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UniProtKB - Q12802 (AKP13_HUMAN)

Entry version 189 (07 Apr 2021)
Sequence version 2 (06 Mar 2007)
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Protein

A-kinase anchor protein 13

Gene

AKAP13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).By similarity9 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1791 – 1838Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q12802

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193648, NRAGE signals death through JNK
R-HSA-194840, Rho GTPase cycle
R-HSA-416482, G alpha (12/13) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q12802

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q12802

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 13
Short name:
AKAP-13
Alternative name(s):
AKAP-Lbc1 Publication
Breast cancer nuclear receptor-binding auxiliary protein1 Publication
Guanine nucleotide exchange factor Lbc
Human thyroid-anchoring protein 311 Publication
Lymphoid blast crisis oncogene1 Publication
Short name:
LBC oncogene1 Publication
Non-oncogenic Rho GTPase-specific GTP exchange factor
Protein kinase A-anchoring protein 13
Short name:
PRKA13
p47
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKAP13
Synonyms:BRX1 Publication, HT311 Publication, LBC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:371, AKAP13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604686, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q12802

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170776.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1251A → P: Abolishes interaction with PRKAR2A and leads to constitutive activation of RHOA; when associated with P-1260. 2 Publications1
Mutagenesisi1260I → P: Abolishes interaction with PRKAR2Aand leads to constitutive activation of RHOA; when associated with P-1251. 2 Publications1
Mutagenesisi1265A → P: Abolishes interaction with PRKAR2A. 1 Publication1
Mutagenesisi1565S → A: Abolishes interaction with YWHAB, leading to constitutive activation of RHOA and MAPK14. 2 Publications1
Mutagenesisi2001E → A: Decreases guanyl nucleotide exchange activity toward RHOA. 1 Publication1
Mutagenesisi2136R → G: Decreases guanyl nucleotide exchange activity toward RHOA. 1 Publication1
Mutagenesisi2148Q → Y: Abolishes guanyl nucleotide exchange activity toward RHOA. 1 Publication1
Mutagenesisi2152K → Y: Abolishes guanyl nucleotide exchange activity toward RHOA. 1 Publication1
Mutagenesisi2153Y → F: Loss of guanyl nucleotide exchange activity toward RHOA. 1 Publication1
Mutagenesisi2189D → A: Reduces guanyl nucleotide exchange activity toward RHOA. 1 Publication1
Mutagenesisi2189D → Y: Abolishes guanyl nucleotide exchange activity toward RHOA. 1 Publication1
Mutagenesisi2289R → A: Decreases guanyl nucleotide exchange activity toward RHOA. 1 Publication1
Mutagenesisi2299F → A: Decreases guanyl nucleotide exchange activity toward RHOA. 1 Publication1
Mutagenesisi2324W → L: Impairs interaction with IKBKB. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		11214

Open Targets

More...OpenTargetsi		ENSG00000170776

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24665

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q12802, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AKAP13

Domain mapping of disease mutations (DMDM)

More...DMDMi		134048676

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809631 – 2813A-kinase anchor protein 13Add BLAST2813

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei790PhosphoserineCombined sources1
Modified residuei815PhosphothreonineCombined sources1
Modified residuei953PhosphothreonineBy similarity1
Modified residuei983PhosphoserineCombined sources1
Modified residuei1489PhosphoserineCombined sources1
Modified residuei1507PhosphoserineCombined sources1
Modified residuei1540PhosphoserineCombined sources1
Modified residuei1565PhosphoserineCombined sources1 Publication1
Modified residuei1602PhosphoserineBy similarity1
Modified residuei1642PhosphoserineCombined sources1
Modified residuei1645PhosphoserineCombined sources1
Modified residuei1647PhosphoserineCombined sources1
Modified residuei1670N6-methyllysineCombined sources1
Modified residuei1876PhosphoserineCombined sources1
Modified residuei1895PhosphoserineCombined sources1
Modified residuei1929PhosphoserineCombined sources1
Modified residuei1930PhosphothreonineCombined sources1
Modified residuei1932PhosphoserineCombined sources1
Modified residuei1945PhosphoserineBy similarity1
Modified residuei2345PhosphoserineBy similarity1
Modified residuei2398PhosphoserineCombined sources1
Modified residuei2467PhosphothreonineCombined sources1
Modified residuei2473PhosphoserineCombined sources1
Modified residuei2563PhosphoserineCombined sources1
Modified residuei2566PhosphoserineBy similarity1
Modified residuei2703PhosphoserineCombined sources1
Modified residuei2709PhosphoserineCombined sources1
Modified residuei2728PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q12802

