TWF1

Functionⁱ

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).By similarity

Caution

Was originally thought to have protein tyrosine kinase activity.1 Publication

GO - Molecular functionⁱ

actin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 28493397
actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
actin monomer binding
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 12807912
- 18837697
ATP binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10406962
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
phosphatidylinositol-4,5-bisphosphate binding
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 12807912

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament depolymerization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
barbed-end actin filament capping
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of actin filament polymerization
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 12807912
peptidyl-tyrosine phosphorylation Source: GOC
positive regulation of cardiac muscle hypertrophy Source: Ensembl
positive regulation of neuron projection development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of actin phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10406962
regulation of lamellipodium assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequestering of actin monomers
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 18837697

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding

Molecular function

Actin-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Twinfilin-1 Alternative name(s): Protein A6 Protein tyrosine kinase 9
Gene namesⁱ	Name:TWF1 Synonyms:PTK9
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151239.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9620 TWF1
MIMⁱ	610932 gene
neXtProtⁱ	NX_Q12792

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Defects in TWF1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.1 Publication

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5756
Open Targets More...OpenTargetsⁱ	ENSG00000151239
PharmGKBⁱ	PA162407406

Polymorphism and mutation databases

BioMutaⁱ	TWF1
DMDMⁱ	259016376

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000214950	2 – 350	Twinfilin-1Add BLAST		349

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserine1 Publication	1
Modified residueⁱ	143	PhosphoserineCombined sources	1
Modified residueⁱ	277	PhosphoserineBy similarity	1
Modified residueⁱ	309	PhosphotyrosineCombined sources	1
Modified residueⁱ	349	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Phosphorylated on serine and threonine residues.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q12792
PaxDbⁱ	Q12792
PeptideAtlas More...PeptideAtlasⁱ	Q12792
PRIDEⁱ	Q12792
ProteomicsDBⁱ	58933 58934 [Q12792-3] 58935 [Q12792-4]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	Q12792

OGPⁱ

Q12792

PTM databases

iPTMnetⁱ	Q12792
PhosphoSitePlusⁱ	Q12792

Expressionⁱ

Tissue specificityⁱ

Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000151239 Expressed in 236 organ(s), highest expression level in palpebral conjunctiva
ExpressionAtlasⁱ	Q12792 baseline and differential
Genevisibleⁱ	Q12792 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018116

HPAⁱ

HPA018116

Interactionⁱ

Subunit structureⁱ

Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated (By similarity). Interacts with ACTG1 (PubMed:28493397).By similarity1 Publication

GO - Molecular functionⁱ

actin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 28493397
actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
actin monomer binding
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 12807912
- 18837697
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111723, 62 interactors
IntActⁱ	Q12792, 30 interactors
Molecular INTeraction database More...MINTⁱ	Q12792
STRINGⁱ	9606.ENSP00000449428

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q12792
SMRⁱ	Q12792
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 139	ADF-H 1PROSITE-ProRule annotationAdd BLAST		138
Domainⁱ	175 – 313	ADF-H 2PROSITE-ProRule annotationAdd BLAST		139

Sequence similaritiesⁱ

Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG1747 Eukaryota ENOG410XS1J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063868
HOVERGENⁱ	HBG000848
InParanoidⁱ	Q12792
KEGG Orthology (KO) More...KOⁱ	K08870
OMAⁱ	YDYLQFR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BWK
PhylomeDBⁱ	Q12792
TreeFamⁱ	TF352598

Family and domain databases

Gene3Dⁱ	3.40.20.10, 2 hits
InterProⁱ	View protein in InterPro IPR002108 ADF-H IPR029006 ADF-H/Gelsolin-like_dom_sf IPR028458 Twinfilin
PANTHERⁱ	PTHR13759 PTHR13759, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00241 Cofilin_ADF, 2 hits
SMARTⁱ	View protein in SMART SM00102 ADF, 2 hits
PROSITEⁱ	View protein in PROSITE PS51263 ADF_H, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1Curated (identifier: Q12792-2) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHQTGIQAS EDVKEIFARA RNGKYRLLKI SIENEQLVIG SYSQPSDSWD 
        60         70         80         90        100
KDYDSFVLPL LEDKQPCYIL FRLDSQNAQG YEWIFIAWSP DHSHVRQKML 
       110        120        130        140        150
YAATRATLKK EFGGGHIKDE VFGTVKEDVS LHGYKKYLLS QSSPAPLTAA 
       160        170        180        190        200
EEELRQIKIN EVQTDVGVDT KHQTLQGVAF PISREAFQAL EKLNNRQLNY 
       210        220        230        240        250
VQLEIDIKNE IIILANTTNT ELKDLPKRIP KDSARYHFFL YKHSHEGDYL 
       260        270        280        290        300
ESIVFIYSMP GYTCSIRERM LYSSCKSRLL EIVERQLQMD VIRKIEIDNG 
       310        320        330        340        350
DELTADFLYE EVHPKQHAHK QSFAKPKGPA GKRGIRRLIR GPAETEATTD

