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Protein

Alpha-globin transcription factor CP2

Gene

TFCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.By similarity4 Publications

Miscellaneous

In PubMed:8114710 authors noted that a 10-fold molar excess of isoform 3 over isoform 1 inhibited DNA-binding.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q12800

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-globin transcription factor CP2
Alternative name(s):
SAA3 enhancer factor
Transcription factor LSF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFCP2
Synonyms:LSF, SEF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000135457.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11748 TFCP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
189889 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi211V → E: Does not affect DNA-binding activity. 1 Publication1
Mutagenesisi213I → R: Does not affect DNA-binding activity. 1 Publication1
Mutagenesisi234Q → L: Significant reduction of DNA-binding activity. 1 Publication1
Mutagenesisi236K → E: Significant reduction of DNA-binding activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7024

Open Targets

More...
OpenTargetsi
ENSG00000135457

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36463

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TFCP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90101767

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002280011 – 502Alpha-globin transcription factor CP2Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei353PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12800

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12800

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12800

PeptideAtlas

More...
PeptideAtlasi
Q12800

PRoteomics IDEntifications database

More...
PRIDEi
Q12800

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58951
58952 [Q12800-2]
58953 [Q12800-3]
58954 [Q12800-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12800

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12800

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal erythroid tissue.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135457 Expressed in 223 organ(s), highest expression level in mucosa of paranasal sinus

CleanEx database of gene expression profiles

More...
CleanExi
HS_TFCP2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12800 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12800 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA070247

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to DNA as a dimer, isoform 3 does not bind to DNA or affect the binding of isoform 1 to DNA. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity). Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ADPRHP549223EBI-717422,EBI-6657604
ASAP3Q8TDY43EBI-717422,EBI-2609717
BAG6P463793EBI-717422,EBI-347552
C19orf73Q9NVV23EBI-717422,EBI-2859285
CA1P009156EBI-717422,EBI-3912102
CAPN3A0A0S2Z3E63EBI-717422,EBI-16430532
CAPN3P20807-23EBI-717422,EBI-16433991
CBX8Q9HC525EBI-717422,EBI-712912
CDC73Q6P1J98EBI-717422,EBI-930143
DNAJC27Q9NZQ05EBI-717422,EBI-10317544
DNAJC5BQ9UF473EBI-717422,EBI-10320535
DPH1Q9BZG83EBI-717422,EBI-10303200
E2F8A0AVK63EBI-717422,EBI-7779316
EAF1Q96JC93EBI-717422,EBI-769261
EIF5BQ8N5A03EBI-717422,EBI-6137508
EPHA10Q5JZY3-33EBI-717422,EBI-10244652
ESR2Q92731-33EBI-717422,EBI-12259414
FANCLQ9NW383EBI-717422,EBI-2339898
FARS2O953633EBI-717422,EBI-2513774
FBXL18Q96D163EBI-717422,EBI-744419
GPANK1O958723EBI-717422,EBI-751540
IRAK1BP1Q5VVH53EBI-717422,EBI-9658404
MOB3CQ70IA83EBI-717422,EBI-9679267
MORF4L1Q9UBU83EBI-717422,EBI-399246
MORF4L1Q9UBU8-23EBI-717422,EBI-10288852
MRPL11Q9Y3B73EBI-717422,EBI-5453723
MRPL40Q9NQ503EBI-717422,EBI-1053902
NABP1Q96AH03EBI-717422,EBI-2889252
NPEPL1Q8NDH3-43EBI-717422,EBI-10269715
PHF1O431894EBI-717422,EBI-530034
PHF21BA0A0S2Z6153EBI-717422,EBI-16434035
PIMREGQ9BSJ63EBI-717422,EBI-2568609
PITPNM1O005623EBI-717422,EBI-2861268
PLCB1Q9NQ663EBI-717422,EBI-3396023
POLLQ9UGP5-23EBI-717422,EBI-10320765
POLR3GLQ9BT433EBI-717422,EBI-2855862
PPIGQ134273EBI-717422,EBI-396072
PPP1R1BQ9UD713EBI-717422,EBI-722119
PPP3R2Q96LZ33EBI-717422,EBI-3906025
PSMD5Q164013EBI-717422,EBI-752143
RBMS1P295583EBI-717422,EBI-5462600
RXRBP28702-33EBI-717422,EBI-16429492
SDCBPO005603EBI-717422,EBI-727004
SHTN1A0MZ66-73EBI-717422,EBI-10171490
STMN2Q930453EBI-717422,EBI-714194
SUMO1P631653EBI-717422,EBI-80140
TCEA2Q155603EBI-717422,EBI-710310
TDRD1Q9BXT4-23EBI-717422,EBI-10301451
TRAPPC12Q53QD43EBI-717422,EBI-10242701
TSPAN12O958593EBI-717422,EBI-2466403
UBE2IP632794EBI-717422,EBI-80168
YJU2Q9BW855EBI-717422,EBI-10300345
ZCCHC10Q8TBK63EBI-717422,EBI-597063
ZCCHC12Q6PEW16EBI-717422,EBI-748373