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q12802

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q12802

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q12802

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q12802

PeptideAtlas

More...PeptideAtlasi		Q12802

PRoteomics IDEntifications database

More...PRIDEi		Q12802

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58955 [Q12802-1]
58956 [Q12802-2]
58957 [Q12802-4]
58958 [Q12802-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q12802

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q12802

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in mammary gland (PubMed:9627117). Detected in heart (at protein level) (PubMed:11546812). Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170776, Expressed in tendon of biceps brachii and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q12802, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q12802, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170776, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the cAMP-dependent protein kinase (PKA) holoenzyme and with the regulatory subunit PRKAR2A (PubMed:11546812, PubMed:1618839, PubMed:15229649, PubMed:21102438, PubMed:11285229).

Interacts with RHOA (PubMed:11546812, PubMed:17537920, PubMed:25186459, PubMed:24993829).

Interacts also with RHOB and RHOC (PubMed:11546812).

Identified in a ternary complex with RHOA and PRKAR2A (PubMed:11546812).

Identified in a complex with NR3C1 and RHOA (PubMed:16469733).

Interacts with BRAF and KSR1 (PubMed:21102438).

Identified in a complex with BRAF and KSR1 (PubMed:21102438).

Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381).

Interacts (phosphorylated form) with YWHAB and YWHAZ (PubMed:15229649, PubMed:21224381). Interaction with YWHAB inhibits activation of RHOA, interferes with PKN1 binding and activation of MAP kinases (PubMed:15229649, PubMed:21224381).

Interacts with GNA12 (PubMed:11546812).

Interacts with IKBKB (PubMed:23090968).

Interacts with ESR1, THRA, PPARA and NME2 (PubMed:9627117, PubMed:15249197).

Interacts (via the C-terminal domain after the PH domain) with MEF2C and RXRB.

Interacts (via the C-terminal domain after the PH domain) with PRKD1 (By similarity).

By similarity12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116383, 59 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q12802

Database of interacting proteins

More...DIPi		DIP-180N

Protein interaction database and analysis system

More...IntActi		Q12802, 42 interactors

Molecular INTeraction database

More...MINTi		Q12802

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354718

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q12802, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12813
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q12802

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q12802

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q12802

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1994 – 2191DHPROSITE-ProRule annotationAdd BLAST198
Domaini2231 – 2333PHPROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni494 – 516Important for interaction with PRKAR2AAdd BLAST23
Regioni1585 – 1715Important for interaction with MAP2K31 PublicationAdd BLAST131
Regioni1919 – 2813Interaction with ESR11 PublicationAdd BLAST895

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1758 – 1790Sequence analysisAdd BLAST33
Coiled coili2345 – 2381Sequence analysisAdd BLAST37
Coiled coili2568 – 2683Sequence analysisAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1471 – 1474Poly-Ser4
Compositional biasi1534 – 1537Poly-Glu4
Compositional biasi2778 – 2790Poly-LysAdd BLAST13

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DH domain is sufficient for interaction with RHOA, and for guanine nucleotide exchange (GEF) activity with RHOA (PubMed:24993829). Forms that lack C-terminal regulatory domains have transforming activity and function as oncogenes (PubMed:9891067).1 Publication2 Publications
The PH domain does not play a role in lipid-binding. Instead, it inhibits the guanine nucleotide exchange (GEF) activity of the isolated DH domain (in vitro).1 Publication
The C-terminal domain after the PH domain is involved in protein-protein interactions that are required for normal, compensatory cardiac hypertrophy in response to pressure overload.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1791 – 1838Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3520, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154146

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_076791_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q12802

