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UniProtKB - Q12789 (TF3C1_HUMAN)

Entry version 173 (12 Aug 2020)
Sequence version 4 (25 Nov 2008)
Previous versions | rss
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Protein

General transcription factor 3C polypeptide 1

Gene

GTF3C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q12789

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
General transcription factor 3C polypeptide 1
Alternative name(s):
TF3C-alpha
TFIIIC box B-binding subunit
Transcription factor IIIC 220 kDa subunit
Short name:
TFIIIC 220 kDa subunit
Short name:
TFIIIC220
Transcription factor IIIC subunit alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GTF3C1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000077235.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:4664, GTF3C1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603246, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q12789

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2975

Open Targets

More...OpenTargetsi		ENSG00000077235

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29052

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q12789, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GTF3C1

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274233

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002097101 – 2109General transcription factor 3C polypeptide 1Add BLAST2109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki529Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei667PhosphoserineCombined sources1
Modified residuei739PhosphoserineCombined sources1
Cross-linki770Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki833Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1062PhosphoserineCombined sources1
Modified residuei1068PhosphoserineCombined sources1
Cross-linki1142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1253PhosphoserineCombined sources1
Modified residuei1611PhosphoserineCombined sources1
Modified residuei1632PhosphoserineCombined sources1
Modified residuei1653PhosphoserineCombined sources1
Modified residuei1856PhosphoserineCombined sources1
Modified residuei1865PhosphoserineCombined sources1
Modified residuei1868PhosphoserineCombined sources1
Modified residuei1896PhosphoserineBy similarity1
Modified residuei1911PhosphoserineCombined sources1
Modified residuei1969PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q12789

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q12789

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q12789

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q12789

PeptideAtlas

More...PeptideAtlasi		Q12789

PRoteomics IDEntifications database

More...PRIDEi		Q12789

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58924 [Q12789-2]
58925 [Q12789-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q12789

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q12789

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q12789

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000077235, Expressed in adenohypophysis and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q12789, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q12789, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000077235, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6 (PubMed:19299493).

Interacts with IGHMBP2.

Interacts with MAF1 (PubMed:18377933).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109230, 129 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q12789

Database of interacting proteins

More...DIPi		DIP-38212N

Protein interaction database and analysis system

More...IntActi		Q12789, 69 interactors

Molecular INTeraction database

More...MINTi		Q12789

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000348510

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q12789, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q12789

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi343 – 351Asp/Glu-rich (acidic)9
Compositional biasi1205 – 1233Arg/Lys-rich (basic)Add BLAST29
Compositional biasi1613 – 1624Asp/Glu-rich (acidic)Add BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TFIIIC subunit 1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4560, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008664

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001556_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q12789

KEGG Orthology (KO)

More...KOi		K15199

Identification of Orthologs from Complete Genome Data

More...OMAi		IFDNAPQ

Database of Orthologous Groups

More...OrthoDBi		143012at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q12789

TreeFam database of animal gene trees

More...TreeFami		TF351624

Family and domain databases

Conserved Domains Database

More...CDDi		cd16169, Tau138_eWH, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035625, Tfc3_eWH
IPR007309, TFIIIC_Bblock-bd

