGT LSTSSSFSSA ASISFGCAHS
810 820 830 840 850
TSTSFSSEAS ISFGGMPCTS ASFSGGVSSS FSGPLSTSAT FSGGASSGFG
860 870 880 890 900
GTLSTTAGFS GVLSTSTSFG SAPTTSTVFS SALSTSTGFG GILSTSVCFG
910 920 930 940 950
GSPSSSGSFG GTLSTSICFG GSPCTSTGFG GTLSTSVSFG GSSSTSANFG
960 970 980 990 1000
GTLSTSICFD GSPSTGAGFG GALNTSASFG SVLNTSTGFG GAMSTSADFG
1010 1020 1030 1040 1050
GTLSTSVCFG GSPGTSVSFG SALNTNAGYG GAVSTNTDFG GTLSTSVCFG
1060 1070 1080 1090 1100
GSPSTSAGFG GALNTNASFG CAVSTSASFS GAVSTSACFS GAPITNPGFG
1110 1120 1130 1140 1150
GAFSTSAGFG GALSTAADFG GTPSNSIGFG AAPSTSVSFG GAHGTSLCFG
1160 1170 1180 1190 1200
GAPSTSLCFG SASNTNLCFG GPPSTSACFS GATSPSFCDG PSTSTGFSFG
1210 1220 1230 1240 1250
NGLSTNAGFG GGLNTSAGFG GGLGTSAGFS GGLSTSSGFD GGLGTSAGFG
1260 1270 1280 1290 1300
GGPGTSTGFG GGLGTSAGFS GGLGTSAGFG GGLVTSDGFG GGLGTNASFG
1310 1320 1330 1340 1350
STLGTSAGFS GGLSTSDGFG SRPNASFDRG LSTIIGFGSG SNTSTGFTGE
1360 1370 1380 1390 1400
PSTSTGFSSG PSSIVGFSGG PSTGVGFCSG PSTSGFSGGP STGAGFGGGP
1410 1420 1430
NTGAGFGGGP STSAGFGSGA ASLGACGFSY G
Length:1,431
Mass (Da):143,716
Last modified:July 10, 2007 - v3
Checksum:i00FB9BFAC34A1699
GO
Isoform 2 (identifier: Q12816-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     663-705: ARAQMGIGEE...DAQAWSRFSF → IYSPCLQIPL...SYGQSAEGVM
     706-1431: Missing.

Note: No experimental confirmation available.
Show »
Length:706
Mass (Da):77,025
Checksum:i0F4A0E6B2F33B8FA
GO
Isoform 3 (identifier: Q12816-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-469: Missing.

Show »
Length:962
Mass (Da):93,745
Checksum:iC70C6D46F1D5FFB5
GO
Isoform 4 (identifier: Q12816-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-412: Missing.

Show »
Length:1,034
Mass (Da):102,278
Checksum:i5DA3F570544D2A00
GO
Isoform 5 (identifier: Q12816-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-412: Missing.
     663-705: ARAQMGIGEE...DAQAWSRFSF → IYSPCLQIPL...SYGQSAEGVM
     706-1431: Missing.

Show »
Length:309
Mass (Da):35,586
Checksum:i75B892ABEED362F2
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9N2G5E9N2_HUMAN
Trophinin, isoform CRA_c
TRO hCG_18641
681Annotation score:
B1AKE8B1AKE8_HUMAN
Trophinin
TRO
102Annotation score:
A0A087X070A0A087X070_HUMAN
Trophinin
TRO
357Annotation score:
B1AKF4B1AKF4_HUMAN
Trophinin
TRO
123Annotation score:
E7ERU6E7ERU6_HUMAN
Trophinin
TRO
121Annotation score:
B1AKF6B1AKF6_HUMAN
Trophinin
TRO
230Annotation score:
B1AKF3B1AKF3_HUMAN
Trophinin
TRO
71Annotation score:
B1AKE7B1AKE7_HUMAN
Trophinin
TRO
176Annotation score:
B1AKF5B1AKF5_HUMAN
Trophinin
TRO
192Annotation score:
B1AKF2B1AKF2_HUMAN
Trophinin
TRO
64Annotation score:
There is more potential isoformShow all

