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Protein

General transcription factor 3C polypeptide 1

Gene

GTF3C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 1
Alternative name(s):
TF3C-alpha
TFIIIC box B-binding subunit
Transcription factor IIIC 220 kDa subunit
Short name:
TFIIIC 220 kDa subunit
Short name:
TFIIIC220
Transcription factor IIIC subunit alpha
Gene namesi
Name:GTF3C1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000077235.17
HGNCiHGNC:4664 GTF3C1
MIMi603246 gene
neXtProtiNX_Q12789

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2975
OpenTargetsiENSG00000077235
PharmGKBiPA29052

Polymorphism and mutation databases

BioMutaiGTF3C1
DMDMi215274233

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097101 – 2109General transcription factor 3C polypeptide 1Add BLAST2109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki529Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei667PhosphoserineCombined sources1
Modified residuei739PhosphoserineCombined sources1
Cross-linki770Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki833Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1062PhosphoserineCombined sources1
Modified residuei1068PhosphoserineCombined sources1
Cross-linki1142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1253PhosphoserineCombined sources1
Modified residuei1611PhosphoserineCombined sources1
Modified residuei1632PhosphoserineCombined sources1
Modified residuei1653PhosphoserineCombined sources1
Modified residuei1856