UniProtKB - Q12798 (CETN1_HUMAN)
Protein
Centrin-1
Gene
CETN1
Organism
Homo sapiens (Human)
Status
Functioni
Plays a fundamental role in microtubule-organizing center structure and function (PubMed:8175926). Plays a role in sperm cilia formation (By similarity).By similarity1 Publication
Miscellaneous
Binds two moles of calcium per mole of protein.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 41 – 52 | 1CuratedAdd BLAST | 12 | |
Calcium bindingi | 150 – 161 | 2CuratedAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: GO_Central
- G-protein beta/gamma-subunit complex binding Source: Ensembl
- heterotrimeric G-protein binding Source: Ensembl
- microtubule binding Source: Ensembl
GO - Biological processi
- cell division Source: UniProtKB-KW
- cellular response to heat Source: Ensembl
- centriole replication Source: GO_Central
- mitotic cell cycle Source: GO_Central
- nucleotide-excision repair Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q12798 |
Reactomei | R-HSA-9613829, Chaperone Mediated Autophagy R-HSA-9615710, Late endosomal microautophagy R-HSA-9646399, Aggrephagy |
SIGNORi | Q12798 |
Names & Taxonomyi
Protein namesi | Recommended name: Centrin-1CuratedAlternative name(s): Caltractin isoform 2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177143.4 |
HGNCi | HGNC:1866, CETN1 |
MIMi | 603187, gene |
neXtProti | NX_Q12798 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
Other locations
- cilium By similarity
Note: Centrosome of interphase and mitotic cells. In the retinal photoreceptor cells, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (By similarity).By similarity1 Publication
Cytoskeleton
- centriole Source: MGI
- centrosome Source: UniProtKB
- spindle pole Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-KW
- photoreceptor connecting cilium Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 1068 |
OpenTargetsi | ENSG00000177143 |
PharmGKBi | PA26419 |
Miscellaneous databases
Pharosi | Q12798, Tbio |
Polymorphism and mutation databases
BioMutai | CETN1 |
DMDMi | 2493440 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073559 | 1 – 172 | Centrin-1Add BLAST | 172 |
Proteomic databases
jPOSTi | Q12798 |
MassIVEi | Q12798 |
MaxQBi | Q12798 |
PaxDbi | Q12798 |
PeptideAtlasi | Q12798 |
PRIDEi | Q12798 |
ProteomicsDBi | 58948 |
PTM databases
iPTMneti | Q12798 |
PhosphoSitePlusi | Q12798 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177143, Expressed in left testis and 40 other tissues |
ExpressionAtlasi | Q12798, baseline and differential |
Genevisiblei | Q12798, HS |
Organism-specific databases
HPAi | ENSG00000177143, Tissue enriched (testis) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ12798
With | #Exp. | IntAct |
---|---|---|
POC5 [Q8NA72] | 6 | EBI-2512818,EBI-2561090 |
POC5 - isoform 3 [Q8NA72-3] | 4 | EBI-2512818,EBI-11751537 |
SGSM1 - isoform 3 [Q2NKQ1-4] | 7 | EBI-2512818,EBI-10182463 |
GO - Molecular functioni
- microtubule binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107495, 46 interactors |
IntActi | Q12798, 43 interactors |
MINTi | Q12798 |
STRINGi | 9606.ENSP00000319052 |
Miscellaneous databases
RNActi | Q12798, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 63 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 64 – 99 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 101 – 136 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 137 – 172 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the centrin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0028, Eukaryota |