Length:350

Mass (Da):40,283

Last modified:September 22, 2009 - v3

Checksum:ⁱ5F68A6946E969A80

GO

Isoform 3 (identifier: Q12792-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
161-161: E → ESPEDHIG

« Hide

        10         20         30         40         50
MSHQTGIQAS EDVKEIFARA RNGKYRLLKI SIENEQLVIG SYSQPSDSWD 
        60         70         80         90        100
KDYDSFVLPL LEDKQPCYIL FRLDSQNAQG YEWIFIAWSP DHSHVRQKML 
       110        120        130        140        150
YAATRATLKK EFGGGHIKDE VFGTVKEDVS LHGYKKYLLS QSSPAPLTAA 
       160        170        180        190        200
EEELRQIKIN ESPEDHIGVQ TDVGVDTKHQ TLQGVAFPIS REAFQALEKL 
       210        220        230        240        250
NNRQLNYVQL EIDIKNEIII LANTTNTELK DLPKRIPKDS ARYHFFLYKH 
       260        270        280        290        300
SHEGDYLESI VFIYSMPGYT CSIRERMLYS SCKSRLLEIV ERQLQMDVIR 
       310        320        330        340        350
KIEIDNGDEL TADFLYEEVH PKQHAHKQSF AKPKGPAGKR GIRRLIRGPA 

ETEATTD

Show »

Length:357

Mass (Da):41,018

Checksum:ⁱ826E95A7D995033B

GO

Isoform 4 (identifier: Q12792-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-98: Missing.

« Hide

        10         20         30         40         50
MLYAATRATL KKEFGGGHIK DEVFGTVKED VSLHGYKKYL LSQSSPAPLT 
        60         70         80         90        100
AAEEELRQIK INEVQTDVGV DTKHQTLQGV AFPISREAFQ ALEKLNNRQL 
       110        120        130        140        150
NYVQLEIDIK NEIIILANTT NTELKDLPKR IPKDSARYHF FLYKHSHEGD 
       160        170        180        190        200
YLESIVFIYS MPGYTCSIRE RMLYSSCKSR LLEIVERQLQ MDVIRKIEID 
       210        220        230        240        250
NGDELTADFL YEEVHPKQHA HKQSFAKPKG PAGKRGIRRL IRGPAETEAT 

TD

Show »

Length:252

Mass (Da):28,823

Checksum:ⁱCCE0A5A82BBE109D

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VS81	F8VS81_HUMAN	Twinfilin-1 Twinfilin-1	TWF1	291	Annotation score:
F8W1Q9	F8W1Q9_HUMAN	Twinfilin-1 Twinfilin-1	TWF1	113	Annotation score:
F8VRG3	F8VRG3_HUMAN	Twinfilin-1 Twinfilin-1	TWF1	59	Annotation score:
F8W645	F8W645_HUMAN	Twinfilin-1 Twinfilin-1	TWF1	15	Annotation score:
F8W1D0	F8W1D0_HUMAN	Twinfilin-1 Twinfilin-1	TWF1	119	Annotation score:

Sequence cautionⁱ

The sequence AAH43148 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH68548 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAD92539 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	12	D → Y in CAG46561 (Ref. 3) Curated	1
Sequence conflictⁱ	246	E → V in BAG54588 (PubMed:14702039).Curated	1
Sequence conflictⁱ	269	R → W in CAG46536 (Ref. 3) Curated	1
Sequence conflictⁱ	302	E → G in BAF83912 (PubMed:14702039).Curated	1
Sequence conflictⁱ	329	P → H in BAG59691 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Isoform 3 (identifier: Q12792-3)
Natural variantⁱ	349	P → S Found in a patient with isolated coloboma, increases interaction with ACTG1. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_038075	1 – 98	Missing in isoform 4. 2 PublicationsAdd BLAST		98
Alternative sequenceⁱVSP_017899	161	E → ESPEDHIG in isoform 3. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U02680 mRNA Translation: AAC50062.1 AK127868 mRNA Translation: BAG54588.1 AK291223 mRNA Translation: BAF83912.1 AK297206 mRNA Translation: BAG59691.1 CR541736 mRNA Translation: CAG46536.1 CR541761 mRNA Translation: CAG46561.1 BT019691 mRNA Translation: AAV38497.1 AB209302 mRNA Translation: BAD92539.1 Different initiation. BC022344 mRNA Translation: AAH22344.1 BC043148 mRNA Translation: AAH43148.2 Different initiation. BC068548 mRNA Translation: AAH68548.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31780.2 [Q12792-2] CCDS55818.1 [Q12792-3]
PIRⁱ	A55922
NCBI Reference Sequences More...RefSeqⁱ	NP_001229326.1, NM_001242397.1 [Q12792-3] NP_002813.3, NM_002822.4 [Q12792-2]
UniGeneⁱ	Hs.189075 Hs.313056