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04182, B-block_TFIIIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q12789-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDALESLLDE VALEGLDGLC LPALWSRLET RVPPFPLPLE PCTQEFLWRA 
        60         70         80         90        100
LATHPGISFY EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVALEDVYPI 
       110        120        130        140        150
HMILENKDGI QGSCRYFKER KNITNDIRTK SLQPRCTMVE AFDRWGKKLI 
       160        170        180        190        200
IVASQAMRYR ALIGQEGDPD LKLPDFSYCI LERLGRSRWQ GELQRDLHTT 
       210        220        230        240        250
AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI LLLLNRFHVD 
       260        270        280        290        300
RRSKYDILME KLSVMLSTRT NHIETLGKLR EELGLCERTF KRLYQYMLNA 
       310        320        330        340        350
GLAKVVSLRL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RNDHDDDEDE 
       360        370        380        390        400
EVISKTVPPV DIVFERDMLT QTYDLIERRG TKGISQAEIR VAMNVGKLEA 
       410        420        430        440        450
RMLCRLLQRF KVVKGFMEDE GRQRTTKYIS CVFAEESDLS RQYQREKARS 
       460        470        480        490        500
ELLTTVSLAS MQEESLLPEG EDTFLSESDS EEERSSSKRR GRGSQKDTRA 
       510        520        530        540        550
SANLRPKTQP HHSTPTKGGW KVVNLHPLKK QPPSFPGAAE ERACQSLASR 
       560        570        580        590        600
DSLLDTSSVS EPNVSFVSHC ADSNSGDIAV IEEVRMENPK ESSSSLKTGR 
       610        620        630        640        650
HSSGQDKPHE TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV 
       660        670        680        690        700
STKCCKKSIV RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND 
       710        720        730        740        750
PLVRSAIEQV RFRISNSSTA NRVKTSQPPV PQGEAEEDSQ GKEGPSGSGD 
       760        770        780        790        800
SQLSASSRSE SGRMKKSDNK MGITPLRNYH PIVVPGLGRS LGFLPKMPRL 
       810        820        830        840        850
RVVHMFLWYL IYGHPASNTV EKPSFISERR TIKQESGRAG VRPSSSGSAW 
       860        870        880        890        900
EACSEAPSKG SQDGVTWEAE VELATETVYV DDASWMRYIP PIPVHRDFGF 
       910        920        930        940        950
GWALVSDILL CLPLSIFIQI VQVSYKVDNL EEFLNDPLKK HTLIRFLPRP 
       960        970        980        990       1000
IRQQLLYKRR YIFSVVENLQ RLCYMGLLQF GPTEKFQDKD QVFIFLKKNA 
      1010       1020       1030       1040       1050
VIVDTTICDP HYNLARSSRP FERRLYVLNS MQDVENYWFD LQCVCLNTPL 
      1060       1070       1080       1090       1100
GVVRCPRVRK NSSTDQGSDE EGSLQKEQES AMDKHNLERK CAMLEYTTGS 
      1110       1120       1130       1140       1150
REVVDEGLIP GDGLGAAGLD SSFYGHLKRN WIWTSYIINQ AKKENTAAEN 
      1160       1170       1180       1190       1200
GLTVRLQTFL SKRPMPLSAR GNSRLNIWGE ARVGSELCAG WEEQFEVDRE 
      1210       1220       1230       1240       1250
PSLDRNRRVR GGKSQKRKRL KKDPGKKIKR KKKGEFPGEK SKRLRYHDEA 
      1260       1270       1280       1290       1300
DQSALQRMTR LRVTWSMQED GLLVLCRIAS NVLNTKVKGP FVTWQVVRDI 
      1310       1320       1330       1340       1350
LHATFEESLD KTSHSVGRRA RYIVKNPQAY LNYKVCLAEV YQDKALVGDF 
      1360       1370       1380       1390       1400
MNRRGDYDDP KVCANEFKEF VEKLKEKFSS ALRNSNLEIP DTLQELFARY 
      1410       1420       1430       1440       1450
RVLAIGDEKD QTRKEDELNS VDDIHFLVLQ NLIQSTLALS DSQMKSYQSF 
      1460       1470       1480       1490       1500
QTFRLYREYK DHVLVKAFME CQKRSLVNRR RVNHTLGPKK NRALPFVPMS 
      1510       1520       1530       1540       1550
YQLSQTYYRI FTWRFPSTIC TESFQFLDRM RAAGKLDQPD RFSFKDQDNN 
      1560       1570       1580       1590       1600
EPTNDMVAFS LDGPGGNCVA VLTLFSLGLI SVDVRIPEQI IVVDSSMVEN 
      1610       1620       1630       1640       1650
EVIKSLGKDG SLEDDEDEED DLDEGVGGKR RSMEVKPAQA SHTNYLLMRG 
      1660       1670       1680       1690       1700
YYSPGIVSTR NLNPNDSIVV NSCQMKFQLR CTPVPARLRP AAAPLEELTM 
      1710       1720       1730       1740       1750
GTSCLPDTFT KLINPQENTC SLEEFVLQLE LSGYSPEDLT AALEILEAII 
      1760       1770       1780       1790       1800
ATGCFGIDKE ELRRRFSALE KAGGGRTRTF ADCIQALLEQ HQVLEVGGNT 
      1810       1820       1830       1840       1850
ARLVAMGSAW PWLLHSVRLK DREDADIQRE DPQARPLEGS SSEDSPPEGQ 
      1860       1870       1880       1890       1900
APPSHSPRGT KRRASWASEN GETDAEGTQM TPAKRPALQD SNLAPSLGPG 
      1910       1920       1930       1940       1950
AEDGAEAQAP SPPPALEDTA AAGAAQEDQE GVGEFSSPGQ EQLSGQAQPP 
      1960       1970       1980       1990       2000
EGSEDPRGFT ESFGAANISQ AARERDCESV CFIGRPWRVV DGHLNLPVCK 
      2010       2020       2030       2040       2050
GMMEAMLYHI MTRPGIPESS LLRHYQGVLQ PVAVLELLQG LESLGCIRKR 
      2060       2070       2080       2090       2100
WLRKPRPVSL FSTPVVEEVE VPSSLDESPM AFYEPTLDCT LRLGRVFPHE 