Identification of Orthologs from Complete Genome Data

More...OMAi		XDQKSTV

Database of Orthologous Groups

More...OrthoDBi		69816at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q12802

TreeFam database of animal gene trees

More...TreeFami		TF325887

Family and domain databases

Conserved Domains Database

More...CDDi		cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00210

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028852, AKAP13
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR018459, RII-bd_1

The PANTHER Classification System

More...PANTHERi		PTHR13944:SF18, PTHR13944:SF18, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17838, PH_16, 1 hit
PF00621, RhoGEF, 1 hit
PF10522, RII_binding_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109, C1, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12802-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLNPQQAPL YGDCVVTVLL AEEDKAEDDV VFYLVFLGST LRHCTSTRKV 
        60         70         80         90        100
SSDTLETIAP GHDCCETVKV QLCASKEGLP VFVVAEEDFH FVQDEAYDAA 
       110        120        130        140        150
QFLATSAGNQ QALNFTRFLD QSGPPSGDVN SLDKKLVLAF RHLKLPTEWN 
       160        170        180        190        200
VLGTDQSLHD AGPRETLMHF AVRLGLLRLT WFLLQKPGGR GALSIHNQEG 
       210        220        230        240        250
ATPVSLALER GYHKLHQLLT EENAGEPDSW SSLSYEIPYG DCSVRHHREL 
       260        270        280        290        300
DIYTLTSESD SHHEHPFPGD GCTGPIFKLM NIQQQLMKTN LKQMDSLMPL 
       310        320        330        340        350
MMTAQDPSSA PETDGQFLPC APEPTDPQRL SSSEETESTQ CCPGSPVAQT 
       360        370        380        390        400
ESPCDLSSIV EEENTDRSCR KKNKGVERKG EEVEPAPIVD SGTVSDQDSC 
       410        420        430        440        450
LQSLPDCGVK GTEGLSSCGN RNEETGTKSS GMPTDQESLS SGDAVLQRDL 
       460        470        480        490        500
VMEPGTAQYS SGGELGGIST TNVSTPDTAG EMEHGLMNPD ATVWKNVLQG 
       510        520        530        540        550
GESTKERFEN SNIGTAGASD VHVTSKPVDK ISVPNCAPAA SSLDGNKPAE 
       560        570        580        590        600
SSLAFSNEET STEKTAETET SRSREESADA PVDQNSVVIP AAAKDKISDG 
       610        620        630        640        650
LEPYTLLAAG IGEAMSPSDL ALLGLEEDVM PHQNSETNSS HAQSQKGKSS 
       660        670        680        690        700
PICSTTGDDK LCADSACQQN TVTSSGDLVA KLCDNIVSES ESTTARQPSS 
       710        720        730        740        750
QDPPDASHCE DPQAHTVTSD PVRDTQERAD FCPFKVVDNK GQRKDVKLDK 
       760        770        780        790        800
PLTNMLEVVS HPHPVVPKME KELVPDQAVI SDSTFSLANS PGSESVTKDD 
       810        820        830        840        850
ALSFVPSQKE KGTATPELHT ATDYRDGPDG NSNEPDTRPL EDRAVGLSTS 
       860        870        880        890        900
STAAELQHGM GNTSLTGLGG EHEGPAPPAI PEALNIKGNT DSSLQSVGKA 
       910        920        930        940        950
TLALDSVLTE EGKLLVVSES SAAQEQDKDK AVTCSSIKEN ALSSGTLQEE 
       960        970        980        990       1000
QRTPPPGQDT QQFHEKSISA DCAKDKALQL SNSPGASSAF LKAETEHNKE 
      1010       1020       1030       1040       1050
VAPQVSLLTQ GGAAQSLVPP GASLATESRQ EALGAEHNSS ALLPCLLPDG 
      1060       1070       1080       1090       1100
SDGSDALNCS QPSPLDVGVK NTQSQGKTSA CEVSGDVTVD VTGVNALQGM 
      1110       1120       1130       1140       1150
AEPRRENISH NTQDILIPNV LLSQEKNAVL GLPVALQDKA VTDPQGVGTP 
      1160       1170       1180       1190       1200
EMIPLDWEKG KLEGADHSCT MGDAEEAQID DEAHPVLLQP VAKELPTDME 
      1210       1220       1230       1240       1250
LSAHDDGAPA GVREVMRAPP SGRERSTPSL PCMVSAQDAP LPKGADLIEE 
      1260       1270       1280       1290       1300