Sequence cautioni

The sequence AAA79334 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA83066 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti747S → T in AAA79334 (PubMed:7758945).Curated1
Sequence conflicti768S → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti812S → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti824S → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti1026N → G in BAA83066 (PubMed:10470851).Curated1
Sequence conflicti1056S → G in BAA83066 (PubMed:10470851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06212265R → W. Corresponds to variant dbSNP:rs60674633Ensembl.1
Natural variantiVAR_053510738S → G1 PublicationCorresponds to variant dbSNP:rs17297490Ensembl.1
Natural variantiVAR_076264951G → S1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0539371 – 469Missing in isoform 3. CuratedAdd BLAST469
Alternative sequenceiVSP_05393816 – 412Missing in isoform 4 and isoform 5. CuratedAdd BLAST397
Alternative sequenceiVSP_043513663 – 705ARAQM…SRFSF → IYSPCLQIPLINCSSPSHGA KVHPWNLCPHSSQGSYGQSA EGVM in isoform 2 and isoform 5. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_043514706 – 1431Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST726

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029037 mRNA Translation: BAA83066.3 Different initiation.
AK027489 mRNA Translation: BAB55149.1
AL049732 Genomic DNA No translation available.
CH471154 Genomic DNA Translation: EAW93200.1
CH471154 Genomic DNA Translation: EAW93205.1
U04811 mRNA Translation: AAA79334.2 Different initiation.
CCDSiCCDS43958.1 [Q12816-2]
CCDS43959.1 [Q12816-1]
CCDS59527.1 [Q12816-5]
CCDS59528.1 [Q12816-4]
CCDS59529.1 [Q12816-3]
PIRiI38488
RefSeqiNP_001034794.1, NM_001039705.2 [Q12816-1]
NP_001258112.1, NM_001271183.1 [Q12816-3]
NP_057241.2, NM_016157.3 [Q12816-2]
NP_808224.1, NM_177556.2 [Q12816-2]
NP_808225.1, NM_177557.2 [Q12816-5]
XP_006724663.1, XM_006724600.2 [Q12816-1]
XP_011529110.1, XM_011530808.1 [Q12816-1]
XP_011529111.1, XM_011530809.1 [Q12816-1]
XP_011529113.1, XM_011530811.2 [Q12816-1]
XP_011529114.1, XM_011530812.1 [Q12816-1]
XP_011529115.1, XM_011530813.1 [Q12816-1]
XP_016885256.1, XM_017029767.1 [Q12816-1]
XP_016885258.1, XM_017029769.1 [Q12816-2]
XP_016885259.1, XM_017029770.1 [Q12816-2]
XP_016885260.1, XM_017029771.1 [Q12816-2]
UniGeneiHs.633653
Hs.743294