VNWNKWIHL
Length:2,109
Mass (Da):238,875
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37A03135EFE695FC
GO
Isoform 2 (identifier: Q12789-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1933-1957: Missing.

Show »
Length:2,084
Mass (Da):236,278
Checksum:iD1D74F05BF1C6051
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BU37H3BU37_HUMAN
General transcription factor 3C pol...
GTF3C1
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU55H3BU55_HUMAN
General transcription factor 3C pol...
GTF3C1
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRD0H3BRD0_HUMAN
General transcription factor 3C pol...
GTF3C1
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1Z3I3L1Z3_HUMAN
General transcription factor 3C pol...
GTF3C1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA17985 differs from that shown. Reason: Frameshift.Curated
The sequence AAA85638 differs from that shown. Contaminating sequence. Potential vector sequence at the N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141A → P in AAA17985 (PubMed:8127861).Curated1
Sequence conflicti153A → P in AAA17985 (PubMed:8127861).Curated1
Sequence conflicti156A → P in AAA17985 (PubMed:8127861).Curated1
Sequence conflicti161A → P in AAA17985 (PubMed:8127861).Curated1
Sequence conflicti164G → A in AAA17985 (PubMed:8127861).Curated1
Sequence conflicti977L → V in AAA17985 (PubMed:8127861).Curated1
Sequence conflicti1015 – 1018ARSS → GRRR in AAA17985 (PubMed:8127861).Curated4
Sequence conflicti1256Q → H in AAA17985 (PubMed:8127861).Curated1
Sequence conflicti1316V → L in AAA17985 (PubMed:8127861).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0475341889Q → E. Corresponds to variant dbSNP:rs35233306Ensembl.1
Natural variantiVAR_0475351959F → S. Corresponds to variant dbSNP:rs12919017Ensembl.1
Natural variantiVAR_0475362077E → K. Corresponds to variant dbSNP:rs2228248Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0218191933 – 1957Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U02619 mRNA Translation: AAA17985.1 Frameshift.
AC002303 Genomic DNA Translation: AAB67637.1
AC025275 Genomic DNA No translation available.
AC002551 Genomic DNA Translation: AAC05811.1
BC044857 mRNA Translation: AAH44857.1
BC137229 mRNA Translation: AAI37230.1
U06485 mRNA Translation: AAA85638.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32414.1 [Q12789-2]
CCDS66988.1 [Q12789-3]