AASRIVDAVI EQVKAAGALL TEGEACHMSL SSPELGPLTK GLESAFTEKV 
      1310       1320       1330       1340       1350
STFPPGESLP MGSTPEEATG SLAGCFAGRE EPEKIILPVQ GPEPAAEMPD 
      1360       1370       1380       1390       1400
VKAEDEVDFR ASSISEEVAV GSIAATLKMK QGPMTQAINR ENWCTIEPCP 
      1410       1420       1430       1440       1450
DAASLLASKQ SPECENFLDV GLGRECTSKQ GVLKRESGSD SDLFHSPSDD 
      1460       1470       1480       1490       1500
MDSIIFPKPE EEHLACDITG SSSSTDDTAS LDRHSSHGSD VSLSQILKPN 
      1510       1520       1530       1540       1550
RSRDRQSLDG FYSHGMGAEG RESESEPADP GDVEEEEMDS ITEVPANCSV 
      1560       1570       1580       1590       1600
LRSSMRSLSP FRRHSWGPGK NAASDAEMNH RSSMRVLGDV VRRPPIHRRS 
      1610       1620       1630       1640       1650
FSLEGLTGGA GVGNKPSSSL EVSSANAEEL RHPFSGEERV DSLVSLSEED 
      1660       1670       1680       1690       1700
LESDQREHRM FDQQICHRSK QQGFNYCTSA ISSPLTKSIS LMTISHPGLD 
      1710       1720       1730       1740       1750
NSRPFHSTFH NTSANLTESI TEENYNFLPH SPSKKDSEWK SGTKVSRTFS 
      1760       1770       1780       1790       1800
YIKNKMSSSK KSKEKEKEKD KIKEKEKDSK DKEKDKKTVN GHTFSSIPVV 
      1810       1820       1830       1840       1850
GPISCSQCMK PFTNKDAYTC ANCSAFVHKG CRESLASCAK VKMKQPKGSL 
      1860       1870       1880       1890       1900
QAHDTSSLPT VIMRNKPSQP KERPRSAVLL VDETATTPIF ANRRSQQSVS 
      1910       1920       1930       1940       1950
LSKSVSIQNI TGVGNDENMS NTWKFLSHST DSLNKISKVN ESTESLTDEG 
      1960       1970       1980       1990       2000
VGTDMNEGQL LGDFEIESKQ LEAESWSRII DSKFLKQQKK DVVKRQEVIY 
      2010       2020       2030       2040       2050
ELMQTEFHHV RTLKIMSGVY SQGMMADLLF EQQMVEKLFP CLDELISIHS 
      2060       2070       2080       2090       2100
QFFQRILERK KESLVDKSEK NFLIKRIGDV LVNQFSGENA ERLKKTYGKF 
      2110       2120       2130       2140       2150
CGQHNQSVNY FKDLYAKDKR FQAFVKKKMS SSVVRRLGIP ECILLVTQRI 
      2160       2170       2180       2190       2200
TKYPVLFQRI LQCTKDNEVE QEDLAQSLSL VKDVIGAVDS KVASYEKKVR 
      2210       2220       2230       2240       2250
LNEIYTKTDS KSIMRMKSGQ MFAKEDLKRK KLVRDGSVFL KNAAGRLKEV 
      2260       2270       2280       2290       2300
QAVLLTDILV FLQEKDQKYI FASLDQKSTV ISLKKLIVRE VAHEEKGLFL 
      2310       2320       2330       2340       2350
ISMGMTDPEM VEVHASSKEE RNSWIQIIQD TINTLNRDED EGIPSENEEE 
      2360       2370       2380       2390       2400
KKMLDTRARE LKEQLHQKDQ KILLLLEEKE MIFRDMAECS TPLPEDCSPT 
      2410       2420       2430       2440       2450
HSPRVLFRSN TEEALKGGPL MKSAINEVEI LQGLVSGNLG GTLGPTVSSP 
      2460       2470       2480       2490       2500
IEQDVVGPVS LPRRAETFGG FDSHQMNASK GGEKEEGDDG QDLRRTESDS 
      2510       2520       2530       2540       2550
GLKKGGNANL VFMLKRNSEQ VVQSVVHLYE LLSALQGVVL QQDSYIEDQK 
      2560       2570       2580       2590       2600
LVLSERALTR SLSRPSSLIE QEKQRSLEKQ RQDLANLQKQ QAQYLEEKRR 
      2610       2620       2630       2640       2650
REREWEARER ELREREALLA QREEEVQQGQ QDLEKEREEL QQKKGTYQYD 
      2660       2670       2680       2690       2700
LERLRAAQKQ LEREQEQLRR EAERLSQRQT ERDLCQVSHP HTKLMRIPSF 
      2710       2720       2730       2740       2750
FPSPEEPPSP SAPSIAKSGS LDSELSVSPK RNSISRTHKD KGPFHILSST 
      2760       2770       2780       2790       2800
SQTNKGPEGQ SQAPASTSAS TRLFGLTKPK EKKEKKKKNK TSRSQPGDGP 
      2810 
ASEVSAEGEE IFC
Length:2,813
Mass (Da):307,550
Last modified:March 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A8FDAC9A3D3B1F2
GO
Isoform 2 (identifier: Q12802-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1583-1598: SMRVLGDVVRRPPIHR → MSWCPSGVQYSAGLSADFNY

