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Protein

Transducin beta-like protein 3

Gene

TBL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ12788

Names & Taxonomyi

Protein namesi
Recommended name:
Transducin beta-like protein 3
Alternative name(s):
WD repeat-containing protein SAZD
Gene namesi
Name:TBL3
Synonyms:SAZD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000183751.14
HGNCiHGNC:11587 TBL3
MIMi605915 gene
neXtProtiNX_Q12788

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10607
OpenTargetsiENSG00000183751
PharmGKBiPA36351

Polymorphism and mutation databases

BioMutaiTBL3
DMDMi223634675

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000512722 – 808Transducin beta-like protein 3Add BLAST807

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Cross-linki407Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ12788
MaxQBiQ12788
PaxDbiQ12788
PeptideAtlasiQ12788
PRIDEiQ12788
ProteomicsDBi58923

2D gel databases

SWISS-2DPAGEiQ12788

PTM databases

iPTMnetiQ12788
PhosphoSitePlusiQ12788
SwissPalmiQ12788

Expressioni

Gene expression databases

BgeeiENSG00000183751
CleanExiHS_TBL3
ExpressionAtlasiQ12788 baseline and differential
GenevisibleiQ12788 HS

Organism-specific databases

HPAiHPA042562
HPA055695

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926244EBI-715766,EBI-743771

Protein-protein interaction databases

BioGridi115853, 60 interactors
CORUMiQ12788
IntActiQ12788, 23 interactors
MINTiQ12788
STRINGi9606.ENSP00000454836

Structurei

3D structure databases

ProteinModelPortaliQ12788
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 105WD 1Add BLAST42
Repeati107 – 146WD 2Add BLAST40
Repeati149 – 190WD 3Add BLAST42
Repeati193 – 232WD 4Add BLAST40
Repeati245 – 284WD 5Add BLAST40
Repeati290 – 329WD 6Add BLAST40
Repeati332 – 372WD 7Add BLAST41
Repeati374 – 413WD 8Add BLAST40
Repeati419 – 459WD 9Add BLAST41
Repeati477 – 516WD 10Add BLAST40
Repeati519 – 560WD 11Add BLAST42
Repeati562 – 602WD 12Add BLAST41
Repeati604 – 642WD 13Add BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0319 Eukaryota
ENOG410XPQD LUCA
GeneTreeiENSGT00910000144102
HOGENOMiHOG000188765
HOVERGENiHBG058869
InParanoidiQ12788
KOiK14555
OMAiDFLWHNM
OrthoDBiEOG091G029V
PhylomeDBiQ12788
TreeFamiTF314872

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011044 Quino_amine_DH_bsu
IPR013934 SSU_processome_Utp13
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08625 Utp13, 1 hit
PF00400 WD40, 8 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 13 hits
SUPFAMiSSF50969 SSF50969, 1 hit
SSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 8 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12788-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETAAGVGR FKTNYAVERK IEPFYKGGKA QLDQTGQHLF CVCGTRVNIL
60 70 80 90 100
EVASGAVLRS LEQEDQEDIT AFDLSPDNEV LVTASRALLL AQWAWQEGSV
110 120 130 140 150
TRLWKAIHTA PVATMAFDPT STLLATGGCD GAVRVWDIVR HYGTHHFRGS
160 170 180 190 200
PGVVHLVAFH PDPTRLLLFS SATDAAIRVW SLQDRSCLAV LTAHYSAVTS
210 220 230 240 250
LAFSADGHTM LSSGRDKICI IWDLQSCQAT RTVPVFESVE AAVLLPEEPV
260 270 280 290 300
SQLGVKSPGL YFLTAGDQGT LRVWEAASGQ CVYTQAQPPG PGQELTHCTL
310 320 330 340 350
AHTAGVVLTA TADHNLLLYE ARSLRLQKQF AGYSEEVLDV RFLGPEDSHV
360 370 380 390 400
VVASNSPCLK VFELQTSACQ ILHGHTDIVL ALDVFRKGWL FASCAKDQSV
410 420 430 440 450
RIWRMNKAGQ VMCVAQGSGH THSVGTVCCS RLKESFLVTG SQDCTVKLWP
460 470 480 490 500
LPKALLSKNT APDNGPILLQ AQTTQRCHDK DINSVAIAPN DKLLATGSQD
510 520 530 540 550
RTAKLWALPQ CQLLGVFSGH RRGLWCVQFS PMDQVLATAS ADGTIKLWAL
560 570 580 590 600
QDFSCLKTFE GHDASVLKVA FVSRGTQLLS SGSDGLVKLW TIKNNECVRT
610 620 630 640 650
LDAHEDKVWG LHCSRLDDHA LTGASDSRVI LWKDVTEAEQ AEEQARQEEQ
660 670 680 690 700
VVRQQELDNL LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE
710 720 730 740 750
ATMLRLRRDQ KEALLRFCVT WNTNSRHCHE AQAVLGVLLR REAPEELLAY
760 770 780 790 800
EGVRAALEAL LPYTERHFQR LSRTLQAAAF LDFLWHNMKL PVPAAAPTPW

ETHKGALP
Length:808
Mass (Da):89,035
Last modified:February 10, 2009 - v2
Checksum:i01BDF217F8D17D30
GO

Sequence cautioni

The sequence AAA18945 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence BAD92410 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104W → S in AAH35409 (PubMed:15489334).Curated1
Sequence conflicti472Q → H in AAA18945 (PubMed:8307582).Curated1
Sequence conflicti566V → L in AAA18945 (PubMed:8307582).Curated1
Sequence conflicti639 – 640EQ → DE in AAA18945 (PubMed:8307582).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054320293Q → R1 PublicationCorresponds to variant dbSNP:rs2230086Ensembl.1
Natural variantiVAR_054321294E → Q. Corresponds to variant dbSNP:rs8052713Ensembl.1
Natural variantiVAR_014479457S → P1 PublicationCorresponds to variant dbSNP:rs17605Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02609 mRNA Translation: AAA18945.1 Frameshift.
AB209173 mRNA Translation: BAD92410.1 Different initiation.
AC005363 Genomic DNA No translation available.
AC005606 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85589.1
BC010231 mRNA Translation: AAH10231.1
BC014007 mRNA Translation: AAH14007.1
BC035409 mRNA Translation: AAH35409.1
CCDSiCCDS10453.1
PIRiA49367
RefSeqiNP_006444.2, NM_006453.2
UniGeneiHs.513267

Genome annotation databases

EnsembliENST00000568546; ENSP00000454836; ENSG00000183751
GeneIDi10607
KEGGihsa:10607
UCSCiuc002cnu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTBL3_HUMAN
AccessioniPrimary (citable) accession number: Q12788
Secondary accession number(s): Q59GD6, Q8IVB7, Q96A78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 10, 2009
Last modified: June 20, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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