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Entry version 160 (22 Apr 2020)
Sequence version 2 (21 Mar 2006)
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Protein

Alpha-globin transcription factor CP2

Gene

TFCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.By similarity4 Publications

Miscellaneous

In PubMed:8114710 authors noted that a 10-fold molar excess of isoform 3 over isoform 1 inhibited DNA-binding.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q12800

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-globin transcription factor CP2
Alternative name(s):
SAA3 enhancer factor
Transcription factor LSF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFCP2
Synonyms:LSF, SEF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:11748 TFCP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
189889 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi211V → E: Does not affect DNA-binding activity. 1 Publication1
Mutagenesisi213I → R: Does not affect DNA-binding activity. 1 Publication1
Mutagenesisi234Q → L: Significant reduction of DNA-binding activity. 1 Publication1
Mutagenesisi236K → E: Significant reduction of DNA-binding activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7024

Open Targets

More...
OpenTargetsi
ENSG00000135457

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36463

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q12800 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TFCP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90101767

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002280011 – 502Alpha-globin transcription factor CP2Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei353PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q12800

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q12800

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q12800

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12800

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q12800

PeptideAtlas

More...
PeptideAtlasi
Q12800

PRoteomics IDEntifications database

More...
PRIDEi
Q12800

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58951 [Q12800-1]
58952 [Q12800-2]
58953 [Q12800-3]
58954 [Q12800-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q12800

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q12800

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal erythroid tissue.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135457 Expressed in mucosa of paranasal sinus and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q12800 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q12800 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135457 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to DNA as a dimer, isoform 3 does not bind to DNA or affect the binding of isoform 1 to DNA.

Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity).

Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q12800
With#Exp.IntAct
ACAA1 [P09110]3EBI-717422,EBI-3926709
ADPRH [P54922]3EBI-717422,EBI-6657604
ASAP3 [Q8TDY4]3EBI-717422,EBI-2609717
BAG6 [P46379]3EBI-717422,EBI-347552
C19orf73 [Q9NVV2]3EBI-717422,EBI-2859285
CA1 [P00915]6EBI-717422,EBI-3912102
CAPN3 [A0A0S2Z3E6]3EBI-717422,EBI-16430532
CAPN3 - isoform II [P20807-2]3EBI-717422,EBI-16433991
CBX8 [Q9HC52]6EBI-717422,EBI-712912
CDC73 [Q6P1J9]8EBI-717422,EBI-930143
DNAJC27 [Q9NZQ0]6EBI-717422,EBI-10317544
DNAJC5B [Q9UF47]3EBI-717422,EBI-10320535
DPH1 [Q9BZG8]3EBI-717422,EBI-10303200
E2F8 [A0AVK6]3EBI-717422,EBI-7779316
EAF1 [Q96JC9]3EBI-717422,EBI-769261
EIF5B [Q8N5A0]3EBI-717422,EBI-6137508
EPHA10 - isoform 3 [Q5JZY3-3]3EBI-717422,EBI-10244652
ESR2 - isoform 3 [Q92731-3]3EBI-717422,EBI-12259414
FANCL [Q9NW38]3EBI-717422,EBI-2339898
FARS2 [O95363]3EBI-717422,EBI-2513774
FBXL18 [Q96D16]3EBI-717422,EBI-744419
GPANK1 [O95872]3EBI-717422,EBI-751540
HAPLN2 [Q9GZV7]3EBI-717422,EBI-11956675
IRAK1BP1 [Q5VVH5]3EBI-717422,EBI-9658404
MOB3C [Q70IA8]3EBI-717422,EBI-9679267
MORF4L1 [Q9UBU8]3EBI-717422,EBI-399246
MORF4L1 - isoform 2 [Q9UBU8-2]3EBI-717422,EBI-10288852
MRPL11 [Q9Y3B7]3EBI-717422,EBI-5453723
MRPL40 [Q9NQ50]3EBI-717422,EBI-1053902
NABP1 [Q96AH0]3EBI-717422,EBI-2889252
NHSL2 [Q5HYW2]3EBI-717422,EBI-2859639
NPEPL1 - isoform 4 [Q8NDH3-4]3EBI-717422,EBI-10269715
PHF1 [O43189]4EBI-717422,EBI-530034
PHF21B [A0A0S2Z615]3EBI-717422,EBI-16434035
PIMREG [Q9BSJ6]3EBI-717422,EBI-2568609
PITPNM1 [O00562]3EBI-717422,EBI-2861268
PLCB1 [Q9NQ66]3EBI-717422,EBI-3396023
POLL - isoform 2 [Q9UGP5-2]3EBI-717422,EBI-10320765
POLR3GL [Q9BT43]3EBI-717422,EBI-2855862
PPIG [Q13427]3EBI-717422,EBI-396072
PPP1R1B [Q9UD71]3EBI-717422,EBI-722119
PPP3R2 [Q96LZ3]3EBI-717422,EBI-3906025
PSMD5 [Q16401]3EBI-717422,EBI-752143
RBMS1 [P29558]3EBI-717422,EBI-5462600
RXRB - isoform 2 [P28702-3]3EBI-717422,EBI-16429492
SDCBP [O00560]3EBI-717422,EBI-727004
SHTN1 - isoform 7 [A0MZ66-7]3EBI-717422,EBI-10171490
STMN2 [Q93045]3EBI-717422,EBI-714194
SUMO1 [P63165]3EBI-717422,EBI-80140
TCEA2 [Q15560]3EBI-717422,EBI-710310
TDRD1 - isoform 2 [Q9BXT4-2]3EBI-717422,EBI-10301451
TLK1 [Q9UKI8]3EBI-717422,EBI-740492
TRAPPC12 [Q53QD4]3EBI-717422,EBI-10242701
TSPAN12 [O95859]3EBI-717422,EBI-2466403
UBE2I [P63279]4EBI-717422,EBI-80168
YJU2 [Q9BW85]6EBI-717422,EBI-10300345
ZCCHC10 [Q8TBK6]4EBI-717422,EBI-597063
ZCCHC12 [Q6PEW1]6EBI-717422,EBI-748373