Show »
Length:2,817
Mass (Da):307,845
Checksum:i4EA29B253C76698E
GO
Isoform 3 (identifier: Q12802-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1581-1598: Missing.
     1950-1951: Missing.

Show »
Length:2,793
Mass (Da):305,281
Checksum:i117C84737CE9A79B
GO
Isoform 4 (identifier: Q12802-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-179: DAGPRETLMHFAVRLGLLRL → GENLYDLQTHFKFVIFLLFF
     180-2813: Missing.

Show »
Length:179
Mass (Da):19,992
Checksum:iD441A72053F1EBC5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MYJ1A8MYJ1_HUMAN
A-kinase anchor protein 13
AKAP13
1,434Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTD7A0A087WTD7_HUMAN
A-kinase anchor protein 13
AKAP13
1,429Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY36A0A087WY36_HUMAN
A-kinase anchor protein 13
AKAP13
967Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX73A0A087WX73_HUMAN
A-kinase anchor protein 13
AKAP13
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLH1H0YLH1_HUMAN
A-kinase anchor protein 13
AKAP13
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMW2H0YMW2_HUMAN
A-kinase anchor protein 13
AKAP13
1,745Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK84H0YK84_HUMAN
A-kinase anchor protein 13
AKAP13
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYS7A0A087WYS7_HUMAN
A-kinase anchor protein 13
AKAP13
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK18H0YK18_HUMAN
A-kinase anchor protein 13
AKAP13
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMI5H0YMI5_HUMAN
A-kinase anchor protein 13
AKAP13
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50065 differs from that shown. Probable cloning artifact.Curated
The sequence AAC50065 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAD21311 differs from that shown. Reason: Frameshift.Curated
The sequence AAD40799 differs from that shown. Intron retention.Curated
The sequence AAD40799 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAL40923 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191G → R in AAL40923 (PubMed:11696353).Curated1
Sequence conflicti354C → R in AAL40923 (PubMed:11696353).Curated1
Sequence conflicti609A → V in AAL40923 (PubMed:11696353).Curated1
Sequence conflicti614A → T in AAL40923 (PubMed:11696353).Curated1
Sequence conflicti618S → P in AAL40923 (PubMed:11696353).Curated1
Sequence conflicti619D → A in AAL11723 (PubMed:11546812).Curated1
Sequence conflicti755M → S in AAA58670 (PubMed:1618839).Curated1
Sequence conflicti1385 – 1387TQA → MLY in AAD21311 (PubMed:9627117).Curated3
Sequence conflicti1547N → H in BAD92651 (Ref. 10) Curated1
Sequence conflicti1766 – 1768EKE → KKK in AAA58670 (PubMed:1618839).Curated3
Sequence conflicti1877A → G in AAD40799 (PubMed:9891067).Curated1
Sequence conflicti1897Q → E in AAD40799 (PubMed:9891067).Curated1
Sequence conflicti2035V → D in AAD21311 (PubMed:9627117).Curated1
Sequence conflicti2488D → G in AAD21311 (PubMed:9627117).Curated1
Sequence conflicti2667 – 2668QL → HV in BAB62913 (Ref. 3) Curated2