Genome annotation databases

Ensemblⁱ	ENST00000395510; ENSP00000378886; ENSG00000151239 [Q12792-2] ENST00000548315; ENSP00000449428; ENSG00000151239 [Q12792-3] ENST00000552521; ENSP00000448750; ENSG00000151239 [Q12792-4]
GeneIDⁱ	5756
KEGGⁱ	hsa:5756
UCSC genome browser More...UCSCⁱ	uc001roa.4 human [Q12792-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q12792	Twinfilin-1	)	MOUSE		350	UniRef90_Q12792
Twinfilin-1		PONAB		350
Twinfilin-1		RAT		350
Isoform 4 of Twinfilin-1		HUMAN		252
Twinfilin-1		MYOBR		377
+92

Protein	Similar proteins		Species	Score	Length	Source
Q12792	Twinfilin-2		MOUSE		349	UniRef50_Q9Z0P5
Twinfilin-2	)	HUMAN		349
Twinfilin-2 (Fragment)		PONAB		341
Twinfilin-2		CHICK		349
Twinfilin-1		RAT		350
+485

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U02680 mRNA Translation: AAC50062.1 AK127868 mRNA Translation: BAG54588.1 AK291223 mRNA Translation: BAF83912.1 AK297206 mRNA Translation: BAG59691.1 CR541736 mRNA Translation: CAG46536.1 CR541761 mRNA Translation: CAG46561.1 BT019691 mRNA Translation: AAV38497.1 AB209302 mRNA Translation: BAD92539.1 Different initiation. BC022344 mRNA Translation: AAH22344.1 BC043148 mRNA Translation: AAH43148.2 Different initiation. BC068548 mRNA Translation: AAH68548.1 Different initiation.
CCDSⁱ	CCDS31780.2 [Q12792-2] CCDS55818.1 [Q12792-3]
PIRⁱ	A55922
RefSeqⁱ	NP_001229326.1, NM_001242397.1 [Q12792-3] NP_002813.3, NM_002822.4 [Q12792-2]
UniGeneⁱ	Hs.189075 Hs.313056

3D structure databases

ProteinModelPortalⁱ	Q12792
SMRⁱ	Q12792
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111723, 62 interactors
IntActⁱ	Q12792, 30 interactors
MINTⁱ	Q12792
STRINGⁱ	9606.ENSP00000449428

PTM databases

iPTMnetⁱ	Q12792
PhosphoSitePlusⁱ	Q12792

Polymorphism and mutation databases

BioMutaⁱ	TWF1
DMDMⁱ	259016376

2D gel databases

OGPⁱ	Q12792

OGPⁱ

Q12792

Proteomic databases

EPDⁱ	Q12792
PaxDbⁱ	Q12792
PeptideAtlasⁱ	Q12792
PRIDEⁱ	Q12792
ProteomicsDBⁱ	58933 58934 [Q12792-3] 58935 [Q12792-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5756
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000395510; ENSP00000378886; ENSG00000151239 [Q12792-2] ENST00000548315; ENSP00000449428; ENSG00000151239 [Q12792-3] ENST00000552521; ENSP00000448750; ENSG00000151239 [Q12792-4]
GeneIDⁱ	5756
KEGGⁱ	hsa:5756
UCSCⁱ	uc001roa.4 human [Q12792-2]

Organism-specific databases

CTDⁱ	5756
DisGeNETⁱ	5756
EuPathDBⁱ	HostDB:ENSG00000151239.13
GeneCardsⁱ	TWF1
HGNCⁱ	HGNC:9620 TWF1
HPAⁱ	HPA018116
MIMⁱ	610932 gene
neXtProtⁱ	NX_Q12792
OpenTargetsⁱ	ENSG00000151239
PharmGKBⁱ	PA162407406
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1747 Eukaryota ENOG410XS1J LUCA
GeneTreeⁱ	ENSGT00530000063868
HOVERGENⁱ	HBG000848
InParanoidⁱ	Q12792
KOⁱ	K08870
OMAⁱ	YDYLQFR
OrthoDBⁱ	EOG091G0BWK
PhylomeDBⁱ	Q12792
TreeFamⁱ	TF352598

Miscellaneous databases

ChiTaRSⁱ	TWF1 human
GeneWikiⁱ	TWF1
GenomeRNAiⁱ	5756
Protein Ontology More...PROⁱ	PR:Q12792
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151239 Expressed in 236 organ(s), highest expression level in palpebral conjunctiva
ExpressionAtlasⁱ	Q12792 baseline and differential
Genevisibleⁱ	Q12792 HS

Family and domain databases

Gene3Dⁱ	3.40.20.10, 2 hits
InterProⁱ	View protein in InterPro IPR002108 ADF-H IPR029006 ADF-H/Gelsolin-like_dom_sf IPR028458 Twinfilin
PANTHERⁱ	PTHR13759 PTHR13759, 1 hit
Pfamⁱ	View protein in Pfam PF00241 Cofilin_ADF, 2 hits
SMARTⁱ	View protein in SMART SM00102 ADF, 2 hits
PROSITEⁱ	View protein in PROSITE PS51263 ADF_H, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TWF1_HUMAN
Accessionⁱ	Q12792Primary (citable) accession number: Q12792 Secondary accession number(s): A8K5A8 Q8TCD3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 2, 2004
	Last sequence update:	September 22, 2009
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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UniProtKB - Q12792 (TWF1_HUMAN)

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Twinfilin-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