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112882, 115 interactors

Protein interaction database and analysis system

More...
IntActi
Q12800, 121 interactors

Molecular INTeraction database

More...
MINTi
Q12800

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000257915

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q12800 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni133 – 395DNA-bindingAdd BLAST263

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi314 – 319Poly-Pro6
Compositional biasi396 – 413Gln-richAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4091 Eukaryota
ENOG410XNZ6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157629

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q12800

KEGG Orthology (KO)

More...
KOi
K09275

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEEYTEH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q12800

TreeFam database of animal gene trees

More...
TreeFami
TF314132

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09589 SAM_TFCP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007604 CP2
IPR013761 SAM/pointed_sf
IPR041418 SAM_3
IPR040167 TF_CP2-like
IPR037599 TFCP2_SAM

The PANTHER Classification System

More...
PANTHERi
PTHR11037 PTHR11037, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04516 CP2, 1 hit
PF18016 SAM_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12800-1) [UniParc]FASTAAdd to basket
Also known as: LBP-1c

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK
60 70 80 90 100
QEESSLPPDN ENKILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML
110 120 130 140 150
DNRKLGELPE INGKLVKSIF RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL
160 170 180 190 200
DIDIPMSVGI IDPRANPTQL NTVEFLWDPA KRTSVFIQVH CISTEFTMRK
210 220 230 240 250
HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASCQIKVFKP KGADRKQKTD
260 270 280 290 300
REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNSP SPGFNSSHSS
310 320 330 340 350
FSLGEGNGSP NHQPEPPPPV TDNLLPTTTP QEAQQWLHRN RFSTFTRLFT
360 370 380 390 400
NFSGADLLKL TRDDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESLQ
410 420 430 440 450
LREQQQQQQQ QQQKHEDGDS NGTFFVYHAI YLEELTAVEL TEKIAQLFSI
460 470 480 490 500
SPCQISQIYK QGPTGIHVLI SDEMIQNFQE EACFILDTMK AETNDSYHII

LK
Length:502
Mass (Da):57,256
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB93825C2687F89FF
GO
Isoform 2 (identifier: Q12800-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-239: Missing.
     491-491: Missing.

Show »
Length:450
Mass (Da):51,308
Checksum:i5004E9DF3925E852
GO
Isoform 3 (identifier: Q12800-3) [UniParc]FASTAAdd to basket
Also known as: LBP-1d

The sequence of this isoform differs from the canonical sequence as follows:
     189-239: Missing.

Show »
Length:451
Mass (Da):51,379
Checksum:i04DAF489CA939B17
GO
Isoform 4 (identifier: Q12800-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-491: Missing.

Show »
Length:501
Mass (Da):57,185
Checksum:i22D5A27DD537009D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VX55F8VX55_HUMAN
Alpha-globin transcription factor C...
TFCP2
424Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWL0F8VWL0_HUMAN
Alpha-globin transcription factor C...
TFCP2
381Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92G → A in M84810 (PubMed:1732747).Curated1
Sequence conflicti92G → A AA sequence (PubMed:1732747).Curated1
Sequence conflicti249T → M in M84810 (PubMed:1732747).Curated1
Sequence conflicti249T → M AA sequence (PubMed:1732747).Curated1
Sequence conflicti491A → Q in AAA21324 (PubMed:8035790).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017647189 – 239Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST51
Alternative sequenceiVSP_017648491Missing in isoform 2 and isoform 4. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M84810 mRNA No translation available.
U03494 mRNA Translation: AAA21324.1
U03495 mRNA Translation: AAA21325.1
AK291264 mRNA Translation: BAF83953.1
CH471111 Genomic DNA Translation: EAW58178.1
BC003634 mRNA Translation: AAH03634.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS55827.1 [Q12800-2]
CCDS8808.1 [Q12800-1]

Protein sequence database of the Protein Information Resource

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PIRi
A42030
A53771
C56205

NCBI Reference Sequences

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RefSeqi
NP_001166923.1, NM_001173452.1 [Q12800-4]
NP_001166924.1, NM_001173453.1 [Q12800-2]
NP_005644.2, NM_005653.4 [Q12800-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000257915; ENSP00000257915; ENSG00000135457 [Q12800-1]
ENST00000548115; ENSP00000447991; ENSG00000135457 [Q12800-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7024

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7024

UCSC genome browser

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UCSCi
uc001rxw.4 human [Q12800-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84810 mRNA No translation available.
U03494 mRNA Translation: AAA21324.1
U03495 mRNA Translation: AAA21325.1
AK291264 mRNA Translation: BAF83953.1
CH471111 Genomic DNA Translation: EAW58178.1
BC003634 mRNA Translation: AAH03634.1
CCDSiCCDS55827.1 [Q12800-2]
CCDS8808.1 [Q12800-1]
PIRiA42030
A53771
C56205
RefSeqiNP_001166923.1, NM_001173452.1 [Q12800-4]
NP_001166924.1, NM_001173453.1 [Q12800-2]
NP_005644.2, NM_005653.4 [Q12800-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112882, 115 interactors
IntActiQ12800, 121 interactors
MINTiQ12800
STRINGi9606.ENSP00000257915

PTM databases

iPTMnetiQ12800
PhosphoSitePlusiQ12800

Polymorphism and mutation databases

BioMutaiTFCP2
DMDMi90101767

Proteomic databases

EPDiQ12800
jPOSTiQ12800
MassIVEiQ12800
MaxQBiQ12800
PaxDbiQ12800
PeptideAtlasiQ12800
PRIDEiQ12800
ProteomicsDBi58951 [Q12800-1]
58952 [Q12800-2]
58953 [Q12800-3]
58954 [Q12800-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26338 190 antibodies

The DNASU plasmid repository

More...
DNASUi
7024

Genome annotation databases

EnsembliENST00000257915; ENSP00000257915; ENSG00000135457 [Q12800-1]
ENST00000548115; ENSP00000447991; ENSG00000135457 [Q12800-2]
GeneIDi7024
KEGGihsa:7024
UCSCiuc001rxw.4 human [Q12800-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7024
DisGeNETi7024

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TFCP2
HGNCiHGNC:11748 TFCP2
HPAiENSG00000135457 Low tissue specificity
MIMi189889 gene
neXtProtiNX_Q12800
OpenTargetsiENSG00000135457
PharmGKBiPA36463

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4091 Eukaryota
ENOG410XNZ6 LUCA
GeneTreeiENSGT00940000157629
InParanoidiQ12800
KOiK09275
OMAiNEEYTEH
PhylomeDBiQ12800
TreeFamiTF314132

Enzyme and pathway databases

SIGNORiQ12800

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TFCP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TFCP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7024
PharosiQ12800 Tbio

Protein Ontology

More...
PROi
PR:Q12800
RNActiQ12800 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135457 Expressed in mucosa of paranasal sinus and 222 other tissues
ExpressionAtlasiQ12800 baseline and differential
GenevisibleiQ12800 HS

Family and domain databases

CDDicd09589 SAM_TFCP2, 1 hit
Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR007604 CP2
IPR013761 SAM/pointed_sf
IPR041418 SAM_3
IPR040167 TF_CP2-like
IPR037599 TFCP2_SAM
PANTHERiPTHR11037 PTHR11037, 1 hit
PfamiView protein in Pfam
PF04516 CP2, 1 hit
PF18016 SAM_3, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFCP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12800
Secondary accession number(s): A8K5E9
, Q12801, Q9UD75, Q9UD77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: April 22, 2020
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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