Protein sequence database of the Protein Information Resource

More...PIRi		B56011
I38414

NCBI Reference Sequences

More...RefSeqi		NP_001273171.1, NM_001286242.1 [Q12789-3]
NP_001511.2, NM_001520.3 [Q12789-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356183; ENSP00000348510; ENSG00000077235 [Q12789-2]
ENST00000561623; ENSP00000455417; ENSG00000077235 [Q12789-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2975

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2975

UCSC genome browser

More...UCSCi		uc002dou.4, human [Q12789-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02619 mRNA Translation: AAA17985.1 Frameshift.
AC002303 Genomic DNA Translation: AAB67637.1
AC025275 Genomic DNA No translation available.
AC002551 Genomic DNA Translation: AAC05811.1
BC044857 mRNA Translation: AAH44857.1
BC137229 mRNA Translation: AAI37230.1
U06485 mRNA Translation: AAA85638.1 Sequence problems.
CCDSiCCDS32414.1 [Q12789-2]
CCDS66988.1 [Q12789-3]
PIRiB56011
I38414
RefSeqiNP_001273171.1, NM_001286242.1 [Q12789-3]
NP_001511.2, NM_001520.3 [Q12789-2]

3D structure databases

SMRiQ12789
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109230, 129 interactors
CORUMiQ12789
DIPiDIP-38212N
IntActiQ12789, 69 interactors
MINTiQ12789
STRINGi9606.ENSP00000348510

PTM databases

iPTMnetiQ12789
MetOSiteiQ12789
PhosphoSitePlusiQ12789

Polymorphism and mutation databases

BioMutaiGTF3C1
DMDMi215274233

Proteomic databases

EPDiQ12789
jPOSTiQ12789
MassIVEiQ12789
PaxDbiQ12789
PeptideAtlasiQ12789
PRIDEiQ12789
ProteomicsDBi58924 [Q12789-2]
58925 [Q12789-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26269, 30 antibodies

Genome annotation databases

EnsembliENST00000356183; ENSP00000348510; ENSG00000077235 [Q12789-2]
ENST00000561623; ENSP00000455417; ENSG00000077235 [Q12789-3]
GeneIDi2975
KEGGihsa:2975
UCSCiuc002dou.4, human [Q12789-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2975
DisGeNETi2975
EuPathDBiHostDB:ENSG00000077235.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		GTF3C1
HGNCiHGNC:4664, GTF3C1
HPAiENSG00000077235, Low tissue specificity
MIMi603246, gene
neXtProtiNX_Q12789
OpenTargetsiENSG00000077235
PharmGKBiPA29052

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4560, Eukaryota
GeneTreeiENSGT00390000008664
HOGENOMiCLU_001556_1_0_1
InParanoidiQ12789
KOiK15199
OMAiIFDNAPQ
OrthoDBi143012at2759
PhylomeDBiQ12789
TreeFamiTF351624

Enzyme and pathway databases

PathwayCommonsiQ12789
ReactomeiR-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2975, 625 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GTF3C1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GTF3C1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2975
PharosiQ12789, Tbio

Protein Ontology

More...PROi		PR:Q12789
RNActiQ12789, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000077235, Expressed in adenohypophysis and 238 other tissues
ExpressionAtlasiQ12789, baseline and differential
GenevisibleiQ12789, HS

Family and domain databases

CDDicd16169, Tau138_eWH, 1 hit
InterProiView protein in InterPro
IPR035625, Tfc3_eWH
IPR007309, TFIIIC_Bblock-bd
PfamiView protein in Pfam
PF04182, B-block_TFIIIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTF3C1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q12789
Secondary accession number(s): B2RP21
, Q12838, Q6DKN9, Q9Y4W9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 25, 2008
Last modified: August 12, 2020
This is version 173 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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