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112882, 101 interactors

Protein interaction database and analysis system

More...
IntActi
Q12800, 109 interactors

Molecular INTeraction database

More...
MINTi
Q12800

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000257915

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q12800

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q12800

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni133 – 395DNA-bindingAdd BLAST263

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi314 – 319Poly-Pro6
Compositional biasi396 – 413Gln-richAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4091 Eukaryota
ENOG410XNZ6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157629

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230625

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053805

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12800

KEGG Orthology (KO)

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KOi
K09275

Identification of Orthologs from Complete Genome Data

More...
OMAi
RQINQIF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0YV2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12800

TreeFam database of animal gene trees

More...
TreeFami
TF314132

Family and domain databases

Conserved Domains Database

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CDDi
cd09589 SAM_TFCP2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007604 CP2
IPR013761 SAM/pointed_sf
IPR040167 TF_CP2-like
IPR037599 TFCP2_SAM

The PANTHER Classification System

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PANTHERi
PTHR11037 PTHR11037, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04516 CP2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12800-1) [UniParc]FASTAAdd to basket
Also known as: LBP-1c

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK
60 70 80 90 100
QEESSLPPDN ENKILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML
110 120 130 140 150
DNRKLGELPE INGKLVKSIF RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL
160 170 180 190 200
DIDIPMSVGI IDPRANPTQL NTVEFLWDPA KRTSVFIQVH CISTEFTMRK
210 220 230 240 250
HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASCQIKVFKP KGADRKQKTD
260 270 280 290 300
REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNSP SPGFNSSHSS
310 320 330 340 350
FSLGEGNGSP NHQPEPPPPV TDNLLPTTTP QEAQQWLHRN RFSTFTRLFT
360 370 380 390 400
NFSGADLLKL TRDDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESLQ
410 420 430 440 450
LREQQQQQQQ QQQKHEDGDS NGTFFVYHAI YLEELTAVEL TEKIAQLFSI
460 470 480 490 500
SPCQISQIYK QGPTGIHVLI SDEMIQNFQE EACFILDTMK AETNDSYHII

LK
Length:502
Mass (Da):57,256
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB93825C2687F89FF
GO
Isoform 2 (identifier: Q12800-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-239: Missing.
     491-491: Missing.

Show »
Length:450
Mass (Da):51,308
Checksum:i5004E9DF3925E852
GO
Isoform 3 (identifier: Q12800-3) [UniParc]FASTAAdd to basket
Also known as: LBP-1d

The sequence of this isoform differs from the canonical sequence as follows:
     189-239: Missing.

Show »
Length:451
Mass (Da):51,379
Checksum:i04DAF489CA939B17
GO
Isoform 4 (identifier: Q12800-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-491: Missing.

Show »
Length:501
Mass (Da):57,185
Checksum:i22D5A27DD537009D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWL0F8VWL0_HUMAN
Alpha-globin transcription factor C...
TFCP2
381Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VX55F8VX55_HUMAN
Alpha-globin transcription factor C...
TFCP2
424Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92G → A in M84810 (PubMed:1732747).Curated1
Sequence conflicti92G → A AA sequence (PubMed:1732747).Curated1
Sequence conflicti249T → M in M84810 (PubMed:1732747).Curated1
Sequence conflicti249T → M AA sequence (PubMed:1732747).Curated1
Sequence conflicti491A → Q in AAA21324 (PubMed:8035790).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017647189 – 239Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST51
Alternative sequenceiVSP_017648491Missing in isoform 2 and isoform 4. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M84810 mRNA No translation available.
U03494 mRNA Translation: AAA21324.1
U03495 mRNA Translation: AAA21325.1
AK291264 mRNA Translation: BAF83953.1
CH471111 Genomic DNA Translation: EAW58178.1
BC003634 mRNA Translation: AAH03634.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS55827.1 [Q12800-2]
CCDS8808.1 [Q12800-1]

