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Protein

Calcium-activated potassium channel subunit alpha-1

Gene

KCNMA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. It is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca2+, caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

Miscellaneous

The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel also contains binding sites for Ca2+ and Mg2+.

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi439MagnesiumBy similarity1
Metal bindingi462MagnesiumBy similarity1
Metal bindingi464MagnesiumBy similarity1
Metal bindingi1012Calcium; via carbonyl oxygen1
Metal bindingi1015Calcium; via carbonyl oxygen1
Metal bindingi1018Calcium1
Metal bindingi1020Calcium1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandCalcium, Magnesium, Metal-binding, Potassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296052 Ca2+ activated K+ channels
R-HSA-418457 cGMP effects

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q12791

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-activated potassium channel subunit alpha-1
Alternative name(s):
BK channel
BKCA alpha
Calcium-activated potassium channel, subfamily M subunit alpha-1
K(VCA)alpha
KCa1.1
Maxi K channel
Short name:
MaxiK
Slo-alpha
Slo1
Slowpoke homolog
Short name:
Slo homolog
Short name:
hSlo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNMA1
Synonyms:KCNMA, SLO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000156113.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6284 KCNMA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600150 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q12791

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 86ExtracellularSequence analysisAdd BLAST86
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei87 – 107Helical; Name=Segment S0Sequence analysisAdd BLAST21
Topological domaini108 – 178CytoplasmicSequence analysisAdd BLAST71
Transmembranei179 – 199Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini200 – 214ExtracellularSequence analysisAdd BLAST15
Transmembranei215 – 235Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini236 – 239CytoplasmicSequence analysis4
Transmembranei240 – 260Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini261 – 264ExtracellularSequence analysis4
Transmembranei265 – 285Helical; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini286 – 300CytoplasmicSequence analysisAdd BLAST15
Transmembranei301 – 321Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini322 – 335ExtracellularSequence analysisAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei336 – 358Pore-forming; Name=P regionSequence analysisAdd BLAST23
Topological domaini359 – 367ExtracellularSequence analysis9
Transmembranei368 – 388Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini389 – 1236CytoplasmicSequence analysisAdd BLAST848

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy (PNKD3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurologic disorder characterized by absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia and involuntary dystonic or choreiform movements. Onset is usually in childhood. Patients may have seizures only, dyskinesia only, or both.
See also OMIM:609446
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023821434D → G in PNKD3; may have a synergistic effect with ethanol in the triggering of symptoms. 1 PublicationCorresponds to variant dbSNP:rs137853333EnsemblClinVar.1
Natural variantiVAR_079156884E → K in PNKD3. 1 Publication1
Natural variantiVAR_0791571053N → S in PNKD3. 1 PublicationCorresponds to variant dbSNP:rs886039469Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi118C → A: Decreased localization to the plasma membrane. Abolishes localization to the plasma membrane; when associated with A-119 and A-121. 2 Publications1
Mutagenesisi119C → A: Decreased localization to the plasma membrane. Abolishes localization to the plasma membrane; when associated with A-118 and A-121. 2 Publications1
Mutagenesisi121C → A: Decreased localization to the plasma membrane. Abolishes localization to the plasma membrane; when associated with A-119 and A-121. 2 Publications1
Mutagenesisi269L → R or H: No effect in the coupling between calcium and channel opening. 1 Publication1
Mutagenesisi272R → E: Induces reduction in the coupling between calcium and channel opening. 1 Publication1
Mutagenesisi275R → N: Induces reduction in the coupling between calcium and channel opening. 1 Publication1
Mutagenesisi278R → Q: Induces reduction in the coupling between calcium and channel opening. 1 Publication1
Mutagenesisi281Q → R: No effect in the coupling between calcium and channel opening. 1 Publication1
Mutagenesisi284E → K: No effect in the coupling between calcium and channel opening. 1 Publication1
Mutagenesisi352T → S: Activated at more negative voltages. Slower rate of inactivation. Impaired inhibition by HMIMP. No effect on channel inhibition by Iberiotoxin. 1 Publication1
Mutagenesisi354 – 356GYG → AAA: Loss of function. 1 Publication3
Mutagenesisi380F → A: Loss of function. 1 Publication1
Mutagenesisi381A → S: Activated at more negative voltages. No effect on inhibition by HMIMP. 1 Publication1
Mutagenesisi384V → I: No effect on activation voltage. No effect on inhibition by HMIMP. 1 Publication1
Mutagenesisi680C → S: Loss of heme-induced channel inhibition. 1 Publication1
Mutagenesisi681H → R: Loss of heme-induced channel inhibition. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
3778

MalaCards human disease database

More...
MalaCardsi
KCNMA1
MIMi609446 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000156113

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79137 Generalized epilepsy-paroxysmal dyskinesia syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA220

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4304

Drug and drug target database

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DrugBanki
DB00436 Bendroflumethiazide
DB00356 Chlorzoxazone
DB01003 Cromoglicic acid
DB01119 Diazoxide
DB01159 Halothane
DB00999 Hydrochlorothiazide
DB00774 Hydroflumethiazide
DB01110 Miconazole
DB00721 Procaine

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
380

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNMA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46396283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000541321 – 1236Calcium-activated potassium channel subunit alpha-1Add BLAST1236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi118S-palmitoyl cysteine2 Publications1
Lipidationi119S-palmitoyl cysteine2 Publications1
Lipidationi121S-palmitoyl cysteine2 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei763PhosphothreonineBy similarity1
Modified residuei765PhosphoserineBy similarity1
Modified residuei778PhosphoserineBy similarity1
Modified residuei782PhosphoserineBy similarity1
Modified residuei970PhosphothreonineBy similarity1
Modified residuei978PhosphoserineBy similarity1
Modified residuei982PhosphoserineBy similarity1
Modified residuei1221PhosphoserineBy similarity1
Modified residuei1224PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity.Curated
Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network.2 Publications

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q12791

PeptideAtlas

More...
PeptideAtlasi
Q12791

PRoteomics IDEntifications database

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PRIDEi
Q12791

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58926
58927 [Q12791-2]
58928 [Q12791-3]
58929 [Q12791-4]
58930 [Q12791-5]
58931 [Q12791-6]
58932 [Q12791-7]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1058

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q12791

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q12791

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q12791

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Except in myocytes, it is almost ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156113 Expressed in 215 organ(s), highest expression level in parotid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q12791 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q12791 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054648

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with RAB11B (By similarity). Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity.By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109979, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q12791

Database of interacting proteins

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DIPi
DIP-29729N

Protein interaction database and analysis system

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IntActi
Q12791, 5 interactors

Molecular INTeraction database

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MINTi
Q12791

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q12791

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q12791

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q12791

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q12791

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini415 – 558RCK N-terminalAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni556 – 576Segment S7Add BLAST21
Regioni613 – 633Segment S8Add BLAST21
Regioni677 – 681Heme-binding motif5
Regioni837 – 857Segment S9Add BLAST21
Regioni1032 – 1052Segment S10Add BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi352 – 355Selectivity for potassium4
Motifi1003 – 1025Calcium bowlAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 10Poly-Gly7
Compositional biasi13 – 20Poly-Gly8
Compositional biasi39 – 60Poly-SerAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The S0 segment is essential for the modulation by the accessory beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4.
The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium.
The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca2+ and Mg2+ (By similarity).By similarity
The calcium bowl constitutes one of the Ca2+ sensors and probably acts as a Ca2+-binding site. There are however other Ca2+ sensors regions required for activation of the channel.
The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154935

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052222

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q12791

KEGG Orthology (KO)

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KOi
K04936

Database for complete collections of gene phylogenies

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PhylomeDBi
Q12791

TreeFam database of animal gene trees

More...
TreeFami
TF314283

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.350, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024939 Ca-act_K_channel_Slo-1
IPR005821 Ion_trans_dom
IPR003929 K_chnl_BK_asu
IPR036291 NAD(P)-bd_dom_sf
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10027:SF28 PTHR10027:SF28, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03493 BK_channel_a, 1 hit
PF00520 Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00169 KCHANNEL

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: May be partially controlled by hormonal stress. Additional isoforms seem to exist.

This entry has 7 described isoforms and 69 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12791-1) [UniParc]FASTAAdd to basket
Also known as: SAKCA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANGGGGGGG SSGGGGGGGG SSLRMSSNIH ANHLSLDASS SSSSSSSSSS
60 70 80 90 100
SSSSSSSSSS VHEPKMDALI IPVTMEVPCD SRGQRMWWAF LASSMVTFFG
110 120 130 140 150
GLFIILLWRT LKYLWTVCCH CGGKTKEAQK INNGSSQADG TLKPVDEKEE
160 170 180 190 200
AVAAEVGWMT SVKDWAGVMI SAQTLTGRVL VVLVFALSIG ALVIYFIDSS
210 220 230 240 250
NPIESCQNFY KDFTLQIDMA FNVFFLLYFG LRFIAANDKL WFWLEVNSVV
260 270 280 290 300
DFFTVPPVFV SVYLNRSWLG LRFLRALRLI QFSEILQFLN ILKTSNSIKL
310 320 330 340 350
VNLLSIFIST WLTAAGFIHL VENSGDPWEN FQNNQALTYW ECVYLLMVTM
360 370 380 390 400
STVGYGDVYA KTTLGRLFMV FFILGGLAMF ASYVPEIIEL IGNRKKYGGS
410 420 430 440 450
YSAVSGRKHI VVCGHITLES VSNFLKDFLH KDRDDVNVEI VFLHNISPNL
460 470 480 490 500
ELEALFKRHF TQVEFYQGSV LNPHDLARVK IESADACLIL ANKYCADPDA
510 520 530 540 550
EDASNIMRVI SIKNYHPKIR IITQMLQYHN KAHLLNIPSW NWKEGDDAIC
560 570 580 590 600
LAELKLGFIA QSCLAQGLST MLANLFSMRS FIKIEEDTWQ KYYLEGVSNE
610 620 630 640 650
MYTEYLSSAF VGLSFPTVCE LCFVKLKLLM IAIEYKSANR ESRILINPGN
660 670 680 690 700
HLKIQEGTLG FFIASDAKEV KRAFFYCKAC HDDITDPKRI KKCGCKRPKM
710 720 730 740 750
SIYKRMRRAC CFDCGRSERD CSCMSGRVRG NVDTLERAFP LSSVSVNDCS
760 770 780 790 800
TSFRAFEDEQ PSTLSPKKKQ RNGGMRNSPN TSPKLMRHDP LLIPGNDQID
810 820 830 840 850
NMDSNVKKYD STGMFHWCAP KEIEKVILTR SEAAMTVLSG HVVVCIFGDV
860 870 880 890 900
SSALIGLRNL VMPLRASNFH YHELKHIVFV GSIEYLKREW ETLHNFPKVS
910 920 930 940 950
ILPGTPLSRA DLRAVNINLC DMCVILSANQ NNIDDTSLQD KECILASLNI
960 970 980 990 1000
KSMQFDDSIG VLQANSQGFT PPGMDRSSPD NSPVHGMLRQ PSITTGVNIP
1010 1020 1030 1040 1050
IITELVNDTN VQFLDQDDDD DPDTELYLTQ PFACGTAFAV SVLDSLMSAT
1060 1070 1080 1090 1100
YFNDNILTLI RTLVTGGATP ELEALIAEEN ALRGGYSTPQ TLANRDRCRV
1110 1120 1130 1140 1150
AQLALLDGPF ADLGDGGCYG DLFCKALKTY NMLCFGIYRL RDAHLSTPSQ
1160 1170 1180 1190 1200
CTKRYVITNP PYEFELVPTD LIFCLMQFDH NAGQSRASLS HSSHSSQSSS
1210 1220 1230
KKSSSVHSIP STANRQNRPK SRESRDKQKY VQEERL
Length:1,236
Mass (Da):137,560
Last modified:April 13, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF9BFEAF374BE553
GO
Isoform 2 (identifier: Q12791-2) [UniParc]FASTAAdd to basket
Also known as: BKTM

The sequence of this isoform differs from the canonical sequence as follows:
     698-756: PKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAF → L
     828-828: L → LVTGWMPYLGPRVLMTCLDIGVVCMPTDIQSTSPASIKKFKE

Show »
Length:1,219
Mass (Da):135,495
Checksum:i932986BE30E0D409
GO
Isoform 3 (identifier: Q12791-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     643-643: R → RSRKR

Show »
Length:1,240
Mass (Da):138,087
Checksum:i83DA8EC8C379A3D9
GO
Isoform 4 (identifier: Q12791-4) [UniParc]FASTAAdd to basket
Also known as: hbr5

The sequence of this isoform differs from the canonical sequence as follows:
     698-756: PKMSIYKRMR...NDCSTSFRAF → LKVAARSRYSKDPFEFKKETPNSRLVTEPV

Show »
Length:1,207
Mass (Da):134,362
Checksum:i7B9C03A8BFA5055B
GO
Isoform 5 (identifier: Q12791-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-756: PKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAF → L

Show »
Length:1,178
Mass (Da):130,999
Checksum:iAD3C9634F8A21EEC
GO
Isoform 6 (identifier: Q12791-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-168: EAQKINNGSS...MTSVKDWAGV → ATHFGSPEMP...ALEVARCRRL
     169-1236: Missing.

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):17,191
Checksum:i101980B6E7017A03
GO
Isoform 7 (identifier: Q12791-7) [UniParc]FASTAAdd to basket
Also known as: gBK

The sequence of this isoform differs from the canonical sequence as follows:
     698-756: PKMSIYKRMR...NDCSTSFRAF → RWEEHCSLWR...PNSRLVTEPV

Show »
Length:1,239
Mass (Da):138,297
Checksum:iCE8B6449D8C7B9CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 69 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PRT6A0A1W2PRT6_HUMAN
Calcium-activated potassium channel...
KCNMA1
383Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SVJ8Q5SVJ8_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D5MRH1D5MRH1_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SVK0Q5SVK0_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZMF5B7ZMF5_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y379H0Y379_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SVJ9Q5SVJ9_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SVK5Q5SVK5_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQ16J3KQ16_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,040Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPY5A0A1W2PPY5_HUMAN
Calcium-activated potassium channel...
KCNMA1
1,230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA50216 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAB65837 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC50353 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK91504 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD06365 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25M → N in AAA50216 (PubMed:7987297).Curated1
Sequence conflicti35S → G in AAA50216 (PubMed:7987297).Curated1
Sequence conflicti38A → V in AAA85104 (PubMed:7877450).Curated1
Sequence conflicti449N → D in AAD31173 (Ref. 12) Curated1
Sequence conflicti805N → H in AAC50353 (PubMed:7993625).Curated1
Sequence conflicti1152T → A in AAD31173 (Ref. 12) Curated1
Sequence conflicti1230 – 1236YVQEERL → KEMVYR in CAI39730 (PubMed:15164054).Curated7
Sequence conflicti1230 – 1236YVQEERL → KEMVYR in CAI40870 (PubMed:15164054).Curated7
Sequence conflicti1230 – 1236YVQEERL → KEMVYR in CAI14074 (PubMed:15164054).Curated7
Sequence conflicti1230 – 1236YVQEERL → KEMVYR in CAI16162 (PubMed:15164054).Curated7
Isoform 7 (identifier: Q12791-7)
Sequence conflicti726 – 727FS → SF no nucleotide entry (PubMed:11880513).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023821434D → G in PNKD3; may have a synergistic effect with ethanol in the triggering of symptoms. 1 PublicationCorresponds to variant dbSNP:rs137853333EnsemblClinVar.1
Natural variantiVAR_079156884E → K in PNKD3. 1 Publication1
Natural variantiVAR_0791571053N → S in PNKD3. 1 PublicationCorresponds to variant dbSNP:rs886039469Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009952127 – 168EAQKI…DWAGV → ATHFGSPEMPPAARSWSGSP PEAAVLRGASSLALEVARCR RL in isoform 6. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_009953169 – 1236Missing in isoform 6. 1 PublicationAdd BLAST1068
Alternative sequenceiVSP_009954643R → RSRKR in isoform 3. 1 Publication1
Alternative sequenceiVSP_009955698 – 756PKMSI…SFRAF → L in isoform 2 and isoform 5. 9 PublicationsAdd BLAST59
Alternative sequenceiVSP_009956698 – 756PKMSI…SFRAF → LKVAARSRYSKDPFEFKKET PNSRLVTEPV in isoform 4. 2 PublicationsAdd BLAST59
Alternative sequenceiVSP_009957698 – 756PKMSI…SFRAF → RWEEHCSLWRLESKGNVRRL NYCRGQQTFSVKVKVAARSR YSKDPFEFKKETPNSRLVTE PV in isoform 7. CuratedAdd BLAST59
Alternative sequenceiVSP_009958828L → LVTGWMPYLGPRVLMTCLDI GVVCMPTDIQSTSPASIKKF KE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U13913 mRNA Translation: AAA85104.1
U23767 mRNA Translation: AAA92290.1
AL157833
, AL731560, AL731556, AL627447, AC021032, AC011439 Genomic DNA Translation: CAI39730.1
AL157833
, AC011439, AC021032, AL627447, AL731556, AL731560 Genomic DNA Translation: CAI39736.1
AL627447
, AL731560, AL731556, AC021032, AC011439, AL157833 Genomic DNA Translation: CAI16162.1
AL627447
, AC011439, AC021032, AL157833, AL731556, AL731560 Genomic DNA Translation: CAI16171.1
AL731556
, AC011439, AL157833, AC021032, AL731560, AL627447 Genomic DNA Translation: CAI14074.1
AL731556
, AC011439, AC021032, AL157833, AL627447, AL731560 Genomic DNA Translation: CAI14082.1
AL731560
, AL157833, AL731556, AC021032, AC011439, AL627447 Genomic DNA Translation: CAI40870.1
AL731560
, AC011439, AC021032, AL157833, AL627447, AL731556 Genomic DNA Translation: CAI40877.1
AC067745 Genomic DNA No translation available.
AL607069 Genomic DNA No translation available.
AL731575 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54599.1
BC062659 mRNA Translation: AAH62659.1
BC137115 mRNA Translation: AAI37116.1
BC137137 mRNA Translation: AAI37138.1
U11717 mRNA Translation: AAC50353.1 Different initiation.
AY040849 mRNA Translation: AAK91504.1 Different initiation.
AB113575 mRNA Translation: BAD06397.1
AB113382 mRNA Translation: BAD06365.1 Different initiation.
U02632 mRNA Translation: AAA50173.1
U09384 mRNA Translation: AAA50216.1 Sequence problems.
AF025999 mRNA Translation: AAB88802.1
U11058 mRNA Translation: AAB65837.1 Different initiation.
AF118141 mRNA Translation: AAD31173.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53545.1 [Q12791-2]
CCDS60569.1 [Q12791-1]
CCDS60571.1 [Q12791-6]
CCDS7352.1 [Q12791-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38596
S62904

NCBI Reference Sequences

More...
RefSeqi
NP_001014797.1, NM_001014797.2
NP_001154824.1, NM_001161352.1 [Q12791-1]
NP_001154825.1, NM_001161353.1 [Q12791-2]
NP_001258447.1, NM_001271518.1
NP_001258451.1, NM_001271522.1 [Q12791-6]
NP_002238.2, NM_002247.3 [Q12791-5]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.144795
Hs.658064

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286627; ENSP00000286627; ENSG00000156113 [Q12791-5]
ENST00000286628; ENSP00000286628; ENSG00000156113 [Q12791-1]
ENST00000434208; ENSP00000402150; ENSG00000156113 [Q12791-4]
ENST00000480683; ENSP00000474686; ENSG00000156113 [Q12791-6]
ENST00000626620; ENSP00000485867; ENSG00000156113 [Q12791-2]
ENST00000638575; ENSP00000492049; ENSG00000156113 [Q12791-7]
ENST00000638759; ENSP00000492632; ENSG00000156113 [Q12791-3]
ENST00000640969; ENSP00000492200; ENSG00000156113 [Q12791-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3778

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3778

UCSC genome browser

More...
UCSCi
uc001jxm.4 human [Q12791-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13913 mRNA Translation: AAA85104.1
U23767 mRNA Translation: AAA92290.1
AL157833
, AL731560, AL731556, AL627447, AC021032, AC011439 Genomic DNA Translation: CAI39730.1
AL157833
, AC011439, AC021032, AL627447, AL731556, AL731560 Genomic DNA Translation: CAI39736.1
AL627447
, AL731560, AL731556, AC021032, AC011439, AL157833 Genomic DNA Translation: CAI16162.1
AL627447
, AC011439, AC021032, AL157833, AL731556, AL731560 Genomic DNA Translation: CAI16171.1
AL731556
, AC011439, AL157833, AC021032, AL731560, AL627447 Genomic DNA Translation: CAI14074.1
AL731556
, AC011439, AC021032, AL157833, AL627447, AL731560 Genomic DNA Translation: CAI14082.1
AL731560
, AL157833, AL731556, AC021032, AC011439, AL627447 Genomic DNA Translation: CAI40870.1
AL731560
, AC011439, AC021032, AL157833, AL627447, AL731556 Genomic DNA Translation: CAI40877.1
AC067745 Genomic DNA No translation available.
AL607069 Genomic DNA No translation available.
AL731575 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54599.1
BC062659 mRNA Translation: AAH62659.1
BC137115 mRNA Translation: AAI37116.1
BC137137 mRNA Translation: AAI37138.1
U11717 mRNA Translation: AAC50353.1 Different initiation.
AY040849 mRNA Translation: AAK91504.1 Different initiation.
AB113575 mRNA Translation: BAD06397.1
AB113382 mRNA Translation: BAD06365.1 Different initiation.
U02632 mRNA Translation: AAA50173.1
U09384 mRNA Translation: AAA50216.1 Sequence problems.
AF025999 mRNA Translation: AAB88802.1
U11058 mRNA Translation: AAB65837.1 Different initiation.
AF118141 mRNA Translation: AAD31173.1
CCDSiCCDS53545.1 [Q12791-2]
CCDS60569.1 [Q12791-1]
CCDS60571.1 [Q12791-6]
CCDS7352.1 [Q12791-5]
PIRiI38596
S62904
RefSeqiNP_001014797.1, NM_001014797.2
NP_001154824.1, NM_001161352.1 [Q12791-1]
NP_001154825.1, NM_001161353.1 [Q12791-2]
NP_001258447.1, NM_001271518.1
NP_001258451.1, NM_001271522.1 [Q12791-6]
NP_002238.2, NM_002247.3 [Q12791-5]
UniGeneiHs.144795
Hs.658064

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K44NMR-A257-284[»]
3MT5X-ray3.00A406-1179[»]
3NAFX-ray3.10A395-681[»]
A782-1182[»]
ProteinModelPortaliQ12791
SMRiQ12791
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109979, 12 interactors
CORUMiQ12791
DIPiDIP-29729N
IntActiQ12791, 5 interactors
MINTiQ12791

Chemistry databases

BindingDBiQ12791
ChEMBLiCHEMBL4304
DrugBankiDB00436 Bendroflumethiazide
DB00356 Chlorzoxazone
DB01003 Cromoglicic acid
DB01119 Diazoxide
DB01159 Halothane
DB00999 Hydrochlorothiazide
DB00774 Hydroflumethiazide
DB01110 Miconazole
DB00721 Procaine
GuidetoPHARMACOLOGYi380

PTM databases

GlyConnecti1058
iPTMnetiQ12791
PhosphoSitePlusiQ12791
SwissPalmiQ12791

Polymorphism and mutation databases

BioMutaiKCNMA1
DMDMi46396283

Proteomic databases

MaxQBiQ12791
PeptideAtlasiQ12791
PRIDEiQ12791
ProteomicsDBi58926
58927 [Q12791-2]
58928 [Q12791-3]
58929 [Q12791-4]
58930 [Q12791-5]
58931 [Q12791-6]
58932 [Q12791-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286627; ENSP00000286627; ENSG00000156113 [Q12791-5]
ENST00000286628; ENSP00000286628; ENSG00000156113 [Q12791-1]
ENST00000434208; ENSP00000402150; ENSG00000156113 [Q12791-4]
ENST00000480683; ENSP00000474686; ENSG00000156113 [Q12791-6]
ENST00000626620; ENSP00000485867; ENSG00000156113 [Q12791-2]
ENST00000638575; ENSP00000492049; ENSG00000156113 [Q12791-7]
ENST00000638759; ENSP00000492632; ENSG00000156113 [Q12791-3]
ENST00000640969; ENSP00000492200; ENSG00000156113 [Q12791-4]
GeneIDi3778
KEGGihsa:3778
UCSCiuc001jxm.4 human [Q12791-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3778
DisGeNETi3778
EuPathDBiHostDB:ENSG00000156113.20

GeneCards: human genes, protein and diseases

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GeneCardsi
KCNMA1
HGNCiHGNC:6284 KCNMA1
HPAiHPA054648
MalaCardsiKCNMA1
MIMi600150 gene
609446 phenotype
neXtProtiNX_Q12791
OpenTargetsiENSG00000156113
Orphaneti79137 Generalized epilepsy-paroxysmal dyskinesia syndrome
PharmGKBiPA220

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154935
HOVERGENiHBG052222
InParanoidiQ12791
KOiK04936
PhylomeDBiQ12791
TreeFamiTF314283

Enzyme and pathway databases

ReactomeiR-HSA-1296052 Ca2+ activated K+ channels
R-HSA-418457 cGMP effects
SIGNORiQ12791

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KCNMA1 human
EvolutionaryTraceiQ12791

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3778

Protein Ontology

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PROi
PR:Q12791

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156113 Expressed in 215 organ(s), highest expression level in parotid gland
ExpressionAtlasiQ12791 baseline and differential
GenevisibleiQ12791 HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR024939 Ca-act_K_channel_Slo-1
IPR005821 Ion_trans_dom
IPR003929 K_chnl_BK_asu
IPR036291 NAD(P)-bd_dom_sf
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10027:SF28 PTHR10027:SF28, 1 hit
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCMA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12791
Secondary accession number(s): F8WA96
, Q12886, Q12917, Q12921, Q12960, Q13150, Q5JQ23, Q5SQR9, Q96LG8, Q9UBB0, Q9UCX0, Q9UQK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: December 5, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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