Genome annotation databases

EnsembliENST00000173898; ENSP00000173898; ENSG00000067445 [Q12816-1]
ENST00000319167; ENSP00000318278; ENSG00000067445 [Q12816-2]
ENST00000375022; ENSP00000364162; ENSG00000067445 [Q12816-2]
ENST00000375041; ENSP00000364181; ENSG00000067445 [Q12816-4]
ENST00000399736; ENSP00000382641; ENSG00000067445 [Q12816-5]
ENST00000420798; ENSP00000405126; ENSG00000067445 [Q12816-3]
GeneIDi7216
KEGGihsa:7216
UCSCiuc004dtq.6 human [Q12816-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029037 mRNA Translation: BAA83066.3 Different initiation.
AK027489 mRNA Translation: BAB55149.1
AL049732 Genomic DNA No translation available.
CH471154 Genomic DNA Translation: EAW93200.1
CH471154 Genomic DNA Translation: EAW93205.1
U04811 mRNA Translation: AAA79334.2 Different initiation.
CCDSiCCDS43958.1 [Q12816-2]
CCDS43959.1 [Q12816-1]
CCDS59527.1 [Q12816-5]
CCDS59528.1 [Q12816-4]
CCDS59529.1 [Q12816-3]
PIRiI38488
RefSeqiNP_001034794.1, NM_001039705.2 [Q12816-1]
NP_001258112.1, NM_001271183.1 [Q12816-3]
NP_057241.2, NM_016157.3 [Q12816-2]
NP_808224.1, NM_177556.2 [Q12816-2]
NP_808225.1, NM_177557.2 [Q12816-5]
XP_006724663.1, XM_006724600.2 [Q12816-1]
XP_011529110.1, XM_011530808.1 [Q12816-1]
XP_011529111.1, XM_011530809.1 [Q12816-1]
XP_011529113.1, XM_011530811.2 [Q12816-1]
XP_011529114.1, XM_011530812.1 [Q12816-1]
XP_011529115.1, XM_011530813.1 [Q12816-1]
XP_016885256.1, XM_017029767.1 [Q12816-1]
XP_016885258.1, XM_017029769.1 [Q12816-2]
XP_016885259.1, XM_017029770.1 [Q12816-2]
XP_016885260.1, XM_017029771.1 [Q12816-2]
UniGeneiHs.633653
Hs.743294

3D structure databases

ProteinModelPortaliQ12816
SMRiQ12816
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113067, 28 interactors
IntActiQ12816, 10 interactors
MINTiQ12816
STRINGi9606.ENSP00000173898

PTM databases

iPTMnetiQ12816
PhosphoSitePlusiQ12816

Polymorphism and mutation databases

DMDMi152031714

Proteomic databases

EPDiQ12816
MaxQBiQ12816
PaxDbiQ12816
PeptideAtlasiQ12816
PRIDEiQ12816
ProteomicsDBi58968
58969 [Q12816-2]

Protocols and materials databases

DNASUi7216
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000173898; ENSP00000173898; ENSG00000067445 [Q12816-1]
ENST00000319167; ENSP00000318278; ENSG00000067445 [Q12816-2]
ENST00000375022; ENSP00000364162; ENSG00000067445 [Q12816-2]
ENST00000375041; ENSP00000364181; ENSG00000067445 [Q12816-4]
ENST00000399736; ENSP00000382641; ENSG00000067445 [Q12816-5]
ENST00000420798; ENSP00000405126; ENSG00000067445 [Q12816-3]
GeneIDi7216
KEGGihsa:7216
UCSCiuc004dtq.6 human [Q12816-1]

Organism-specific databases

CTDi7216
DisGeNETi7216
EuPathDBiHostDB:ENSG00000067445.20
GeneCardsiTRO
H-InvDBiHIX0176771
HGNCiHGNC:12326 TRO
HPAiHPA053358
MIMi300132 gene
neXtProtiNX_Q12816
OpenTargetsiENSG00000067445
PharmGKBiPA37002
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00760000118824
HOGENOMiHOG000049038
HOVERGENiHBG003714
InParanoidiQ12816
OMAiALTHIFM
OrthoDBiEOG091G09D3
PhylomeDBiQ12816
TreeFamiTF352132

Miscellaneous databases

ChiTaRSiTRO human
GeneWikiiTRO_(gene)
GenomeRNAii7216
PROiPR:Q12816
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000067445 Expressed in 200 organ(s), highest expression level in adenohypophysis
CleanExiHS_TRO
ExpressionAtlasiQ12816 baseline and differential
GenevisibleiQ12816 HS

Family and domain databases

InterProiView protein in InterPro
IPR037445 MAGE
IPR002190 MHD_dom
PANTHERiPTHR11736 PTHR11736, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTROP_HUMAN
AccessioniPrimary (citable) accession number: Q12816
Secondary accession number(s): B1AKE9
, B1AKF1, F5GY27, Q96SX2, Q9NU89, Q9UPN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 10, 2007
Last modified: November 7, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again