GeneTreei | ENSGT00940000157209 |
HOGENOMi | CLU_061288_18_2_1 |
InParanoidi | Q12798 |
OMAi | GIQKIFA |
OrthoDBi | 1382571at2759 |
PhylomeDBi | Q12798 |
TreeFami | TF101141 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000629, RNA-helicase_DEAD-box_CS |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q12798-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASGFKKPSA ASTGQKRKVA PKPELTEDQK QEVREAFDLF DVDGSGTIDA
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK KMISEVDREG TGKISFNDFL AVMTQKMSEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA NELGENLTDE ELQEMIDEAD
160 170
RDGDGEVNEE EFLRIMKKTS LY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03270 mRNA Translation: AAC27343.1 AK312047 mRNA Translation: BAG34983.1 CH471113 Genomic DNA Translation: EAX01727.1 BC029515 mRNA Translation: AAH29515.1 |
CCDSi | CCDS11820.1 |
PIRi | I38424 |
RefSeqi | NP_004057.1, NM_004066.2 |
Genome annotation databases
Ensembli | ENST00000327228; ENSP00000319052; ENSG00000177143 |
GeneIDi | 1068 |
KEGGi | hsa:1068 |
UCSCi | uc002kko.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03270 mRNA Translation: AAC27343.1 AK312047 mRNA Translation: BAG34983.1 CH471113 Genomic DNA Translation: EAX01727.1 BC029515 mRNA Translation: AAH29515.1 |
CCDSi | CCDS11820.1 |
PIRi | I38424 |
RefSeqi | NP_004057.1, NM_004066.2 |
3D structure databases
SMRi | Q12798 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107495, 46 interactors |
IntActi | Q12798, 43 interactors |
MINTi | Q12798 |
STRINGi | 9606.ENSP00000319052 |
PTM databases
iPTMneti | Q12798 |
PhosphoSitePlusi | Q12798 |
Polymorphism and mutation databases
BioMutai | CETN1 |
DMDMi | 2493440 |
Proteomic databases
jPOSTi | Q12798 |
MassIVEi | Q12798 |
MaxQBi | Q12798 |
PaxDbi | Q12798 |
PeptideAtlasi | Q12798 |
PRIDEi | Q12798 |
ProteomicsDBi | 58948 |
Protocols and materials databases
Antibodypediai | 5901, 249 antibodies |
DNASUi | 1068 |
Genome annotation databases
Ensembli | ENST00000327228; ENSP00000319052; ENSG00000177143 |
GeneIDi | 1068 |
KEGGi | hsa:1068 |
UCSCi | uc002kko.2, human |
Organism-specific databases
CTDi | 1068 |
DisGeNETi | 1068 |
EuPathDBi | HostDB:ENSG00000177143.4 |
GeneCardsi | CETN1 |
HGNCi | HGNC:1866, CETN1 |
HPAi | ENSG00000177143, Tissue enriched (testis) |
MIMi | 603187, gene |
neXtProti | NX_Q12798 |
OpenTargetsi | ENSG00000177143 |
PharmGKBi | PA26419 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0028, Eukaryota |
GeneTreei | ENSGT00940000157209 |
HOGENOMi | CLU_061288_18_2_1 |
InParanoidi | Q12798 |
OMAi | GIQKIFA |
OrthoDBi | 1382571at2759 |
PhylomeDBi | Q12798 |
TreeFami | TF101141 |
Enzyme and pathway databases
PathwayCommonsi | Q12798 |
Reactomei | R-HSA-9613829, Chaperone Mediated Autophagy R-HSA-9615710, Late endosomal microautophagy R-HSA-9646399, Aggrephagy |
SIGNORi | Q12798 |
Miscellaneous databases
BioGRID-ORCSi | 1068, 3 hits in 840 CRISPR screens |
GeneWikii | CETN1 |
GenomeRNAii | 1068 |
Pharosi | Q12798, Tbio |
PROi | PR:Q12798 |
RNActi | Q12798, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177143, Expressed in left testis and 40 other tissues |
ExpressionAtlasi | Q12798, baseline and differential |
Genevisiblei | Q12798, HS |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000629, RNA-helicase_DEAD-box_CS |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CETN1_HUMAN | |
Accessioni | Q12798Primary (citable) accession number: Q12798 Secondary accession number(s): B2R536 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM