Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proline-rich nuclear receptor coactivator 1

Gene

PNRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear receptor coactivator. May play a role in signal transduction.1 Publication

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich nuclear receptor coactivator 1
Alternative name(s):
Proline-rich protein 2
Protein B4-2
Gene namesi
Name:PNRC1
Synonyms:PROL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146278.10
HGNCiHGNC:17278 PNRC1
MIMi606714 gene
neXtProtiNX_Q12796

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi287P → A: Abolishes the interaction with the nuclear receptors; when associated with A-290. 1 Publication1
Mutagenesisi290P → A: Abolishes the interaction with the nuclear receptors; when associated with A-287. 1 Publication1

Organism-specific databases

DisGeNETi10957
OpenTargetsiENSG00000146278
PharmGKBiPA33804

Polymorphism and mutation databases

BioMutaiPNRC1
DMDMi21362754

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584821 – 327Proline-rich nuclear receptor coactivator 1Add BLAST327

Proteomic databases

PaxDbiQ12796
PeptideAtlasiQ12796
PRIDEiQ12796
ProteomicsDBi58943

PTM databases

iPTMnetiQ12796
PhosphoSitePlusiQ12796

Expressioni

Tissue specificityi

Expressed in liver, lung, fat and NK/T cells.1 Publication

Gene expression databases

BgeeiENSG00000146278 Expressed in 228 organ(s), highest expression level in urinary bladder
CleanExiHS_PNRC1
ExpressionAtlasiQ12796 baseline and differential
GenevisibleiQ12796 HS

Organism-specific databases

HPAiHPA029839
HPA066513

Interactioni

Subunit structurei

Interacts with many nuclear receptors including AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR. Interacts with GRB2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POLR3FQ9H1D93EBI-2827376,EBI-710067

Protein-protein interaction databases

BioGridi116157, 17 interactors
IntActiQ12796, 8 interactors
MINTiQ12796
STRINGi9606.ENSP00000336931

Structurei

3D structure databases

ProteinModelPortaliQ12796
SMRiQ12796
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi94 – 101Nuclear localization signal1 Publication8
Motifi285 – 291SH3-binding7

Domaini

The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif.

Sequence similaritiesi

Belongs to the PNRC family. PNRC1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IITX Eukaryota
ENOG410YIYX LUCA
GeneTreeiENSGT00530000063881
HOGENOMiHOG000059555
HOVERGENiHBG053626
InParanoidiQ12796
KOiK18774
OMAiPAALPNC
OrthoDBiEOG091G0SY3
PhylomeDBiQ12796
TreeFamiTF333211

Family and domain databases

InterProiView protein in InterPro
IPR026780 PNRC1/2
PANTHERiPTHR15405 PTHR15405, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12796-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVVSVPQRE PLVLGGRLAP LGFSSRGYFG ALPMVTTAPP PLPRIPDPRA
60 70 80 90 100
LPPTLFLPHF LGGDGPCLTP QPRAPAALPN RSLAVAGGTP RAAPKKRRKK
110 120 130 140 150
KVRASPAGQL PSRFHQYQQH RPSLEGGRSP ATGPSGAQEV PGPAAALAPS
160 170 180 190 200
PAAAAGTEGA SPDLAPLRPA APGQTPLRKE VLKSKMGKSE KIALPHGQLV
210 220 230 240 250
HGIHLYEQPK INRQKSKYNL PLTKITSAKR NENNFWQDSV SSDRIQKQEK
260 270 280 290 300
KPFKNTENIK NSHLKKSAFL TEVSQKENYA GAKFSDPPSP SVLPKPPSHW
310 320
MGSTVENSNQ NRELMAVHLK TLLKVQT
Length:327
Mass (Da):35,225
Last modified:November 1, 1996 - v1
Checksum:i97E0D65C2E690763
GO
Isoform 2 (identifier: Q12796-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-180: Missing.

Show »
Length:248
Mass (Da):27,374
Checksum:i734F69C11B023FA7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q49A59Q49A59_HUMAN
PNRC1 protein
PNRC1
142Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218Y → N in AAP76184 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051284252P → L. Corresponds to variant dbSNP:rs2231277Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055501102 – 180Missing in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03105 mRNA Translation: AAA85576.1
AY303779 mRNA Translation: AAP76184.1
AK312665 mRNA Translation: BAG35547.1
AL353135 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48563.1
CH471051 Genomic DNA Translation: EAW48564.1
BC018112 mRNA Translation: AAH18112.1
CCDSiCCDS5018.1 [Q12796-1]
PIRiS59960
RefSeqiNP_006804.1, NM_006813.2 [Q12796-1]
UniGeneiHs.75969

Genome annotation databases

EnsembliENST00000336032; ENSP00000336931; ENSG00000146278 [Q12796-1]
GeneIDi10957
KEGGihsa:10957
UCSCiuc003pmv.4 human [Q12796-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03105 mRNA Translation: AAA85576.1
AY303779 mRNA Translation: AAP76184.1
AK312665 mRNA Translation: BAG35547.1
AL353135 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48563.1
CH471051 Genomic DNA Translation: EAW48564.1
BC018112 mRNA Translation: AAH18112.1
CCDSiCCDS5018.1 [Q12796-1]
PIRiS59960
RefSeqiNP_006804.1, NM_006813.2 [Q12796-1]
UniGeneiHs.75969

3D structure databases

ProteinModelPortaliQ12796
SMRiQ12796
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116157, 17 interactors
IntActiQ12796, 8 interactors
MINTiQ12796
STRINGi9606.ENSP00000336931

PTM databases

iPTMnetiQ12796
PhosphoSitePlusiQ12796

Polymorphism and mutation databases

BioMutaiPNRC1
DMDMi21362754

Proteomic databases

PaxDbiQ12796
PeptideAtlasiQ12796
PRIDEiQ12796
ProteomicsDBi58943

Protocols and materials databases

DNASUi10957
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336032; ENSP00000336931; ENSG00000146278 [Q12796-1]
GeneIDi10957
KEGGihsa:10957
UCSCiuc003pmv.4 human [Q12796-1]

Organism-specific databases

CTDi10957
DisGeNETi10957
EuPathDBiHostDB:ENSG00000146278.10
GeneCardsiPNRC1
HGNCiHGNC:17278 PNRC1
HPAiHPA029839
HPA066513
MIMi606714 gene
neXtProtiNX_Q12796
OpenTargetsiENSG00000146278
PharmGKBiPA33804
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IITX Eukaryota
ENOG410YIYX LUCA
GeneTreeiENSGT00530000063881
HOGENOMiHOG000059555
HOVERGENiHBG053626
InParanoidiQ12796
KOiK18774
OMAiPAALPNC
OrthoDBiEOG091G0SY3
PhylomeDBiQ12796
TreeFamiTF333211

Miscellaneous databases

ChiTaRSiPNRC1 human
GeneWikiiPNRC1
GenomeRNAii10957
PROiPR:Q12796
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146278 Expressed in 228 organ(s), highest expression level in urinary bladder
CleanExiHS_PNRC1
ExpressionAtlasiQ12796 baseline and differential
GenevisibleiQ12796 HS

Family and domain databases

InterProiView protein in InterPro
IPR026780 PNRC1/2
PANTHERiPTHR15405 PTHR15405, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPNRC1_HUMAN
AccessioniPrimary (citable) accession number: Q12796
Secondary accession number(s): B2R6Q0
, E1P515, Q5T7J6, Q7Z5N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again