Protein sequence database of the Protein Information Resource

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PIRi
A42030
A53771
C56205

NCBI Reference Sequences

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RefSeqi
NP_001166923.1, NM_001173452.1 [Q12800-4]
NP_001166924.1, NM_001173453.1 [Q12800-2]
NP_005644.2, NM_005653.4 [Q12800-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.48849

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000257915; ENSP00000257915; ENSG00000135457 [Q12800-1]
ENST00000548115; ENSP00000447991; ENSG00000135457 [Q12800-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7024

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7024

UCSC genome browser

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UCSCi
uc001rxw.4 human [Q12800-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84810 mRNA No translation available.
U03494 mRNA Translation: AAA21324.1
U03495 mRNA Translation: AAA21325.1
AK291264 mRNA Translation: BAF83953.1
CH471111 Genomic DNA Translation: EAW58178.1
BC003634 mRNA Translation: AAH03634.1
CCDSiCCDS55827.1 [Q12800-2]
CCDS8808.1 [Q12800-1]
PIRiA42030
A53771
C56205
RefSeqiNP_001166923.1, NM_001173452.1 [Q12800-4]
NP_001166924.1, NM_001173453.1 [Q12800-2]
NP_005644.2, NM_005653.4 [Q12800-1]
UniGeneiHs.48849

3D structure databases

ProteinModelPortaliQ12800
SMRiQ12800
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112882, 101 interactors
IntActiQ12800, 109 interactors
MINTiQ12800
STRINGi9606.ENSP00000257915

PTM databases

iPTMnetiQ12800
PhosphoSitePlusiQ12800

Polymorphism and mutation databases

BioMutaiTFCP2
DMDMi90101767

Proteomic databases

EPDiQ12800
MaxQBiQ12800
PaxDbiQ12800
PeptideAtlasiQ12800
PRIDEiQ12800
ProteomicsDBi58951
58952 [Q12800-2]
58953 [Q12800-3]
58954 [Q12800-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7024
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257915; ENSP00000257915; ENSG00000135457 [Q12800-1]
ENST00000548115; ENSP00000447991; ENSG00000135457 [Q12800-2]
GeneIDi7024
KEGGihsa:7024
UCSCiuc001rxw.4 human [Q12800-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7024
DisGeNETi7024
EuPathDBiHostDB:ENSG00000135457.9

GeneCards: human genes, protein and diseases

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GeneCardsi
TFCP2
HGNCiHGNC:11748 TFCP2
HPAiHPA070247
MIMi189889 gene
neXtProtiNX_Q12800
OpenTargetsiENSG00000135457
PharmGKBiPA36463

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4091 Eukaryota
ENOG410XNZ6 LUCA
GeneTreeiENSGT00940000157629
HOGENOMiHOG000230625
HOVERGENiHBG053805
InParanoidiQ12800
KOiK09275
OMAiRQINQIF
OrthoDBiEOG091G0YV2
PhylomeDBiQ12800
TreeFamiTF314132

Enzyme and pathway databases

SIGNORiQ12800

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TFCP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TFCP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7024

Protein Ontology

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PROi
PR:Q12800

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135457 Expressed in 223 organ(s), highest expression level in mucosa of paranasal sinus
CleanExiHS_TFCP2
ExpressionAtlasiQ12800 baseline and differential
GenevisibleiQ12800 HS

Family and domain databases

CDDicd09589 SAM_TFCP2, 1 hit
InterProiView protein in InterPro
IPR007604 CP2
IPR013761 SAM/pointed_sf
IPR040167 TF_CP2-like
IPR037599 TFCP2_SAM
PANTHERiPTHR11037 PTHR11037, 1 hit
PfamiView protein in Pfam
PF04516 CP2, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFCP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12800
Secondary accession number(s): A8K5E9
, Q12801, Q9UD75, Q9UD77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: December 5, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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