Sequence conflicti2667 – 2668QL → HV in AAD21311 (PubMed:9627117).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030925452M → T1 PublicationCorresponds to variant dbSNP:rs2061821Ensembl.1
Natural variantiVAR_030926494W → R1 PublicationCorresponds to variant dbSNP:rs2061822Ensembl.1
Natural variantiVAR_051986526K → Q. Corresponds to variant dbSNP:rs34434221Ensembl.1
Natural variantiVAR_030927574R → C2 PublicationsCorresponds to variant dbSNP:rs2061824Ensembl.1
Natural variantiVAR_030928624G → V1 PublicationCorresponds to variant dbSNP:rs745191Ensembl.1
Natural variantiVAR_030929689E → K1 PublicationCorresponds to variant dbSNP:rs7177107Ensembl.1
Natural variantiVAR_030930845V → A1 PublicationCorresponds to variant dbSNP:rs4075256Ensembl.1
Natural variantiVAR_030931897V → M2 PublicationsCorresponds to variant dbSNP:rs4075254Ensembl.1
Natural variantiVAR_0309321062P → A1 PublicationCorresponds to variant dbSNP:rs4843074Ensembl.1
Natural variantiVAR_0309331086D → N1 PublicationCorresponds to variant dbSNP:rs4843075Ensembl.1
Natural variantiVAR_0309341216M → T1 PublicationCorresponds to variant dbSNP:rs7162168Ensembl.1
Natural variantiVAR_0519871525S → G. Corresponds to variant dbSNP:rs35079107EnsemblClinVar.1
Natural variantiVAR_0309352457G → S4 PublicationsCorresponds to variant dbSNP:rs2241268Ensembl.1
Natural variantiVAR_0309362801A → T. Corresponds to variant dbSNP:rs2614668Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023486160 – 179DAGPR…GLLRL → GENLYDLQTHFKFVIFLLFF in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_023487180 – 2813Missing in isoform 4. 1 PublicationAdd BLAST2634
Alternative sequenceiVSP_0234891581 – 1598Missing in isoform 3. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_0234901583 – 1598SMRVL…PPIHR → MSWCPSGVQYSAGLSADFNY in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0234911950 – 1951Missing in isoform 3. 3 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF387101 mRNA Translation: AAL40923.1 Frameshift.
AF406992 mRNA Translation: AAL11723.1
AB055890 mRNA Translation: BAB62913.1
BC050312 mRNA Translation: AAH50312.1
AF126008 mRNA Translation: AAD21311.1 Frameshift.
AF127481 mRNA Translation: AAD40799.1 Sequence problems.
U03634 mRNA Translation: AAC50065.1 Sequence problems.
M90360 mRNA Translation: AAA58670.1 Different termination.
AB209414 mRNA Translation: BAD92651.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32319.1 [Q12802-1]
CCDS32320.1 [Q12802-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A42915
I38434

NCBI Reference Sequences

More...RefSeqi		NP_001257475.1, NM_001270546.1
NP_006729.4, NM_006738.5 [Q12802-2]
NP_009131.2, NM_007200.4 [Q12802-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361243; ENSP00000354718; ENSG00000170776 [Q12802-2]
ENST00000394518; ENSP00000378026; ENSG00000170776 [Q12802-1]
ENST00000560302; ENSP00000453634; ENSG00000170776 [Q12802-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11214

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11214

UCSC genome browser

More...UCSCi		uc002bls.5, human [Q12802-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387101 mRNA Translation: AAL40923.1 Frameshift.
AF406992 mRNA Translation: AAL11723.1
AB055890 mRNA Translation: BAB62913.1
BC050312 mRNA Translation: AAH50312.1
AF126008 mRNA Translation: AAD21311.1 Frameshift.
AF127481 mRNA Translation: AAD40799.1 Sequence problems.
U03634 mRNA Translation: AAC50065.1 Sequence problems.
M90360 mRNA Translation: AAA58670.1 Different termination.
AB209414 mRNA Translation: BAD92651.1
CCDSiCCDS32319.1 [Q12802-1]
CCDS32320.1 [Q12802-2]
PIRiA42915
I38434
RefSeqiNP_001257475.1, NM_001270546.1
NP_006729.4, NM_006738.5 [Q12802-2]
NP_009131.2, NM_007200.4 [Q12802-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DRNNMR-C1246-1269[»]
2LG1NMR-A2164-2346[»]
4D0NX-ray2.10B1968-2338[»]
4D0OX-ray2.75A/B1972-2207[»]
6BCAX-ray2.00A/B2193-2333[»]
BMRBiQ12802
SMRiQ12802
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116383, 59 interactors
CORUMiQ12802
DIPiDIP-180N
IntActiQ12802, 42 interactors
MINTiQ12802
STRINGi9606.ENSP00000354718

PTM databases

iPTMnetiQ12802
PhosphoSitePlusiQ12802

Genetic variation databases

BioMutaiAKAP13
DMDMi134048676

Proteomic databases

EPDiQ12802
jPOSTiQ12802
MassIVEiQ12802
MaxQBiQ12802
PaxDbiQ12802
PeptideAtlasiQ12802
PRIDEiQ12802
ProteomicsDBi58955 [Q12802-1]
58956 [Q12802-2]
58957 [Q12802-4]
58958 [Q12802-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15576, 191 antibodies

Genome annotation databases

EnsembliENST00000361243; ENSP00000354718; ENSG00000170776 [Q12802-2]
ENST00000394518; ENSP00000378026; ENSG00000170776 [Q12802-1]
ENST00000560302; ENSP00000453634; ENSG00000170776 [Q12802-5]
GeneIDi11214
KEGGihsa:11214
UCSCiuc002bls.5, human [Q12802-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11214
DisGeNETi11214

GeneCards: human genes, protein and diseases

More...GeneCardsi		AKAP13
HGNCiHGNC:371, AKAP13
HPAiENSG00000170776, Low tissue specificity
MIMi604686, gene
neXtProtiNX_Q12802
OpenTargetsiENSG00000170776
PharmGKBiPA24665
VEuPathDBiHostDB:ENSG00000170776.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3520, Eukaryota
GeneTreeiENSGT00940000154146
HOGENOMiCLU_076791_0_0_1
InParanoidiQ12802
OMAiXDQKSTV
OrthoDBi69816at2759
PhylomeDBiQ12802
TreeFamiTF325887

Enzyme and pathway databases

PathwayCommonsiQ12802
ReactomeiR-HSA-193648, NRAGE signals death through JNK
R-HSA-194840, Rho GTPase cycle
R-HSA-416482, G alpha (12/13) signalling events
SignaLinkiQ12802
SIGNORiQ12802

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11214, 10 hits in 992 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AKAP13, human
EvolutionaryTraceiQ12802

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AKAP13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11214
PharosiQ12802, Tbio

Protein Ontology

More...PROi		PR:Q12802
RNActiQ12802, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170776, Expressed in tendon of biceps brachii and 252 other tissues
ExpressionAtlasiQ12802, baseline and differential
GenevisibleiQ12802, HS

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
IDEALiIID00210
InterProiView protein in InterPro
IPR028852, AKAP13
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR018459, RII-bd_1
PANTHERiPTHR13944:SF18, PTHR13944:SF18, 1 hit
PfamiView protein in Pfam
PF17838, PH_16, 1 hit
PF00621, RhoGEF, 1 hit
PF10522, RII_binding_1, 1 hit
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKP13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12802
Secondary accession number(s): Q14572
, Q59FP6, Q86W90, Q8WXQ6, Q96JP6, Q96P79, Q9Y5T0, Q9Y5T6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 6, 2007
Last modified: April 7, 2021
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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